#ID ; Name ; CAS ; Year ; Status ; Primary_Target ; ATC_code ; PDB_code ; DrugCentral_main_targets 1 ; SULFAPYRIDINE ; 144-83-2 ; 1939 ; DISCONTINUED ; ; ATC (SULFAPYRIDINE) J01EB04 ; PDB 4HWK (CRYSTAL STRUCTURE OF HUMAN SEPIAPTERIN REDUCTASE IN COMPLEX WITH SULFAPYRIDINE) - ligand code SFY ; Dihydropteroate synthase UNIPROT P0AC13 folP 2 ; TRIPTORELIN ; 57773-63-4 ; 2000 ; ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR (GNRH RECEPTOR) ; ATC (TRIPTORELIN) L02AE04 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 3 ; HISTAMINE ; 51-45-6 ; 1939 ; DISCONTINUED ; TARGET HISTAMINE RECEPTOR ; ATC (HISTAMINE PHOSPHATE) V04CG03 ; PDB 1AVN (HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR) - ligand code HSM ; Histamine H1 receptor UNIPROT P35367 HRH1 4 ; BUTABARBITAL ; 125-40-6 ; 1939 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA) ; ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 5 ; DESOXYCORTICOSTERONE ACETATE ; 56-47-3 ; 1939 ; DISCONTINUED ; TARGET ALDOSTERONE SYNTHASE ; ATC (DESOXYCORTONE) H02AA03 ; PDB 4DVQ (HUMAN ALDOSTERONE SYNTHASE PMID23322723) ; Mineralocorticoid receptor UNIPROT P08235 NR3C2 6 ; DESOXYCORTICOSTERONE PIVALATE ; 808-48-0 ; 0 ; DISCONTINUED ; TARGET ALDOSTERONE SYNTHASE ; ATC (DESOXYCORTONE) H02AA03 ; PDB 4DVQ (HUMAN ALDOSTERONE SYNTHASE PMID23322723) ; Mineralocorticoid receptor UNIPROT P08235 NR3C2 7 ; GUANIDINE ; 113-00-8 ; 1939 ; DISCONTINUED ; ; ; PDB 1O04 (CYS302SER MUTANT OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+) - ligand code GAI ; Voltage-gated potassium channel UNIPROT O43525 KCNQ3 8 ; MENADIONE ; 58-27-5 ; 0 ; DISCONTINUED ; ; ATC (MENADIONE) B02BA02 ; PDB 1TUV (CRYSTAL STRUCTURE OF YGIN IN COMPLEX WITH MENADIONE) - ligand code VK3 ; Amine oxidase flavin-containing A UNIPROT P21397 MAOA 9 ; THEOPHYLLINE ; 58-55-9 ; 1940 ; ; TARGET PHOSPHODIESTERASE III -- PHOSPHODIESTERASE IV ; ATC (THEOPHYLLINE) R03DA04 R03DB04 R03DA54 R03DA74 ; PDB 1EHT (THEOPHYLLINE-BINDING RNA IN COMPLEX WITH THEOPHYLLINE, NMR, 10 STRUCTURES) - ligand code TEP ; Adenosine receptor A2a UNIPROT P29274 ADORA2A -- cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A 10 ; ERGOCALCIFEROL ; 50-14-6 ; 1941 ; ; TARGET VITAMIN D3 RECEPTOR ; ATC (ERGOCALCIFEROL) A11CC01 ; PDB 3CZH (CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITH VITAMIN D2) - ligand code D2V ; Vitamin D3 receptor UNIPROT P11473 VDR 11 ; ESTRONE ; 53-16-7 ; 1941 ; DISCONTINUED ; TARGET ESTROGEN RECEPTOR ; ATC (ESTRONE) G03CA07 G03CC04 ; PDB 3HM1 (CRYSTAL STRUCTURE OF HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE AND ESTRONE ((8R,9S,13S,14S)-3-HYDROXY-13-METHYL-7,8,9,11,12,14,15,16-OCTAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-ONE)) - ligand code J3Z ; Estrogen receptor UNIPROT P03372 ESR1 12 ; DIETHYLSTILBESTROL ; 56-53-1 ; 1973 ; DISCONTINUED ; TARGET ESTROGEN RECEPTOR ; ATC (DIETHYLSTILBESTROL) G03CB02 G03CC05 L02AA01 ; PDB 1TT6 (THE ORTHORHOMBIC CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH DIETHYLSTILBESTROL) - ligand code DES ; Estrogen receptor UNIPROT P03372 ESR1 13 ; SULFADIAZINE ; 68-35-9 ; 1941 ; ; ; ATC (SULFADIAZINE) J01EC02 J01EE06 J01EE02 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 14 ; MEPERIDINE ; 57-42-1 ; 1942 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (MEPERIDINE) N02AB02 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 15 ; HOMATROPINE METHYLBROMIDE ; 80-49-9 ; 1943 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (HOMATROPINE METHYLBROMIDE) A03BB06 A03CB04 ; ; GPCR ACM1_HUMAN UNIPROT P11229 16 ; HYDROCODONE ; 125-29-1 ; 1943 ; ; TARGET DELTA-TYPE OPIOID RECEPTOR -- KAPPA-TYPE OPIOID RECEPTOR -- MU-TYPE OPIOID RECEPTOR ; ATC (HYDROCODONE) R05DA03 N02AJ23 N02AJ22 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 17 ; ESTRADIOL ; 50-28-2 ; 1957 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ESTRADIOL) G03AB08 H01CC53 G03CA03 G03CA53 G03AA17 G03AA14 H01CC54 ; PDB 1FDU (HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH ESTRADIOL AND NADP+) - ligand code EST ; Estrogen receptor UNIPROT P03372 ESR1 18 ; ETHINYL ESTRADIOL ; 57-63-6 ; 1943 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ETHINYL ESTRADIOL) G03CA01 ; PDB 4X1G (CRYSTAL STRUCTURE OF THE HPXR-LBD IN COMPLEX WITH THE SYNTHETIC ESTROGEN 17ALPHA-ETHINYLESTRADIOL AND THE PESTICIDE TRANS-NONACHLOR) - ligand code 3WF ; Estrogen receptor UNIPROT P03372 ESR1 19 ; ESTRADIOL VALERATE ; 979-32-8 ; 1954 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ESTRADIOL) G03AB08 H01CC53 G03CA03 G03CA53 G03AA17 G03AA14 H01CC54 ; ; Estrogen receptor UNIPROT P03372 ESR1 20 ; ESTRADIOL CYPIONATE ; 313-06-4 ; 1979 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ESTRADIOL) G03AB08 H01CC53 G03CA03 G03CA53 G03AA17 G03AA14 H01CC54 ; ; Estrogen receptor UNIPROT P03372 ESR1 21 ; ESTRADIOL ACETATE ; 4245-41-4 ; 2003 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ESTRADIOL) G03AB08 H01CC53 G03CA03 G03CA53 G03AA17 G03AA14 H01CC54 ; ; Estrogen receptor UNIPROT P03372 ESR1 22 ; METHAMPHETAMINE ; 537-46-2 ; 1943 ; ; TARGET DOPAMINE TRANSPORTER (DAT) -- SEROTONINE TRANSPORTER ; ATC (METAMFETAMINE) N06BA03 ; PDB 4XP6 (X-RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO PSYCHOSTIMULANT METHAMPHETAMINE) - ligand code B40 ; Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 23 ; DICUMAROL ; 66-76-2 ; 1944 ; DISCONTINUED ; TARGET XANTHINE OXIDASE (XO) -- XANTHINE DEHYDROGENASE (XDH) (PMID1281039) ; ATC (DICOUMAROL) B01AA01 ; ; Vitamin K epoxide reductase complex subunit 1 UNIPROT Q9BQB6 VKORC1 24 ; VITAMIN A ; 68-26-8 ; 1953 ; ; ; ATC (VITAMIN A) A11CA01 V04CB01 ; PDB 1EII (NMR STRUCTURE OF HOLO CELLULAR RETINOL-BINDING PROTEIN II) - ligand code RTL ; SECRETED RET4_HUMAN UNIPROT P02753 25 ; TUBOCURARINE ; 57-95-4 ; 1945 ; DISCONTINUED ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR (PMID16723497) ; ATC (TUBOCURARINE) M03AA02 ; PDB 3PMZ (CRYSTAL STRUCTURE OF THE COMPLEX OF ACETYLCHOLINE BINDING PROTEIN AND D-TUBOCURARINE) - ligand code TUB ; Acetylcholine receptor UNIPROT P02708 CHRNA1 26 ; SULFABENZAMIDE ; 127-71-9 ; 1945 ; DISCONTINUED ; ; ; PDB 3RCF (HUMAN CYCLOPHILIN D COMPLEXED WITH N-[(4-AMINOPHENYL)SULFONYL]BENZAMIDE) - ligand code BS4 ; UNKNOWN 27 ; SULFACETAMIDE ; 144-80-9 ; 1945 ; ; ; ATC (SULFACETAMIDE) D10AF06 S01AB04 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 28 ; SULFATHIAZOLE ; 72-14-0 ; 1945 ; DISCONTINUED ; ; ATC (SULFATHIAZOLE) D06BA02 J01EB07 ; PDB 3TYE (DIHYDROPTEROATE SYNTHASE IN COMPLEX WITH DHP-STZ) - ligand code YTZ ; Dihydropteroate synthase UNIPROT P0AC13 folP 29 ; NITROFURAZONE ; 59-87-0 ; 1945 ; DISCONTINUED ; TARGET DNA (PMID25497730) -- AZOREDUCTASE ; ATC (NITROFURAL) B05CA03 D08AF01 D09AA03 P01CC02 S01AX04 S02AA02 ; PDB 3R6W (PAAZOR1 BINDING TO NITROFURAZONE) - ligand code NFZ ; UNKNOWN 30 ; DIPHENHYDRAMINE ; 58-73-1 ; 1946 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DIPHENHYDRAMINE) D04AA32 R06AA02 D04AA33 R06AA52 M01AE57 ; PDB 2AOT (HISTAMINE METHYLTRANSFERASE COMPLEXED WITH THE ANTIHISTAMINE DRUG DIPHENHYDRAMINE) - ligand code 2PM ; Histamine H1 receptor UNIPROT P35367 HRH1 31 ; SILODOSIN ; 160970-54-7 ; 2008 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR ; ATC (SILODOSIN) G04CA04 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 32 ; TRIMETHADIONE ; 127-48-0 ; 1946 ; DISCONTINUED ; TARGET VOLTAGE DEPENDENT CALCIUM CHANNEL (PMID24846538) ; ATC (TRIMETHADIONE) N03AC02 ; ; Voltage-dependent T-type calcium channel subunit alpha-1G UNIPROT O43497 CACNA1G 33 ; FOLIC ACID ; 59-30-3 ; 1946 ; ; ; ATC (FOLIC ACID) B03AD04 B03AD01 B03AD02 B03AD05 B03AD03 B03BB01 V04CX02 B03BB51 B03AE02 B03AE01 ; PDB 4P3R (CRYOGENIC WT DHFR, TIME-AVERAGED ENSEMBLE) - ligand code FOL ; Thymidylate synthase UNIPROT P04818 TYMS 34 ; TRIPELENNAMINE ; 91-81-6 ; 1948 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (TRIPELENNAMINE) D04AA04 R06AC04 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 35 ; HOMATROPINE METHYLBROMIDE ; 80-49-9 ; 1943 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (HOMATROPINE METHYLBROMIDE) A03BB06 A03CB04 ; ; GPCR ACM1_HUMAN UNIPROT P11229 36 ; DIHYDROERGOTAMINE ; 511-12-6 ; 1946 ; ; TARGET 5-HYDROXYTRYPTAMINE 1 RECEPTOR -- 5-HYDROXYTRYPTAMINE 2 RECEPTOR -- ALPHA ADRENERGIC RECEPTOR -- DOPAMINE RECEPTOR ; ATC (DIHYDROERGOTAMINE) N02CA01 N02CA51 ; PDB 4IAQ (CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH DIHYDROERGOTAMINE (PSI COMMUNITY TARGET)) - ligand code 2GM ; 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 37 ; DIMERCAPROL ; 59-52-9 ; 1946 ; ; ; ATC (DIMERCAPROL) V03AB09 ; PDB 5ZJ8 (CRYSTAL STRUCTURE OF NDM-1 IN COMPLEX WITH D-CAPTOPRIL DERIVATIVE CY32) - ligand code 9DC ; UNKNOWN 38 ; CHLOROQUINE ; 54-05-7 ; 1949 ; ; TARGET DNA -- LACTATE DEHYDROGENASE ; ATC (CHLOROQUINE) P01BA01 P01BB52 ; PDB 4V2O (STRUCTURE OF SAPOSIN B IN COMPLEX WITH CHLOROQUINE) - ligand code CLQ ; UNKNOWN 39 ; MEPHENYTOIN ; 50-12-4 ; 1946 ; DISCONTINUED ; TARGET NA+ CHANNELS (NAV) ; ATC (MEPHENYTOIN) N03AB04 N03AB54 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 40 ; METHYLERGONOVINE ; 113-42-8 ; 1946 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR -- SEROTONERGIC (5-HT2) RECEPTOR ; ATC (METHYLERGOMETRINE) G02AB01 G02AC01 ; PDB 6DRY (STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR) - ligand code H8D ; D(1A) dopamine receptor UNIPROT P21728 DRD1 41 ; SULFOXONE ; 144-76-3 ; 1974 ; DISCONTINUED ; ; ; ; Dihydropteroate synthase 1 UNIPROT P0C0X1 folP1 42 ; ASCORBIC ACID ; 50-81-7 ; 1947 ; ; ; ATC (ASCORBIC ACID) G01AD03 S01XA15 A11GA01 A11GB01 ; PDB 1F9G (CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE COCRYSTALLIZED WITH ASCORBIC ACID) - ligand code ASC ; Solute carrier family 23 member 1 UNIPROT Q9UHI7 SLC23A1 43 ; BIOTIN ; 58-85-5 ; 1947 ; ; ; ATC (BIOTIN) A11HA05 ; PDB 1SWR (CORE-STREPTAVIDIN MUTANT W120A IN COMPLEX WITH BIOTIN AT PH 7.5) - ligand code BTN ; Insulin-degrading enzyme UNIPROT P14735 IDE 44 ; MOMETASONE FUROATE ; 83919-23-7 ; 1987 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (MOMETASONE) R03AK09 R03AK14 R03AL12 D07AC13 D07XC03 R01AD09 R03BA07 R01AD59 ; PDB 4P6W (CRYSTAL STRUCTURE OF MOMETASONE FUROATE-BOUND GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN) - ligand code MOF ; Glucocorticoid receptor UNIPROT P04150 NR3C1 45 ; NIACINAMIDE ; 98-92-0 ; 1947 ; ; ; ATC (NICOTINAMIDE) A11HA01 ; PDB 2E5D (CRYSTAL STRUCTURE OF HUMAN NMPRTASE COMPLEXED WITH NICOTINAMIDE) - ligand code NCA ; Nicotinamide N-methyltransferase UNIPROT P40261 46 ; PYRIDOXINE ; 65-23-6 ; 1947 ; ; ; ATC (PYRIDOXINE) J04AM08 A11HA02 ; PDB 4C5L (STRUCTURE OF THE PYRIDOXAL KINASE FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH PYRIDOXAL) - ligand code UEG ; Phosphoserine aminotransferase UNIPROT Q9Y617 PSAT1 47 ; THIAMINE ; 59-43-8 ; 1947 ; ; ; ATC (THIAMINE) A11DA01 ; PDB 3MYU (MYCOPLASMA GENITALIUM MG289) - ligand code VIB ; Heat shock protein HSP 90-alpha UNIPROT P07900 HSP90AA1 48 ; ALPHA-TOCOPHEROL ; 59-02-9 ; 1953 ; ; TARGET ALPHA-TOCOPHEROL TRANSFER PROTEIN (ALPHA-TTP) (PMID24231105) ; ATC (VITAMIN E) A11HA03 ; PDB 5MUG (SELF-ASSEMBLED ALPHA-TOCOPHEROL TRANSFER PROTEIN NANOPARTICLES PROMOTE VITAMIN E DELIVERY ACROSS AN ENDOTHELIAL BARRIER) - ligand code VIV ; Glutathione S-transferase P UNIPROT P09211 -- Alpha-tocopherol transfer protein UNIPROT P49638 49 ; DIENESTROL ; 84-17-3 ; 1947 ; DISCONTINUED ; TARGET ESTROGEN RECEPTOR ; ATC (DIENESTROL) G03CB01 G03CC02 ; ; Estrogen receptor UNIPROT P03372 ESR1 50 ; METHADONE ; 76-99-3 ; 1947 ; ; TARGET MU-TYPE OPIOID RECEPTOR -- N-METHYL-D-ASPARTATE RECEPTOR (NMDA) ; ATC (METHADONE) N07BC02 N02AC52 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 51 ; PROPYLTHIOURACIL ; 51-52-5 ; 1947 ; ; TARGET THYROPEROXIDASE (PMID12755690) ; ATC (PROPYLTHIOURACIL) H03BA02 ; PDB 5HPW (MODE OF BINDING OF ANTITHYROID DRUG, PROPYLTHIOURACIL TO LACTOPEROXIDASE: BINDING STUDIES AND STRUCTURE DETERMINATION) - ligand code 3CJ ; Thyroid peroxidase UNIPROT P07202 TPO -- Type I iodothyronine deiodinase UNIPROT P49895 DIO1 52 ; DIBUCAINE ; 85-79-0 ; 0 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ATC (CINCHOCAINE) C05AD04 D04AB02 N01BB06 S01HA06 S02DA04 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 10 subunit alpha UNIPROT Q9Y5Y9 SCN10A 53 ; HEXACHLOROPHENE ; 70-30-4 ; 1949 ; ; TARGET ENOYL-ACYL CARRIER PROTEIN REDUCTASE (FABI) (PMID10671494) ; ATC (HEXACHLOROPHENE) D08AE01 ; PDB 3ETE (CRYSTAL STRUCTURE OF BOVINE GLUTAMATE DEHYDROGENASE COMPLEXED WITH HEXACHLOROPHENE) - ligand code H3P ; Enoyl-acyl-carrier-protein reductase NADH FabI UNIPROT P0AEK4 fabI 54 ; DIMERCAPROL ; 59-52-9 ; 1946 ; ; ; ATC (DIMERCAPROL) V03AB09 ; ; UNKNOWN 55 ; SULFAMERAZINE ; 127-79-7 ; 1949 ; DISCONTINUED ; ; ATC (SULFAMERAZINE) D06BA06 J01ED07 J01EE07 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 56 ; SULFAMETHAZINE ; 57-68-1 ; 1949 ; DISCONTINUED ; TARGET THYROID PEROXIDASE (TPO) -- LACTOPEROXIDASE (LPO) (PMID8199304) ; ATC (SULFADIMIDINE) J01EB03 J01EE05 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 57 ; ISOPROTERENOL ; 7683-59-2 ; 1948 ; ; TARGET BETA ADRENERGIC RECEPTOR ; ATC (ISOPRENALINE) C01CA02 R03AB02 R03CB01 R03AK02 R03CB51 ; PDB 4A7T (STRUCTURE OF HUMAN I113T SOD1 MUTANT COMPLEXED WITH ISOPROTERANOL IN THE P21 SPACE GROUP) - ligand code 5FW ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 58 ; ISOPROTERENOL ; 7683-59-2 ; 1948 ; ; TARGET BETA ADRENERGIC RECEPTOR ; ATC (ISOPRENALINE) C01CA02 R03AB02 R03CB01 R03AK02 R03CB51 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 59 ; TOLAZOLINE ; 59-98-3 ; 1948 ; DISCONTINUED ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (TOLAZOLINE) C04AB02 M02AX02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 60 ; DOXYLAMINE ; 469-21-6 ; 1948 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DOXYLAMINE) R06AA09 R06AA59 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 61 ; AMODIAQUINE ; 86-42-0 ; 0 ; DISCONTINUED ; ; ATC (AMODIAQUINE) P01BA06 P01BF03 ; PDB 4FGZ (CRYSTAL STRUCTURE OF PHOSPHOETHANOLAMINE METHYLTRANSFERASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH AMODIAQUINE) - ligand code CQA ; UNKNOWN 62 ; DIETHYLCARBAMAZINE ; 90-89-1 ; 1950 ; DISCONTINUED ; TARGET PROSTAGLANDIN H SYNTHASE (PMID19426666) ; ATC (DIETHYLCARBAMAZINE) P02CB02 ; ; Nematode GABA-A receptor UNIPROT E1FVX6 63 ; LIDOCAINE ; 137-58-6 ; 1948 ; ; TARGET SODIUM CHANNEL ; ATC (LIDOCAINE) C01BB01 C05AD01 D04AB01 N01BB02 R02AD02 S01HA07 S02DA01 N01BB52 ; PDB 3JQZ (CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH LIDOCAINE) - ligand code LQZ ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A 64 ; EPINEPHRINE ; 51-43-4 ; 1948 ; ; TARGET ALPHA ADRENERGIC RECEPTOR -- BETA ADRENERGIC RECEPTOR ; ATC (EPINEPHRINE) A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01 R03AK01 S01EA51 ; PDB 4LDO (STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO ADRENALINE AND AN ENGINEERED NANOBODY) - ligand code ALE ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 -- Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A 65 ; SULFISOXAZOLE ; 127-69-5 ; 1948 ; DISCONTINUED ; TARGET DIHYDROPTEROATE SYNTHASE ; ATC (SULFAFURAZOLE) J01EB05 S01AB02 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 66 ; SULFISOXAZOLE ACETYL ; 80-74-0 ; 1953 ; DISCONTINUED ; TARGET DIHYDROPTEROATE SYNTHASE ; ATC (SULFAFURAZOLE) J01EB05 S01AB02 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 67 ; SULFANILAMIDE ; 63-74-1 ; 1965 ; DISCONTINUED ; TARGET CARBONIC ANHYDRASE ; ATC (SULFANILAMIDE) D06BA05 J01EB06 ; PDB 4COQ (THE COMPLEX OF ALPHA-CARBONIC ANHYDRASE FROM THERMOVIBRIO AMMONIFICANS WITH INHIBITOR SULFANILAMIDE) - ligand code SAN ; Dihydropteroate synthase UNIPROT P0AC13 folP 68 ; BETHANECHOL ; 590-63-6 ; 1948 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (BETHANECHOL) N07AB02 ; ; Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 69 ; CAFFEINE ; 58-08-2 ; 1948 ; ; TARGET ADENOSINE RECEPTOR ; ATC (CAFFEINE) D11AX26 N06BC01 V04CG30 ; PDB 5TAU (STRUCTURE OF RABBIT RYR1 (CAFFEINE, ATP, EGTA DATASET, CLASS 3)) - ligand code CFF ; Adenosine receptor A2a UNIPROT P29274 ADORA2A -- Adenosine receptor A1 UNIPROT P30542 ADORA1 70 ; ERGOTAMINE ; 113-15-5 ; 1948 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (ERGOTAMINE) N02CA02 N02CA52 N02CA72 ; PDB 5TUD (STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR RECOGNITION OF THE HUMAN SEROTONIN 2B RECEPTOR BY AN ANTIBODY) - ligand code ERM ; 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 71 ; METOCURINE ; 5152-30-7 ; 1949 ; DISCONTINUED ; ; ; PDB 3PEO (CRYSTAL STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN COMPLEXED WITH METOCURINE) - ligand code CU9 ; Acetylcholine receptor UNIPROT P02708 CHRNA1 72 ; MECHLORETHAMINE ; 51-75-2 ; 1949 ; ; TARGET DNA ; ATC (CHLORMETHINE) L01AA05 ; ; UNKNOWN 73 ; METHOXAMINE ; 390-28-3 ; 1949 ; DISCONTINUED ; TARGET ALPHA-1 ADRENERGIC RECEPTOR ; ATC (METHOXAMINE) C01CA10 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 74 ; TRIHEXYPHENIDYL ; 144-11-6 ; 1949 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (TRIHEXYPHENIDYL) N04AA01 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 75 ; PARAMETHADIONE ; 115-67-3 ; 1949 ; DISCONTINUED ; ; ATC (PARAMETHADIONE) N03AC01 ; ; Voltage-gated T-type calcium channel UNIPROT O43497 CACNA1G 76 ; AMINOSALICYLIC ACID ; 65-49-6 ; 1950 ; ; TARGET DIHYDROFOLATE REDUCTASE (DHFR) (PMID26848874) ; ATC (AMINOSALICYLIC ACID) J04AA01 ; PDB 5X7Z (CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH P-AMINOSALICYLIC ACID) - ligand code BHA ; Cyclooxygenase UNIPROT P23219 PTGS1 77 ; CHLORPHENIRAMINE ; 132-22-9 ; 1949 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (CHLORPHENIRAMINE) R06AB04 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 78 ; PHENYL AMINOSALICYLATE ; 133-11-9 ; 0 ; DISCONTINUED ; TARGET DIHYDROFOLATE REDUCTASE (DHFR) (PMID26848874) ; ATC (AMINOSALICYLIC ACID) J04AA01 ; ; Cyclooxygenase UNIPROT P23219 PTGS1 79 ; DEXCHLORPHENIRAMINE ; 25523-97-1 ; 1950 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DEXCHLORPHENIRAMINE) R06AB02 R06AB52 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 80 ; CROTAMITON ; 483-63-6 ; 1949 ; ; ; ; ; UNKNOWN 81 ; SULFASALAZINE ; 599-79-1 ; 1950 ; ; ; ATC (SULFASALAZINE) A07EC01 ; ; Arachidonate 5-lipoxygenase UNIPROT P09917 ALOX5 -- Cyclooxygenase UNIPROT P23219 PTGS1 82 ; CORTISONE ACETATE ; 50-04-4 ; 1950 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (CORTISONE) H02AB10 S01BA03 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 83 ; PROCAINAMIDE ; 51-06-9 ; 1950 ; ; TARGET SODIUM CHANNEL ; ATC (PROCAINAMIDE) C01BA02 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 84 ; ASPIRIN ; 50-78-2 ; 1950 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (ACETYLSALICYLIC ACID) A01AD05 B01AC06 N02BA01 M01BA03 N02BA51 B01AC56 N02BA71 C10BX08 C10BX12 C10BX06 C07FX04 N02AJ07 N02AJ02 C07FX03 N02AJ18 C10BX02 B01AF51 C10BX05 C10BX01 C10BX04 C07FX02 ; PDB 4NSB (CRYSTAL STRUCTURE OF THE COMPLEX OF SIGNALING GLYCOPROTEIN, SPB-40 AND N-ACETYL SALICYLIC ACID AT 3.05 A RESOLUTION) - ligand code AIN ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 85 ; OXYCODONE ; 76-42-6 ; 1950 ; ; TARGET OPIOID RECEPTOR ; ATC (OXYCODONE) N02AA05 N02AJ18 N02AJ19 N02AA55 N02AA56 N02AJ17 ; PDB 7U63 (CRYSTAL STRUCTURE ANTI-OXYCODONE ANTIBODY HY2-A12 FAB COMPLEXED WITH OXYCODONE) - ligand code OOX ; Mu-type opioid receptor UNIPROT P35372 OPRM1 86 ; SECOBARBITAL ; 76-73-3 ; 1950 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (SECOBARBITAL) N05CA06 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 87 ; DICYCLOMINE ; 77-19-0 ; 1950 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (DICYCLOVERINE) A03AA07 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 88 ; METHIMAZOLE ; 60-56-0 ; 1950 ; ; ; ATC (THIAMAZOLE) H03BB02 H03BB52 ; PDB 2GVC (CRYSTAL STRUCTURE OF FLAVIN-CONTAINING MONOOXYGENASE (FMO)FROM S.POMBE AND SUBSTRATE (METHIMAZOLE) COMPLEX) - ligand code MMZ ; Thyroid peroxidase UNIPROT P07202 TPO 89 ; QUINIDINE ; 56-54-2 ; 1950 ; ; TARGET ADRENERGIC ALPHA-1 RECEPTOR -- P-GLYCOPROTEIN ; ATC (QUINIDINE) C01BA01 C01BA51 C01BA71 ; PDB 4WNU (HUMAN CYTOCHROME P450 2D6 QUINIDINE COMPLEX) - ligand code QDN ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel alpha subunits 90 ; THIAMYLAL ; 77-27-0 ; 1954 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ; ; GABA-A receptor 91 ; THIAMYLAL ; 77-27-0 ; 1954 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ; ; GABA-A receptor 92 ; PHENACEMIDE ; 63-98-9 ; 1951 ; DISCONTINUED ; ; ATC (PHENACEMIDE) N03AX07 ; ; UNKNOWN 93 ; DYPHYLLINE ; 479-18-5 ; 1951 ; DISCONTINUED ; TARGET PHOSPHODIESTERASE ; ATC (DIPROPHYLLINE) R03DA01 R03DB01 R03DA51 ; PDB 2X0Y (SCREENING-BASED DISCOVERY OF DRUG-LIKE O-GLCNACASE INHIBITOR SCAFFOLDS) - ligand code X0T ; cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A -- cAMP-specific 3,5-cyclic phosphodiesterase 4B UNIPROT Q07343 PDE4B 94 ; GALLAMINE ; 153-76-4 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (GALLAMINE) M03AC02 ; ; Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 95 ; DISULFIRAM ; 97-77-8 ; 1951 ; ; TARGET ALCOHOL DEHYDROGENASE ; ATC (DISULFIRAM) N07BB01 P03AA04 P03AA54 ; ; Aldehyde dehydrogenase, mitochondrial UNIPROT P05091 ALDH2 96 ; PROBENECID ; 57-66-9 ; 1951 ; ; TARGET ORGANIC ANION TRANSPORTER ; ATC (PROBENECID) M04AC51 M04AB01 ; PDB 8BVT (CRYO-EM STRUCTURE OF RAT SLC22A6 BOUND TO PROBENECID) - ligand code RTO ; Solute carrier family 22 member 6 UNIPROT Q4U2R8 SLC22A6 -- Solute carrier family 22 member 8 UNIPROT Q8TCC7 SLC22A8 97 ; PROMETHAZINE ; 60-87-7 ; 1951 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (PROMETHAZINE) V03AB05 D04AA10 R06AD02 R06AD52 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 98 ; PHENYLEPHRINE ; 59-42-7 ; 1952 ; ; TARGET ADRENERGIC ALPHA-1 RECEPTOR ; ATC (PHENYLEPHRINE) C01CA06 C05AX06 R01AA04 R01AB01 R01BA03 S01FB01 S01GA05 S01FB51 R01BA53 S01GA55 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 99 ; HEXYLCAINE ; 532-77-4 ; 0 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ; ; Sodium channel alpha subunits 100 ; PYRILAMINE ; 91-84-9 ; 1973 ; DISCONTINUED ; TARGET HISTAMINE RECEPTOR ; ATC (MEPYRAMINE) D04AA02 R06AC01 R03DA12 ; PDB 8X63 (CRYOEM STRUCTURE OF THE HISTAMINE H1 RECEPTOR-BRIL, ANTI BRIL FAB COMPLEX WITH MEPYRAMINE) - ligand code Y5E ; Histamine H1 receptor UNIPROT P35367 HRH1 101 ; EDROPHONIUM ; 312-48-1 ; 1951 ; DISCONTINUED ; TARGET ACETYLCHOLINESTERASE ; ATC (EDROPHONIUM) V04CX07 ; PDB 2ACK (ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA) - ligand code EDR ; Acetylcholinesterase UNIPROT P22303 ACHE 102 ; BROMODIPHENHYDRAMINE ; 1808-12-4 ; 1954 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DIPHENHYDRAMINE) D04AA32 R06AA02 D04AA33 R06AA52 M01AE57 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 103 ; METHOTREXATE ; 59-05-2 ; 1953 ; ; TARGET DIHYDROFOLATE REDUCTASE ; ATC (METHOTREXATE) L01BA01 L04AX03 ; PDB 5X66 (HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTREXATE) - ligand code MTX ; Dihydrofolate reductase UNIPROT P00374 DHFR 104 ; CHLOROTRIANISENE ; 569-57-3 ; 0 ; DISCONTINUED ; ; ATC (CHLOROTRIANISENE) G03CA06 ; ; Estrogen receptor beta UNIPROT Q92731 ESR2 105 ; LEUCOVORIN ; 58-05-9 ; 1952 ; ; ; ATC (FOLIC ACID) B03AD04 B03AD01 B03AD02 B03AD05 B03AD03 B03BB01 V04CX02 B03BB51 B03AE02 B03AE01 ; PDB 4LXX (CRYSTAL STRUCTURE WLARD, A SUGAR 3N-FORMYL TRANSFERASE IN THE PRESENCE OF DTDP-FUC3NFO AND 5-N-FORMYL-THF) - ligand code FON ; Thymidylate synthase UNIPROT P04818 TYMS -- Dihydrofolate reductase UNIPROT P00374 DHFR 106 ; DIPHEMANIL ; 15394-62-4 ; 1976 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (DIPHEMANIL) A03AB15 A03CA08 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 107 ; MONOBENZONE ; 103-16-2 ; 1952 ; DISCONTINUED ; ; ATC (MONOBENZONE) D11AX13 ; ; Tyrosinase UNIPROT P14679 TYR 108 ; HYDROCORTISONE ; 50-23-7 ; 1952 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (HYDROCORTISONE) A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01 D07AC16 D07CA01 S01CA03 S02CA03 S03CA04 D07BA04 S01BB01 D07AB11 D07AB02 D07BB04 R01AD60 ; PDB 2VDY (CRYSTAL STRUCTURE OF THE REACTIVE LOOP CLEAVED CORTICOSTEROID BINDING GLOBULIN COMPLEXED WITH CORTISOL) - ligand code HCY ; Glucocorticoid receptor UNIPROT P04150 NR3C1 109 ; HYDROCORTISONE ACETATE ; 50-03-3 ; 1951 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (HYDROCORTISONE) A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01 D07AC16 D07CA01 S01CA03 S02CA03 S03CA04 D07BA04 S01BB01 D07AB11 D07AB02 D07BB04 R01AD60 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 110 ; HYDROCORTISONE VALERATE ; 57524-89-7 ; 1978 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (HYDROCORTISONE) A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01 D07AC16 D07CA01 S01CA03 S02CA03 S03CA04 D07BA04 S01BB01 D07AB11 D07AB02 D07BB04 R01AD60 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 111 ; HYDROCORTISONE BUTYRATE ; 13609-67-1 ; 1982 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (HYDROCORTISONE BUTYRATE) D07AB02 D07BB04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 112 ; MEPHENTERMINE ; 100-92-5 ; 1951 ; DISCONTINUED ; ; ATC (MEPHENTERMINE) C01CA11 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 113 ; HYDRALAZINE ; 86-54-4 ; 1953 ; ; ; ATC (HYDRALAZINE) C02DB02 C02LG02 ; PDB 3LTW (THE STRUCTURE OF MYCOBACTERIUM MARINUM ARYLAMINE N-ACETYLTRANSFERASE IN COMPLEX WITH HYDRALAZINE) - ligand code HLZ ; Ryanodine receptor 2 UNIPROT Q92736 RYR2 114 ; CODEINE ; 76-57-3 ; 1952 ; ; TARGET OPIOID RECEPTOR ; ATC (CODEINE) R05DA04 N02AJ07 N02AJ08 N02AJ09 N02AJ06 N02AA59 N02AA79 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 115 ; PHENYLBUTAZONE ; 50-33-9 ; 1977 ; DISCONTINUED ; TARGET CARBONYL REDUCTASE ; ATC (PHENYLBUTAZONE) M01AA01 M02AA01 M01BA01 ; PDB 2BXQ (HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE, PHENYLBUTAZONE AND INDOMETHACIN) - ligand code P1Z ; Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 116 ; METHARBITAL ; 50-11-3 ; 0 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (METHARBITAL) N03AA30 ; PDB 5STF (PANDDA ANALYSIS GROUP DEPOSITION -- AAR2, RNASEH IN COMPLEX WITH FRAGMENT P02H02 FROM THE F2X-UNIVERSAL LIBRARY) - ligand code VOK ; GABA-A receptor 117 ; ISONIAZID ; 54-85-3 ; 1952 ; ; TARGET CATALASE PEROXIDASE (KATG) ; ATC (ISONIAZID) J04AM03 J04AC01 J04AC51 J04AM08 J04AM02 J04AM07 J04AM05 J04AM06 J04AM01 J04AM04 ; PDB 4PAE (CRYSTAL STRUCTURE OF CATALASE-PEROXIDASE (KATG) W78F MUTANT FROM SYNECHOCOCCUS ELONGATUS PCC7942) - ligand code NIZ ; Enoyl-acyl-carrier-protein reductase NADH UNIPROT P9WGR1 inhA 118 ; SUCCINYLCHOLINE ; 306-40-1 ; 1952 ; ; TARGET ACETYLCHOLINE RECEPTOR ; ATC (SUXAMETHONIUM) M03AB01 ; PDB 2HA6 (CRYSTAL STRUCTURE OF MUTANT S203A OF MOUSE ACETYLCHOLINESTERASE COMPLEXED WITH SUCCINYLCHOLINE) - ligand code SCK ; Muscle-type nicotinic acetylcholine receptor UNIPROT P02708 CHRNA1 119 ; HEXYLCAINE ; 532-77-4 ; 0 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ; ; Sodium channel alpha subunits 120 ; SULFAMETHIZOLE ; 144-82-1 ; 1953 ; DISCONTINUED ; TARGET DIHYDROPTEROATE SYNTHASE ; ATC (SULFAMETHIZOLE) B05CA04 D06BA04 J01EB02 S01AB01 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 121 ; PYRIMETHAMINE ; 58-14-0 ; 1953 ; ; TARGET DIHYDROFOLATE REDUCTASE ; ATC (PYRIMETHAMINE) P01BF09 P01BF04 P01BD01 P01BD51 ; PDB 4KM0 (CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PYRIMETHAMINE) - ligand code CP6 ; Bifunctional dihydrofolate reductase-thymidylate synthase UNIPROT P13922 122 ; PROCAINE ; 59-46-1 ; 1952 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ATC (PROCAINE) C05AD05 N01BA02 S01HA05 J01CE09 N01BA52 ; ; Sodium channel protein type 10 subunit alpha UNIPROT Q9Y5Y9 SCN10A 123 ; PHENOXYBENZAMINE ; 59-96-1 ; 1953 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (PHENOXYBENZAMINE) C04AX02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 124 ; LEVONORDEFRIN ; 829-74-3 ; 1960 ; DISCONTINUED ; ; ; ; Adrenergic receptor alpha-2 UNIPROT P08913 ADRA2A 125 ; NITROFURANTOIN ; 67-20-9 ; 1953 ; ; TARGET RIBOSOME ; ATC (NITROFURANTOIN) J01XE01 J01XE51 ; ; UNKNOWN 126 ; PHENOXYBENZAMINE ; 59-96-1 ; 1953 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (PHENOXYBENZAMINE) C04AX02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 127 ; LEVORPHANOL ; 77-07-6 ; 1953 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 128 ; PROPANTHELINE ; 298-50-0 ; 1953 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (PROPANTHELINE) A03AB05 A03CA34 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 129 ; PHENYTOIN ; 57-41-0 ; 1953 ; ; TARGET VOLTAGE-DEPENDENT SODIUM CHANNEL ; ATC (PHENYTOIN) N03AB02 N03AB52 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A 130 ; CARBINOXAMINE ; 486-16-8 ; 1974 ; ; TARGET HISTAMINE RECEPTOR ; ATC (CARBINOXAMINE) R06AA08 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 131 ; PHENINDIONE ; 83-12-5 ; 0 ; DISCONTINUED ; ; ATC (PHENINDIONE) B01AA02 ; PDB 6WV6 (HUMAN VKOR WITH PHENINDIONE) - ligand code UAS ; Vitamin K epoxide reductase complex subunit 1 UNIPROT Q9BQB6 VKORC1 132 ; METHSCOPOLAMINE ; 13265-10-6 ; 1953 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (METHYLSCOPOLAMINE) A03BB03 S01FA03 A03CB01 ; PDB 4U16 (M3-MT4L RECEPTOR BOUND TO NMS) - ligand code 3C0 ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 133 ; PHENSUXIMIDE ; 86-34-0 ; 1953 ; DISCONTINUED ; ; ATC (PHENSUXIMIDE) N03AD02 ; ; Voltage-gated T-type calcium channel UNIPROT O43497 CACNA1G 134 ; PROPARACAINE ; 499-67-2 ; 1953 ; ; TARGET SODIUM CHANNEL ; ATC (PROXYMETACAINE) S01HA04 ; ; Sodium channel protein type 10 subunit alpha UNIPROT Q9Y5Y9 SCN10A -- Sodium channel alpha subunits 135 ; CARBINOXAMINE ; 486-16-8 ; 1974 ; ; TARGET HISTAMINE RECEPTOR ; ATC (CARBINOXAMINE) R06AA08 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 136 ; ACETAZOLAMIDE ; 59-66-5 ; 1953 ; ; TARGET CARBONIC ANHYDRASE ; ATC (ACETAZOLAMIDE) S01EC01 ; PDB 1AZM (DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I) - ligand code AZM ; Carbonic anhydrase 2 UNIPROT P00918 CA2 -- Carbonic anhydrase 1 UNIPROT P00915 CA1 137 ; CYCRIMINE ; 77-39-4 ; 1953 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 138 ; METHOXSALEN ; 298-81-7 ; 1954 ; ; TARGET DNA ; ATC (METHOXSALEN) D05AD02 D05BA02 ; PDB 1Z11 (CRYSTAL STRUCTURE OF HUMAN MICROSOMAL P450 2A6 WITH METHOXSALEN BOUND) - ligand code 8MO ; UNKNOWN 139 ; MERCAPTOPURINE ; 50-44-2 ; 1953 ; ; TARGET HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) ; ATC (MERCAPTOPURINE) L01BB02 ; ; Amidophosphoribosyltransferase UNIPROT Q06203 PPAT 140 ; ETHOPROPAZINE ; 522-00-9 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (PROFENAMINE) N04AA05 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 141 ; RESERPINE ; 50-55-5 ; 1954 ; DISCONTINUED ; ; ATC (RESERPINE) C02AA02 C02LA01 C02LA51 C02LA71 C02AA52 ; PDB 8JTC (HUMAN VMAT2 COMPLEX WITH RESERPINE) - ligand code YHR ; Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 142 ; CHLORPROMAZINE ; 50-53-3 ; 1957 ; ; TARGET DOPAMINE RECEPTOR ; ATC (CHLORPROMAZINE) N05AA01 ; PDB 5LG3 (X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH CHLORPROMAZINE) - ligand code Z80 ; D(2) dopamine receptor UNIPROT P14416 DRD2 143 ; TESTOSTERONE ; 58-22-0 ; 1972 ; ; TARGET ANDROGEN RECEPTOR ; ATC (TESTOSTERONE) G03BA03 G03EA02 ; PDB 1AFS (RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE) - ligand code TES ; Androgen receptor UNIPROT P10275 AR 144 ; TESTOSTERONE PROPIONATE ; 57-85-2 ; 1973 ; DISCONTINUED ; TARGET ANDROGEN RECEPTOR ; ATC (TESTOSTERONE) G03BA03 G03EA02 ; ; Androgen receptor UNIPROT P10275 AR 145 ; HYDROXYSTILBAMIDINE ; 495-99-8 ; 1953 ; DISCONTINUED ; ; ; ; UNKNOWN 146 ; PRIMIDONE ; 125-33-7 ; 1954 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (PRIMIDONE) N03AA03 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 147 ; WARFARIN ; 81-81-2 ; 1954 ; ; TARGET VITAMIN K EPOXIDE REDUCTASE COMPLEX ; ATC (WARFARIN) B01AA03 ; ; Vitamin K epoxide reductase complex subunit 1 UNIPROT Q9BQB6 VKORC1 148 ; PROGESTERONE ; 57-83-0 ; 1974 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (PROGESTERONE) G03DA04 G03FA04 ; PDB 4L1W (CRYSTAL STRUCTUER OF HUMAN 3-ALPHA HYDROXYSTEROID DEHYDROGENASE TYPE 3 IN COMPLEX WITH NADP+ AND PROGESTERONE) - ligand code STR ; Progesterone receptor UNIPROT P06401 PGR 149 ; OXTRIPHYLLINE ; 46155-92-4 ; 1981 ; DISCONTINUED ; ; ATC (CHOLINE THEOPHYLLINATE) R03DA02 R03DB02 ; ; Adenosine receptor A2a UNIPROT P29274 ADORA2A -- Adenosine receptor A1 UNIPROT P30542 ADORA1 150 ; DESLANOSIDE ; 17598-65-1 ; 0 ; DISCONTINUED ; TARGET SODIUM/POTASSIUM ATPASE ; ATC (DESLANOSIDE) C01AA07 ; ; Sodium,potassium-transporting ATPase UNIPROT P05023 ATP1A1 151 ; TRIDIHEXETHYL ; 4310-35-4 ; 1954 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (TRIDIHEXETHYL) A03AB08 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 152 ; DIGOXIN ; 20830-75-5 ; 1954 ; ; TARGET SODIUM-POTASSIUM ATPASE ; ATC (DIGOXIN) C01AA05 ; PDB 4RET (CRYSTAL STRUCTURE OF THE NA,K-ATPASE E2P-DIGOXIN COMPLEX WITH BOUND MAGNESIUM) - ligand code DGX ; Sodium,potassium-transporting ATPase UNIPROT P05023 ATP1A1 153 ; BETAZOLE ; 105-20-4 ; 0 ; DISCONTINUED ; TARGET HISTAMINE H2 RECEPTOR ; ATC (BETAZOLE) V04CG02 ; ; Histamine H2 receptor UNIPROT P25021 HRH2 154 ; PENTOLINIUM ; 144-44-5 ; 0 ; DISCONTINUED ; ; ; ; Neuronal acetylcholine receptor alpha3, beta4 UNIPROT P30926 CHRNB4 155 ; BUSULFAN ; 55-98-1 ; 1954 ; ; TARGET DNA ; ATC (BUSULFAN) L01AB01 ; ; UNKNOWN 156 ; TALBUTAL ; 115-44-6 ; 1954 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA) ; ATC (TALBUTAL) N05CA07 ; ; GABA-A receptor 157 ; CHLOROPROCAINE ; 133-16-4 ; 1955 ; ; TARGET SODIUM CHANNEL ; ATC (CHLOROPROCAINE) N01BA04 S01HA08 ; ; Sodium channel protein type 10 subunit alpha UNIPROT Q9Y5Y9 SCN10A 158 ; ACETYLDIGITOXIN ; 1111-39-3 ; 1975 ; DISCONTINUED ; TARGET NA-K ATPASE ; ATC (ACETYLDIGITOXIN) C01AA01 ; ; Sodium,potassium-transporting ATPase UNIPROT P05023 ATP1A1 159 ; TRIDIHEXETHYL ; 4310-35-4 ; 1954 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (TRIDIHEXETHYL) A03AB08 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 160 ; METARAMINOL ; 54-49-9 ; 1954 ; DISCONTINUED ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (METARAMINOL) C01CA09 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 161 ; GLUTETHIMIDE ; 77-21-4 ; 1957 ; DISCONTINUED ; ; ATC (GLUTETHIMIDE) N05CE01 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 162 ; HYDROXYCHLOROQUINE ; 118-42-3 ; 1955 ; ; ; ATC (HYDROXYCHLOROQUINE) P01BA02 ; ; Toll-like receptor 7 UNIPROT Q9NYK1 TLR7 -- Toll-like receptor 9 UNIPROT Q9NR96 TLR9 163 ; METHYPRYLON ; 125-64-4 ; 1955 ; DISCONTINUED ; ; ATC (METHYPRYLON) N05CE02 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 164 ; MEPROBAMATE ; 57-53-4 ; 1955 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR (GABA) (PMID9067327) ; ATC (MEPROBAMATE) N05BC01 N05BC51 N05CX01 ; ; GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 -- GABA-A receptor alpha-3,beta-3,gamma-2 UNIPROT P18507 GABRG2 165 ; ETHINAMATE ; 126-52-3 ; 1955 ; DISCONTINUED ; ; ; ; UNKNOWN 166 ; PREDNISONE ; 53-03-2 ; 1955 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (PREDNISONE) A07EA03 H02AB07 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 167 ; HYDROXYCHLOROQUINE ; 118-42-3 ; 1955 ; ; ; ATC (HYDROXYCHLOROQUINE) P01BA02 ; ; Toll-like receptor 7 UNIPROT Q9NYK1 TLR7 -- Toll-like receptor 9 UNIPROT Q9NR96 TLR9 168 ; PROCYCLIDINE ; 77-37-2 ; 1955 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (PROCYCLIDINE) N04AA04 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 169 ; PYRIDOSTIGMINE ; 155-97-5 ; 1955 ; ; TARGET CHOLINESTERASE ; ATC (PYRIDOSTIGMINE) N07AA02 ; ; Acetylcholinesterase UNIPROT P22303 ACHE 170 ; DYCLONINE ; 586-60-7 ; 2018 ; ; ; ATC (DYCLONINE) N01BX02 R02AD04 ; PDB 7UGG (CRYO-EM STRUCTURE OF TRPV3 IN COMPLEX WITH THE ANESTHETIC DYCLONINE) - ligand code N8R ; Sodium channel protein type 10 subunit alpha UNIPROT Q9Y5Y9 SCN10A 171 ; PREDNISOLONE ; 50-24-8 ; 1955 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (PREDNISOLONE) L02BX53 A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02 D07CA03 S01CA02 S02CA01 S03CA02 D07BA01 S01BB02 V03AB05 A01AC54 R01AD52 ; PDB 6W9K (STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH PREDNISOLONE AND PGC1A COREGULATOR FRAGMENT) - ligand code TUA ; Glucocorticoid receptor UNIPROT P04150 NR3C1 172 ; PREDNISOLONE ACETATE ; 52-21-1 ; 1955 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (PREDNISOLONE) L02BX53 A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02 D07CA03 S01CA02 S02CA01 S03CA02 D07BA01 S01BB02 V03AB05 A01AC54 R01AD52 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 173 ; RIBOFLAVIN ; 83-88-5 ; 1953 ; ; TARGET FLAVOKINASE -- FLAVIN ADENIN DINUCLEOTIDE (FAD) SYNTHASE ; ATC (RIBOFLAVIN) S01XA26 A11HA04 ; PDB 2CCB (COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS) - ligand code RBF ; Riboflavin kinase K UNIPROT Q969G6 RFK 174 ; ETHCHLORVYNOL ; 113-18-8 ; 1961 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (ETHCHLORVYNOL) N05CM08 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 175 ; FLUDROCORTISONE ACETATE ; 514-36-3 ; 1955 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (FLUDROCORTISONE) H02AA02 S01CA06 S02CA07 S03CA05 ; ; Mineralocorticoid receptor UNIPROT P08235 NR3C2 176 ; M MIDODRINE ; 3600-87-1 ; 0 ; ; TARGET ALPHA-1A ADRENERGIC RECEPTOR -- ALPHA-1B ADRENERGIC RECEPTOR ; ATC (MIDODRINE) C01CA17 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 177 ; HYDROXYAMPHETAMINE ; 103-86-6 ; 1969 ; DISCONTINUED ; TARGET MONOAMINE TRANSPORTER ; ATC (AMFETAMINE) N06BA01 ; PDB 3BUF (BACE-1 COMPLEXED WITH COMPOUND 2) - ligand code AEG ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 178 ; PHYTONADIONE ; 84-80-0 ; 1955 ; ; ; ATC (PHYTOMENADIONE) B02BA01 ; PDB 4XK8 (CRYSTAL STRUCTURE OF PLANT PHOTOSYSTEM I-LHCI SUPER-COMPLEX AT 2.8 ANGSTROM RESOLUTION) - ligand code PQN ; Alpha-synuclein UNIPROT P37840 179 ; AMBENONIUM ; 7648-98-8 ; 1956 ; DISCONTINUED ; TARGET CHOLINESTERASE ; ATC (AMBENONIUM) N07AA30 ; ; Acetylcholinesterase UNIPROT P22303 ACHE 180 ; METHYLPHENIDATE ; 1037510-61-4 ; 1955 ; ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT DOPAMINE TRANSPORTER -- SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (METHYLPHENIDATE) N06BA04 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 181 ; MECAMYLAMINE ; 60-40-2 ; 1956 ; ; TARGET ACETYLCHOLINE RECEPTORS ; ATC (MECAMYLAMINE) C02BB01 ; ; Neuronal acetylcholine receptor 182 ; HYDROXYPROGESTERONE CAPROATE ; 630-56-8 ; 1974 ; DISCONTINUED ; TARGET PROGESTERONE RECEPTOR ; ; ; Progesterone receptor UNIPROT P06401 PGR 183 ; PROMAZINE ; 58-40-2 ; 1956 ; DISCONTINUED ; TARGET DOPAMINE RECEPTOR ; ATC (PROMAZINE) N05AA03 ; PDB 4MA7 (CRYSTAL STRUCTURE OF MOUSE PRION PROTEIN COMPLEXED WITH PROMAZINE) - ligand code P2Z ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 184 ; CLIDINIUM ; 3485-62-9 ; 1966 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (CLIDINIUM) A03CA02 ; PDB 8GTU (CRYSTAL STRUCTURE OF PUTATIVE AMINO ACID BINDING PERIPLASMIC ABC TRANSPORTER PROTEIN FROM CANDIDATUS LIBERIBACTER ASIATICUS IN COMPLEX WITH CLIDINIUM) - ligand code KG2 ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 185 ; LIOTHYRONINE ; 6893-02-3 ; 1956 ; ; TARGET THYROID HORMONE RECEPTOR ; ATC (LIOTHYRONINE) H03AA03 H03AA02 ; PDB 4LNW (CRYSTAL STRUCTURE OF TR-ALPHA BOUND TO T3 IN A SECOND SITE) - ligand code T3 ; Thyroid hormone receptor alpha UNIPROT P10827 THRA -- Thyroid hormone receptor beta UNIPROT P10828 THRB 186 ; HYDROXYZINE ; 68-88-2 ; 1956 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (HYDROXYZINE) N05BB01 N05BB51 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 187 ; METHSUXIMIDE ; 39122-23-1 ; 1957 ; ; ; ATC (MESUXIMIDE) N03AD03 ; ; Voltage-gated T-type calcium channel UNIPROT O43497 CACNA1G 188 ; LEVALLORPHAN ; 152-02-3 ; 1956 ; DISCONTINUED ; TARGET OPIOID RECEPTOR ; ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 189 ; PHENMETRAZINE ; 134-49-6 ; 0 ; DISCONTINUED ; TARGET NORADRENALINE TRANSPORTER -- DOPAMINE TRANSPORTER ; ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 190 ; ANILERIDINE ; 144-14-9 ; 1957 ; DISCONTINUED ; TARGET OPIOID RECEPTOR ; ATC (ANILERIDINE) N01AH05 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 191 ; HYDROCORTAMATE ; 76-47-1 ; 1956 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (HYDROCORTISONE) A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01 D07AC16 D07CA01 S01CA03 S02CA03 S03CA04 D07BA04 S01BB01 D07AB11 D07AB02 D07BB04 R01AD60 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 192 ; PROCHLORPERAZINE ; 58-38-8 ; 1956 ; ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (PROCHLORPERAZINE) N05AB04 ; PDB 3M0W (STRUCTURE OF S100A4 WITH PCP) - ligand code P77 ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- D(3) dopamine receptor UNIPROT P35462 DRD3 193 ; ORPHENADRINE ; 83-98-7 ; 1957 ; ; TARGET GLUTAMATE [NMDA] RECEPTOR -- HISTAMINE RECEPTOR -- MUSCARINIC RECEPTOR ; ATC (ORPHENADRINE CHLORIDE) N04AB02 M03BC01 M03BC51 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Histamine H1 receptor UNIPROT P35367 HRH1 194 ; METHSUXIMIDE ; 39122-22-0 ; 1957 ; ; ; ATC (MESUXIMIDE) N03AD03 ; ; Voltage-gated T-type calcium channel UNIPROT O43497 CACNA1G 195 ; FLUOXYMESTERONE ; 76-43-7 ; 1956 ; DISCONTINUED ; TARGET ANDROGEN RECEPTOR ; ATC (FLUOXYMESTERONE) G03BA01 ; ; Androgen receptor UNIPROT P10275 AR 196 ; ORPHENADRINE ; 83-98-7 ; 1957 ; ; TARGET GLUTAMATE [NMDA] RECEPTOR -- HISTAMINE RECEPTOR -- MUSCARINIC RECEPTOR ; ATC (ORPHENADRINE CHLORIDE) N04AB02 M03BC01 M03BC51 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Histamine H1 receptor UNIPROT P35367 HRH1 197 ; MECLIZINE ; 569-65-3 ; 1957 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (MECLOZINE) R06AE05 R06AE55 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 198 ; ISOFLUROPHATE ; 55-91-4 ; 1957 ; DISCONTINUED ; TARGET CHOLINESTERASE ; ATC (FLUOSTIGMINE) S01EB07 ; ; Acetylcholinesterase UNIPROT P22303 ACHE 199 ; CHLORAMBUCIL ; 305-03-3 ; 1957 ; ; TARGET DNA ; ATC (CHLORAMBUCIL) L01AA02 ; PDB 3CSJ (HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH CHLORAMBUCIL) - ligand code CBL ; UNKNOWN 200 ; TOLBUTAMIDE ; 64-77-7 ; 1957 ; DISCONTINUED ; TARGET K(ATP) CHANNEL ; ATC (TOLBUTAMIDE) A10BB03 V04CA01 ; ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 201 ; MEPENZOLATE ; 25990-43-6 ; 1956 ; DISCONTINUED ; TARGET MUSCARINIC RECEPTOR ; ATC (MEPENZOLATE) A03AB12 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 202 ; RESCINNAMINE ; 24815-24-5 ; 1956 ; DISCONTINUED ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (RESCINNAMINE) C02AA01 C02LA02 C02LA52 ; ; Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 203 ; MECLIZINE ; 569-65-3 ; 1957 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (MECLOZINE) R06AE05 R06AE55 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 204 ; ISOPROPAMIDE ; 7492-32-2 ; 1957 ; DISCONTINUED ; ; ATC (ISOPROPAMIDE) A03AB09 A03CA01 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 205 ; PERPHENAZINE ; 58-39-9 ; 1957 ; ; TARGET D(1A) DOPAMINE RECEPTOR -- D(2) DOPAMINE RECEPTOR ; ATC (PERPHENAZINE) N05AB03 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 206 ; DESERPIDINE ; 131-01-1 ; 1957 ; DISCONTINUED ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (DESERPIDINE) C02AA05 C02LA03 ; ; Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 207 ; DEXBROMPHENIRAMINE ; 132-21-8 ; 1957 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (BROMPHENIRAMINE) R06AB01 R06AB51 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 208 ; ETHOTOIN ; 86-35-1 ; 1957 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ATC (ETHOTOIN) N03AB01 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 209 ; NORETHINDRONE ; 68-22-4 ; 1962 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (NORETHISTERONE) H01CC53 G03AC01 G03DC02 G03FA01 G03FB05 G03AA05 G03AB04 H01CC54 ; PDB 2W8Y (RU486 BOUND TO THE PROGESTERONE RECEPTOR IN A DESTABILIZED AGONISTIC CONFORMATION) - ligand code NDR ; Progesterone receptor UNIPROT P06401 PGR 210 ; NORETHINDRONE ACETATE ; 51-98-9 ; 1973 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (NORETHISTERONE) H01CC53 G03AC01 G03DC02 G03FA01 G03FB05 G03AA05 G03AB04 H01CC54 ; ; Progesterone receptor UNIPROT P06401 PGR 211 ; ANISINDIONE ; 117-37-3 ; 1957 ; DISCONTINUED ; ; ; ; Vitamin K-dependent gamma-carboxylase UNIPROT P38435 GGCX 212 ; BUCLIZINE ; 82-95-1 ; 1957 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (BUCLIZINE) R06AE01 R06AE51 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 213 ; MESTRANOL ; 72-33-3 ; 1961 ; DISCONTINUED ; TARGET ESTROGEN RECEPTOR ; ; ; Estrogen receptor UNIPROT P03372 ESR1 214 ; NORETHYNODREL ; 68-23-5 ; 1961 ; DISCONTINUED ; TARGET PROGESTERONE RECEPTOR ; ATC (NORETYNODREL) G03FA09 ; ; Progesterone receptor UNIPROT P06401 PGR 215 ; PROPOXYPHENE ; 469-62-5 ; 1957 ; DISCONTINUED ; TARGET OPIOID RECEPTOR ; ATC (DEXTROPROPOXYPHENE) N02AC04 N02AC54 N02AC74 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 216 ; METHOCARBAMOL ; 532-03-6 ; 1957 ; ; ; ATC (METHOCARBAMOL) M03BA03 M03BA53 M03BA73 ; ; Carbonic anhydrase 1 UNIPROT P00915 CA1 217 ; ETHOXZOLAMIDE ; 452-35-7 ; 1966 ; DISCONTINUED ; TARGET CARBONIC ANHYDRASE ; ; PDB 5TT3 (CRYSTAL STRUCTURE OF THE COMPLEX OF HELICOBACTER PYLORI ALPHA-CARBONIC ANHYDRASE WITH ETHOXZOLAMIDE) - ligand code EZL ; Carbonic anhydrase 2 UNIPROT P00918 CA2 -- Carbonic anhydrase 1 UNIPROT P00915 CA1 218 ; NIACIN ; 59-67-6 ; 1957 ; ; ; ATC (NICOTINIC ACID) C10BA01 C04AC01 C10AD02 C10AD52 ; PDB 1ICV (THE STRUCTURE OF ESCHERICHIA COLI NITROREDUCTASE COMPLEXED WITH NICOTINIC ACID) - ligand code NIO ; Hydroxycarboxylic acid receptor 2 UNIPROT Q8TDS4 HCAR2 219 ; TRIPROLIDINE ; 486-12-4 ; 1977 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (TRIPROLIDINE) R06AX07 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 220 ; TRIFLUPROMAZINE ; 146-54-3 ; 1957 ; DISCONTINUED ; TARGET SEROTONIN TRANSPORTER (PMID10193665) ; ATC (TRIFLUPROMAZINE) N05AA05 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 221 ; CHLOROTHIAZIDE ; 58-94-6 ; 1958 ; ; TARGET CARBONIC ANHYDRASE ; ATC (CHLOROTHIAZIDE) C03AA04 C03AB04 C03AH01 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 222 ; METHYLPREDNISOLONE ; 83-43-2 ; 1957 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (METHYLPREDNISOLONE) D07AA01 D10AA02 H02AB04 D07AC14 D07CA02 S01CA08 S03CA07 H02BX01 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 223 ; METHYLPREDNISOLONE SUCCINATE ; 2921-57-5 ; 1959 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (METHYLPREDNISOLONE) D07AA01 D10AA02 H02AB04 D07AC14 D07CA02 S01CA08 S03CA07 H02BX01 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 224 ; TRIAMCINOLONE ; 124-94-7 ; 1957 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (TRIAMCINOLONE) A01AC01 C05AA12 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05 D07CB01 S02CA04 D07BB03 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 225 ; TRIAMCINOLONE ACETONIDE ; 76-25-5 ; 1958 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ; PDB 5UFS (X-RAY CRYSTAL STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH TRIAMCINOLONE ACETONIDE AND SHP COREGULATOR FRAGMENT) - ligand code 1TA ; Glucocorticoid receptor UNIPROT P04150 NR3C1 226 ; TRIAMCINOLONE DIACETATE ; 67-78-7 ; 1959 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (TRIAMCINOLONE) A01AC01 C05AA12 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05 D07CB01 S02CA04 D07BB03 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 227 ; BENZONATATE ; 104-31-4 ; 1958 ; ; TARGET VOLTAGE-GATED SODIUM CHANNELS (PMID26386152) ; ATC (BENZONATATE) R05DB01 ; ; UNKNOWN 228 ; PHENPROCOUMON ; 435-97-2 ; 1957 ; DISCONTINUED ; TARGET VITAMIN K EPOXIDE REDUCTASE ; ATC (PHENPROCOUMON) B01AA04 ; ; Vitamin K epoxide reductase complex subunit 1 UNIPROT Q9BQB6 VKORC1 229 ; DEXTROMETHORPHAN ; 125-71-3 ; 1957 ; ; TARGET SIGMA 1-TYPE OPIOID RECEPTOR -- GLUTAMATE [NMDA] RECEPTOR ; ATC (DEXTROMETHORPHAN) N06AX62 R05DA09 N07XX59 ; ; UNKNOWN 230 ; CHLORMEZANONE ; 80-77-3 ; 1960 ; DISCONTINUED ; ; ATC (CHLORMEZANONE) M03BB02 M03BB52 M03BB72 ; ; UNKNOWN 231 ; FURAZOLIDONE ; 67-45-8 ; 1958 ; DISCONTINUED ; TARGET MONOAMINE OXIDASE ; ATC (FURAZOLIDONE) G01AX06 P01AB51 ; ; UNKNOWN 232 ; CHLORZOXAZONE ; 95-25-0 ; 1958 ; ; TARGET NITRIC OXIDE SYNTHASE (NOS) OXYGENASE ; ATC (CHLORZOXAZONE) M03BB03 M03BB53 M03BB73 ; PDB 1M9J (HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH CHLORZOXAZONE BOUND) - ligand code CLW ; Calcium-activated potassium channel subunit alpha-1 UNIPROT Q12791 KCNMA1 233 ; TRIMEPRAZINE ; 84-96-8 ; 0 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (ALIMEMAZINE) R06AD01 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 234 ; HALOTHANE ; 151-67-7 ; 1958 ; DISCONTINUED ; TARGET POLYPHARMACOLOGY (VOLTAGE-DEPENDENT ANION CHANNEL, GABA, PMID24563623) ; ATC (HALOTHANE) N01AB01 ; PDB 2JST (FOUR-ALPHA-HELIX BUNDLE WITH DESIGNED ANESTHETIC BINDING POCKETS II: HALOTHANE EFFECTS ON STRUCTURE AND DYNAMICS) - ligand code HLT ; Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 -- Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 235 ; DICHLORPHENAMIDE ; 120-97-8 ; 1958 ; ; TARGET CARBONIC ANHYDRASE ; ATC (DICLOFENAMIDE) S01EC02 ; PDB 2POU (THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4,5-DICHLORO-BENZENE-1,3-DISULFONAMIDE) - ligand code I7A ; Carbonic anhydrase 2 UNIPROT P00918 CA2 -- Carbonic anhydrase 1 UNIPROT P00915 CA1 236 ; CHLORMEZANONE ; 80-77-3 ; 1960 ; DISCONTINUED ; ; ATC (CHLORMEZANONE) M03BB02 M03BB52 M03BB72 ; ; UNKNOWN 237 ; TRIFLUOPERAZINE ; 117-89-5 ; 1959 ; ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (TRIFLUOPERAZINE) N05AB06 ; PDB 3KO0 (STRUCTURE OF THE TFP-CA2+-BOUND ACTIVATED FORM OF THE S100A4 METASTASIS FACTOR) - ligand code TFP ; D(2) dopamine receptor UNIPROT P14416 DRD2 238 ; SULFINPYRAZONE ; 57-96-5 ; 1959 ; DISCONTINUED ; ; ATC (SULFINPYRAZONE) M04AB02 ; ; Solute carrier family 22 member 12 UNIPROT Q96S37 SLC22A12 239 ; METHOHEXITAL ; 151-83-7 ; 1960 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 ; ATC (METHOHEXITAL) N01AF01 N05CA15 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 240 ; OXYPHENCYCLIMINE ; 125-53-1 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (OXYPHENCYCLIMINE) A03AA01 A03CA03 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 241 ; PHENTERMINE ; 122-09-8 ; 1959 ; ; ; ATC (PHENTERMINE) A08AA01 A08AA51 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 242 ; CHLORPROPAMIDE ; 94-20-2 ; 1958 ; DISCONTINUED ; TARGET K(ATP) CHANNEL ; ATC (CHLORPROPAMIDE) A10BB02 ; ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 243 ; DEXAMETHASONE ; 50-02-2 ; 1958 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DEXAMETHASONE) A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01 D07CB04 S01CA01 S02CA06 S03CA01 R01AD53 ; PDB 4UDC (GR IN COMPLEX WITH DEXAMETHASONE) - ligand code DEX ; Glucocorticoid receptor UNIPROT P04150 NR3C1 244 ; DEXAMETHASONE PHOSPHATE ; 312-93-6 ; 1959 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DEXAMETHASONE) A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01 D07CB04 S01CA01 S02CA06 S03CA01 R01AD53 ; PDB 3TC5 (SELECTIVE TARGETING OF DISEASE-RELEVANT PROTEIN BINDING DOMAINS BY O-PHOSPHORYLATED NATURAL PRODUCT DERIVATIVES) - ligand code 3T5 ; Glucocorticoid receptor UNIPROT P04150 NR3C1 245 ; DEXAMETHASONE ACETATE ; 1177-87-3 ; 1973 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DEXAMETHASONE) A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01 D07CB04 S01CA01 S02CA06 S03CA01 R01AD53 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 246 ; DIETHYLPROPION ; 90-84-6 ; 1959 ; ; TARGET NORADRENALINE TRANSPORTER -- DOPAMINE TRANSPORTER ; ATC (AMFEPRAMONE) A08AA03 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 247 ; THIOPENTAL ; 76-75-5 ; 1959 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (THIOPENTAL) N01AF03 N05CA19 ; PDB 5L4E (X-RAY STRUCTURE OF THE 2-22' LOCALLY-CLOSED MUTANT OF GLIC IN COMPLEX WITH THIOPENTAL) - ligand code EDP ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 248 ; THIOTEPA ; 52-24-4 ; 1959 ; ; TARGET DNA ; ATC (THIOTEPA) L01AC01 ; ; UNKNOWN 249 ; PHENYLPROPANOLAMINE ; 14838-15-4 ; 1958 ; DISCONTINUED ; TARGET ALPHA-1 ADRENERGIC RECEPTOR ; ATC (PHENYLPROPANOLAMINE) R01BA01 R01BA51 ; PDB 3U6K (EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH NVP-LDK733) - ligand code BB8 ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 250 ; OXYMORPHONE ; 76-41-5 ; 1959 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (OXYMORPHONE) N02AA11 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 251 ; METHAZOLAMIDE ; 554-57-4 ; 1959 ; ; TARGET CARBONIC ANHYDRASE ; ATC (METHAZOLAMIDE) S01EC05 ; PDB 3DAZ (USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES) - ligand code MZM ; Carbonic anhydrase 2 UNIPROT P00918 CA2 -- Carbonic anhydrase 1 UNIPROT P00915 CA1 252 ; FLUOROMETHOLONE ; 426-13-1 ; 1972 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (FLUOROMETHOLONE) C05AA06 D07AB06 D07XB04 D10AA01 S01BA07 S01CB05 D07CB03 S01CA07 S01BB03 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 253 ; FLUPHENAZINE ; 69-23-8 ; 1959 ; ; TARGET D(1) DOPAMINE RECEPTOR -- D(2) DOPAMINE RECEPTOR ; ATC (FLUPHENAZINE) N05AB02 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 254 ; CARISOPRODOL ; 78-44-4 ; 1959 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA) ; ATC (CARISOPRODOL) M03BA02 M03BA52 M03BA72 ; ; UNKNOWN 255 ; CARISOPRODOL ; 78-44-4 ; 1959 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA) ; ATC (CARISOPRODOL) M03BA02 M03BA52 M03BA72 ; ; UNKNOWN 256 ; HYDROCHLOROTHIAZIDE ; 58-93-5 ; 1959 ; ; TARGET CARBONIC ANHYDRASE ; ATC (HYDROCHLOROTHIAZIDE) C09XA52 C09XA54 C09DX06 C03AA03 C03AB03 C03EA01 C03AX01 C09DX07 C09DX03 C09BX03 C09DX08 C09DX01 ; PDB 3IJX (CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, HYDROCHLOROTHIAZIDE) - ligand code HCZ ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 257 ; THIORIDAZINE ; 50-52-2 ; 1962 ; ; TARGET DOPAMINE RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- ALPHA-1A ADRENERGIC RECEPTOR ; ATC (THIORIDAZINE) N05AC02 ; PDB 3TBG (HUMAN CYTOCHROME P450 2D6 WITH TWO THIORIDAZINES BOUND IN ACTIVE SITE) - ligand code RTZ ; D(2) dopamine receptor UNIPROT P14416 DRD2 258 ; IMIPRAMINE ; 50-49-7 ; 1959 ; ; TARGET NORADRENALINE TRANSPORTER ; ATC (IMIPRAMINE) N06AA02 N06AA03 ; PDB 2Q72 (CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-LEUCINE, SODIUM, AND IMIPRAMINE) - ligand code IXX ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 259 ; METHDILAZINE ; 1982-37-2 ; 1981 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (METHDILAZINE) R06AD04 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 260 ; MEDROXYPROGESTERONE ACETATE ; 71-58-9 ; 1959 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (MEDROXYPROGESTERONE) G03AC06 G03DA02 L02AB02 G03AA17 G03FA12 G03FB06 G03AA08 ; ; Progesterone receptor UNIPROT P06401 PGR 261 ; DEMECARIUM ; 16505-84-3 ; 1959 ; DISCONTINUED ; TARGET CHOLINESTERASE ; ATC (DEMECARIUM) S01EB04 ; ; Acetylcholinesterase UNIPROT P22303 ACHE 262 ; NANDROLONE ; 434-22-0 ; 0 ; ; TARGET ANDROGEN RECEPTOR ; ATC (NANDROLONE) A14AB01 S01XA11 ; PDB 5KP4 (CRYSTAL STRUCTURE OF KETOSTEROID ISOMERASE FROM PSEUDOMONAS PUTIDA (PKSI) BOUND TO 19-NORTESTOSTERONE) - ligand code 6VW ; Androgen receptor UNIPROT P10275 AR 263 ; PHENELZINE ; 51-71-8 ; 1961 ; ; TARGET MONOAMINE OXIDASE (MAO) ; ATC (PHENELZINE) N06AF03 ; ; Amine oxidase flavin-containing B UNIPROT P27338 MAOB -- Amine oxidase flavin-containing A UNIPROT P21397 MAOA 264 ; DIPHENYLPYRALINE ; 147-20-6 ; 0 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DIPHENYLPYRALINE) R06AA07 R06AA57 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 265 ; HYDROFLUMETHIAZIDE ; 135-09-1 ; 1959 ; DISCONTINUED ; TARGET CARBONIC ANHYDRASE ; ATC (HYDROFLUMETHIAZIDE) C03AA02 C03AB02 C03AH02 ; PDB 3ILU (CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, HYDROFLUMETHIAZIDE) - ligand code HFZ ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 266 ; METHDILAZINE ; 1982-37-2 ; 1981 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (METHDILAZINE) R06AD04 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 267 ; ISOCARBOXAZID ; 59-63-2 ; 1959 ; ; TARGET MONOAMINE OXIDASE ; ATC (ISOCARBOXAZID) N06AF01 ; ; Amine oxidase flavin-containing B UNIPROT P27338 MAOB -- Amine oxidase flavin-containing A UNIPROT P21397 MAOA 268 ; ECHOTHIOPHATE ; 6736-03-4 ; 1960 ; ; TARGET CHOLINESTERASE ; ATC (ECOTHIOPATE) S01EB03 ; ; Acetylcholinesterase UNIPROT P22303 ACHE 269 ; PYRVINIUM ; 7187-62-4 ; 0 ; DISCONTINUED ; ; ATC (PYRVINIUM) P02CX01 ; ; Androgen receptor UNIPROT P10275 AR 270 ; BIPERIDEN ; 514-65-8 ; 1959 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (BIPERIDEN) N04AA02 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 271 ; ISOSORBIDE DINITRATE ; 87-33-2 ; 1959 ; ; ; ATC (ISOSORBIDE DINITRATE) C01DA08 C05AE02 C01DA58 ; ; Soluble guanylate cyclase UNIPROT O75343 GUCY1B2 272 ; ISOSORBIDE MONONITRATE ; 16051-77-7 ; 1991 ; ; ; ATC (ISOSORBIDE MONONITRATE) C01DA14 ; ; Soluble guanylate cyclase UNIPROT O75343 GUCY1B2 273 ; TROPICAMIDE ; 1508-75-4 ; 1960 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (TROPICAMIDE) S01FA06 S01FA56 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 274 ; MEPIVACAINE ; 96-88-8 ; 1960 ; ; TARGET SODIUM CHANNEL PROTEIN ; ATC (MEPIVACAINE) N01BB03 N01BB53 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A 275 ; CHLOPHEDIANOL ; 791-35-5 ; 0 ; DISCONTINUED ; ; ATC (CLOFEDANOL) R05DB10 ; ; UNKNOWN 276 ; BENZTHIAZIDE ; 91-33-8 ; 1960 ; DISCONTINUED ; ; ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 277 ; CYCLOPHOSPHAMIDE ; 50-18-0 ; 1959 ; ; TARGET DNA ; ATC (CYCLOPHOSPHAMIDE) L01AA01 ; ; UNKNOWN 278 ; SPIRONOLACTONE ; 52-01-7 ; 1960 ; ; TARGET MINERALOCORTICOID RECEPTOR ; ATC (SPIRONOLACTONE) C03DA01 ; PDB 3VHU (MINERALOCORTICOID RECEPTOR LIGAND-BINDING DOMAIN WITH SPIRONOLACTONE) - ligand code SNL ; Mineralocorticoid receptor UNIPROT P08235 NR3C2 279 ; BENDROFLUMETHIAZIDE ; 73-48-3 ; 1959 ; DISCONTINUED ; TARGET SODIUM CHLORIDE SYMPORTER -- CARBONIC ANHYDRASE ; ATC (BENDROFLUMETHIAZIDE) C03AA01 C03AB01 C03EA13 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 280 ; FLUOROURACIL ; 51-21-8 ; 1962 ; ; TARGET THYMIDYLATE SYNTHASE ; ATC (FLUOROURACIL) L01BC02 L01BC52 ; PDB 3KVR (TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS) - ligand code URF ; Thymidylate synthase UNIPROT P04818 TYMS 281 ; PHENDIMETRAZINE ; 634-03-7 ; 1975 ; ; TARGET NORADRENALINE TRANSPORTER -- DOPAMINE TRANSPORTER ; ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 282 ; CHLORDIAZEPOXIDE ; 58-25-3 ; 1960 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (CHLORDIAZEPOXIDE) N05BA02 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 283 ; TRICHLORMETHIAZIDE ; 133-67-5 ; 1960 ; DISCONTINUED ; TARGET SODIUM CHLORIDE SYMPORTER ; ATC (TRICHLORMETHIAZIDE) C03AA06 C03AB06 C03EA02 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 284 ; CHLORTHALIDONE ; 77-36-1 ; 1960 ; ; TARGET SODIUM CHLORIDE SYMPORTER ; ATC (CHLORTALIDONE) C03BA04 C03BB04 C03EA06 ; PDB 3F4X (CARBONIC ANHYDRASE INHIBITORS. COMPARISON OF CHLORTHALIDONE AND INDAPAMIDE X-RAY CRYSTAL STRUCTURES IN ADDUCTS WITH ISOZYME II: WHEN THREE WATER MOLECULES MAKE THE DIFFERENCE) - ligand code KLT ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 285 ; OXYTOCIN ; 50-56-6 ; 1980 ; ; TARGET OXYTOCIN RECEPTOR (OTR) ; ATC (OXYTOCIN) G02AC01 H01BB02 ; PDB 1NPO (BOVINE NEUROPHYSIN II) ; Oxytocin receptor UNIPROT P30559 OXTR 286 ; DEXTROTHYROXINE ; 51-49-0 ; 1967 ; DISCONTINUED ; ; ATC (DEXTROTHYROXINE) C10AX01 ; PDB 5CR1 (CRYSTAL STRUCTURE OF TTR, RESVERATROL, T4 COMPLEX) - ligand code T44 ; Thyroid hormone receptor UNIPROT P10827 THRA 287 ; ISOETHARINE ; 788763-51-9 ; 1978 ; DISCONTINUED ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (ISOETARINE) R03AC07 R03CC06 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 288 ; TRANYLCYPROMINE ; 155-09-9 ; 1961 ; ; TARGET MONOAMINE OXIDASE MAO ; ATC (TRANYLCYPROMINE) N06AF04 ; PDB 3MDR (TRANYLCYPROMINE COMPLEX OF CYTOCHROME P450 46A1) - ligand code GJZ ; Amine oxidase flavin-containing B UNIPROT P27338 MAOB 289 ; ETHOSUXIMIDE ; 77-67-8 ; 1960 ; ; TARGET VOLTAGE-DEPENDENT CHANNEL ; ATC (ETHOSUXIMIDE) N03AD01 N03AD51 ; ; Voltage-dependent T-type calcium channel subunit alpha-1G UNIPROT O43497 CACNA1G 290 ; PROPIOMAZINE ; 362-29-8 ; 1960 ; DISCONTINUED ; TARGET DOPAMINE RECEPTOR -- MUSCARINIC ACETYLCHOLINE RECEPTOR -- HISTAMINE H1 RECEPTOR ; ATC (PROPIOMAZINE) N05CM06 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 291 ; COLCHICINE ; 64-86-8 ; 1961 ; ; TARGET TUBULIN ; ATC (COLCHICINE) M04AC01 M04AC51 ; PDB 4X1K (DISCOVERY OF CYTOTOXIC DOLASTATIN 10 ANALOGS WITH N-TERMINAL MODIFICATIONS) - ligand code LOC ; UNKNOWN 292 ; PSEUDOEPHEDRINE ; 90-82-4 ; 1963 ; ; TARGET ADRENERGIC RECEPTOR ; ATC (PSEUDOEPHEDRINE) R01BA02 R01BA52 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 293 ; ATROPINE ; 51-55-8 ; 1960 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (ATROPINE) A03BA01 S01FA01 A03CB03 V03AB54 ; PDB 1TH6 (RUSSELLS VIPER PHOSPHOLIPASE A2) ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 294 ; BENZPHETAMINE ; 156-08-1 ; 1960 ; ; TARGET NORADRENALINE TRANSPORTER (NAT) -- DOPAMINE TRANSPORTER (DAT) ; ATC (AMFETAMINE) N06BA01 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 295 ; THIOGUANINE ; 154-42-7 ; 1966 ; ; TARGET HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRTASE) ; ATC (TIOGUANINE) L01BB03 ; ; Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1 -- Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2 296 ; ATROPINE ; 51-55-8 ; 1960 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (ATROPINE) A03BA01 S01FA01 A03CB03 V03AB54 ; PDB 1TH6 (CRYSTAL STRUCTURE OF PHOSPHOLIPASE A2 IN COMPLEX WITH ATROPINE AT 1.23A RESOLUTION) - ligand code OIN ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 297 ; DIPHENOXYLATE ; 915-30-0 ; 1960 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (DIPHENOXYLATE) A07DA01 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 298 ; ACRISORCIN ; 7527-91-5 ; 0 ; DISCONTINUED ; ; ATC (HEXYLRESORCINOL) R02AA12 ; ; UNKNOWN 299 ; CHLORPROTHIXENE ; 113-59-7 ; 1962 ; DISCONTINUED ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (CHLORPROTHIXENE) N05AF03 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 300 ; METHYCLOTHIAZIDE ; 135-07-9 ; 1960 ; DISCONTINUED ; TARGET SODIUM CHLORIDE SYMPORTER ; ATC (METHYCLOTHIAZIDE) C03AA08 C03AB08 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 301 ; OXYPHENBUTAZONE ; 129-20-4 ; 1960 ; DISCONTINUED ; ; ATC (OXYPHENBUTAZONE) M01AA03 M02AA04 S01BC02 ; PDB 1Q7A (CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN RUSSELL'S VIPER PHOSPHOLIPASE A2 AND AN ANTIINFLAMMATORY AGENT OXYPHENBUTAZONE AT 1.6A RESOLUTION) - ligand code OPB ; Cyclooxygenase UNIPROT P23219 PTGS1 302 ; METRONIDAZOLE ; 443-48-1 ; 1963 ; ; ; ATC (METRONIDAZOLE) A02BD08 J01RA03 J01RA10 A02BD03 A02BD02 A01AB17 D06BX01 G01AF01 J01XD01 P01AB01 P01AB52 P01AB51 J01RA14 A02BD01 A02BD11 A02BD13 J01RA04 A02BD15 ; PDB 1W3R (NIMA FROM D. RADIODURANS WITH METRONIDAZOLE AND PYRUVATE) - ligand code 2MN ; UNKNOWN 303 ; CYPROHEPTADINE ; 129-03-3 ; 1961 ; ; TARGET HISTAMINE H1 RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR ; ATC (CYPROHEPTADINE) R06AX02 ; PDB 5AYF (CRYSTAL STRUCTURE OF SET7, 9 IN COMPLEX WITH CYPROHEPTADINE) - ligand code C7H ; Histamine H1 receptor UNIPROT P35367 HRH1 304 ; BETAMETHASONE ; 378-44-9 ; 1961 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BETAMETHASONE) A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03 D07CC01 S01CA05 S03CA06 D07BC01 S01BB04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 305 ; BETAMETHASONE ACETATE ; 987-24-6 ; 1965 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BETAMETHASONE) A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03 D07CC01 S01CA05 S03CA06 D07BC01 S01BB04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 306 ; BETAMETHASONE VALERATE ; 2152-44-5 ; 1967 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BETAMETHASONE) A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03 D07CC01 S01CA05 S03CA06 D07BC01 S01BB04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 307 ; VINBLASTINE ; 865-21-4 ; 1965 ; ; TARGET TUBULIN ; ATC (VINBLASTINE) L01CA01 ; PDB 4EB6 (TUBULIN-VINBLASTINE: STATHMIN-LIKE COMPLEX) - ligand code VLB ; Tubulin beta UNIPROT P07437 TUBB 308 ; TRIOXSALEN ; 3902-71-4 ; 1964 ; DISCONTINUED ; ; ATC (TRIOXYSALEN) D05AD01 D05BA01 ; ; UNKNOWN 309 ; AMITRIPTYLINE ; 50-48-6 ; 1961 ; ; TARGET NORADRENALINE TRANSPORTER ; ATC (AMITRIPTYLINE) N06AA09 N06CA01 ; PDB 3APV (CRYSTAL STRUCTURE OF THE A VARIANT OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND AMITRIPTYLINE COMPLEX) - ligand code TP0 ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 310 ; SULFAMETHOXAZOLE ; 723-46-6 ; 1965 ; ; TARGET DIHYDROPTEROATE SYNTHASE (DHPS) ; ATC (SULFAMETHOXAZOLE) J01EC01 J01EE01 ; PDB 3TZF (CRYSTAL STRUCTURE OF THE YERSINIA PESTIS DIHYDROPTEROATE SYNTHASE WITH SULFONAMIDE DRUG COMPLEX.) - ligand code 08D ; Dihydropteroate synthase UNIPROT P0AC13 folP 311 ; THIETHYLPERAZINE ; 1420-55-9 ; 1961 ; DISCONTINUED ; TARGET D(1A) DOPAMINE RECEPTOR -- D(2) DOPAMINE RECEPTOR ; ATC (THIETHYLPERAZINE) R06AD03 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 312 ; FLUOCINOLONE ACETONIDE ; 67-73-2 ; 1963 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (FLUOCINOLONE ACETONIDE) C05AA10 D07AC04 S01BA15 S02BA08 D07CC02 S01CA10 S02CA05 D07BC02 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 313 ; FLURANDRENOLIDE ; 1524-88-5 ; 1963 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (FLUDROXYCORTIDE) D07AC07 D07CC03 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 314 ; GLYCOPYRROLATE ; 596-51-0 ; 1961 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (GLYCOPYRRONIUM) R03AL07 R03AL09 R03AL11 D11AA01 A03AB02 R03BB06 A03CA05 R03AL04 R03AL12 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 315 ; DIPYRIDAMOLE ; 58-32-2 ; 1961 ; ; TARGET PHOSPHODIESTERASE ; ATC (DIPYRIDAMOLE) B01AC07 ; PDB 8I4A (CRYO-EM STRUCTURE OF DIPYRIDAMOLE-BOUND ABCC4) - ligand code H9F ; cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A -- cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A UNIPROT Q9Y233 PDE10A 316 ; POLYTHIAZIDE ; 346-18-9 ; 1961 ; DISCONTINUED ; TARGET SODIUM CHLORIDE SYMPORTER ; ATC (POLYTHIAZIDE) C03AA05 C03AB05 ; PDB 8FHQ (CRYO-EM STRUCTURE OF HUMAN NCC (CLASS 3-2)) - ligand code XZF ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 317 ; URACIL MUSTARD ; 66-75-1 ; 1962 ; DISCONTINUED ; TARGET DNA ; ATC (URAMUSTINE) L01AD08 ; ; UNKNOWN 318 ; METYRAPONE ; 54-36-4 ; 1961 ; ; TARGET CYTOCHROME P450 CYP11B1 ; ATC (METYRAPONE) V04CD01 ; PDB 1W0G (CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4) - ligand code MYT ; Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1 319 ; ETHIONAMIDE ; 536-33-4 ; 1965 ; ; TARGET ETHA-ENCODED NADPH-SPECIFIC FAD-CONTAINING MONO-OXYGENASE (ETHA) (PMID20974869) ; ATC (ETHIONAMIDE) J04AD03 ; ; Enoyl-acyl-carrier-protein reductase NADH UNIPROT P9WGR1 inhA 320 ; METHOXYFLURANE ; 76-38-0 ; 1962 ; DISCONTINUED ; TARGET VOLTAGE-GATED SODIUM CHANNELS (NAV) ; ATC (METHOXYFLURANE) N02BG09 ; ; Glycine receptor subunit alpha-1 UNIPROT P23415 GLRA1 -- GABA-A receptor 321 ; CYCLOTHIAZIDE ; 177468-84-7 ; 1963 ; DISCONTINUED ; TARGET GLUTAMATE RECEPTOR 2 ; ATC (CYCLOTHIAZIDE) C03AA09 C03AB09 ; PDB 1LBC (GLUTAMATE RECEPTOR LIGAND BINDING CORE GLUR2 RATTUS NORVEGICUS) ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 322 ; TRIAMTERENE ; 396-01-0 ; 1964 ; ; ; ATC (TRIAMTERENE) C03DB02 ; PDB 3JQ7 (CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 6-PHENYLPTERIDINE-2,4,7-TRIAMINE (DX2)) - ligand code DX2 ; Amiloride-sensitive sodium channel, ENaC UNIPROT P37088 SCNN1A 323 ; METAXALONE ; 1665-48-1 ; 1962 ; ; ; ; ; UNKNOWN 324 ; DIAZEPAM ; 439-14-5 ; 1963 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (DIAZEPAM) N05BA01 ; PDB 2BXF (HUMAN SERUM ALBUMIN COMPLEXED WITH DIAZEPAM) - ligand code DZP ; GABA A receptor alpha-5,beta-2,gamma-3 UNIPROT P31644 GABRA5 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 325 ; QUINETHAZONE ; 73-49-4 ; 1963 ; DISCONTINUED ; TARGET CARBONIC ANHYDRASE ; ATC (QUINETHAZONE) C03BA02 C03BB02 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 326 ; PHENAZOPYRIDINE ; 94-78-0 ; 1990 ; DISCONTINUED ; ; ATC (PHENAZOPYRIDINE) G04BX06 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 327 ; ACETOHEXAMIDE ; 968-81-0 ; 1964 ; DISCONTINUED ; TARGET ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL ; ATC (ACETOHEXAMIDE) A10BB31 ; PDB 8J2O (CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN-COMPLEX WITH ACETOHEXAMIDE AT 2.6 A RESOLUTION) - ligand code TF9 ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 328 ; METHYLDOPA ; 555-30-6 ; 1962 ; ; TARGET DOPA DECARBOXYLASE ; ATC (METHYLDOPA) C02AB01 C02LB01 C02AB02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A 329 ; METHYLDOPATE ; 2508-79-4 ; 1962 ; DISCONTINUED ; TARGET DOPA DECARBOXYLASE ; ATC (METHYLDOPA) C02AB01 C02LB01 C02AB02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Adrenergic receptor alpha-2 UNIPROT P08913 ADRA2A 330 ; ANISOTROPINE ; 25333-49-7 ; 1962 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 331 ; PARGYLINE ; 555-57-7 ; 0 ; DISCONTINUED ; TARGET MONOAMINE OXIDASE ; ATC (PARGYLINE) C02KC01 C02LL01 ; ; Amine oxidase flavin-containing B UNIPROT P27338 MAOB -- Amine oxidase flavin-containing A UNIPROT P21397 MAOA 332 ; ACETYLCYSTEINE ; 616-91-1 ; 1963 ; ; ; ATC (ACETYLCYSTEINE) R05CB01 S01XA08 V03AB23 ; PDB 2J2P (L-FICOLIN COMPLEXED TO N-ACETYL-CYSTEIN (150MM)) - ligand code SC2 ; Superoxide dismutase Mn mitochondrial UNIPROT P04179 SOD2 333 ; DESIPRAMINE ; 50-47-5 ; 1964 ; ; TARGET NORADRENALINE TRANSPORTER -- SEROTONIN TRANSPORTER ; ATC (DESIPRAMINE) N06AA01 ; PDB 2QB4 (CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-LEUCINE, SODIUM AND DESIPRAMINE) - ligand code DSM ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 334 ; OXANDROLONE ; 53-39-4 ; 1964 ; DISCONTINUED ; TARGET ANDROGEN RECEPTOR ; ATC (OXANDROLONE) A14AA08 ; ; Androgen receptor UNIPROT P10275 AR 335 ; IDOXURIDINE ; 54-42-2 ; 1963 ; DISCONTINUED ; TARGET DNA ; ATC (IDOXURIDINE) D06BB01 J05AB02 S01AD01 ; PDB 1KI7 (CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-IODODEOXYURIDINE) - ligand code ID2 ; UNKNOWN 336 ; ETHYLESTRENOL ; 965-90-2 ; 1964 ; DISCONTINUED ; ; ATC (ETHYLESTRENOL) A14AB02 ; ; Androgen receptor UNIPROT P10275 AR 337 ; VINCRISTINE ; 57-22-7 ; 1963 ; ; TARGET TUBULIN BETA CHAIN ; ATC (VINCRISTINE) L01CA02 ; PDB 7A69 (NANODISC RECONSTITUTED HUMAN ABCB1 IN COMPLEX WITH MRK16 FAB AND VINCRISTINE) - ligand code R1Q ; Tubulin beta UNIPROT P07437 TUBB 338 ; PRALIDOXIME ; 6735-59-7 ; 1964 ; ; TARGET CHOLINESTERASE ; ATC (PRALIDOXIME) V03AB04 V03AB54 ; ; Acetylcholinesterase UNIPROT P22303 ACHE 339 ; NALIDIXIC ACID ; 389-08-2 ; 1964 ; DISCONTINUED ; TARGET DNA GYRASE ; ATC (NALIDIXIC ACID) J01MB02 ; ; DNA gyrase UNIPROT P0AES4 gyrA 340 ; NONOXYNOL-9 ; 26027-38-3 ; 1963 ; DISCONTINUED ; ; ; ; UNKNOWN 341 ; NORTRIPTYLINE ; 72-69-5 ; 1964 ; ; TARGET NORADRENALINE TRANSPORTER -- SEROTONIN TRANSPORTER ; ATC (NORTRIPTYLINE) N06AA10 ; PDB 4M48 (X-RAY STRUCTURE OF DOPAMINE TRANSPORTER ELUCIDATES ANTIDEPRESSANT MECHANISM) - ligand code 21B ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 342 ; MELPHALAN ; 148-82-3 ; 1964 ; ; TARGET DNA ; ATC (MELPHALAN) L01AA03 L01AA10 ; ; UNKNOWN 343 ; CHLORPHENTERMINE ; 461-78-9 ; 0 ; DISCONTINUED ; ; ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 344 ; PRILOCAINE ; 721-50-6 ; 1965 ; ; TARGET SODIUM CHANNEL ; ATC (PRILOCAINE) N01BB04 N01BB54 ; ; Sodium channel alpha subunits 345 ; DOXAPRAM ; 309-29-5 ; 1965 ; ; ; ATC (DOXAPRAM) R07AB01 ; ; Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 -- Potassium channel subfamily K member 9 UNIPROT Q9NPC2 KCNK9 346 ; MEFENAMIC ACID ; 61-68-7 ; 1967 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (MEFENAMIC ACID) M01AG01 ; PDB 4JQA (AKR1C2 COMPLEX WITH MEFENAMIC ACID) - ligand code ID8 ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 347 ; AMINOCAPROIC ACID ; 60-32-2 ; 1964 ; ; TARGET PLASMINOGEN ; ATC (AMINOCAPROIC ACID) B02AA01 ; PDB 2ZM9 (STRUCTURE OF 6-AMINOHEXANOATE-DIMER HYDROLASE, A61V, S112A, A124V, R187S, F264C, G291R, G338A, D370Y MUTANT (HYB-S4M94) WITH SUBSTRATE) - ligand code ACA ; Plasminogen UNIPROT P00747 PLG -- Tissue-type plasminogen activator UNIPROT P00750 PLAT 348 ; TOLAZAMIDE ; 1156-19-0 ; 1966 ; DISCONTINUED ; TARGET ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL ; ATC (TOLAZAMIDE) A10BB05 ; ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 349 ; OXAZEPAM ; 604-75-1 ; 1965 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (OXAZEPAM) N05BA04 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 350 ; HALOPERIDOL ; 52-86-8 ; 1967 ; ; TARGET D(1A) DOPAMINE RECEPTOR -- D(2) DOPAMINE RECEPTOR ; ATC (HALOPERIDOL) N05AD01 ; PDB 6DJZ (HUMAN SIGMA-1 RECEPTOR BOUND TO HALOPERIDOL) - ligand code GMJ ; D(2) dopamine receptor UNIPROT P14416 DRD2 351 ; SULFAMETER ; 651-06-9 ; 1966 ; DISCONTINUED ; ; ATC (SULFAMETOXYDIAZINE) J01ED04 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 352 ; PROTRIPTYLINE ; 438-60-8 ; 1967 ; ; ; ATC (PROTRIPTYLINE) N06AA11 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 353 ; AMANTADINE ; 768-94-5 ; 1968 ; ; TARGET (PUTATIVE) NICOTINIC ACETYLCHOLINE RECEPTOR ; ATC (AMANTADINE) N04BB01 ; PDB 2KQT (SOLID-STATE NMR STRUCTURE OF THE M2 TRANSMEMBRANE PEPTIDE OF THE INFLUENZA A VIRUS IN DMPC LIPID BILAYERS BOUND TO DEUTERATED AMANTADINE) - ligand code 308 ; Matrix protein 2 UNIPROT P63231 M -- Glutamate NMDA receptor UNIPROT O15399 GRIN2D 354 ; ETHYNODIOL DIACETATE ; 297-76-7 ; 1966 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (ETYNODIOL) G03DC06 G03FA06 G03AA01 ; ; Progesterone receptor UNIPROT P06401 PGR 355 ; DIPHENIDOL ; 972-02-1 ; 1967 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M2 ; ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 356 ; DROPERIDOL ; 548-73-2 ; 1970 ; ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (DROPERIDOL) N05AD08 ; PDB 6X6G (CRYSTAL STRUCTURE OF ACETYLTRANSFERASE EIS FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH DROPERIDOL) - ligand code USS ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 357 ; FENTANYL ; 437-38-7 ; 1968 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (FENTANYL) N01AH01 N02AB03 N01AH51 ; PDB 5TZO (COMPUTATIONALLY DESIGNED FENTANYL BINDER - FEN49*-COMPLEX) - ligand code 7V7 ; Mu-type opioid receptor UNIPROT P35372 OPRM1 358 ; INDOMETHACIN ; 53-86-1 ; 1965 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (INDOMETACIN) C01EB03 M01AB01 M02AA23 S01BC01 S01CC02 M01AB51 ; PDB 4IKI (CRYSTAL STRUCTURE OF WILD-TYPE HUMAN TRANSTHYRETIN IN COMPLEX WITH INDOMETHACIN) - ligand code IMN ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 359 ; ALLOPURINOL ; 315-30-0 ; 1966 ; ; TARGET XANTHINE OXIDASE ; ATC (ALLOPURINOL) M04AA01 M04AA51 ; ; Xanthine dehydrogenase,oxidase UNIPROT P47989 XDH 360 ; M MIDODRINE ; 3600-87-1 ; 0 ; ; TARGET ALPHA-1A ADRENERGIC RECEPTOR -- ALPHA-1B ADRENERGIC RECEPTOR ; ATC (MIDODRINE) C01CA17 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 361 ; THIABENDAZOLE ; 148-79-8 ; 1967 ; DISCONTINUED ; TARGET FUMARATE REDUCTASE ; ATC (TIABENDAZOLE) D01AC06 P02CA02 ; PDB 1YVM (E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH THIABENDAZOLE) - ligand code TMG ; Tubulin UNIPROT C4PKY4 -- Tubulin UNIPROT F1L005 362 ; CLOFIBRATE ; 637-07-0 ; 1967 ; DISCONTINUED ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ; ATC (CLOFIBRATE) C10AB01 ; ; Peroxisome proliferator-activated receptor alpha UNIPROT Q07869 PPARA 363 ; TESTOLACTONE ; 968-93-4 ; 1969 ; DISCONTINUED ; TARGET CYTOCHROME P450 19 (AROMATASE) ; ; ; Aromatase UNIPROT P11511 CYP19A1 364 ; CLOMIPHENE ; 911-45-5 ; 1967 ; ; TARGET ESTROGEN RECEPTOR ; ATC (CLOMIFENE) G03GB02 ; ; Estrogen receptor UNIPROT P03372 ESR1 365 ; PENTAZOCINE ; 359-83-1 ; 1967 ; ; TARGET SIGMA OPIOID RECEPTOR ; ATC (PENTAZOCINE) N02AD01 N02AD51 ; PDB 6DK1 (HUMAN SIGMA-1 RECEPTOR BOUND TO (+)-PENTAZOCINE) - ligand code GM4 ; Sigma non-opioid intracellular receptor 1 UNIPROT Q99720 SIGMAR1 366 ; ACETYLCHOLINE ; 51-84-3 ; 1973 ; ; TARGET MUSCARINIC ACHRS -- NICOTINIC ACHRS -- ACETYLCHOLINESTERASE ; ATC (ACETYLCHOLINE) S01EB09 ; PDB 2XZ5 (MMTS-MODIFIED Y53C MUTANT OF APLYSIA ACHBP IN COMPLEX WITH ACETYLCHOLINE) - ligand code ACH ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 367 ; PIPOBROMAN ; 54-91-1 ; 1966 ; DISCONTINUED ; ; ATC (PIPOBROMAN) L01AX02 ; ; UNKNOWN 368 ; DEFEROXAMINE ; 70-51-9 ; 1968 ; ; TARGET XANTHINE DEHYDROGENASE/OXIDASE (PMID12169576) ; ATC (DEFEROXAMINE) V03AC01 ; ; UNKNOWN 369 ; FUROSEMIDE ; 54-31-9 ; 1966 ; ; TARGET NKCC1 -- CFTR ; ATC (FUROSEMIDE) C03CA01 C03CB01 C03EB01 ; PDB 3RF4 (ANCYLOSTOMA CEYLANICUM MIF IN COMPLEX WITH FUROSEMIDE) - ligand code FUN ; Solute carrier family 12 member 1 UNIPROT Q13621 SLC12A1 370 ; HYDROXYUREA ; 127-07-1 ; 1967 ; ; TARGET RIBONUCLEOSIDE REDUCTASE ; ATC (HYDROXYCARBAMIDE) L01XX05 ; PDB 3UB9 (PERIPLASMIC PORTION OF THE HELICOBACTER PYLORI CHEMORECEPTOR TLPB WITH HYDROXYUREA BOUND) - ligand code NHY ; Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 -- Ribonucleoside-diphosphate reductase subunit M2 UNIPROT P31350 RRM2 371 ; ETHAMBUTOL ; 74-55-5 ; 1967 ; ; TARGET ARABINOSYLTRANSFERASES (PMID19596878) ; ATC (ETHAMBUTOL) J04AK02 J04AM03 J04AM07 J04AM06 ; PDB 5NR3 (HUMAN DNMT3B PWWP DOMAIN IN COMPLEX WITH ETHAMBUTOL) - ligand code 95E ; Probable arabinosyltransferase A UNIPROT P9WNL9 embA 372 ; AZATHIOPRINE ; 446-86-6 ; 1968 ; ; TARGET DNA ; ATC (AZATHIOPRINE) L04AX01 ; ; UNKNOWN 373 ; FLUMETHASONE PIVALATE ; 2002-29-1 ; 0 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (FLUOCINOLONE ACETONIDE) C05AA10 D07AC04 S01BA15 S02BA08 D07CC02 S01CA10 S02CA05 D07BC02 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 374 ; ACETAMINOPHEN ; 103-90-2 ; 1968 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (PARACETAMOL) N02AJ06 N02AJ01 N02AJ22 N02AJ17 N02BE01 N02BE51 N02BE71 N02AJ13 ; PDB 2DPZ (STRUCTURE OF THE COMPLEX OF PHOSPHOLIPASE A2 WITH N-(4-HYDROXYPHENYL)- ACETAMIDE AT 2.1 A RESOLUTION) - ligand code TYL ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Transient receptor potential cation channel subfamily V member 1 UNIPROT Q8NER1 TRPV1 375 ; PROPRANOLOL ; 525-66-6 ; 1967 ; ; TARGET BETA ADRENERGIC RECEPTOR ; ATC (PROPRANOLOL) C07AA05 C07FX01 C07BA05 ; PDB 5FUK (CRYSTALLIZATION OF A DIMERIC HEME PEROXYGENASE FROM THE FUNGUS MARASMIUS ROTULA) - ligand code SNP ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 376 ; THIOTHIXENE ; 3313-26-6 ; 1967 ; ; ; ATC (TIOTIXENE) N05AF04 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 377 ; CARBAMAZEPINE ; 298-46-4 ; 1968 ; ; TARGET VOLTAGE-GATED SODIUM CHANNELS ; ATC (CARBAMAZEPINE) N03AF01 ; PDB 6TFB (CARBAMAZEPINE BINDS FRIZZLED8) - ligand code N6W ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A 378 ; MEDRYSONE ; 2668-66-8 ; 1969 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (MEDRYSONE) S01BA08 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 379 ; NALOXONE ; 465-65-6 ; 1971 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (NALOXONE) N02AA53 A06AH04 V03AB15 N02AA55 N02AD51 N02AX51 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 380 ; NORGESTREL ; 6533-00-2 ; 1968 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (NORGESTREL) G03FA10 G03FB01 G03AA06 ; ; Progesterone receptor UNIPROT P06401 PGR 381 ; FLURAZEPAM ; 17617-23-1 ; 1970 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (FLURAZEPAM) N05CD01 ; PDB 2YOE (X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH GABA AND FLURAZEPAM) - ligand code FL7 ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 382 ; CYCLOTHIAZIDE ; 134077-76-2 ; 1963 ; DISCONTINUED ; TARGET GLUTAMATE RECEPTOR 2 ; ATC (CYCLOTHIAZIDE) C03AA09 C03AB09 ; PDB 5WEO (ACTIVATED GLUA2 COMPLEX BOUND TO GLUTAMATE, CYCLOTHIAZIDE, AND STZ IN DIGITONIN) - ligand code CYZ ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 383 ; QUINESTROL ; 152-43-2 ; 1996 ; DISCONTINUED ; TARGET ESTROGEN RECEPTOR ; ATC (ETHINYL ESTRADIOL) G03CA01 ; ; Estrogen receptor UNIPROT P03372 ESR1 384 ; FLAVOXATE ; 15301-69-6 ; 1970 ; ; ; ATC (FLAVOXATE) G04BD02 ; PDB 7E4A (CRYSTAL STRUCTURE OF MIF BOUND TO COMPOUND 13) - ligand code HWL ; Phosphodiesterase 4 UNIPROT P27815 PDE4A -- Phosphodiesterase 7 UNIPROT Q13946 PDE7A 385 ; PROCARBAZINE ; 671-16-9 ; 1969 ; ; TARGET DNA ; ATC (PROCARBAZINE) L01XB01 ; ; UNKNOWN 386 ; TRIMIPRAMINE ; 739-71-9 ; 1979 ; ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (TRIMIPRAMINE) N06AA06 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 387 ; CYTARABINE ; 147-94-4 ; 1969 ; ; TARGET CYTIDINE KINASE ; ATC (CYTARABINE) L01BC01 L01XY01 ; PDB 1P5Z (STRUCTURE OF HUMAN DCK COMPLEXED WITH CYTARABINE AND ADP-MG) - ligand code AR3 ; DNA polymerase (alpha,delta,epsilon) UNIPROT P09884 POLA1 388 ; DOXEPIN ; 1668-19-5 ; 1969 ; ; TARGET HISTAMINE H2 RECEPTOR -- HISTAMINE H1 RECEPTOR ; ATC (DOXEPIN) D04AX01 N06AA12 ; PDB 3RZE (STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR IN COMPLEX WITH DOXEPIN) - ligand code D7V ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Histamine H1 receptor UNIPROT P35367 HRH1 389 ; ESKETAMINE ; 33643-46-8 ; 1970 ; ; TARGET GLUTAMATE [NMDA] RECEPTOR -- AMPA RECEPTOR ; ATC (ESKETAMINE) N01AX14 N06AX27 ; PDB 7SAC (S-(+)-KETAMINE BOUND GLUN1A-GLUN2B NMDA RECEPTORS AT 3.69 ANGSTROM RESOLUTION) - ligand code JC9 ; Glutamate NMDA receptor UNIPROT O15399 GRIN2D -- Glutamate receptor ionotropic AMPA UNIPROT P42261 GRIA1 390 ; BENZQUINAMIDE ; 23844-24-8 ; 1974 ; DISCONTINUED ; TARGET P-GLYCOPROTEIN (PMID1362504) ; ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 391 ; PEMOLINE ; 2152-34-3 ; 1975 ; DISCONTINUED ; ; ATC (PEMOLINE) N06BA05 ; ; Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 392 ; MITOTANE ; 53-19-0 ; 1970 ; ; TARGET SXR RECEPTOR ; ATC (MITOTANE) L01XX23 ; ; Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1 -- Cholesterol side-chain cleavage enzyme, mitochondrial UNIPROT P05108 CYP11A1 393 ; FLUOCINONIDE ; 356-12-7 ; 1971 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (FLUOCINONIDE) C05AA11 D07AC08 D07CC05 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 394 ; LEVODOPA ; 59-92-7 ; 1970 ; ; TARGET DOPA DECARBOXYLASE (DDC) ; ATC (LEVODOPA) N04BA01 N04BA02 N04BA03 ; PDB 3TEH (CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS PHENYLALANYL-TRNA SYNTHETASE COMPLEXED WITH L-DOPA) - ligand code DAH ; D(1A) dopamine receptor UNIPROT P21728 DRD1 -- D(2) dopamine receptor UNIPROT P14416 DRD2 395 ; TRETINOIN ; 302-79-4 ; 1971 ; ; TARGET RETINOIC ACID RECEPTOR (RAR) -- CRABP I -- CRABP II ; ATC (TRETINOIN) D10AD01 L01XF01 D10AD51 ; PDB 3CWK (CRYSTAL STRUCTURE OF THE R132K:Y134F:R111L:T54V:L121E MUTANT OF CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AT 1.57 ANGSTROMS RESOLUTION) - ligand code REA_3CWK ; Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor beta UNIPROT P10826 RARB 396 ; FLOXURIDINE ; 50-91-9 ; 1970 ; ; TARGET URIDINE 5-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) ; ATC (FLOXURIDINE) L01BC09 ; PDB 2QCF (CRYSTAL STRUCTURE OF THE OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASE DOMAIN (ASP312ASN MUTANT) OF HUMAN UMP SYNTHASE BOUND TO 5-FLUORO-UMP) - ligand code 5FU ; Thymidylate synthase UNIPROT P04818 TYMS 397 ; HALOPROGIN ; 777-11-7 ; 1971 ; DISCONTINUED ; ; ATC (HALOPROGIN) D01AE11 ; ; UNKNOWN 398 ; TAPENTADOL ; 175591-23-8 ; 2008 ; ; TARGET MU OPIOID RECEPTOR ; ATC (TAPENTADOL) N02AX06 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 399 ; CARBACHOL ; 51-83-2 ; 1972 ; ; ; ATC (CARBACHOL) N07AB01 S01EB02 ; PDB 1UV6 (X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH CARBAMYLCHOLINE) - ligand code CCE ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 400 ; MEGESTROL ACETATE ; 595-33-5 ; 1971 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (MEGESTROL) G03AC05 G03DB02 L02AB01 G03FA08 G03FB04 G03AA04 G03AB01 ; ; Progesterone receptor UNIPROT P06401 PGR 401 ; CROMOLYN ; 16110-51-3 ; 1982 ; ; ; ATC (CROMOLYN) A07EB01 ; ; UNKNOWN 402 ; DIAZOXIDE ; 364-98-7 ; 1973 ; ; TARGET MITOCHONDRIAL KATP-CHANNEL (PMID9400389) ; ATC (DIAZOXIDE) C02DA01 V03AH01 ; ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 403 ; FLUCYTOSINE ; 2022-85-7 ; 1971 ; ; TARGET CYTOSINE DEAMINASE ; ATC (FLUCYTOSINE) D01AE21 J02AX01 ; ; Thymidylate synthase UNIPROT P0CS13 TMP1 -- Thymidylate synthase UNIPROT P12461 TMP1 404 ; DESONIDE ; 638-94-8 ; 1972 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DESONIDE) D07AB08 S01BA11 D07BB02 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 405 ; PANCURONIUM ; 15500-66-0 ; 1972 ; ; TARGET NICOTINIC ACETYLCHOLINE RECEPTOR (NACHR) -- MUSCARINIC RECEPTOR ; ATC (PANCURONIUM) M03AC01 ; ; Acetylcholine receptor UNIPROT P02708 CHRNA1 406 ; PENTAGASTRIN ; 5534-95-2 ; 1974 ; DISCONTINUED ; TARGET GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR ; ATC (PENTAGASTRIN) V04CG04 ; ; GPCR GASR_HUMAN UNIPROT P32239 CCKBR 407 ; ENFLURANE ; 13838-16-9 ; 1972 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR -- GLYCINE RECEPTOR ; ATC (ENFLURANE) N01AB04 ; ; Glycine receptor subunit alpha-1 UNIPROT P23415 GLRA1 -- Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 408 ; MOLINDONE ; 7416-34-4 ; 1974 ; ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (MOLINDONE) N05AE02 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 409 ; MAZINDOL ; 22232-71-9 ; 1973 ; DISCONTINUED ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT DOPAMINE TRANSPORTER ; ATC (MAZINDOL) A08AA05 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 410 ; TRIMETHOPRIM ; 738-70-5 ; 1973 ; ; TARGET DIHYDROFOLATE REDUCTASE ; ATC (TRIMETHOPRIM) J04AM08 J01EE02 J01EE05 J01EE07 J01EE01 J01EE03 J01EE04 J01EA01 ; PDB 3FRB (S. AUREUS F98Y DHFR COMPLEXED WITH TMP) - ligand code TOP ; Dihydrofolate reductase UNIPROT P0ABQ4 folA 411 ; METOLAZONE ; 17560-51-9 ; 1973 ; ; TARGET NA-CL COTRANSPORTER (NCC) ; ATC (METOLAZONE) C03BA08 C03EA12 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 412 ; DYDROGESTERONE ; 152-62-5 ; 0 ; DISCONTINUED ; TARGET PROGESTERONE RECEPTOR ; ATC (DYDROGESTERONE) G03DB01 G03FA14 G03FB08 ; ; Progesterone receptor UNIPROT P06401 PGR 413 ; DOPAMINE ; 51-61-6 ; 1974 ; ; TARGET BETA ADRENERGIC RECEPTOR -- DOPAMINE RECEPTOR -- CATECHOL O-METHYLTRANSFERASE (COMT) -- MONOAMINE OXIDASE ; ATC (DOPAMINE) C01CA04 ; PDB 4XP1 (X-RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO NEUROTRANSMITTER DOPAMINE) - ligand code LDP ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 414 ; CLONIDINE ; 4205-90-7 ; 1974 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (CLONIDINE) C02AC01 N02CX02 S01EA04 C02LC01 C02LC51 ; PDB 2PNC (CRYSTAL STRUCTURE OF BOVINE PLASMA COPPER-CONTAINING AMINE OXIDASE IN COMPLEX WITH CLONIDINE) - ligand code CLU ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B 415 ; PRAZEPAM ; 2955-38-6 ; 1979 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (PRAZEPAM) N05BA11 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 416 ; CARMUSTINE ; 154-93-8 ; 1977 ; ; TARGET DNA -- RNA ; ATC (CARMUSTINE) L01AD01 ; ; Glutathione reductase, mitochondrial UNIPROT P00390 GSR 417 ; PILOCARPINE ; 92-13-7 ; 1974 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 -- MUSCARINIC ACETYLCHOLINE RECEPTOR M2 ; ATC (PILOCARPINE) N07AX01 S01EB01 S01EB51 ; PDB 3T3R (HUMAN CYTOCHROME P450 2A6 IN COMPLEX WITH PILOCARPINE) - ligand code 9PL ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 418 ; DINOPROST ; 551-11-1 ; 1975 ; DISCONTINUED ; TARGET PROSTAGLANDIN E2 RECEPTOR EP2 ; ATC (DINOPROST) G02AD01 ; PDB 8IUK (CRYO-EM STRUCTURE OF THE PGF2-ALPHA-BOUND HUMAN PTGFR-GQ COMPLEX) - ligand code UGU ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 419 ; PRAZOSIN ; 19216-56-9 ; 1976 ; ; TARGET ALPHA-1A ADRENERGIC RECEPTOR -- ALPHA-1B ADRENERGIC RECEPTOR -- ALPHA-1D ADRENERGIC RECEPTOR ; ATC (PRAZOSIN) C02CA01 C02LE01 ; PDB 3OWX (X-RAY STRUCTURAL STUDY OF QUINONE REDUCTASE II INHIBITION BY COMPOUNDS WITH MICROMOLAR TO NANOMOLAR RANGE IC50 VALUES) - ligand code XRA ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 420 ; DANTROLENE ; 7261-97-4 ; 1974 ; ; TARGET RYANODINE RECEPTOR 1 ; ATC (DANTROLENE) M03CA01 ; ; Ryanodine receptor 1 UNIPROT P21817 RYR1 -- Ryanodine receptor 3 UNIPROT Q15413 RYR3 421 ; DISOPYRAMIDE ; 3737-09-5 ; 1977 ; ; TARGET VOLTAGE GATED SODIUM CHANNEL -- KV1.5 ; ATC (DISOPYRAMIDE) C01BA03 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 422 ; MICONAZOLE ; 22916-47-8 ; 1974 ; ; TARGET CYTOCHROME P450 14ALPHA-DEMETHYLASE ; ATC (MICONAZOLE) A01AB09 A07AC01 D01AC02 G01AF04 J02AB01 S02AA13 D01AC52 ; PDB 3OZU (THE CRYSTAL STRUCTURE OF FLAVOHEMOGLOBIN FROM R. EUTROPHUS IN COMPLEX WITH MICONAZOLE) - ligand code X89 ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 423 ; IBUPROFEN ; 15687-27-1 ; 1974 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (IBUPROFEN) N02AJ08 N02AJ23 C01EB16 G02CC01 M01AE01 M02AA13 R02AX02 M01AE51 N02AJ19 ; PDB 3R8G (AKR1C3 COMPLEX WITH IBUPROFEN) - ligand code IZP ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 424 ; PIMOZIDE ; 2062-78-4 ; 1984 ; ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (PIMOZIDE) N05AG02 ; PDB 8GU1 (CRYSTAL STRUCTURE OF PUTATIVE AMINO ACID BINDING PERIPLASMIC ABC TRANSPORTER PROTEIN FROM CANDIDATUS LIBERIBACTER ASIATICUS IN COMPLEX WITH PIMOZIDE) - ligand code 1II ; D(2) dopamine receptor UNIPROT P14416 DRD2 425 ; MEBENDAZOLE ; 31431-39-7 ; 1974 ; ; TARGET TUBULIN ; ATC (MEBENDAZOLE) P02CA01 P02CA51 ; PDB 7OGN (CRYSTAL STRUCTURE OF T2R-TTL -MEBENDAZOLE COMPLEX) - ligand code V95 ; Tubulin UNIPROT C4PKY4 -- Tubulin UNIPROT F1L005 426 ; LOXAPINE ; 1977-10-2 ; 1975 ; ; TARGET D(2) DOPAMINE RECEPTOR -- SEROTONIN 5-HT2 RECEPTOR (PMID24937085) ; ATC (LOXAPINE) N05AH01 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 427 ; OXYBUTYNIN ; 5633-20-5 ; 1975 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (OXYBUTYNIN) G04BD04 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 428 ; TRIMETHOBENZAMIDE ; 138-56-7 ; 1974 ; ; ; ATC (TRIMETHOBENZAMIDE) R06AA10 ; ; UNKNOWN 429 ; CLONAZEPAM ; 1622-61-3 ; 1975 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (CLONAZEPAM) N03AE01 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 430 ; BUTALBITAL ; 77-26-9 ; 1976 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 431 ; PROBUCOL ; 23288-49-5 ; 1977 ; DISCONTINUED ; ; ATC (PROBUCOL) C10AX02 ; ; ATP-binding cassette sub-family A member 1 UNIPROT O95477 ABCA1 432 ; MAPROTILINE ; 10262-69-8 ; 1980 ; DISCONTINUED ; TARGET NORADRENALINE TRANSPORTER ; ATC (MAPROTILINE) N06AA21 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 433 ; CARBIDOPA ; 28860-95-9 ; 1975 ; ; TARGET AROMATIC-L-AMINO-ACID DECARBOXYLASE (AADC) ; ; PDB 1JS3 (CRYSTAL STRUCTURE OF DOPA DECARBOXYLASE IN COMPLEX WITH THE INHIBITOR CARBIDOPA) - ligand code 142 ; Aromatic-L-amino-acid decarboxylase UNIPROT P20711 DDC 434 ; HALCINONIDE ; 3093-35-4 ; 1974 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (HALCINONIDE) D07AD02 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 435 ; DANAZOL ; 17230-88-5 ; 1976 ; ; TARGET ESTROGEN RECEPTOR -- PROGESTERONE RECEPTOR -- ANDROGEN RECEPTOR ; ATC (DANAZOL) G03XA01 ; PDB 6ULB (SEX HORMONE-BINDING GLOBULIN MUTANT E176K IN COMPLEX WITH DANAZOL) - ligand code QA1 ; Androgen receptor UNIPROT P10275 AR -- Progesterone receptor UNIPROT P06401 PGR 436 ; FENOPROFEN ; 29679-58-1 ; 1976 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (FENOPROFEN) M01AE04 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 437 ; SULFACYTINE ; 17784-12-2 ; 1975 ; DISCONTINUED ; TARGET DIHYDROPTEROATE SYNTHASE (DHPS) ; ; ; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase 438 ; BECLOMETHASONE DIPROPIONATE ; 5534-09-8 ; 1976 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BECLOMETASONE) A07EA07 D07AC15 R01AD01 R03BA01 D07CC04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 439 ; ISOFLURANE ; 26675-46-7 ; 1979 ; ; TARGET CYS-LOOP FAMILY OF PENTAMERIC LIGAND-GATED ION CHANNELS (PLGIC) ; ATC (ISOFLURANE) N01AB06 ; PDB 3F78 (CRYSTAL STRUCTURE OF WILD TYPE LFA1 I DOMAIN COMPLEXED WITH ISOFLURANE) - ligand code ICF ; Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 -- Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 440 ; DACARBAZINE ; 4342-03-4 ; 1975 ; ; TARGET DNA ; ATC (DACARBAZINE) L01AX04 ; ; UNKNOWN 441 ; OXYBUTYNIN ; 5633-20-5 ; 1975 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (OXYBUTYNIN) G04BD04 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 442 ; NAPROXEN ; 22204-53-1 ; 1976 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (NAPROXEN) G02CC02 M01AE02 M02AA12 M01AE57 M01AE52 M01AE56 N02CC51 ; PDB 4OR0 (CRYSTAL STRUCTURE OF BOVINE SERUM ALBUMIN IN COMPLEX WITH NAPROXEN) - ligand code NPS ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 443 ; LOMUSTINE ; 13010-47-4 ; 1976 ; ; TARGET DNA -- RNA ; ATC (LOMUSTINE) L01AD02 ; ; UNKNOWN 444 ; CHLOROXINE ; 773-76-2 ; 1976 ; DISCONTINUED ; ; ; ; UNKNOWN 445 ; FENOPROFEN ; 29679-58-1 ; 1976 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (FENOPROFEN) M01AE04 ; PDB 4NED (CRYSTAL STRUCTURE OF C-LOBE OF BOVINE LACTOFERRIN COMPLEXED WITH FENOPROFEN AT 2.1 ANGSTROM RESOLUTION) - ligand code PFN ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 446 ; CLOTRIMAZOLE ; 23593-75-1 ; 1975 ; ; TARGET CYTOCHROME P450 51 ; ATC (CLOTRIMAZOLE) A01AB18 D01AC01 G01AF02 ; PDB 2XFH (STRUCTURE OF CYTOCHROME P450 ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE.) - ligand code CL6 ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 447 ; ISOFLURANE ; 26675-46-7 ; 1979 ; ; TARGET CYS-LOOP FAMILY OF PENTAMERIC LIGAND-GATED ION CHANNELS (PLGIC) ; ATC (ISOFLURANE) N01AB06 ; PDB 4Z90 (ELIC BOUND WITH THE ANESTHETIC ISOFLURANE IN THE RESTING STATE) - ligand code 4LE ; Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 -- Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 448 ; TOLMETIN ; 26171-23-3 ; 1976 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (TOLMETIN) M01AB03 M02AA21 ; PDB 3S3G (CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH TOLMETIN) - ligand code TLT ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 449 ; LACTULOSE ; 4618-18-2 ; 1976 ; ; TARGET EVOLVED BETA-GALACTOSIDASE SUBUNIT ALPHA ; ATC (LACTULOSE) A06AD11 A06AD61 ; PDB 3W9T (PORE-FORMING CEL-III) - ligand code W9T ; UNKNOWN 450 ; LOPERAMIDE ; 53179-11-6 ; 1976 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (LOPERAMIDE) A07DA03 A07DA05 A07DA53 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 451 ; HALAZEPAM ; 23092-17-3 ; 1981 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (HALAZEPAM) N05BA13 ; ; GABA-A receptor 452 ; DIFENOXIN ; 28782-42-5 ; 1978 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (DIFENOXIN) A07DA04 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 453 ; GLIPIZIDE ; 29094-61-9 ; 1984 ; ; TARGET ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL ; ATC (GLIPIZIDE) A10BB07 ; ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 454 ; VASOPRESSIN ; 11000-17-2 ; 2014 ; ; TARGET VASOPRESSIN RECEPTOR ; ATC (VASOPRESSIN) H01BA01 ; PDB 1JK4 (DES 1-6 BOVINE NEUROPHYSIN II) ; Vasopressin V1a receptor UNIPROT P37288 AVPR1A -- Vasopressin V1b receptor UNIPROT P47901 AVPR1B 455 ; LORAZEPAM ; 846-49-1 ; 1977 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (LORAZEPAM) N05BA06 N05BA56 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 456 ; DINOPROSTONE ; 363-24-6 ; 1977 ; ; TARGET PROSTAGLANDIN E2 RECEPTOR EP2 ; ATC (DINOPROSTONE) G02AD02 ; PDB 3WFH (CRYSTAL STRUCTURE OF ANTI-PROSTAGLANDIN E2 FAB FRAGMENT PGE2 COMPLEX) - ligand code P2E ; Prostaglandin E2 receptor EP1 subtype UNIPROT P34995 PTGER1 -- Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3 457 ; DOBUTAMINE ; 34368-04-2 ; 1978 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- CATECHOL O-METHYLTRANSFERASE (COMT) ; ATC (DOBUTAMINE) C01CA07 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 458 ; CYCLOBENZAPRINE ; 303-53-7 ; 1977 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR ; ATC (CYCLOBENZAPRINE) M03BX08 ; ; 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 459 ; ETIDRONATE ; 2809-21-4 ; 1977 ; DISCONTINUED ; TARGET FARNESYL PYROPHOSPHATE SYNTHASE ; ATC (ETIDRONIC ACID) M05BA01 M05BB01 ; PDB 3SDV (STRUCTURE OF A THREE-DOMAIN SESQUITERPENE SYNTHASE: A PROSPECTIVE TARGET FOR ADVANCED BIOFUELS PRODUCTION) - ligand code 911 ; Type IV secretion-like conjugative transfer relaxase protein TraI UNIPROT B1LRJ1 traI 460 ; BACLOFEN ; 1134-47-0 ; 1977 ; ; TARGET GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR ; ATC (BACLOFEN) M03BX01 ; ; GABA-B receptor UNIPROT O75899 GABBR2 461 ; METOCLOPRAMIDE ; 364-62-5 ; 1979 ; ; TARGET DOPAMINE RECEPTOR ; ATC (METOCLOPRAMIDE) A03FA01 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 462 ; DESOXIMETASONE ; 382-67-2 ; 1977 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DESOXIMETASONE) D07AC03 D07XC02 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 463 ; BUTORPHANOL ; 42408-82-2 ; 1978 ; ; TARGET KAPPA-TYPE OPIOID RECEPTOR -- MU-TYPE OPIOID RECEPTOR ; ATC (BUTORPHANOL) N02AF01 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 464 ; METOPROLOL ; 37350-58-6 ; 1978 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (METOPROLOL) C07AB02 C07FX03 C07FB13 C07FB02 C07FX05 C07CB02 C07BB02 C07BB52 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 465 ; METYROSINE ; 672-87-7 ; 1979 ; ; TARGET TYROSINE HYDROXYLASE ; ATC (METIROSINE) C02KB01 ; ; Tyrosine 3-monooxygenase UNIPROT P07101 TH 466 ; SCOPOLAMINE ; 51-34-3 ; 1979 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (SCOPOLAMINE) A04AD01 N05CM05 S01FA02 A04AD51 ; PDB 8CVD (STRUCTURE OF HYOSCYAMINE 6-BETA HYDROXYLASE IN COMPLEX WITH IRON, SUCCINATE, AND SCOPOLAMINE) - ligand code OW0 ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 467 ; TRIAZOLAM ; 28911-01-5 ; 1982 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR (GABA) ; ATC (TRIAZOLAM) N05CD05 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 468 ; SULINDAC ; 38194-50-2 ; 1978 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (SULINDAC) M01AB02 ; PDB 2KAW (NMR STRUCTURE OF THE MDVL1 PDZ DOMAIN IN COMPLEX WITH ITS INHIBITOR) - ligand code SUZ ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 469 ; CIMETIDINE ; 51481-61-9 ; 1977 ; ; TARGET HISTAMINE H2 RECEPTOR ; ATC (CIMETIDINE) A02BA01 A02BA51 ; ; Histamine H2 receptor UNIPROT P25021 HRH2 470 ; BROMOCRIPTINE ; 25614-03-3 ; 1978 ; ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (BROMOCRIPTINE) G02CB01 N04BC01 ; PDB 5VCG (CRYSTAL STRUCTURE OF THE CYSTEINE DEPLETED CYP3A4 BOUND TO BROMOERGOCRYPTINE) - ligand code 08Y ; D(2) dopamine receptor UNIPROT P14416 DRD2 471 ; METOPROLOL ; 37350-58-6 ; 1978 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (METOPROLOL) C07AB02 C07FX03 C07FB13 C07FB02 C07FX05 C07CB02 C07BB02 C07BB52 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 472 ; NADOLOL ; 42200-33-9 ; 1979 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (NADOLOL) C07AA12 C07BA12 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 473 ; TAMOXIFEN ; 10540-29-1 ; 1977 ; ; TARGET ESTROGEN RECEPTOR ; ATC (TAMOXIFEN) L02BA01 ; PDB 1YA4 (CRYSTAL STRUCTURE OF HUMAN LIVER CARBOXYLESTERASE 1 IN COMPLEX WITH TAMOXIFEN) - ligand code CTX ; Estrogen receptor UNIPROT P03372 ESR1 474 ; OXAMNIQUINE ; 21738-42-1 ; 1980 ; DISCONTINUED ; TARGET SULFOTRANSFERASES (PMID17308787) ; ATC (OXAMNIQUINE) P02BA02 ; PDB 5TIX (SCHISTOSOMA HAEMATOBIUM (BLOOD FLUKE) SULFOTRANSFERASE, R-OXAMNIQUINE COMPLEX) - ligand code OQR ; UNKNOWN 475 ; CARBOPROST ; 35700-23-3 ; 1979 ; ; TARGET PROSTAGLANDIN F2ALPHA FP RECEPTOR ; ATC (CARBOPROST) G02AD04 ; ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 476 ; MECLOFENAMATE ; 644-62-2 ; 1980 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- LEUKOCYTE 5-LIPOXYGENASE -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (MECLOFENAMIC ACID) M01AG04 M02AA18 ; PDB 5IKQ (THE STRUCTURE OF MECLOFENAMIC ACID BOUND TO HUMAN CYCLOOXYGENASE-2) - ligand code JMS ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 477 ; TIMOLOL ; 26839-75-8 ; 1978 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (TIMOLOL) C07AA06 S01ED01 C07BA06 S01ED51 C07DA06 ; PDB 3D4S (CHOLESTEROL BOUND FORM OF HUMAN BETA2 ADRENERGIC RECEPTOR.) - ligand code TIM ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 478 ; AMOXAPINE ; 14028-44-5 ; 1980 ; ; ; ATC (AMOXAPINE) N06AA17 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 479 ; NALBUPHINE ; 20594-83-6 ; 1979 ; ; TARGET DELTA-TYPE OPIOID RECEPTOR -- KAPPA-TYPE OPIOID RECEPTOR -- MU-TYPE OPIOID RECEPTOR ; ATC (NALBUPHINE) N02AF02 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 480 ; CALCITRIOL ; 32222-06-3 ; 1978 ; ; TARGET VITAMIN D3 RECEPTOR ; ATC (CALCITRIOL) A11CC04 D05AX03 ; PDB 1DB1 (CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D) - ligand code VDX ; Vitamin D3 receptor UNIPROT P11473 VDR 481 ; GUANADREL ; 40580-59-4 ; 1982 ; DISCONTINUED ; ; ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 482 ; NADOLOL ; 42200-33-9 ; 1979 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (NADOLOL) C07AA12 C07BA12 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 483 ; CINOXACIN ; 28657-80-9 ; 1980 ; DISCONTINUED ; ; ATC (CINOXACIN) J01MB06 ; ; DNA gyrase UNIPROT P0AES4 gyrA 484 ; OXAMNIQUINE ; 21738-42-1 ; 1980 ; DISCONTINUED ; TARGET SULFOTRANSFERASES (PMID17308787) ; ATC (OXAMNIQUINE) P02BA02 ; PDB 5TIW (SCHISTOSOMA HAEMATOBIUM (BLOOD FLUKE) SULFOTRANSFERASE, RACEMIC OXAMNIQUINE COMPLEX) - ligand code OAQ ; UNKNOWN 485 ; VALPROIC ACID ; 99-66-1 ; 1978 ; ; ; ATC (VALPROIC ACID) N03AG01 ; ; Succinate-semialdehyde dehydrogenase, mitochondrial UNIPROT P51649 ALDH5A1 486 ; GUANADREL ; 40580-59-4 ; 1982 ; DISCONTINUED ; ; ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 487 ; AMCINONIDE ; 51022-69-6 ; 1979 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (AMCINONIDE) D07AC11 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 488 ; PIROXICAM ; 36322-90-4 ; 1982 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE ; ATC (PIROXICAM) M01AC01 M02AA07 S01BC06 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 489 ; FLUNISOLIDE ; 3385-03-3 ; 1981 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (FLUNISOLIDE) R01AD04 R03BA03 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 490 ; MINOXIDIL ; 38304-91-5 ; 1979 ; ; TARGET ADENOSINE TRIPHOSPHATE-SENSITIVE POTASSIUM CHANNEL (PMID15133413) ; ATC (MINOXIDIL) C02DC01 D11AX01 ; ; Sulfonylurea receptor 2, Kir6.2 UNIPROT O60706 ABCC9 491 ; TEMAZEPAM ; 846-50-4 ; 1981 ; ; TARGET GABA RECEPTOR ; ATC (TEMAZEPAM) N05CD07 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 492 ; OXPRENOLOL ; 6452-71-7 ; 0 ; DISCONTINUED ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (OXPRENOLOL) C07AA02 C07CA02 C07BA02 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 493 ; AMILORIDE ; 2609-46-3 ; 1981 ; ; TARGET AMILORIDE-SENSITIVE SODIUM CHANNEL -- UROKINASE-TYPE PLASMINOGEN ACTIVATOR ; ATC (AMILORIDE) C03DB01 ; PDB 4NTX (STRUCTURE OF ACID-SENSING ION CHANNEL IN COMPLEX WITH SNAKE TOXIN AND AMILORIDE) - ligand code AMR ; Amiloride-sensitive sodium channel, ENaC UNIPROT P37088 SCNN1A 494 ; AMINOGLUTETHIMIDE ; 125-84-8 ; 1980 ; DISCONTINUED ; TARGET CYTOCHROME P450 ; ATC (AMINOGLUTETHIMIDE) L02BG01 ; PDB 5OH1 (CEREBLON ISOFORM 4 FROM MAGNETOSPIRILLUM GRYPHISWALDENSE IN COMPLEX WITH AMINOGLUTETHIMIDE) - ligand code 9UQ ; Aromatase UNIPROT P11511 CYP19A1 -- Cholesterol side-chain cleavage enzyme, mitochondrial UNIPROT P05108 CYP11A1 495 ; TRAZODONE ; 19794-93-5 ; 1981 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- 5-HYDROXYTRYPTAMINE 2C RECEPTOR -- ALPHA 1-ADRENERGIC RECEPTOR ; ATC (TRAZODONE) N06AX05 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 496 ; BUMETANIDE ; 28395-03-1 ; 1983 ; ; TARGET SODIUM POTASSIUM CHLORIDE COTRANSPORTER (NKCC1) ; ATC (BUMETANIDE) C03CA02 C03CB02 C03EB02 ; PDB 7S1Y (CRYO-EM STRUCTURE OF HUMAN NKCC1 K289NA492E BOUND WITH BUMETANIDE) - ligand code 82U ; Solute carrier family 12 member 1 UNIPROT Q13621 SLC12A1 497 ; ETOMIDATE ; 33125-97-2 ; 1982 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (ETOMIDATE) N01AX07 ; PDB 6X3V (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS ETOMIDATE) - ligand code V8D ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 498 ; DIPIVEFRIN ; 52365-63-6 ; 1980 ; DISCONTINUED ; TARGET ALPHA-2A ADRENERGIC RECEPTOR ; ATC (DIPIVEFRIN) S01EA02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B -- Alpha-2C adrenergic receptor UNIPROT P18825 ADRA2C 499 ; ATENOLOL ; 29122-68-7 ; 1981 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ATENOLOL) C07AB03 C07FB03 C07CB03 C07CB53 C07BB03 C07DB01 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 500 ; TOCAINIDE ; 41708-72-9 ; 1984 ; DISCONTINUED ; TARGET SODIUM CHANNEL PROTEIN ; ATC (TOCAINIDE) C01BB03 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 501 ; ALPRAZOLAM ; 28981-97-7 ; 1981 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (ALPRAZOLAM) N05BA12 ; PDB 3U5J (CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH ALPRAZOLAM) - ligand code 08H ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 502 ; PINDOLOL ; 13523-86-9 ; 1982 ; ; TARGET BETA ADRENERGIC RECEPTOR ; ATC (PINDOLOL) C07AA03 C07CA03 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 503 ; TRIFLURIDINE ; 70-00-8 ; 1980 ; ; TARGET DNA ; ATC (TRIFLURIDINE) S01AD02 L01BC59 ; ; UNKNOWN 504 ; CAPTOPRIL ; 62571-86-2 ; 1981 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME (ACE) ; ATC (CAPTOPRIL) C09AA01 C09BA01 ; PDB 1UZF (COMPLEX OF THE ANTI-HYPERTENSIVE DRUG CAPTOPRIL AN THE HUMAN TESTICULAR ANGIOTENSIN I-CONVERTING ENZYME) - ligand code MCO ; Angiotensin-converting enzyme UNIPROT P12821 ACE 505 ; VERAPAMIL ; 52-53-9 ; 1981 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (VERAPAMIL) C09BB10 C08DA01 C08DA51 ; PDB 5C6O (PROTEIN B) - ligand code 4YH ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1S UNIPROT Q13698 CACNA1S 506 ; BUPRENORPHINE ; 52485-79-7 ; 1981 ; ; TARGET KAPPA-TYPE OPIOID RECEPTOR -- MU-TYPE OPIOID RECEPTOR ; ATC (BUPRENORPHINE) N02AE01 N07BC01 N07BC51 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 507 ; GEMFIBROZIL ; 25812-30-0 ; 1981 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA ; ATC (GEMFIBROZIL) C10AB04 ; PDB 5BOJ (CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH GEMFIBROZIL) - ligand code 4TX ; Peroxisome proliferator-activated receptor alpha UNIPROT Q07869 PPARA 508 ; DIFLUNISAL ; 22494-42-4 ; 1982 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (DIFLUNISAL) N02BA11 ; PDB 4I89 (CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH DIFLUNISAL AT ACIDIC PH) - ligand code 1FL ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 509 ; OXYMETAZOLINE ; 1491-59-4 ; 1986 ; ; TARGET ALPHA-2A ADRENERGIC RECEPTOR -- ALPHA-1A ADRENERGIC RECEPTOR ; ATC (OXYMETAZOLINE) D11AX27 R01AA05 R01AB07 S01GA04 ; PDB 7EJK (STRUCTURE OF THE ALPHA2A-ADRENERGIC RECEPTOR GOA SIGNALING COMPLEX BOUND TO OXYMETAZOLINE) - ligand code J5C ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B 510 ; NIFEDIPINE ; 21829-25-4 ; 1981 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (NIFEDIPINE) C07FB03 C08CA05 C08GA01 C08CA55 ; PDB 6JP5 (RABBIT CAV1.1-NIFEDIPINE COMPLEX) - ligand code C5U ; Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D -- Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C 511 ; ALPROSTADIL ; 745-65-3 ; 1981 ; ; ; ATC (ALPROSTADIL) C01EA01 G04BE01 ; PDB 3WHX (CRYSTAL STRUCTURE OF ANTI-PROSTAGLANDIN E2 FAB FRAGMENT PGE1 COMPLEX) - ligand code XPG ; Prostaglandin E2 receptor EP1 subtype UNIPROT P34995 PTGER1 -- Prostaglandin E2 receptor EP2 subtype UNIPROT P43116 PTGER2 512 ; VERAPAMIL ; 52-53-9 ; 1981 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (VERAPAMIL) C09BB10 C08DA01 C08DA51 ; PDB 7QKR (CRYO-EM STRUCTURE OF ABC TRANSPORTER STE6-2P FROM PICHIA PASTORIS WITH VERAPAMIL AT 3.2 A RESOLUTION) - ligand code I6H ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1S UNIPROT Q13698 CACNA1S 513 ; CHENODIOL ; 474-25-9 ; 1983 ; ; TARGET HYDROXYSTEROID DEHYDROGENASE/BILE ACID BINDING PROTEIN ; ATC (CHENODEOXYCHOLIC ACID) A05AA01 ; PDB 2JN3 (NMR STRUCTURE OF CL-BABP COMPLEXED TO CHENODEOXYCHOLIC ACID) - ligand code JN3 ; Bile acid receptor UNIPROT Q96RI1 NR1H4 514 ; INDAPAMIDE ; 26807-65-8 ; 1983 ; ; TARGET ION CHANNELS ; ATC (INDAPAMIDE) C03BA11 C09BX01 C09BX06 C10BX13 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 515 ; NITROGLYCERIN ; 55-63-0 ; 1981 ; ; ; ATC (GLYCERYL TRINITRATE) C01DA02 C05AE01 C01DA52 ; PDB 4FR8 (CRYSTAL STRUCTURE OF HUMAN ALDEHYDE DEHYDROGENASE-2 IN COMPLEX WITH NITROGLYCERIN) - ligand code TNG ; Soluble guanylate cyclase UNIPROT O75343 GUCY1B2 516 ; KETOCONAZOLE ; 65277-42-1 ; 1981 ; ; TARGET CYTOCHROME P450 51 ; ATC (KETOCONAZOLE) D01AC08 G01AF11 H02CA03 J02AB02 ; PDB 6AYB (NAEGLERIA FOWLERI CYP51-KETOCONAZOLE COMPLEX) - ligand code KKK ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 -- Steroid 17-alpha-hydroxylase,17,20 lyase UNIPROT P05093 CYP17A1 517 ; INDAPAMIDE ; 26807-65-8 ; 1983 ; ; TARGET ION CHANNELS ; ATC (INDAPAMIDE) C03BA11 C09BX01 C09BX06 C10BX13 ; PDB 3BL1 (CARBONIC ANHYDRASE INHIBITORS. SULFONAMIDE DIURETICS REVISITED OLD LEADS FOR NEW APPLICATIONS) - ligand code BL1 ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 518 ; CARPROFEN ; 53716-49-7 ; 1987 ; DISCONTINUED ; TARGET PROSTAGLANDIN G/H SYNTHASE 2 ; ; PDB 5RH4 (PANDDA ANALYSIS GROUP DEPOSITION SARS-COV-2 MAIN PROTEASE FRAGMENT SCREEN -- CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE IN COMPLEX WITH Z1530425063 (MPRO-X2659)) - ligand code UHG ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 519 ; FLUTAMIDE ; 13311-84-7 ; 1989 ; ; TARGET ANDROGEN RECEPTOR ; ATC (FLUTAMIDE) L02BB01 ; ; Androgen receptor UNIPROT P10275 AR 520 ; RITODRINE ; 26652-09-5 ; 1980 ; DISCONTINUED ; TARGET BETA 2 ADRENERGIC RECEPTOR ; ATC (RITODRINE) G02CA01 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 521 ; SULFADOXINE ; 2447-57-6 ; 1981 ; DISCONTINUED ; TARGET DIHYDROPTEROATE SYNTHASE ; ATC (SULFADOXINE) P01BF09 ; ; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase 522 ; GUANABENZ ; 5051-62-7 ; 1982 ; DISCONTINUED ; TARGET ALPHA 2 ADRENERGIC RECEPTOR ; ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B 523 ; DILTIAZEM ; 42399-41-7 ; 1982 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (DILTIAZEM) C05AE03 C08DB01 ; PDB 6JPB (RABBIT CAV1.1-DILTIAZEM COMPLEX) - ligand code C9F ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C 524 ; BUPROPION ; 34911-55-2 ; 1985 ; ; TARGET DOPAMINE TRANSPORTER -- NOREPINEPHRINE TRANSPORTER ; ATC (BUPROPION) N06AX12 N06AX62 A08AA62 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 525 ; ACYCLOVIR ; 59277-89-3 ; 1982 ; ; TARGET THYMIDINE KINASE ; ATC (ACYCLOVIR) D06BB03 ; PDB 5I3C (CRYSTAL STRUCTURE OF E.COLI PURINE NUCLEOSIDE PHOSPHORYLASE WITH ACYCLOGUANOSINE) - ligand code AC2 ; DNA polymerase catalytic subunit UNIPROT P04293 -- DNA polymerase catalytic subunit UNIPROT P09252 526 ; TIOCONAZOLE ; 65899-73-2 ; 1983 ; ; TARGET CYTOCHROME P450 51 ; ATC (TIOCONAZOLE) D01AC07 G01AF08 ; PDB 7LYX (CRYSTAL STRUCTURE OF HUMAN CYP8B1 IN COMPLEX WITH (S)-TIOCONAZOLE) - ligand code YHM ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 527 ; PENTOXIFYLLINE ; 6493-05-6 ; 1984 ; ; TARGET PHOSPHODIESTERASE ; ATC (PENTOXIFYLLINE) C04AD03 ; PDB 3ARR (CRYSTAL STRUCTURE ANALYSIS OF CHITINASE A FROM VIBRIO HARVEYI WITH NOVEL INHIBITORS - COMPLEX STRUCTURE WITH PENTOXIFYLLINE) - ligand code PNX ; Adenosine receptor A2b UNIPROT P29275 ADORA2B -- cAMP-specific 3,5-cyclic phosphodiesterase 4B UNIPROT Q07343 PDE4B 528 ; BUPROPION ; 34911-55-2 ; 1985 ; ; TARGET DOPAMINE TRANSPORTER -- NOREPINEPHRINE TRANSPORTER ; ATC (BUPROPION) N06AX12 N06AX62 A08AA62 ; PDB 8HFL (CRYO-EM STRUCTURE OF HUMAN NOREPINEPHRINE TRANSPORTER NET IN THE PRESENCE OF THE ANTIDEPRESSANT BUPROPION IN AN INWARD-OPEN STATE AT RESOLUTION OF 3.0 ANGSTROM) - ligand code 1XR ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 529 ; MIDAZOLAM ; 59467-70-8 ; 1985 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (MIDAZOLAM) N05CD08 ; PDB 5TE8 (CRYSTAL STRUCTURE OF THE MIDAZOLAM-BOUND HUMAN CYP3A4) - ligand code 08J ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-5,beta-3,gamma-2 UNIPROT P18507 GABRG2 530 ; ISOTRETINOIN ; 4759-48-2 ; 1982 ; ; TARGET RETINOIC ACID RECEPTOR ALPHA ; ATC (ISOTRETINOIN) D10AD04 D10BA01 D10AD54 ; PDB 1GX9 (BOVINE BETA-LACTOGLOBULIN COMPLEXED WITH RETINOIC ACID, TRIGONAL LATTICE Z) - ligand code REA ; Retinoic acid receptor beta UNIPROT P10826 RARB 531 ; LEVONORGESTREL ; 797-63-7 ; 1979 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (LEVONORGESTREL) G03AC03 G03AD01 G03FA11 G03FB09 G03AA07 G03AB03 ; PDB 3D90 (CRYSTAL STRUCTURE OF THE HUMAN PROGESTERONE RECEPTOR LIGAND-BINDING DOMAIN BOUND TO LEVONORGESTREL) - ligand code NOG ; Progesterone receptor UNIPROT P06401 PGR 532 ; NICLOSAMIDE ; 50-65-7 ; 0 ; DISCONTINUED ; ; ATC (NICLOSAMIDE) P02DA01 ; PDB 8SUR (TMEM16F BOUND WITH NICLOSAMIDE) - ligand code VUT ; UNKNOWN 533 ; NABILONE ; 51022-71-0 ; 1985 ; ; TARGET CANNABINOID RECEPTOR 1 ; ATC (NABILONE) A04AD11 ; ; Cannabinoid receptor 1 UNIPROT P21554 CNR1 534 ; TIOCONAZOLE ; 65899-73-2 ; 1983 ; ; TARGET CYTOCHROME P450 51 ; ATC (TIOCONAZOLE) D01AC07 G01AF08 ; PDB 6H1L (STRUCTURE OF THE BM3 HEME DOMAIN IN COMPLEX WITH TIOCONAZOLE) - ligand code FJQ ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 535 ; LABETALOL ; 36894-69-6 ; 1984 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR -- BETA ADRENERGIC RECEPTOR ; ATC (LABETALOL) C07AG01 C07CG01 C07BG01 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 536 ; PRAZIQUANTEL ; 55268-74-1 ; 1982 ; ; TARGET GLUTATHIONE S-TRANSFERASE ; ATC (PRAZIQUANTEL) P02BA01 ; PDB 1GTB (CRYSTAL STRUCTURES OF A SCHISTOSOMAL DRUG AND VACCINE TARGET: GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICA AND ITS COMPLEX WITH THE LEADING ANTISCHISTOSOMAL DRUG PRAZIQUANTEL) - ligand code PZQ ; High voltage-activated calcium channel beta subunit CavB1 UNIPROT Q95US7 -- High voltage-activated calcium channel beta subunit CavB2 UNIPROT Q962H3 537 ; RANITIDINE ; 66357-35-5 ; 1983 ; ; TARGET HISTAMINE H2 RECEPTOR ; ATC (RANITIDINE) A02BA02 A02BA07 ; ; Histamine H2 receptor UNIPROT P25021 HRH2 538 ; QUAZEPAM ; 36735-22-5 ; 1985 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (QUAZEPAM) N05CD10 ; ; GABA A receptor alpha-1,beta-1,gamma-2 UNIPROT P14867 GABRA1 -- GABA A receptor alpha-3,beta-1,gamma-2 UNIPROT P18505 GABRB1 539 ; PRAZIQUANTEL ; 55268-74-1 ; 1982 ; ; TARGET GLUTATHIONE S-TRANSFERASE ; ATC (PRAZIQUANTEL) P02BA01 ; PDB 1GTB (GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICA) ; High voltage-activated calcium channel beta subunit CavB1 UNIPROT Q95US7 -- High voltage-activated calcium channel beta subunit CavB2 UNIPROT Q962H3 540 ; TRILOSTANE ; 13647-35-3 ; 1984 ; DISCONTINUED ; TARGET 3-BETA-HYDROXYSTEROID DEHYDROGENASE ; ATC (TRILOSTANE) H02CA01 ; ; 3 beta-hydroxysteroid dehydrogenase,Delta 5-->4-isomerase type 2 UNIPROT P26439 HSD3B2 541 ; MILNACIPRAN ; 92623-85-3 ; 2009 ; ; TARGET SEROTONIN TRANSPORTER -- NOREPINEPHRINE TRANSPORTER ; ATC (MILNACIPRAN) N06AX17 ; PDB 6M3Z (X-RAY STRUCTURE OF A DROSOPHILA DOPAMINE TRANSPORTER WITH NET-LIKE MUTATIONS (D121G, S426M, F471L) IN MILNACIPRAN BOUND FORM) - ligand code F0F ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 542 ; BUSPIRONE ; 36505-84-7 ; 1986 ; ; TARGET 5-HYDROXYTRYPTAMINE 1A RECEPTOR ; ATC (BUSPIRONE) N05BE01 ; PDB 8FYX (BUSPIRONE-BOUND SEROTONIN 1A (5-HT1A) RECEPTOR-GI1 PROTEIN COMPLEX) - ligand code YLX ; 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 543 ; SULCONAZOLE ; 61318-90-9 ; 1985 ; ; TARGET CYTOCHROME P450 ; ATC (SULCONAZOLE) D01AC09 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 544 ; ANTAZOLINE ; 91-75-8 ; 1990 ; DISCONTINUED ; TARGET NMDA RECEPTOR (PMID10974308) -- ALPHA 2 ADRENERGIC RECEPTOR ; ATC (ANTAZOLINE) R01AC04 R06AX05 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 545 ; NAPHAZOLINE ; 835-31-4 ; 1971 ; ; TARGET ALPHA 2 ADRENERGIC RECEPTOR (PMID241844--PMID17852165) ; ATC (NAPHAZOLINE) R01AA08 R01AB02 S01GA01 S01GA51 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B 546 ; CICLOPIROX ; 29342-05-0 ; 1982 ; ; ; ATC (CICLOPIROX) D01AE14 G01AX12 ; PDB 6J10 (CICLOPIROX INHIBITS HEPATITIS B VIRUS SECRETION BY BLOCKING CAPSID ASSEMBLY) - ligand code B4O ; UNKNOWN 547 ; ACETOHYDROXAMIC ACID ; 546-88-3 ; 1983 ; ; TARGET UREASE -- MACROPHAGE METALLOELASTASE (MATRIX METALLOPROTEINASE-12 (MMP-12)) ; ATC (ACETOHYDROXAMIC ACID) G04BX03 ; PDB 1Y93 (CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH ACETOHYDROXAMIC ACID AT ATOMIC RESOLUTION) - ligand code HAE ; Bacterial urease UNIPROT Q03282 ureA 548 ; ECONAZOLE ; 27220-47-9 ; 1982 ; ; TARGET CYTOCHROME P450 ; ATC (ECONAZOLE) D01AC03 G01AF05 G01AF55 ; PDB 2UVN (CRYSTAL STRUCTURE OF ECONAZOLE-BOUND CYP130 FROM MYCOBACTERIUM TUBERCULOSIS) - ligand code ECN ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 549 ; KETOPROFEN ; 22071-15-4 ; 1986 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (KETOPROFEN) M01AE03 M02AA10 M01AE53 ; PDB 5ZWR (STRUCTURAL BASIS FOR THE ENANTIOSELECTIVITY OF EST-Y29 TOWARD (S)-KETOPROFEN) - ligand code 9KL ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 550 ; FLURBIPROFEN ; 5104-49-4 ; 1986 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (FLURBIPROFEN) M01AE09 M02AA19 R02AX01 S01BC04 ; PDB 1CQE (PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN) - ligand code FLP ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 551 ; ETOPOSIDE ; 33419-42-0 ; 1983 ; ; TARGET DNA TOPOISOMERASE 2 ; ATC (ETOPOSIDE) L01CB01 ; PDB 5CDN (2.8A STRUCTURE OF ETOPOSIDE WITH S.AUREUS DNA GYRASE AND DNA) - ligand code EVP ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 552 ; VECURONIUM ; 50700-72-6 ; 1984 ; ; TARGET NICOTINIC ACETYLCHOLINE RECEPTOR (NACHR) -- MUSCARINIC RECEPTOR ; ATC (VECURONIUM) M03AC03 ; ; Acetylcholine receptor UNIPROT P02708 CHRNA1 553 ; FLECAINIDE ; 54143-55-4 ; 1985 ; ; TARGET SODIUM CHANNEL NAV1.5 ; ATC (FLECAINIDE) C01BC04 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 554 ; OXAPROZIN ; 21256-18-8 ; 1992 ; ; ; ATC (OXAPROZIN) M01AE12 ; PDB 7XC4 (CRYSTAL STRUCTURE OF SARS-COV-2 NSP3 MACRODOMAIN 3 (SARS-UNIQUE DOMAIN-M) IN COMPLEX WITH OXAPROZIN) - ligand code BJ6 ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 555 ; RIBAVIRIN ; 36791-04-5 ; 1985 ; ; TARGET ADENOSINE KINASE -- CYTOSOLIC PURINE 5'-NUCLEOTIDASE -- RNA-DIRECTED RNA POLYMERASE CATALYTIC SUBUNIT -- ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1 -- LARGE STRUCTURAL PROTEIN -- INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 -- DNA ; ATC (RIBAVIRIN) J05AP01 ; PDB 3SFU (CRYSTAL STRUCTURE OF MURINE NOROVIRUS RNA DEPENDENT RNA POLYMERASE IN COMPLEX WITH RIBAVIRIN) - ligand code RBV ; Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1 -- NS5B protein UNIPROT Q8JXU8 NS5B 556 ; NIMODIPINE ; 66085-59-4 ; 1988 ; ; TARGET CALCIUM CHANNEL ; ATC (NIMODIPINE) C08CA06 ; PDB 5KMF (STRUCTURE OF CAVAB IN COMPLEX WITH NIMODIPINE) - ligand code 6U9 ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 557 ; MEXILETINE ; 31828-71-4 ; 1985 ; ; TARGET SODIUM CHANNEL ; ATC (MEXILETINE) C01BB02 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A 558 ; ACEBUTOLOL ; 37517-30-9 ; 1984 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ACEBUTOLOL) C07AB04 C07BB04 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 559 ; ETODOLAC ; 41340-25-4 ; 1991 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (ETODOLAC) M01AB08 ; PDB 5V0V (CRYSTAL STRUCTURE OF EQUINE SERUM ALBUMIN COMPLEX WITH ETODOLAC) - ligand code 8QS ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 560 ; NALTREXONE ; 16590-41-3 ; 1984 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (NALTREXONE) A08AA62 N07BB04 N02AA56 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 561 ; FLUOXETINE ; 54910-89-3 ; 1987 ; ; TARGET SODIUM-DEPENDENT SEROTONIN TRANSPORTER -- POTASSIUM CHANNEL TREKS ; ATC (FLUOXETINE) N06AB03 N06CA03 ; PDB 4MM8 (CRYSTAL STRUCTURE OF LEUBAT (DELTA13 MUTANT) IN COMPLEX WITH (R)-FLUOXETINE) - ligand code RFX ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 562 ; LEVOCARNITINE ; 541-15-1 ; 1985 ; ; TARGET MITOCHONDRIAL CARNITINE/ACYLCARNITINE CARRIER PROTEIN -- ORGANIC CATION/CARNITINE TRANSPORTER ; ATC (LEVOCARNITINE) A16AA01 ; PDB 2H3U (CRYSTAL STRUCTURE OF MURINE CARNITINE ACETYLTRANSFERASE IN COMPLEX WITH CARNITINE AND COA) - ligand code 152 ; Carnitine O-palmitoyltransferase 1 liver isoform UNIPROT P50416 CPT1A 563 ; AMIODARONE ; 1951-25-3 ; 1985 ; ; TARGET SODIUM CHANNEL -- POTASSIUM CHANNEL ; ATC (AMIODARONE) C01BD01 ; PDB 4O8Z (CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH COMPOUND (2-BUTYLBENZOFURAN-3-YL)(4-(2-(DIETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL)METHANONE) - ligand code BBI ; Potassium voltage-gated channel subfamily H member 2 UNIPROT Q12809 KCNH2 564 ; ENALAPRIL ; 75847-73-3 ; 1985 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (ENALAPRIL) C09AA02 C09BA02 C09BB02 C09BB06 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 565 ; BEPRIDIL ; 64706-54-3 ; 1990 ; DISCONTINUED ; TARGET CALCIUM CHANNEL ; ATC (BEPRIDIL) C08EA02 ; PDB 1LXF (STRUCTURE OF THE REGULATORY N-DOMAIN OF HUMAN CARDIAC TROPONIN C IN COMPLEX WITH HUMAN CARDIAC TROPONIN-I(147-163) AND BEPRIDIL) - ligand code BEP ; Voltage-dependent T-type calcium channel subunit alpha-1H UNIPROT O95180 CACNA1H -- Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C 566 ; LEUPROLIDE ; 53714-56-0 ; 1985 ; ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR ; ATC (LEUPRORELIN) L02AE02 L02AE51 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 567 ; GUANFACINE ; 29110-47-2 ; 1986 ; ; TARGET ALPHA-2A ADRENERGIC RECEPTOR ; ATC (GUANFACINE) C02AC02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A 568 ; HYDROMORPHONE ; 466-99-9 ; 1984 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (HYDROMORPHONE) N02AA03 N02AG04 N02AA53 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 569 ; TERAZOSIN ; 63590-64-7 ; 1987 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR ; ATC (TERAZOSIN) G04CA03 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 570 ; ESTAZOLAM ; 29975-16-4 ; 1990 ; ; TARGET GABA RECEPTOR ; ATC (ESTAZOLAM) N05CD04 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 571 ; DEZOCINE ; 53648-55-8 ; 0 ; DISCONTINUED ; TARGET KAPPA-TYPE OPIOID RECEPTOR -- MU-TYPE OPIOID RECEPTOR ; ATC (DEZOCINE) N02AX03 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 572 ; IPRATROPIUM ; 60205-81-4 ; 1986 ; ; TARGET MUSCARINIC RECEPTOR ; ATC (IPRATROPIUM BROMIDE) R03AL01 R01AX03 R03BB01 R03AL02 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 573 ; PROPAFENONE ; 54063-53-5 ; 1989 ; ; TARGET POTASSIUM VOLTAGE-GATED CHANNEL -- SODIUM CHANNEL ; ATC (PROPAFENONE) C01BC03 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 574 ; METHACHOLINE ; 55-92-5 ; 1986 ; ; ; ATC (METHACHOLINE) V04CX03 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 575 ; TRIENTINE ; 112-24-3 ; 1985 ; ; ; ATC (TRIENTINE) A16AX12 ; PDB 1DJ6 (COMPLEX OF A Z-DNA HEXAMER, D(CG)3, WITH SYNTHETIC POLYAMINE AT ROOM TEMPERATURE) - ligand code 104 ; UNKNOWN 576 ; DICLOFENAC ; 15307-86-5 ; 1988 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (DICLOFENAC) D11AX18 M01AB05 M02AA15 S01BC03 S01CC01 M01AB55 ; PDB 3IB0 (STRUCTURAL BASIS OF THE PREVENTION OF NSAID-INDUCED DAMAGE OF THE GASTROINTESTINAL TRACT BY C-TERMINAL HALF (C-LOBE) OF BOVINE COLOSTRUM PROTEIN LACTOFERRIN: BINDING AND STRUCTURAL STUDIES OF C-LOBE COMPLEX WITH DICLOFENAC) - ligand code DIF ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 577 ; MISOPROSTOL ; 59122-46-2 ; 1988 ; ; TARGET PROSTAGLANDIN RECEPTOR ; ATC (MISOPROSTOL) A02BB01 G02AD06 M01AE56 ; ; Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3 578 ; CARTEOLOL ; 51781-06-7 ; 1988 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (CARTEOLOL) C07AA15 S01ED05 S01ED55 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 579 ; LEVOBUNOLOL ; 47141-42-4 ; 1985 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (LEVOBUNOLOL) S01ED03 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 580 ; MISOPROSTOL ; 59122-46-2 ; 1988 ; ; TARGET PROSTAGLANDIN RECEPTOR ; ATC (MISOPROSTOL) A02BB01 G02AD06 M01AE56 ; ; Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3 581 ; LEVOBETAXOLOL ; 63659-18-7 ; 1985 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (BETAXOLOL) C07AB05 S01ED02 S01ED52 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 582 ; TRANEXAMIC ACID ; 1197-18-8 ; 1986 ; ; TARGET PLASMINOGEN ; ATC (TRANEXAMIC ACID) B02AA02 ; PDB 1B2I (KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN: NMR SOLUTION STRUCTURE OF TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID (AMCHA) COMPLEX) - ligand code AMH ; Plasminogen UNIPROT P00747 PLG 583 ; MITOXANTRONE ; 65271-80-9 ; 1987 ; ; TARGET DNA -- DNA TOPOISOMERASE 2 ; ATC (MITOXANTRONE) L01DB07 ; PDB 2KGP (STRUCTURAL BASIS FOR STABILIZATION OF THE TAU PRE-MRNA SPLICING REGULATORY ELEMENT BY NOVANTRONE (MITOXANTRONE)) - ligand code MIX ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 584 ; FENOFIBRATE ; 49562-28-9 ; 1993 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA ; ATC (FENOFIBRATE) C10AB05 C10BA03 C10BA12 C10BA09 C10BA04 ; PDB 8K8J (CANNABINOID RECEPTOR 1 BOUND TO FENOFIBRATE COUPLING MINIGSQ AND NB35 COMPLEX) - ligand code J3O ; Peroxisome proliferator-activated receptor alpha UNIPROT Q07869 PPARA 585 ; CLOBETASOL PROPIONATE ; 25122-46-7 ; 1985 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (CLOBETASOL) D07AD01 D07CD01 ; PDB 7LAD (CLOBETASOL PROPIONATE BOUND TO CYP3A5) - ligand code XRD ; Glucocorticoid receptor UNIPROT P04150 NR3C1 586 ; SELEGILINE ; 14611-51-9 ; 1989 ; ; TARGET MONOAMINE OXIDASE TYPE B ; ATC (SELEGILINE) N04BD01 ; ; Amine oxidase flavin-containing B UNIPROT P27338 MAOB 587 ; ALFENTANIL ; 71195-58-9 ; 1986 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (ALFENTANIL) N01AH02 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 588 ; NAFTIFINE ; 65472-88-0 ; 1988 ; ; TARGET SQUALENE 2, 3-EPOXIDASE ; ATC (NAFTIFINE) D01AE22 ; ; Squalene epoxidase UNIPROT Q4JEY0 589 ; ETHANOLAMINE OLEATE ; 3282-75-5 ; 1988 ; ; ; ATC (MONOETHANOLAMINE OLEATE) C05BB01 ; ; UNKNOWN 590 ; ETRETINATE ; 54350-48-0 ; 1986 ; DISCONTINUED ; TARGET RETINOIC ACID RECEPTOR (RAR) -- RETINOIC X RECEPTOR (RXR) ; ATC (ETRETINATE) D05BB01 ; ; Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor RXR-gamma UNIPROT P48443 RXRG 591 ; NORFLOXACIN ; 70458-96-7 ; 1986 ; DISCONTINUED ; TARGET DNA GYRASE ; ATC (NORFLOXACIN) J01MA06 S01AE02 J01RA14 J01RA13 ; ; DNA topoisomerase 4 subunit A UNIPROT P0AFI2 parC -- DNA gyrase subunit A UNIPROT P0AES4 gyrA 592 ; PERGOLIDE ; 66104-22-1 ; 1988 ; DISCONTINUED ; TARGET D1 DOPAMINE RECEPTOR -- D2 DOPAMINE RECEPTOR ; ATC (PERGOLIDE) N04BC02 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- D(1A) dopamine receptor UNIPROT P21728 DRD1 593 ; ESMOLOL ; 81147-92-4 ; 1986 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ESMOLOL) C07AB09 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 594 ; SUPROFEN ; 40828-46-4 ; 1988 ; DISCONTINUED ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (SUPROFEN) M01AE07 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 595 ; PINACIDIL ; 60560-33-0 ; 1989 ; DISCONTINUED ; TARGET ATP-DEPENDENT POTASSIUM CHANNEL ; ATC (PINACIDIL) C02DG01 C02LX01 ; ; Sulfonylurea receptor 2, Kir6.2 UNIPROT O60706 ABCC9 596 ; M MISOPROSTOL ; 259218-80-9 ; 0 ; ; TARGET PROSTAGLANDIN RECEPTOR ; ATC (MISOPROSTOL) A02BB01 G02AD06 M01AE56 ; ; Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3 597 ; ISRADIPINE ; 75695-93-1 ; 1990 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (ISRADIPINE) C08CA03 ; ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 598 ; PINACIDIL ; 60560-33-0 ; 1989 ; DISCONTINUED ; TARGET ATP-DEPENDENT POTASSIUM CHANNEL ; ATC (PINACIDIL) C02DG01 C02LX01 ; ; Sulfonylurea receptor 2, Kir6.2 UNIPROT O60706 ABCC9 599 ; FAMOTIDINE ; 76824-35-6 ; 1986 ; ; TARGET HISTAMINE H2 RECEPTOR ; ATC (FAMOTIDINE) A02BA03 A02BA53 ; ; Histamine H2 receptor UNIPROT P25021 HRH2 600 ; GLUCONOLACTONE ; 90-80-2 ; 1990 ; ; ; ; PDB 2E40 (CRYSTAL STRUCTURE OF INTRACELLULAR FAMILY 1 BETA-GLUCOSIDASE BGL1A FROM THE BASIDIOMYCETE PHANEROCHAETE CHRYSOSPORIUM IN COMPLEX WITH GLUCONOLACTONE) - ligand code LGC ; Lysosomal acid glucosylceramidase UNIPROT P04062 GBA1 601 ; NICARDIPINE ; 55985-32-5 ; 1988 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (NICARDIPINE) C08CA04 ; ; Voltage-gated L-type calcium channel UNIPROT Q01668 CACNA1D 602 ; CLOFAZIMINE ; 2030-63-9 ; 1986 ; DISCONTINUED ; TARGET DNA ; ATC (CLOFAZIMINE) J04BA01 J04BA51 ; ; UNKNOWN 603 ; NIZATIDINE ; 76963-41-2 ; 1988 ; ; TARGET HISTAMINE H2 RECEPTOR ; ATC (NIZATIDINE) A02BA04 ; ; Histamine H2 receptor UNIPROT P25021 HRH2 604 ; CIPROFLOXACIN ; 85721-33-1 ; 1987 ; ; TARGET DNA GYRASE -- TOPOISOMERASE 4 ; ATC (CIPROFLOXACIN) J01MA02 S01AE03 S02AA15 S03AA07 J01RA10 J01RA12 J01RA11 ; PDB 2XCT (THE TWINNED 3.35A STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH CIPROFLOXACIN AND DNA) - ligand code CPF ; DNA gyrase subunit A UNIPROT P0AES4 gyrA 605 ; MOMETASONE ; 105102-22-5 ; 0 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (MOMETASONE) R03AK09 R03AK14 R03AL12 D07AC13 D07XC03 R01AD09 R03BA07 R01AD59 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 606 ; ISRADIPINE ; 75695-93-1 ; 1990 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (ISRADIPINE) C08CA03 ; ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 607 ; LISINOPRIL ; 76547-98-3 ; 1987 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (LISINOPRIL) C09AA03 C09BB03 C09BA03 C10BX07 ; PDB 1O86 (CRYSTAL STRUCTURE OF HUMAN ANGIOTENSIN CONVERTING ENZYME IN COMPLEX WITH LISINOPRIL.) - ligand code LPR ; Angiotensin-converting enzyme UNIPROT P12821 ACE 608 ; PREDNICARBATE ; 73771-04-7 ; 1991 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (PREDNICARBATE) D07AC18 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 609 ; MEFLOQUINE ; 53230-10-7 ; 1989 ; ; TARGET POTASSIUM CHANNEL (PMID21502926) ; ATC (MEFLOQUINE) P01BF02 P01BC02 ; ; UNKNOWN 610 ; TERCONAZOLE ; 67915-31-5 ; 1987 ; ; TARGET CYTOCHROME P450 14 ALPHA-DEMETHYLASE ; ATC (TERCONAZOLE) G01AG02 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 611 ; NABUMETONE ; 42924-53-8 ; 1991 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (NABUMETONE) M01AX01 ; PDB 3TAJ (CRYSTAL STRUCTURE OF C-LOBE OF BOVINE LACTOFERRIN COMPLEXED WITH NABUMETONE AT 1.7A RESOLUTION) - ligand code NBO ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 612 ; URSODIOL ; 128-13-2 ; 1987 ; ; TARGET HYDROXYSTEROID DEHYDROGENASE, BILE ACID BINDING PROTEIN (PMID22223860) ; ATC (URSODEOXYCHOLIC ACID) A05AA02 ; PDB 1IHI (CRYSTAL STRUCTURE OF HUMAN TYPE III 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, BILE ACID BINDING PROTEIN (AKR1C2) COMPLEXED WITH NADP+ AND URSODEOXYCHOLATE) - ligand code IU5 ; Bile acid receptor UNIPROT Q96RI1 NR1H4 613 ; KETOROLAC ; 74103-06-3 ; 1989 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (KETOROLAC) M01AB15 S01BC05 S01FB51 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 614 ; ENOXACIN ; 74011-58-8 ; 1991 ; DISCONTINUED ; TARGET DNA GYRASE ; ATC (ENOXACIN) J01MA04 ; ; Topoisomerase IV UNIPROT P48374 parC -- DNA gyrase UNIPROT P22118 gyrB 615 ; PROPOFOL ; 2078-54-8 ; 1989 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA(A)) -- BETA-ADRENOCEPTOR (BETA-AR) (PMID21793316) ; ATC (PROPOFOL) N01AX10 ; PDB 5MVN (X-RAY STRUCTURE OF THE M205W MUTANT OF GLIC IN COMPLEX WITH PROPOFOL) - ligand code PFL ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 616 ; LOVASTATIN ; 75330-75-5 ; 1987 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE ; ATC (LOVASTATIN) C10AA02 C10BA01 ; PDB 1CQP (CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN, LOVASTATIN AT 2.6 A RESOLUTION) - ligand code 803 ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 617 ; KETOROLAC ; 74103-06-3 ; 1989 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (KETOROLAC) M01AB15 S01BC05 S01FB51 ; PDB 2MJI (HIFABP_KETOROLAC_COMPLEX) - ligand code KTR ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 618 ; RIMANTADINE ; 13392-28-4 ; 1993 ; ; TARGET PROTON TRANSPORTER M2 (PMID23480101) ; ATC (RIMANTADINE) J05AC02 ; PDB 2RLF (PROTON CHANNEL M2 FROM INFLUENZA A IN COMPLEX WITH INHIBITOR RIMANTADINE) - ligand code RIM ; Matrix protein 2 UNIPROT P63231 M 619 ; NORGESTIMATE ; 35189-28-7 ; 1989 ; ; TARGET PROGESTERONE RECEPTOR -- ANDROGEN RECEPTOR ; ATC (NORGESTIMATE) G03FA13 G03AA11 G03AB09 ; ; Progesterone receptor UNIPROT P06401 PGR 620 ; ZIDOVUDINE ; 30516-87-1 ; 1987 ; ; TARGET HIV REVERSE TRANSCRIPTASE ; ATC (ZIDOVUDINE) J05AF01 J05AR01 J05AR04 J05AR05 ; PDB 3B9L (HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND AZT) - ligand code AZZ ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 621 ; LORATADINE ; 79794-75-5 ; 1993 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (LORATADINE) R06AX13 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 622 ; NEDOCROMIL ; 69049-73-6 ; 1992 ; DISCONTINUED ; ; ATC (NEDOCROMIL) R01AC07 R03BC03 S01GX04 ; ; G-protein coupled receptor 35 UNIPROT Q9HC97 GPR35 623 ; GANCICLOVIR ; 82410-32-0 ; 1989 ; ; TARGET THYMIDINE KINASE ; ATC (GANCICLOVIR) J05AB06 S01AD09 ; PDB 1KI2 (THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I) - ligand code GA2 ; DNA polymerase catalytic subunit UNIPROT P04293 624 ; INDECAINIDE ; 74517-78-5 ; 1989 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 625 ; OLSALAZINE ; 15722-48-2 ; 1990 ; ; ; ATC (OLSALAZINE) A07EC03 ; ; Arachidonate 5-lipoxygenase UNIPROT P09917 ALOX5 -- Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 626 ; OFLOXACIN ; 82419-36-1 ; 1990 ; ; TARGET DNA TOPOISOMERASE 4 -- DNA GYRASE ; ATC (OFLOXACIN) J01MA01 S01AE01 S02AA16 J01RA09 ; PDB 2BML (OFLOXACIN-LIKE ANTIBIOTICS INHIBIT PNEUMOCOCCAL CELL WALL DEGRADING VIRULENCE FACTORS) - ligand code XED ; DNA gyrase subunit A UNIPROT P0AES4 gyrA 627 ; MORICIZINE ; 31883-05-3 ; 1990 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ATC (MORACIZINE) C01BG01 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 628 ; CLOZAPINE ; 5786-21-0 ; 1989 ; ; TARGET DOPAMINE RECEPTOR ; ATC (CLOZAPINE) N05AH02 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 629 ; IFOSFAMIDE ; 3778-73-2 ; 1987 ; ; ; ATC (IFOSFAMIDE) L01AA06 ; ; UNKNOWN 630 ; MESNA ; 19767-45-4 ; 1987 ; ; TARGET METABOLITES ACROLEIN AND 4-HYDROXY-IFOSFAMIDE ; ATC (MESNA) R05CB05 V03AF01 ; PDB 4RQX (CRYSTAL STRUCTURE OF HUMAN PEROXIREDOXIN 4(THIOREDOXIN PEROXIDASE) WITH MESNA) - ligand code COM ; UNKNOWN 631 ; SIMVASTATIN ; 79902-63-9 ; 1991 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA) ; ATC (SIMVASTATIN) C10AA01 C10BX01 C10BA02 C10BA04 C10BX04 A10BH51 ; ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 632 ; APRACLONIDINE ; 66711-21-5 ; 1987 ; ; TARGET ALPHA-2A ADRENERGIC RECEPTOR ; ATC (APRACLONIDINE) S01EA03 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B 633 ; LEVAMLODIPINE ; 103129-82-4 ; 1992 ; ; TARGET CALCIUM CHANNEL ; ATC (AMLODIPINE) C09XA53 C09XA54 C08CA01 C08CA51 C08GA02 C10BX03 C10BX19 C10BX11 C10BX18 C09BB13 C07FB07 C09DB07 C09DX06 C09DB09 C09DB05 C09DX07 C09BB03 C09DB06 C07FB13 C07FB12 C09DB02 C09DX03 C09BB04 C09BX01 C09BX04 C09BX06 C09BB07 C09BX03 C10BX09 C10BX07 C10BX14 C09DB04 C09DX08 C09DB01 C09DX01 ; PDB 5KMD (STRUCTURE OF CAVAB IN COMPLEX WITH AMLODIPINE) - ligand code 6UB ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 634 ; PODOFILOX ; 518-28-5 ; 1990 ; ; ; ATC (PODOFILOX) D06BB04 ; PDB 1SA1 (TUBULIN-PODOPHYLLOTOXIN: STATHMIN-LIKE DOMAIN COMPLEX) - ligand code POD ; UNKNOWN 635 ; OMEPRAZOLE ; 73590-58-6 ; 1989 ; ; TARGET H+/K+ ATPASE ; ATC (OMEPRAZOLE) A02BC01 A02BD05 A02BD01 A02BD16 A02BC51 ; ; Potassium-transporting ATPase UNIPROT P20648 ATP4A 636 ; MIDODRINE ; 42794-76-3 ; 1996 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (MIDODRINE) C01CA17 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 637 ; ACITRETIN ; 55079-83-9 ; 1996 ; ; TARGET RETINOIC ACID RECEPTOR (RAR) -- RETINOIC X RECEPTOR (RXR) ; ATC (ACITRETIN) D05BB02 ; ; Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor gamma UNIPROT P13631 RARG 638 ; OXICONAZOLE ; 64211-45-6 ; 1988 ; ; TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450) ; ATC (OXICONAZOLE) D01AC11 G01AF17 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 639 ; FELODIPINE ; 72509-76-3 ; 1991 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM L-CHANNEL ; ATC (FELODIPINE) C08CA02 C07FB02 C09BB05 ; ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 640 ; CETIRIZINE ; 83881-52-1 ; 1995 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (CETIRIZINE) R06AE07 S01GX12 ; PDB 5DQF (HORSE SERUM ALBUMIN (ESA) IN COMPLEX WITH CETIRIZINE) - ligand code CZE ; Histamine H1 receptor UNIPROT P35367 HRH1 641 ; SERTRALINE ; 79617-96-2 ; 1991 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (SERTRALINE) N06AB06 ; PDB 6F6N (CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH SERTRALINE) - ligand code SRE ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 642 ; DAPIPRAZOLE ; 72822-12-9 ; 1990 ; DISCONTINUED ; TARGET ALPHA-1A ADRENERGIC RECEPTOR -- ALPHA-1B ADRENERGIC RECEPTOR -- ALPHA-1D ADRENERGIC RECEPTOR ; ATC (DAPIPRAZOLE) S01EX02 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 643 ; BENAZEPRIL ; 86541-75-5 ; 1991 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (BENAZEPRIL) C09AA07 C09BB13 C09BA07 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 644 ; PENICILLAMINE ; 52-67-5 ; 1970 ; ; ; ATC (PENICILLAMINE) M01CC01 ; ; UNKNOWN 645 ; SOTALOL ; 3930-20-9 ; 1992 ; ; TARGET ADRENERGIC BETA RECEPTOR ; ATC (SOTALOL) C07AA07 C07FX02 C07BA07 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 646 ; SOTALOL ; 3930-20-9 ; 1992 ; ; TARGET ADRENERGIC BETA RECEPTOR ; ATC (SOTALOL) C07AA07 C07FX02 C07BA07 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 647 ; QUINAPRIL ; 85441-61-8 ; 1991 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (QUINAPRIL) C09AA06 C09BA06 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 648 ; PRAVASTATIN ; 81093-37-0 ; 1991 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE ; ATC (PRAVASTATIN) C10AA03 C10BX02 C10BA11 C10BA03 C10BA12 ; ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 649 ; RAMIPRIL ; 87333-19-5 ; 1991 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (RAMIPRIL) C10BX06 C10BX18 C09AA05 C09BB07 C09BX05 C09BA05 C09BB05 C09BX03 C10BX17 C10BX04 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 650 ; CLOMIPRAMINE ; 303-49-1 ; 1989 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (CLOMIPRAMINE) N06AA04 ; PDB 4MMA (CRYSTAL STRUCTURE OF LEUBAT (DELTA13 MUTANT) IN COMPLEX WITH CLOMIPRAMINE) - ligand code CXX ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 651 ; METIPRANOLOL ; 22664-55-7 ; 1989 ; DISCONTINUED ; TARGET BETA ADRENERGIC RECEPTOR ; ATC (METIPRANOLOL) S01ED04 C07BA68 S01ED54 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 652 ; ZOLPIDEM ; 82626-48-0 ; 1992 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (ZOLPIDEM) N05CF02 ; PDB 8DD2 (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS ZOLPIDEM) - ligand code R5R ; Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 653 ; FOSINOPRIL ; 98048-97-6 ; 1991 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (FOSINOPRIL) C09AA09 C09BA09 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 654 ; ALTRETAMINE ; 645-05-6 ; 1990 ; DISCONTINUED ; ; ATC (ALTRETAMINE) L01XX03 ; ; UNKNOWN 655 ; ADENOSINE ; 58-61-7 ; 1989 ; ; TARGET A1 AND A2 ADENOSINE RECEPTOR -- ADENOSINE DEAMINASE -- ADENOSINE KINASE ; ATC (ADENOSINE) C01EB10 ; PDB 4OGR (CRYSTAL STRUCTURE OF P-TEFB COMPLEX WITH AFF4 AND TAT) - ligand code ADN ; Adenosine receptor A2a UNIPROT P29274 ADORA2A -- Adenosine receptor A1 UNIPROT P30542 ADORA1 656 ; MASOPROCOL ; 27686-84-6 ; 1992 ; DISCONTINUED ; TARGET LIPOXYGENASE ; ATC (MASOPROCOL) L01XX10 ; ; Polyunsaturated fatty acid 5-lipoxygenase UNIPROT P09917 ALOX5 657 ; DOXACURIUM ; 106819-53-8 ; 1991 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M2 -- NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2 ; ATC (DOXACURIUM CHLORIDE) M03AC07 ; ; Acetylcholine receptor UNIPROT P02708 CHRNA1 658 ; FLUCONAZOLE ; 86386-73-4 ; 1990 ; ; TARGET CYTOCHROME P450 51 ; ATC (FLUCONAZOLE) J01RA07 D01AC15 J02AC01 ; PDB 2WUZ (X-RAY STRUCTURE OF CYP51 FROM TRYPANOSOMA CRUZI IN COMPLEX WITH FLUCONAZOLE IN ALTERNATIVE CONFORMATION) - ligand code TPF ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 659 ; FLUTICASONE PROPIONATE ; 80474-14-2 ; 1990 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (FLUTICASONE) D07AC17 R01AD08 R03BA05 R01AD12 R03BA09 R01AD58 R03AK11 R03AK06 R03AK10 R03AL08 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 660 ; HALOBETASOL PROPIONATE ; 66852-54-8 ; 1990 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (ULOBETASOL) D05AX55 D07AC21 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 661 ; TICLOPIDINE ; 55142-85-3 ; 1991 ; ; TARGET P2Y PURINOCEPTOR 12 ; ATC (TICLOPIDINE) B01AC05 ; PDB 3KW4 (CRYSTAL STRUCTURE OF CYTOCHROME 2B4 IN COMPLEX WITH THE ANTI-PLATELET DRUG TICLOPIDINE) - ligand code TIC ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 662 ; BISOPROLOL ; 66722-44-9 ; 1992 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- ADRENERGIC BETA-2 RECEPTOR ; ATC (BISOPROLOL) C07AB07 C07FX04 C07FB07 C07BB07 C09BX02 C09BX04 C09BX05 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 663 ; SUCCIMER ; 304-55-2 ; 1991 ; ; ; ATC (TECHNETIUM (99MTC) SUCCIMER) V09CA02 ; ; UNKNOWN 664 ; ONDANSETRON ; 99614-02-5 ; 1991 ; ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR ; ATC (ONDANSETRON) A04AA01 ; PDB 6W1M (CRYO-EM STRUCTURE OF 5HT3A RECEPTOR IN PRESENCE OF ONDANSETRON) - ligand code S87_6W1M ; 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 665 ; LOMEFLOXACIN ; 98079-51-7 ; 1992 ; DISCONTINUED ; TARGET DNA GYRASE -- DNA TOPOISOMERASE ; ATC (LOMEFLOXACIN) J01MA07 S01AE04 ; ; DNA gyrase UNIPROT P0AES4 gyrA 666 ; PAROXETINE ; 61869-08-7 ; 1992 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (PAROXETINE) N06AB05 ; PDB 6F6I (CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH PAROXETINE) - ligand code 8PR ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 667 ; PHENIRAMINE ; 86-21-5 ; 1994 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (PHENIRAMINE) D04AA16 R06AB05 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 668 ; LEVAMISOLE ; 14769-73-4 ; 1990 ; DISCONTINUED ; TARGET NEMATODE ACETYLCHOLINE RECEPTOR ; ATC (LEVAMISOLE) P02CE01 ; ; Nicotinic acetylcholine receptor alpha subunit UNIPROT O96760 669 ; FLUDARABINE PHOSPHATE ; 75607-67-9 ; 1991 ; ; TARGET DNA POLYMERASE ALPHA, GAMMA AND DELTA -- RIBONUCLEOTIDE DIPHOSPHATE REDUCTASE -- DNA PRIMASE -- DNA LIGASE I ; ATC (FLUDARABINE) L01BB05 ; ; DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 670 ; TYLOXAPOL ; 140-66-9 ; 1990 ; DISCONTINUED ; ; ATC (TYLOXAPOL) R05CA01 ; PDB 4MGA (CRYSTAL STRUCTURE OF HERA-LBD (Y537S) IN COMPLEX WITH 4-TERT-OCTYLPHENOL) - ligand code 27L ; UNKNOWN 671 ; ITRACONAZOLE ; 84625-61-6 ; 1992 ; ; TARGET CYTOCHROME P450 ; ATC (ITRACONAZOLE) J02AC02 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 672 ; AZELASTINE ; 58581-89-8 ; 1996 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (AZELASTINE) R01AC03 R06AX19 S01GX07 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 673 ; PHENIRAMINE ; 86-21-5 ; 1994 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (PHENIRAMINE) D04AA16 R06AB05 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 674 ; FOSCARNET ; 4428-95-9 ; 1991 ; ; TARGET DNA POLYMERASE ; ATC (FOSCARNET) J05AD01 ; PDB 1NKI (CRYSTAL STRUCTURE OF THE FOSFOMYCIN RESISTANCE PROTEIN A (FOSA) CONTAINING BOUND PHOSPHONOFORMATE) - ligand code PPF ; DNA polymerase catalytic subunit UNIPROT P04293 675 ; TACRINE ; 321-64-2 ; 1993 ; DISCONTINUED ; TARGET CHOLINESTERASE ; ATC (TACRINE) N06DA01 ; PDB 2AOW (HISTAMINE METHYLTRANSFERASE (NATURAL VARIANT I105) COMPLEXED WITH THE ACETYLCHOLINESTERASE INHIBITOR AND ALTZHEIMER'S DISEASE DRUG TACRINE) - ligand code THA ; Acetylcholinesterase UNIPROT P22303 ACHE -- Cholinesterase UNIPROT P06276 BCHE 676 ; DESOGESTREL ; 54024-22-5 ; 1992 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (DESOGESTREL) G03AC09 G03FB10 G03AA09 G03AB05 ; ; Progesterone receptor UNIPROT P06401 PGR 677 ; FLUMAZENIL ; 78755-81-4 ; 1991 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (FLUMAZENIL) V03AB25 ; PDB 6D6T (HUMAN GABA-A RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA AND FLUMAZENIL, CONFORMATION B) - ligand code FYP ; Gamma-aminobutyric acid receptor subunit alpha-4 UNIPROT P48169 GABRA4 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 678 ; ITRACONAZOLE ; 84625-61-6 ; 1992 ; ; TARGET CYTOCHROME P450 ; ATC (ITRACONAZOLE) J02AC02 ; PDB 5EQB (CRYSTAL STRUCTURE OF LANOSTEROL 14-ALPHA DEMETHYLASE WITH INTACT TRANSMEMBRANE DOMAIN BOUND TO ITRACONAZOLE) - ligand code 1YN ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 679 ; MIVACURIUM ; 133814-19-4 ; 1992 ; ; TARGET NICOTINIC ACETYLCHOLINE RECEPTOR (NACHR) ; ATC (MIVACURIUM) M03AC10 ; ; Acetylcholine receptor UNIPROT P02708 CHRNA1 680 ; AZELASTINE ; 58581-89-8 ; 1996 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (AZELASTINE) R01AC03 R06AX19 S01GX07 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 681 ; DESFLURANE ; 57041-67-5 ; 1992 ; ; TARGET ION CHANNEL ; ATC (DESFLURANE) N01AB07 ; ; Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 -- Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 682 ; TENIPOSIDE ; 29767-20-2 ; 1992 ; DISCONTINUED ; TARGET DNA TOPOISOMERASE 2 ; ATC (TENIPOSIDE) L01CB02 ; PDB 4L9Q (X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH TENIPOSIDE) - ligand code 9TP ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 683 ; PENTOSTATIN ; 53910-25-1 ; 1991 ; ; TARGET ADENOSINE DEAMINASE ; ATC (PENTOSTATIN) L01XX08 ; ; Adenosine deaminase UNIPROT P00813 ADA 684 ; BUDESONIDE ; 51333-22-3 ; 1994 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BUDESONIDE) A07EA06 D07AC09 R01AD05 R03BA02 R03AK07 R03AL11 R03AK15 R03AK12 ; PDB 5NFP (GLUCOCORTICOID RECEPTOR IN COMPLEX WITH BUDESONIDE) - ligand code 8W5 ; Glucocorticoid receptor UNIPROT P04150 NR3C1 685 ; VENLAFAXINE ; 93413-69-5 ; 1993 ; ; TARGET SEROTONIN REUPTAKE TRANSPORTER ; ATC (VENLAFAXINE) N06AX16 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 686 ; VENLAFAXINE ; 93413-69-5 ; 1993 ; ; TARGET SEROTONIN REUPTAKE TRANSPORTER ; ATC (VENLAFAXINE) N06AX16 ; PDB 8F4W (CRYSTAL STRUCTURE OF ACETYLTRANSFERASE EIS FROM M. TUBERCULOSIS IN COMPLEX WITH VENLAFAXINE) - ligand code VFX ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 687 ; NEFAZODONE ; 83366-66-9 ; 1994 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- ALPHA-1A ADRENERGIC RECEPTOR -- ALPHA-1B ADRENERGIC RECEPTOR -- SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (NEFAZODONE) N06AX06 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 688 ; DIDANOSINE ; 69655-05-6 ; 1991 ; DISCONTINUED ; TARGET REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) ; ATC (DIDANOSINE) J05AF02 ; ; Reverse transcriptase,RNaseH UNIPROT Q72549 pol 689 ; ALATROFLOXACIN ; 146961-76-4 ; 1997 ; DISCONTINUED ; TARGET DNA GYRASE SUBUNIT A -- DNA TOPOISOMERASE 4 SUBUNIT A -- DNA TOPOISOMERASE 2-ALPHA ; ATC (TROVAFLOXACIN) J01MA13 ; ; Topoisomerase IV UNIPROT P0AFI2 parC -- DNA gyrase UNIPROT P0AES4 gyrA 690 ; NILUTAMIDE ; 63612-50-0 ; 1996 ; ; TARGET ANDROGEN RECEPTOR ; ATC (NILUTAMIDE) L02BB02 ; ; Androgen receptor UNIPROT P10275 AR 691 ; FINASTERIDE ; 98319-26-7 ; 1992 ; ; TARGET 5-ALPHA DEHYDROGENASE ; ATC (FINASTERIDE) G04CA51 G04CA55 D11AX10 G04CB01 G04CB51 ; PDB 3G1R (CRYSTAL STRUCTURE OF HUMAN LIVER 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADP AND FINASTERIDE. RESOLUTION 1.70 A) - ligand code FIT ; 3-oxo-5-alpha-steroid 4-dehydrogenase 2 UNIPROT P31213 SRD5A2 -- 3-oxo-5-alpha-steroid 4-dehydrogenase 1 UNIPROT P18405 SRD5A1 692 ; PERINDOPRIL ; 82834-16-0 ; 1993 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (PERINDOPRIL) C10BX15 C10BX12 C10BX11 C09AA04 C09BB04 C09BX02 C09BA04 C09BX01 C09BX04 C09BX06 C10BX21 C10BX14 C10BX13 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 693 ; FELBAMATE ; 25451-15-4 ; 1993 ; ; TARGET GLUTAMATE [NMDA] RECEPTOR ; ATC (FELBAMATE) N03AX10 ; ; Glutamate receptor ionotropic, NMDA 2A UNIPROT Q12879 GRIN2A -- Glutamate receptor ionotropic, NMDA 2B UNIPROT Q13224 GRIN2B 694 ; TERBINAFINE ; 91161-71-6 ; 1992 ; ; TARGET SQUALENE EPOXIDASE ENZYME ; ATC (TERBINAFINE) D01AE15 D01BA02 ; ; Squalene epoxidase UNIPROT Q4JEY0 695 ; ZALCITABINE ; 7481-89-2 ; 1992 ; DISCONTINUED ; TARGET DEOXYCYTIDINE KINASE ; ATC (ZALCITABINE) J05AF03 ; PDB 2VP9 (STRUCTURAL STUDIES OF NUCLEOSIDE ANALOG AND FEEDBACK INHIBITOR BINDING TO DROSOPHILA MELANOGASTER MULTISUBSTRATE DEOXYRIBONUCLEOSIDE KINASE) - ligand code DOC ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 696 ; CISAPRIDE ; 81098-60-4 ; 1993 ; DISCONTINUED ; TARGET 5-HYDROXYTRYPTAMINE 4 RECEPTOR ; ATC (CISAPRIDE) A03FA02 ; ; 5-hydroxytryptamine receptor 4 UNIPROT Q13639 HTR4 697 ; DEXRAZOXANE ; 24584-09-6 ; 1995 ; ; TARGET TOPOISOMERASE II ; ATC (DEXRAZOXANE) V03AF02 ; ; UNKNOWN 698 ; LEVOCABASTINE ; 79516-68-0 ; 1993 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (LEVOCABASTINE) R01AC02 S01GX02 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 699 ; AMIFOSTINE ; 20537-88-6 ; 1995 ; ; TARGET ALKALINE PHOSPHATASE ; ATC (AMIFOSTINE) V03AF05 ; ; UNKNOWN 700 ; CANDESARTAN CILEXETIL ; 145040-37-5 ; 1998 ; ; TARGET ANGIOTENSIN II RECEPTOR AT1 ; ATC (CANDESARTAN) C10BX19 C09CA06 C09DB07 C09DA06 C09DX06 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 701 ; CLADRIBINE ; 4291-63-8 ; 1993 ; ; TARGET DEOXYCYTIDINE KINASE ; ATC (CLADRIBINE) L01BB04 L04AA40 ; PDB 2ZIA (C4S DCK VARIANT OF DCK IN COMPLEX WITH CLADRIBINE+UDP) - ligand code CL9 ; UNKNOWN 702 ; TRICLOSAN ; 3380-34-5 ; 1997 ; DISCONTINUED ; TARGET ENOYL REDUCTASE ; ATC (TRICLOSAN) D08AE04 D09AA06 ; PDB 1QG6 (CRYSTAL STRUCTURE OF E. COLI ENOYL ACYL CARRIER PROTEIN REDUCTASE IN COMPLEX WITH NAD AND TRICLOSAN) - ligand code TCL ; Enoyl-acyl-carrier-protein reductase NADH FabI UNIPROT P0AEK4 fabI 703 ; BUDESONIDE ; 51333-22-3 ; 1994 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BUDESONIDE) A07EA06 D07AC09 R01AD05 R03BA02 R03AK07 R03AL11 R03AK15 R03AK12 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 704 ; GABAPENTIN ; 60142-96-3 ; 1993 ; ; TARGET VOLTAGE-GATED CALCIUM CHANNEL (PMID26680202) ; ATC (GABAPENTIN) N02BF01 ; PDB 2COI (CRYSTAL STRUCTURE OF OXIDIZED HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE COMPLEXED WITH GABAPENTIN) - ligand code GBN ; Voltage-dependent calcium channel subunit alpha-2,delta-1 UNIPROT P54289 CACNA2D1 -- Voltage-dependent calcium channel subunit alpha-2,delta-2 UNIPROT Q9NY47 CACNA2D2 705 ; GRANISETRON ; 109889-09-0 ; 1993 ; ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR ; ATC (GRANISETRON) A04AA02 ; PDB 2YME (CRYSTAL STRUCTURE OF A MUTANT BINDING PROTEIN (5HTBP-ACHBP) IN COMPLEX WITH GRANISETRON) - ligand code CWB ; 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 706 ; SPIRAPRIL ; 83647-97-6 ; 0 ; DISCONTINUED ; TARGET ANGIOTENSIN-CONVERTING ENZYME (ACE) ; ATC (SPIRAPRIL) C09AA11 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 707 ; LAMOTRIGINE ; 84057-84-1 ; 1994 ; ; TARGET VOLTAGE-SENSITIVE SODIUM CHANNEL ; ATC (LAMOTRIGINE) N03AX09 ; PDB 8THH (CRYO-EM STRUCTURE OF NAV1.7 WITH LTG) - ligand code IYJ ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A 708 ; FLUVOXAMINE ; 54739-18-3 ; 1994 ; ; TARGET SEROTONIN TRANSPORTER (SERT) ; ATC (FLUVOXAMINE) N06AB08 ; PDB 6AWP (X-RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH FLUVOXAMINE AT THE CENTRAL SITE) - ligand code FVX ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 709 ; HALOFANTRINE ; 69756-53-2 ; 1992 ; DISCONTINUED ; TARGET FERRIPROTOPORPHYRIN IX (FE(III)PPIX) (PMID18508124) ; ATC (HALOFANTRINE) P01BX01 ; ; UNKNOWN 710 ; ATOVAQUONE ; 95233-18-4 ; 1992 ; ; TARGET UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN I, MITOCHONDRIAL (BC1) ; ATC (ATOVAQUONE) P01AX06 P01BB51 ; ; Cytochrome b UNIPROT Q02768 MT-CYB 711 ; FLUVASTATIN ; 93957-54-1 ; 1993 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA) ; ATC (FLUVASTATIN) C10AA04 ; ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 712 ; PACLITAXEL ; 33069-62-4 ; 1992 ; ; TARGET TUBULIN ; ATC (PACLITAXEL) L01CD01 L01CD51 L01CD03 ; PDB 4AQW (MODEL OF HUMAN KINESIN-5 MOTOR DOMAIN (1II6, 3HQD) AND MAMMALIAN TUBULIN HETERODIMER (1JFF) DOCKED INTO THE 9.5-ANGSTROM CRYO-EM MAP OF MICROTUBULE-BOUND KINESIN-5 MOTOR DOMAIN IN THE RIGOR STATE.) - ligand code TA1 ; Tubulin beta UNIPROT P07437 TUBB 713 ; RISPERIDONE ; 106266-06-2 ; 1993 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- D(2) DOPAMINE RECEPTOR -- ALPHA 1 ADRENERGIC RECEPTOR -- ALPHA 2 ADRENERGIC RECEPTOR -- H1 HISTAMINIC RECEPTOR ; ATC (RISPERIDONE) N05AX08 ; PDB 6C38 (STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE) - ligand code 8NU ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 714 ; TRAMADOL ; 181289-59-8 ; 1995 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (TRAMADOL) N02AX02 N02AJ16 N02AJ14 N02AJ15 N02AJ13 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 715 ; CARVEDILOL ; 72956-09-3 ; 1995 ; ; TARGET BETA ADRENERGIC RECEPTOR -- ALPHA-1A ADRENERGIC RECEPTOR ; ATC (CARVEDILOL) C07AG02 C07FX06 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 716 ; MOEXIPRIL ; 103775-10-6 ; 1995 ; ; TARGET ANGIOTENSIN CONVERTING ENZYME (ACE) -- KININASE II ; ATC (MOEXIPRIL) C09AA13 C09BA13 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 717 ; ANAGRELIDE ; 68475-42-3 ; 1997 ; ; TARGET CYCLIC AMP PHOSPHODIESTERASE III ; ATC (ANAGRELIDE) L01XX35 ; PDB 7EG0 (CRYO-EM STRUCTURE OF ANAGRELIDE-INDUCED PDE3A-SLFN12 COMPLEX) - ligand code J33 ; cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A 718 ; ADAPALENE ; 106685-40-9 ; 1996 ; ; TARGET RETINOIC ACID RECEPTOR ALPHA -- RETINOIC ACID RECEPTOR BETA -- RETINOIC ACID RECEPTOR GAMMA ; ATC (ADAPALENE) D10AD03 D10AD53 ; ; Retinoic acid receptor beta UNIPROT P10826 RARB -- Retinoic acid receptor gamma UNIPROT P13631 RARG 719 ; MIRTAZAPINE ; 61337-67-5 ; 1996 ; ; TARGET ALPHA-2A ADRENERGIC RECEPTOR -- 5-HYDROXYTRYPTAMINE 2 RECEPTOR -- 5-HYDROXYTRYPTAMINE 3 RECEPTOR -- HISTAMINE H1 RECEPTOR ; ATC (MIRTAZAPINE) N06AX11 ; ; 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A -- 5-hydroxytryptamine receptor 2C UNIPROT P28335 HTR2C 720 ; NISOLDIPINE ; 63675-72-9 ; 1995 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (NISOLDIPINE) C08CA07 ; ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 721 ; METFORMIN ; 657-24-9 ; 1995 ; ; ; ATC (METFORMIN) A10BA02 A10BD17 A10BD13 A10BD16 A10BD15 A10BD20 A10BD23 A10BD22 A10BD18 A10BD11 A10BD26 A10BD05 A10BD14 A10BD03 A10BD10 A10BD07 A10BD02 A10BD28 A10BD08 A10BD27 A10BD25 ; PDB 8JTT (HOCT1 IN COMPLEX WITH METFORMIN IN OUTWARD OCCLUDED CONFORMATION) - ligand code MF8 ; Mitochondrial complex I (NADH dehydrogenase) UNIPROT O00217 NDUFS8 722 ; FAMCICLOVIR ; 104227-87-4 ; 1994 ; ; ; ATC (FAMCICLOVIR) J05AB09 S01AD07 ; ; DNA polymerase catalytic subunit UNIPROT P04293 723 ; LOSARTAN ; 114798-26-4 ; 1995 ; ; TARGET TYPE-1 ANGIOTENSIN II RECEPTOR ; ATC (LOSARTAN) C09CA01 C09DB06 C09DA01 ; PDB 5X24 (CRYSTAL STRUCTURE OF CYP2C9 GENETIC VARIANT I359L (*3) IN COMPLEX WITH MULTIPLE LOSARTAN MOLECULES) - ligand code LSN ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 724 ; VINORELBINE ; 71486-22-1 ; 1994 ; ; TARGET TUBULIN ; ATC (VINORELBINE) L01CA04 ; ; Tubulin beta UNIPROT P07437 TUBB 725 ; TIZANIDINE ; 51322-75-9 ; 1996 ; ; TARGET ALPHA-2A ADRENERGIC RECEPTOR ; ATC (TIZANIDINE) M03BX02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B 726 ; LANSOPRAZOLE ; 103577-45-3 ; 1995 ; ; TARGET (H+,K+) ATPASE ; ATC (LANSOPRAZOLE) A02BC03 A02BD07 A02BD10 A02BD03 A02BD09 A02BC53 A02BD02 ; ; Potassium-transporting ATPase UNIPROT P20648 ATP4A 727 ; DORZOLAMIDE ; 120279-96-1 ; 1994 ; ; TARGET CARBONIC ANHYDRASE II ; ATC (DORZOLAMIDE) S01EC03 ; PDB 3FW3 (CRYSTAL STRUCTURE OF SOLUBLE DOMAIN OF CA4 IN COMPLEX WITH DORZOLAMIDE) - ligand code ETS ; Carbonic anhydrase 2 UNIPROT P00918 CA2 728 ; STAVUDINE ; 3056-17-5 ; 1994 ; ; TARGET HIV REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) ; ATC (STAVUDINE) J05AF04 J05AR28 J05AR07 ; ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 729 ; MIRTAZAPINE ; 61337-67-5 ; 1996 ; ; TARGET ALPHA-2A ADRENERGIC RECEPTOR -- 5-HYDROXYTRYPTAMINE 2 RECEPTOR -- 5-HYDROXYTRYPTAMINE 3 RECEPTOR -- HISTAMINE H1 RECEPTOR ; ATC (MIRTAZAPINE) N06AX11 ; ; 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A -- 5-hydroxytryptamine receptor 2C UNIPROT P28335 HTR2C 730 ; ARBUTAMINE ; 128470-16-6 ; 1997 ; DISCONTINUED ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ARBUTAMINE) C01CA22 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 731 ; AZELAIC ACID ; 123-99-9 ; 1995 ; ; TARGET DIAMINOPIMELATE DECARBOXYLASE ; ATC (AZELAIC ACID) D10AX03 ; PDB 1TUF (CRYSTAL STRUCTURE OF DIAMINOPIMELATE DECARBOXYLASE FROM M. JANNASCHI) - ligand code AZ1 ; 3-oxo-5-alpha-steroid 4-dehydrogenase 2 UNIPROT P31213 SRD5A2 732 ; EPOPROSTENOL ; 35121-78-9 ; 1995 ; ; ; ATC (EPOPROSTENOL) B01AC09 ; ; Prostaglandin E2 receptor EP1 subtype UNIPROT P34995 PTGER1 -- Prostacyclin receptor UNIPROT P43119 PTGIR 733 ; DOCETAXEL ; 114977-28-5 ; 1996 ; ; TARGET TUBULIN ; ATC (DOCETAXEL) L01CD02 ; PDB 1TUB (TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION) - ligand code TXL ; Tubulin beta UNIPROT P07437 TUBB 734 ; FOSPHENYTOIN ; 93390-81-9 ; 1996 ; ; TARGET VOLTAGE-DEPENDENT SODIUM CHANNEL ; ATC (FOSPHENYTOIN) N03AB05 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 735 ; ZILEUTON ; 111406-87-2 ; 1996 ; ; TARGET 5-LIPOXYGENASE ; ; ; Arachidonate 5-lipoxygenase UNIPROT P09917 ALOX5 736 ; ZILEUTON ; 111406-87-2 ; 1996 ; ; TARGET 5-LIPOXYGENASE ; ; ; Arachidonate 5-lipoxygenase UNIPROT P09917 ALOX5 737 ; RIMEXOLONE ; 49697-38-3 ; 1994 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (RIMEXOLONE) H02AB12 S01BA13 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 738 ; SEVOFLURANE ; 28523-86-6 ; 1995 ; ; TARGET VOLTAGE-GATED SODIUM CHANNELS (NAV) ; ATC (SEVOFLURANE) N01AB08 ; ; Glycine receptor subunit alpha-1 UNIPROT P23415 GLRA1 -- Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 739 ; ACARBOSE ; 56180-94-0 ; 1995 ; ; TARGET LYSOSOMAL ALPHA-GLUCOSIDASE -- PANCREATIC ALPHA-AMYLASE ; ATC (ACARBOSE) A10BF01 A10BD17 ; PDB 5HQA (A GLYCOSIDE HYDROLASE FAMILY 97 ENZYME IN COMPLEX WITH ACARBOSE FROM PSEUDOALTEROMONAS SP. STRAIN K8) - ligand code ACR ; Maltase-glucoamylase, intestinal UNIPROT O43451 MGAM -- Pancreatic alpha-amylase UNIPROT P04746 AMY2A 740 ; VALACYCLOVIR ; 124832-26-4 ; 1995 ; ; TARGET DNA POLYMERASE ; ATC (VALACYCLOVIR) J05AB11 ; PDB 4AQL (HUMAN GUANINE DEAMINASE IN COMPLEX WITH VALACYCLOVIR) - ligand code TXC ; DNA polymerase catalytic subunit UNIPROT P04293 741 ; BRIMONIDINE ; 59803-98-4 ; 1996 ; ; TARGET ALPHA-2 ADRENERGIC RECEPTOR ; ATC (BRIMONIDINE) D11AX21 S01EA05 S01GA07 ; PDB 7EJ8 (STRUCTURE OF THE ALPHA2A-ADRENERGIC RECEPTOR GOA SIGNALING COMPLEX BOUND TO BRIMONIDINE) - ligand code J59 ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B 742 ; GLIMEPIRIDE ; 93479-97-1 ; 1995 ; ; TARGET ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL ; ATC (GLIMEPIRIDE) A10BB12 A10BD06 A10BD04 ; PDB 4YVX (CRYSTAL STRUCTURE OF AKR1C3 COMPLEXED WITH GLIMEPIRIDE) - ligand code GMR ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 743 ; BICALUTAMIDE ; 90357-06-5 ; 1995 ; ; TARGET ANDROGEN RECEPTOR ; ATC (BICALUTAMIDE) L02BB03 L02AE51 ; PDB 4FIA (CRYSTAL STRUCTURE OF HUMAN CYP46A1 P450 WITH BICALUTAMIDE BOUND) - ligand code 0U9 ; Androgen receptor UNIPROT P10275 AR 744 ; TOPIRAMATE ; 97240-79-4 ; 1996 ; ; TARGET VOLTAGE-DEPENDENT SODIUM CHANNEL -- GLUTAMATE RECEPTOR -- CARBONIC ANHYDRASE ; ATC (TOPIRAMATE) A08AA51 N03AX11 ; PDB 3LXE (HUMAN CARBONIC ANHYDRASE I IN COMPLEX WITH TOPIRAMATE) - ligand code TOR ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A 745 ; GEMCITABINE ; 95058-81-4 ; 1996 ; ; TARGET DEOXYCYTIDINE KINASE ; ATC (GEMCITABINE) L01BC05 ; PDB 2NO0 (C4S DCK VARIANT OF DCK IN COMPLEX WITH GEMCITABINE+ADP) - ligand code GEO ; Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 -- Ribonucleoside-diphosphate reductase subunit M2 UNIPROT P31350 RRM2 746 ; AMLEXANOX ; 68302-57-8 ; 1996 ; DISCONTINUED ; TARGET G PROTEIN-COUPLED RECEPTOR KINASES (GRKS) (PMID25340299) ; ATC (AMLEXANOX) A01AD07 R03DX01 ; PDB 2KOT (SOLUTION STRUCTURE OF S100A13 WITH A DRUG AMLEXANOX) - ligand code ANW ; Phosphodiesterase 4 UNIPROT P27815 PDE4A 747 ; BUTENAFINE ; 101828-21-1 ; 1996 ; ; TARGET SQUALENE EPOXIDASE ; ATC (BUTENAFINE) D01AE23 ; ; Squalene epoxidase UNIPROT Q4JEY0 748 ; TRANDOLAPRIL ; 87679-37-6 ; 1996 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (TRANDOLAPRIL) C09AA10 C09BB10 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 749 ; FEXOFENADINE ; 138452-21-8 ; 1996 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (FEXOFENADINE) R06AX26 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 750 ; ANASTROZOLE ; 120511-73-1 ; 1995 ; ; TARGET CYTOCHROME P450 19 (AROMATASE) ; ATC (ANASTROZOLE) L02BG03 ; ; Aromatase UNIPROT P11511 CYP19A1 751 ; ZAFIRLUKAST ; 107753-78-6 ; 1996 ; ; TARGET PEPTIDE LEUKOTRIENE RECEPTOR LTD4 -- PEPTIDE LEUKOTRIENE RECEPTOR LTE4 ; ATC (ZAFIRLUKAST) R03DC01 ; PDB 6RZ5 (XFEL CRYSTAL STRUCTURE OF THE HUMAN CYSTEINYL LEUKOTRIENE RECEPTOR 1 IN COMPLEX WITH ZAFIRLUKAST) - ligand code ZLK ; Cysteinyl leukotriene receptor 1 UNIPROT Q9Y271 CYSLTR1 752 ; CISATRACURIUM ; 96946-41-7 ; 1983 ; ; TARGET ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2 ; ATC (CISATRACURIUM) M03AC11 ; ; Acetylcholine receptor UNIPROT P02708 CHRNA1 753 ; ALENDRONATE ; 129318-43-0 ; 1995 ; ; TARGET FARNESYL PYROPHOSPHATE SYNTHASE ; ATC (ALENDRONIC ACID) M05BA04 M05BB06 M05BB03 M05BB05 ; PDB 5DZ2 (GEOSMIN SYNTHASE FROM STREPTOMYCES COELICOLOR N-TERMINAL DOMAIN COMPLEXED WITH THREE MG2+ IONS AND ALENDRONIC ACID) - ligand code 212 ; Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS 754 ; LAMIVUDINE ; 134678-17-4 ; 1995 ; ; TARGET REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) ; ATC (LAMIVUDINE) J05AF05 J05AR02 J05AR25 J05AR16 J05AR12 J05AR13 J05AR27 J05AR24 J05AR11 J05AR28 J05AR07 J05AR01 J05AR04 J05AR05 ; PDB 2NOA (THE STRUCTURE OF DEOXYCYTIDINE KINASE COMPLEXED WITH LAMIVUDINE AND ADP.) - ligand code 3TC ; Protein P UNIPROT Q9IF40 P -- Reverse transcriptase,RNaseH UNIPROT Q72547 pol 755 ; IRINOTECAN ; 97682-44-5 ; 1996 ; ; TARGET DNA TOPOISOMERASE I COMPLEX ; ATC (IRINOTECAN) L01CE02 ; PDB 1U65 (ACHE W. CPT-11) - ligand code CP0 ; DNA topoisomerase 1 UNIPROT P11387 TOP1 756 ; BETAINE ; 107-43-7 ; 1996 ; ; ; ATC (BETAINE) A16AA06 A09AB02 ; PDB 5C2W (KUENENIA STUTTGARTIENSIS HYDRAZINE SYNTHASE PRESSURIZED WITH 20 BAR XENON) - ligand code BET ; UNKNOWN 757 ; TAMSULOSIN ; 106133-20-4 ; 1997 ; ; TARGET ALPHA-1A ADRENERGIC RECEPTOR -- ALPHA-1B ADRENERGIC RECEPTOR -- ALPHA-1D ADRENERGIC RECEPTOR ; ATC (TAMSULOSIN) G04CA02 G04CA52 G04CA53 G04CA54 ; PDB 7YMJ (CRYO-EM STRUCTURE OF ALPHA1AAR-NB6 COMPLEX BOUND TO TAMSULOSIN) - ligand code JGX ; UNKNOWN 758 ; LOTEPREDNOL ETABONATE ; 82034-46-6 ; 1998 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (LOTEPREDNOL) S01BA14 S01CA12 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 759 ; OLANZAPINE ; 132539-06-1 ; 1996 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5HT-2) -- D(2) DOPAMINE RECEPTOR ; ATC (OLANZAPINE) N05AH03 N05AH53 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 760 ; FEBUXOSTAT ; 144060-53-7 ; 2009 ; ; TARGET XANTHINE OXIDASE ; ATC (FEBUXOSTAT) M04AA03 ; PDB 1N5X (XANTHINE DEHYDROGENASE FROM BOVINE MILK WITH INHIBITOR TEI-6720 BOUND) - ligand code TEI ; Xanthine dehydrogenase,oxidase UNIPROT P47989 XDH 761 ; LATANOPROST ; 130209-82-4 ; 1996 ; ; TARGET ESTERASE ; ATC (LATANOPROST) S01EE01 S01EE51 ; ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 762 ; RILUZOLE ; 1744-22-5 ; 1995 ; ; TARGET SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS (PMID26311432) ; ATC (RILUZOLE) N07XX02 ; PDB 5V02 (A POSITIVE ALLOSTERIC MODULATOR BINDING POCKET IN SK2 ION CHANNELS IS SHARED BY RILUZOLE AND CYPPA) - ligand code 657 ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 763 ; TAZAROTENE ; 118292-40-3 ; 1997 ; ; TARGET RETINOIC ACID RECEPTOR ; ATC (TAZAROTENE) D05AX05 D05AX55 ; ; Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor beta UNIPROT P10826 RARB 764 ; SIBUTRAMINE ; 106650-56-0 ; 1997 ; DISCONTINUED ; TARGET MONOAMINE REUPTAKE ; ATC (SIBUTRAMINE) A08AA10 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 765 ; FEXOFENADINE ; 138452-21-8 ; 1996 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (FEXOFENADINE) R06AX26 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 766 ; PENCICLOVIR ; 39809-25-1 ; 1996 ; ; TARGET THYMIDINE KINASE ; ATC (PENCICLOVIR) D06BB06 J05AB13 ; ; DNA polymerase catalytic subunit UNIPROT P04293 767 ; REMIFENTANIL ; 132875-61-7 ; 1996 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (REMIFENTANIL) N01AH06 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 768 ; SIBUTRAMINE ; 106650-56-0 ; 1997 ; DISCONTINUED ; TARGET MONOAMINE REUPTAKE ; ATC (SIBUTRAMINE) A08AA10 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 769 ; LEVOFLOXACIN ; 100986-85-4 ; 1990 ; ; TARGET DNA TOPOISOMERASE IV -- DNA GYRASE ; ATC (LEVOFLOXACIN) A02BD10 J01MA12 S01AE05 J01RA05 ; PDB 5EIX (QUINOLONE-STABILIZED CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM KLEBSIELLA PNEUMONIAE) - ligand code LFX ; DNA topoisomerase 4 UNIPROT P72525 parC -- DNA gyrase UNIPROT P0A4L9 gyrB 770 ; NEVIRAPINE ; 129618-40-2 ; 1996 ; ; TARGET HIV REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) ; ATC (NEVIRAPINE) J05AG01 J05AR07 J05AR05 ; PDB 1JLF (CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE) - ligand code NVP ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 771 ; CIDOFOVIR ; 113852-37-2 ; 1996 ; ; TARGET DNA POLYMERASE ; ATC (CIDOFOVIR) J05AB12 ; PDB 5KM8 (HUMAN HISTIDINE TRIAD NUCLEOTIDE BINDING PROTEIN 2 (HHINT2) CIDOFOVIR COMPLEX) - ligand code L8P ; DNA polymerase catalytic subunit UNIPROT P04293 772 ; TIAGABINE ; 115103-54-3 ; 1997 ; ; TARGET GAMMA AMINOBUTYRIC ACID (GABA) UPTAKE CARRIER ; ATC (TIAGABINE) N03AG06 ; PDB 7Y7Z (CRYO-EM STRUCTURE OF HUMAN GABA TRANSPORTER GAT1 BOUND WITH TIAGABINE IN NACL SOLUTION IN AN INWARD-OPEN STATE AT 3.2 ANGSTROM) - ligand code TGI ; Sodium- and chloride-dependent GABA transporter 1 UNIPROT P30531 SLC6A1 773 ; ROPINIROLE ; 91374-21-9 ; 1997 ; ; TARGET D(3) DOPAMINE RECEPTOR -- D(2) DOPAMINE RECEPTOR ; ATC (ROPINIROLE) N04BC04 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 774 ; RITONAVIR ; 155213-67-5 ; 1996 ; ; TARGET HIV PROTEASE ; ATC (RITONAVIR) J05AR23 J05AR26 J05AP52 J05AR10 J05AE30 J05AP53 J05AE03 ; PDB 1N49 (VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE VARIANT: STRUCTURAL INSIGHTS FOR BETTER ANTI-VIRAL THERAPY) - ligand code RIT ; Pol polyprotein UNIPROT Q72874 pol 775 ; CABERGOLINE ; 81409-90-7 ; 1996 ; ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (CABERGOLINE) G02CB03 N04BC06 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 776 ; VALSARTAN ; 137862-53-4 ; 1996 ; ; TARGET TYPE-1 ANGIOTENSIN II RECEPTOR ; ATC (VALSARTAN) C10BX10 C09CA03 C09DX02 C09DB01 C09DA03 C09DB08 C09DX05 C09DX04 C09DX01 ; PDB 8DQT (HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH VALSARTAN) - ligand code U35 ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 777 ; ALBENDAZOLE ; 54965-21-8 ; 1996 ; ; TARGET TUBULIN ; ATC (ALBENDAZOLE) P02CA03 ; ; Tubulin UNIPROT C4PKY4 -- Tubulin UNIPROT F1L005 778 ; TOPOTECAN ; 123948-87-8 ; 1996 ; ; TARGET TOPOISOMERASE I ; ATC (TOPOTECAN) L01CE01 ; PDB 1RRJ (STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I) - ligand code TTC ; DNA topoisomerase I, mitochondrial UNIPROT Q969P6 TOP1MT 779 ; SPARFLOXACIN ; 110871-86-8 ; 1996 ; DISCONTINUED ; TARGET DNA GYRASE ; ATC (SPARFLOXACIN) J01MA09 ; ; Topoisomerase IV UNIPROT P0AFI2 parC -- DNA gyrase UNIPROT P0AES4 gyrA 780 ; MIGLITOL ; 72432-03-2 ; 1996 ; ; TARGET ALPHA-GLUCOSIDASE ; ATC (MIGLITOL) A10BF02 ; PDB 5NN6 (CRYSTAL STRUCTURE OF HUMAN LYSOSOMAL ACID-ALPHA-GLUCOSIDASE, GAA, IN COMPLEX WITH N-HYDROXYETHYL-1-DEOXYNOJIRIMYCIN) - ligand code MIG ; Maltase-glucoamylase, intestinal UNIPROT O43451 MGAM -- Lysosomal alpha-glucosidase UNIPROT P10253 GAA 781 ; MIFEPRISTONE ; 84371-65-3 ; 2000 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (MIFEPRISTONE) G03XB01 G03XB51 ; PDB 3H52 (CRYSTAL STRUCTURE OF THE ANTAGONIST FORM OF HUMAN GLUCOCORTICOID RECEPTOR) - ligand code 486 ; Glucocorticoid receptor UNIPROT P04150 NR3C1 -- Progesterone receptor UNIPROT P06401 PGR 782 ; OLOPATADINE ; 113806-05-6 ; 1996 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (OLOPATADINE) R01AC08 S01GX09 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 783 ; DONEPEZIL ; 120014-06-4 ; 1996 ; ; TARGET ACETYLCHOLINESTERASE ; ATC (DONEPEZIL) N06DA02 N06DA52 N06DA53 ; ; Acetylcholinesterase UNIPROT P22303 ACHE 784 ; GREPAFLOXACIN ; 119914-60-2 ; 1997 ; DISCONTINUED ; TARGET DNA TOPOISOMERASE II (DNA GYRASE) -- DNA TOPOISOMERASE IV ; ATC (GREPAFLOXACIN) J01MA11 ; ; DNA topoisomerase 4 UNIPROT P72525 parC -- DNA gyrase UNIPROT P0A4L9 gyrB 785 ; FOMEPIZOLE ; 7554-65-6 ; 1997 ; ; TARGET ALCOHOL DEHYDROGENASE ; ATC (FOMEPIZOLE) V03AB34 ; PDB 3E4E (HUMAN CYTOCHROME P450 2E1 IN COMPLEX WITH THE INHIBITOR 4-METHYLPYRAZOLE) - ligand code 4PZ ; Alcohol dehydrogenase UNIPROT P00325 ADH1B 786 ; TOLCAPONE ; 134308-13-7 ; 1998 ; ; TARGET CATECHOL O-METHYLTRANSFERASE ; ATC (TOLCAPONE) N04BX01 ; PDB 5A6I (V122I TRANSTHYRETIN STRUCTURE IN COMPLEX WITH TOLCALPONE) - ligand code TCW ; Catechol O-methyltransferase UNIPROT P21964 COMT 787 ; ATORVASTATIN ; 134523-00-5 ; 1996 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE ; ATC (ATORVASTATIN) C10AA05 C10BX08 C10BX03 C10BA05 C10BA08 C10BX15 C10BX12 C10BX06 C10BX19 C10BX11 C10BX18 ; PDB 1HWK (COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ATORVASTATIN) - ligand code 117 ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 788 ; MODAFINIL ; 68693-11-8 ; 1998 ; ; ; ATC (MODAFINIL) N06BA07 ; ; Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 789 ; EPTIFIBATIDE ; 148031-34-9 ; 1998 ; ; TARGET PLATELET RECEPTOR GLYCOPROTEIN IIB/IIIA ; ATC (EPTIFIBATIDE) B01AC16 ; ; Integrin alpha-IIb,beta-3 UNIPROT P05106 ITGB3 790 ; TROGLITAZONE ; 97322-87-7 ; 1997 ; DISCONTINUED ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR) ; ATC (TROGLITAZONE) A10BG01 ; ; Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 791 ; IMIQUIMOD ; 99011-02-6 ; 1997 ; ; TARGET TOLL-LIKE RECEPTOR 7 ; ATC (IMIQUIMOD) D06BB10 ; PDB 5LBT (STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH IMIQUIMOD) - ligand code 6T0 ; Toll-like receptor 7 UNIPROT Q9NYK1 TLR7 792 ; LETROZOLE ; 112809-51-5 ; 1997 ; ; TARGET CYTOCHROME P450 19 (AROMATASE) ; ATC (LETROZOLE) L02BG04 ; ; Aromatase UNIPROT P11511 CYP19A1 793 ; CERIVASTATIN ; 145599-86-6 ; 1997 ; DISCONTINUED ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE ; ATC (CERIVASTATIN) C10AA06 ; ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 794 ; REPAGLINIDE ; 135062-02-1 ; 1997 ; ; TARGET ATP DEPENDANT POTASSIUM CHANNEL ; ATC (REPAGLINIDE) A10BD14 A10BX02 ; PDB 6JB3 (STRUCTURE OF SUR1 SUBUNIT BOUND WITH REPAGLINIDE) - ligand code BJX ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 795 ; EXEMESTANE ; 107868-30-4 ; 1999 ; ; TARGET CYTOCHROME P450 19A1 (AROMATASE) ; ATC (L02BG06) L02BG06 ; PDB 3S7S (CRYSTAL STRUCTURE OF HUMAN PLACENTAL AROMATASE COMPLEXED WITH BREAST CANCER DRUG EXEMESTANE) - ligand code EXM ; Aromatase UNIPROT P11511 CYP19A1 796 ; IRBESARTAN ; 138402-11-6 ; 1997 ; ; TARGET TYPE-1 ANGIOTENSIN II RECEPTOR ; ATC (IRBESARTAN) C09CA04 C09DB05 C09DA04 C09DX07 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 797 ; NARATRIPTAN ; 121679-13-8 ; 1998 ; ; TARGET 5-HYDROXYTRYPTAMINE 1D RECEPTOR -- 5-HYDROXYTRYPTAMINE 1B RECEPTOR ; ATC (NARATRIPTAN) N02CC02 ; ; 5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B -- 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 798 ; ORLISTAT ; 96829-58-2 ; 1999 ; ; TARGET GASTRIC LIPASE -- PANCREATIC LIPASE ; ATC (ORLISTAT) A08AB01 ; ; Pancreatic triacylglycerol lipase UNIPROT P16233 PNLIP -- Gastric triacylglycerol lipase UNIPROT P07098 LIPF 799 ; ZOLMITRIPTAN ; 139264-17-8 ; 1997 ; ; TARGET 5-HYDROXYTRYPTAMINE 1B RECEPTOR -- 5-HYDROXYTRYPTAMINE 1D RECEPTOR ; ATC (ZOLMITRIPTAN) N02CC03 ; ; 5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B -- 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 800 ; TOLTERODINE ; 124937-51-5 ; 1998 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (TOLTERODINE) G04BD07 ; ; Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 801 ; THALIDOMIDE ; 50-35-1 ; 1998 ; ; ; ATC (THALIDOMIDE) L04AX02 ; PDB 5AMH (CEREBLON ISOFORM 4 FROM MAGNETOSPIRILLUM GRYPHISWALDENSE IN COMPLEX WITH THALIDOMIDE, TRIGONAL CRYSTAL FORM) - ligand code EF2 ; Protein cereblon UNIPROT Q96SW2 CRBN 802 ; ZONISAMIDE ; 68291-97-4 ; 2000 ; ; TARGET SODIUM CHANNEL -- VOLTAGE-DEPENDENT CALCIUM CHANNEL -- GABA/BENZODIAZEPINE RECEPTOR IONOPHORE COMPLEX -- CARBONIC ANHYDRASE ; ATC (ZONISAMIDE) N03AX15 ; PDB 3PO7 (HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH ZONISAMIDE) - ligand code ZON ; Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A 803 ; ENTACAPONE ; 130929-57-6 ; 1999 ; ; TARGET CATECHOL O-METHYLTRANSFERASE (COMT) ; ATC (ENTACAPONE) N04BX02 ; PDB 6AK4 (CRYSTAL STRUCTURE OF HUMAN FTO IN COMPLEX WITH SMALL-MOLECULE INHIBITORS) - ligand code PD9 ; Catechol O-methyltransferase UNIPROT P21964 COMT 804 ; RALOXIFENE ; 84449-90-1 ; 1997 ; ; TARGET ESTROGEN RECEPTOR BETA ; ATC (RALOXIFENE) G03XC01 ; PDB 1ERR (HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE) - ligand code RAL ; Estrogen receptor UNIPROT P03372 ESR1 -- Estrogen receptor beta UNIPROT Q92731 ESR2 805 ; BRINZOLAMIDE ; 138890-62-7 ; 1998 ; ; TARGET CARBONIC ANHYDRASE II ; ATC (BRINZOLAMIDE) S01EC04 S01EC54 ; PDB 4M2V (GENETICALLY ENGINEERED CARBONIC ANHYDRASE IX IN COMPLEX WITH BRINZOLAMIDE) - ligand code BZ1 ; Carbonic anhydrase 2 UNIPROT P00918 CA2 806 ; PARICALCITOL ; 131918-61-1 ; 1998 ; ; TARGET VITAMIN D3 RECEPTOR ; ATC (PARICALCITOL) H05BX02 ; ; Vitamin D3 receptor UNIPROT P11473 VDR 807 ; RIVASTIGMINE ; 123441-03-2 ; 2000 ; ; TARGET CHOLINESTERASE ; ATC (RIVASTIGMINE) N06DA03 ; ; Acetylcholinesterase UNIPROT P22303 ACHE -- Cholinesterase UNIPROT P06276 BCHE 808 ; ZIPRASIDONE ; 146939-27-7 ; 2001 ; ; TARGET ALPHA 1 ADRENERGIC RECEPTOR -- 5-HYDROXYTRYPTAMINE 1A RECEPTOR -- D(2) DOPAMINE RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- 5-HYDROXYTRYPTAMINE 2C RECEPTOR -- D(3) DOPAMINE RECEPTOR -- 5-HYDROXYTRYPTAMINE 1D RECEPTOR ; ATC (ZIPRASIDONE) N05AE04 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 809 ; MONTELUKAST ; 158966-92-8 ; 1998 ; ; TARGET CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLT1) ; ATC (MONTELUKAST) R03DC03 R03DC53 ; PDB 2NNI (CYP2C8DH COMPLEXED WITH MONTELUKAST) - ligand code MTK ; Cysteinyl leukotriene receptor 1 UNIPROT Q9Y271 CYSLTR1 810 ; FORMOTEROL ; 73573-87-2 ; 2001 ; ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (FORMOTEROL) R03AC13 R03CC15 R03AL05 R03AK08 R03AK07 R03AK11 R03AL07 R03AK09 R03AL10 R03AL09 R03AL11 ; PDB 6H7K (ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL) - ligand code FVN ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 811 ; ARGATROBAN ; 74863-84-6 ; 2000 ; ; TARGET THROMBIN ; ATC (ARGATROBAN) B01AE03 ; ; Prothrombin UNIPROT P00734 F2 812 ; RISEDRONATE ; 105462-24-6 ; 1998 ; ; TARGET FARNESYL PYROPHOSPHATE SYNTHASE ; ATC (RISEDRONIC ACID) M05BA07 M05BB02 M05BB07 M05BB04 ; PDB 4KPD (CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE (Y204F) MUTANT COMPLEXED WITH MG, RISEDRONATE AND ISOPENTENYL PYROPHOSPHATE) - ligand code RIS ; Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS 813 ; LEVALBUTEROL ; 34391-04-3 ; 1999 ; ; TARGET BETA2-ADRENERGIC ; ATC (SALBUTAMOL) R03AC02 R03CC02 R03AK13 R03AK15 R03AL02 R03AK04 ; PDB 2Y04 (TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST SALBUTAMOL) - ligand code 68H ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 814 ; TELMISARTAN ; 144701-48-4 ; 1998 ; ; TARGET ANGIOTENSIN II RECEPTOR ; ATC (TELMISARTAN) C10BX20 C09CA07 C09DB04 C09DA07 C09DX08 ; PDB 3VN2 (CRYSTAL STRUCTURE OF PPARGAMMA COMPLEXED WITH TELMISARTAN) - ligand code TLS ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 815 ; ZALEPLON ; 151319-34-5 ; 1999 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR (GABA) BRAIN OMEGA-1 RECEPTOR ; ATC (ZALEPLON) N05CF03 ; ; GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 816 ; CILOSTAZOL ; 73963-72-1 ; 1999 ; ; TARGET PHOSPHODIESTERASE III (PDE) ; ATC (CILOSTAZOL) B01AC23 ; ; cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A 817 ; CYCLOPENTOLATE ; 204990-63-6 ; 1974 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (CYCLOPENTOLATE) S01FA04 S01FA54 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 818 ; ARGATROBAN ; 74863-84-6 ; 2000 ; ; TARGET THROMBIN ; ATC (ARGATROBAN) B01AE03 ; ; Prothrombin UNIPROT P00734 F2 819 ; ALITRETINOIN ; 5300-03-8 ; 1999 ; ; TARGET RETINOIC X RECEPTOR (RXR) -- RETINOIC ACID RECEPTOR (RAR) ; ATC (ALITRETINOIN) D11AH04 L01XF02 ; PDB 5UAN (CRYSTAL STRUCTURE OF MULTI-DOMAIN RAR-BETA-RXR-ALPHA HETERODIMER ON DNA) - ligand code 9CR ; Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor RXR-alpha UNIPROT P19793 RXRA 820 ; VALRUBICIN ; 56124-62-0 ; 1998 ; ; TARGET DNA TOPOISOMERASE II ; ATC (VALRUBICIN) L01DB09 ; ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 821 ; CAPECITABINE ; 154361-50-9 ; 1998 ; ; TARGET CARBOXYLESTERASE ; ATC (CAPECITABINE) L01BC06 ; ; Thymidylate synthase UNIPROT P04818 TYMS 822 ; LEFLUNOMIDE ; 75706-12-6 ; 1998 ; ; TARGET DIHYDROOROTATE DEHYDROGENASE ; ATC (LEFLUNOMIDE) L04AK01 ; ; Dihydroorotate dehydrogenase (quinone), mitochondrial UNIPROT Q02127 DHODH 823 ; TIROFIBAN ; 144494-65-5 ; 1998 ; ; TARGET PLATELET GLYCOPROTEIN (PG) IIB/IIIA ; ATC (TIROFIBAN) B01AC17 ; PDB 2VDM (RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN) - ligand code AGG ; Integrin alpha-IIb,beta-3 UNIPROT P05106 ITGB3 824 ; CHOLECALCIFEROL ; 67-97-0 ; 2000 ; ; TARGET VITAMIN D3-25-HYDROXYLASE (25-OHASE) ; ATC (COLECALCIFEROL) M05BB03 A11CC05 A11CC55 M05BB09 M05BB07 M05BX53 ; ; Vitamin D3 receptor UNIPROT P11473 VDR 825 ; PIOGLITAZONE ; 111025-46-8 ; 1999 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA ; ATC (PIOGLITAZONE) A10BD06 A10BD05 A10BG03 A10BD09 A10BD12 ; PDB 5Y2O (STRUCTURE OF PPARGAMMA LIGAND BINDING DOMAIN-PIOGLITAZONE COMPLEX) - ligand code 8N6 ; Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 826 ; DOFETILIDE ; 115256-11-6 ; 1999 ; ; TARGET POTASSIUM VOLTAGE-GATED CHANNEL ; ATC (DOFETILIDE) C01BD04 ; ; Potassium voltage-gated channel subfamily H member 2 UNIPROT Q12809 KCNH2 827 ; GEMIFLOXACIN ; 175463-14-6 ; 2003 ; DISCONTINUED ; TARGET DNA GYRASE -- DNA TOPOISOMERASE 4 ; ATC (GEMIFLOXACIN) J01MA15 ; ; DNA topoisomerase 4 subunit A UNIPROT P72525 parC 828 ; MELOXICAM ; 71125-38-7 ; 2000 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE ; ATC (MELOXICAM) N01BB59 M01AC06 M01AC56 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 829 ; DOCOSANOL ; 661-19-8 ; 2000 ; ; ; ATC (DOCOSANOL) D06BB11 ; ; Envelope glycoprotein UNIPROT O09800 gN 830 ; AMINOLEVULINIC ACID ; 106-60-5 ; 1999 ; ; ; ATC (AMINOLEVULINIC ACID) L01XD04 ; PDB 6HZP (CRYSTAL STRUCTURE OF A POT FAMILY TRANSPORTER IN COMPLEX WITH 5-AMINOLEVULINIC ACID) - ligand code FVT ; UNKNOWN 831 ; EFAVIRENZ ; 154598-52-4 ; 1998 ; ; TARGET HIV-1 REVERSE TRANSCRIPTASE ; ATC (EFAVIRENZ) J05AG03 J05AR06 J05AR11 ; PDB 6BSJ (STRUCTURE OF HIV-1 RT COMPLEXED WITH AN RNA, DNA HYBRID SEQUENCE NON-PREFERRED FOR RNA HYDROLYSIS) - ligand code EFZ ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 832 ; RABEPRAZOLE ; 117976-89-3 ; 1999 ; ; TARGET POTASSIUM-TRANSPORTING ATPASE ; ATC (RABEPRAZOLE) A02BC04 A02BD12 A02BD13 A02BC54 ; PDB 3PGL (CRYSTAL STRUCTURE OF HUMAN SMALL C-TERMINAL DOMAIN PHOSPHATASE 1 (SCP1) BOUND TO RABEPRAZOLE) - ligand code RZX ; Potassium-transporting ATPase UNIPROT P20648 ATP4A 833 ; PANTOPRAZOLE ; 102625-70-7 ; 2000 ; ; TARGET POTASSIUM TRANSPORTING ATPASE ; ATC (PANTOPRAZOLE) A02BC02 A02BD04 A02BD11 ; ; Potassium-transporting ATPase UNIPROT P20648 ATP4A 834 ; CEVIMELINE ; 107233-08-9 ; 2000 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M3 -- MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (CEVIMELINE) N07AX03 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 835 ; LEVOBUPIVACAINE ; 27262-47-1 ; 1972 ; ; TARGET ACETYLCHOLINE RECEPTOR -- NMDA RECEPTOR -- 5HT3 ; ATC (LEVOBUPIVACAINE) N01BB10 ; PDB 8I5B (STRUCTURE OF HUMAN NAV1.7 IN COMPLEX WITH BUPIVACAINE) - ligand code OJ0 ; Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A 836 ; CELECOXIB ; 169590-42-5 ; 1998 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (CELECOXIB) C08CA51 L01XX33 M01AH01 N02AJ16 ; PDB 3KK6 (CRYSTAL STRUCTURE OF CYCLOOXYGENASE-1 IN COMPLEX WITH CELECOXIB) - ligand code CEL ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 837 ; AMPRENAVIR ; 161814-49-9 ; 1999 ; DISCONTINUED ; TARGET HIV-1 PROTEASE ; ATC (AMPRENAVIR) J05AE05 ; PDB 4JEC (JOINT NEUTRON AND X-RAY STRUCTURE OF PER-DEUTERATED HIV-1 PROTEASE IN COMPLEX WITH CLINICAL INHIBITOR AMPRENAVIR) - ligand code 478 ; Pol polyprotein UNIPROT Q72874 pol 838 ; OXCARBAZEPINE ; 28721-07-5 ; 2000 ; ; TARGET VOLTAGE SENSITIVE SODIUM CHANNEL ; ATC (OXCARBAZEPINE) N03AF02 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 839 ; ELETRIPTAN ; 143322-58-1 ; 2002 ; ; TARGET 5-HYDROXYTRYPTAMINE 1B RECEPTOR -- 5-HYDROXYTRYPTAMINE 1D RECEPTOR -- 5-HYDROXYTRYPTAMINE 1F RECEPTOR ; ATC (ELETRIPTAN) N02CC06 ; ; 5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B -- 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 840 ; CYCLOSPORINE ; 59865-13-3 ; 1983 ; ; TARGET PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (CYCLOPHILIN) ; ATC (CICLOSPORIN) L04AD01 S01XA18 ; PDB 2WFJ (ATOMIC RESOLUTION CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF HUMAN CYCLOPHILIN G IN COMPLEX WITH CYCLOSPORIN A) - ligand code CYCLOSPORINEA ; Peptidyl-prolyl cis-trans isomerase A UNIPROT P62937 PPIA 841 ; RIFAPENTINE ; 61379-65-5 ; 1998 ; ; TARGET DNA-DIRECTED RNA POLYMERASE ; ATC (RIFAPENTINE) J04AB05 ; PDB 2A69 (CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFAPENTIN) - ligand code RPT ; Bacterial DNA-directed RNA polymerase UNIPROT P0A7Z4 rpoA 842 ; TEMOZOLOMIDE ; 85622-93-1 ; 1999 ; ; TARGET DNA ; ATC (TEMOZOLOMIDE) L01AX03 ; ; UNKNOWN 843 ; LEVETIRACETAM ; 102767-28-2 ; 1999 ; ; ; ATC (LEVETIRACETAM) N03AX14 ; PDB 8JS8 (CRYO-EM STRUCTURE OF SV2A IN COMPLEX WITH BONT, A2 HC AND LEVETIRACETAM) - ligand code UKX ; Synaptic vesicle glycoprotein 2A UNIPROT Q7L0J3 SV2A 844 ; ZANAMIVIR ; 139110-80-8 ; 1999 ; ; TARGET NEURAMINIDASE ; ATC (ZANAMIVIR) J05AH01 ; PDB 3TIC (CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR) - ligand code ZMR ; Neuraminidase UNIPROT P03468 -- Neuraminidase UNIPROT P03474 845 ; DEXMEDETOMIDINE ; 113775-47-6 ; 1999 ; ; TARGET ALPHA-2A ADRENERGIC RECEPTOR ; ATC (DEXMEDETOMIDINE) N05CM18 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B 846 ; ROFECOXIB ; 162011-90-7 ; 1999 ; DISCONTINUED ; TARGET PROSTAGLANDIN G/H SYNTHASE 2 (COX-2) ; ATC (ROFECOXIB) M01AH02 ; PDB 5KIR (THE STRUCTURE OF VIOXX BOUND TO HUMAN COX-2) - ligand code RCX ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 847 ; BEXAROTENE ; 153559-49-0 ; 1999 ; ; TARGET RETINOIC ACID RECEPTOR RXR ALPHA -- RETINOIC ACID RECEPTOR RXR BETA -- RETINOIC ACID RECEPTOR RXR GAMMA ; ATC (BEXAROTENE) L01XF03 ; PDB 4K6I (CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH TARGRETIN AND THE COACTIVATOR PEPTIDE GRIP-1) - ligand code 9RA ; Retinoic acid receptor RXR-alpha UNIPROT P19793 RXRA -- Retinoic acid receptor RXR-beta UNIPROT P28702 RXRB 848 ; GUAIFENESIN ; 93-14-1 ; 2002 ; ; ; ATC (GUAIFENESIN) R05CA03 ; ; UNKNOWN 849 ; KETOTIFEN ; 34580-13-7 ; 1999 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (KETOTIFEN) R06AX17 S01GX08 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 850 ; PIOGLITAZONE ; 111025-46-8 ; 1999 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA ; ATC (PIOGLITAZONE) A10BD06 A10BD05 A10BG03 A10BD09 A10BD12 ; PDB 4A79 (CRYSTAL STRUCTURE OF HUMAN MONOAMINE OXIDASE B (MAO B) IN COMPLEX WITH PIOGLITAZONE) - ligand code P1B ; Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 851 ; PROGUANIL ; 500-92-5 ; 2000 ; ; TARGET DIHYDROFOLATE REDUCTASE ; ATC (PROGUANIL) P01BB52 P01BB01 P01BB51 ; ; Bifunctional dihydrofolate reductase-thymidylate synthase UNIPROT P13922 852 ; PEMIROLAST ; 69372-19-6 ; 1999 ; DISCONTINUED ; ; ; ; UNKNOWN 853 ; SIROLIMUS ; 53123-88-9 ; 1999 ; ; TARGET FK BINDING PROTEIN-12 (FKBP-12) ; ATC (SIROLIMUS) L01EG04 L04AH01 S01XA23 ; PDB 5HKG (TOTAL CHEMICAL SYNTHESIS, REFOLDING AND CRYSTALLOGRAPHIC STRUCTURE OF A FULLY ACTIVE IMMUNOPHILIN: CALSTABIN 2 (FKBP12.6).) - ligand code RAP ; Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A 854 ; MOXIFLOXACIN ; 151096-09-2 ; 1999 ; ; TARGET TOPOISOMERASE II (DNA GYRASE) -- TOPOISOMERASE 4 ; ATC (MOXIFLOXACIN) J01MA14 S01AE07 ; PDB 5CDQ (2.95A STRUCTURE OF MOXIFLOXACIN WITH S.AUREUS DNA GYRASE AND DNA) - ligand code MFX ; Topoisomerase IV UNIPROT P0AFI2 parC -- DNA gyrase UNIPROT P0AES4 gyrA 855 ; DROSPIRENONE ; 67392-87-4 ; 2001 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (DROSPIRENONE) G03AC10 G03AA18 G03FA17 G03AA12 ; ; Mineralocorticoid receptor UNIPROT P08235 NR3C2 -- Progesterone receptor UNIPROT P06401 PGR 856 ; ALOSETRON ; 122852-42-0 ; 2000 ; ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR ; ATC (ALOSETRON) A03AE01 ; ; 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 857 ; HYDROQUINONE ; 123-31-9 ; 2002 ; ; ; ATC (HYDROQUINONE) D11AX11 ; PDB 4QOP (STRUCTURE OF BACILLUS PUMILUS CATALASE WITH HYDROQUINONE BOUND.) - ligand code HQE ; Carbonic anhydrase 14 UNIPROT Q9ULX7 CA14 858 ; LEVOTHYROXINE ; 51-48-9 ; 2000 ; ; TARGET THYROID HORMONE RECEPTOR ; ATC (LEVOTHYROXINE SODIUM) H03AA01 H03AA51 ; PDB 4X30 (CRYSTAL STRUCTURE OF HUMAN THYROXINE-BINDING GLOBULIN COMPLEXED WITH THYROINE AT 1.55 ANGSTROM RESOLUTION) - ligand code T44_4X30 ; Thyroid hormone receptor alpha UNIPROT P10827 THRA -- Thyroid hormone receptor beta UNIPROT P10828 THRB 859 ; ALFUZOSIN ; 81403-80-7 ; 2003 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (ALFUZOSIN) G04CA01 G04CA51 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 860 ; LINEZOLID ; 165800-03-3 ; 2000 ; ; TARGET 50S RIBOSOMAL SUBUNIT ; ATC (LINEZOLID) J01XX08 ; PDB 4WFA (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LINEZOLID) - ligand code ZLD ; UNKNOWN 861 ; VALGANCICLOVIR ; 175865-60-8 ; 2001 ; ; ; ATC (VALGANCICLOVIR) J05AB14 ; ; DNA polymerase catalytic subunit UNIPROT P04293 862 ; TELITHROMYCIN ; 191114-48-4 ; 2004 ; DISCONTINUED ; TARGET 50S RIBOSOMAL SUBUNIT ; ATC (TELITHROMYCIN) J01FA15 ; PDB 4V7Z (STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH TELITHROMYCIN.) - ligand code TEL ; UNKNOWN 863 ; M TICAGRELOR ; 220347-05-7 ; 0 ; ; TARGET P2Y12 ADP-RECEPTOR ; ATC (TRICAGRELOR) B01AC24 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 864 ; GEMIFLOXACIN ; 175463-14-6 ; 2003 ; DISCONTINUED ; TARGET DNA GYRASE -- DNA TOPOISOMERASE 4 ; ATC (GEMIFLOXACIN) J01MA15 ; ; DNA topoisomerase 4 subunit A UNIPROT P72525 parC 865 ; DESLORATADINE ; 100643-71-8 ; 2001 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DESLORATADINE) R06AX27 ; PDB 8X64 (CRYOEM STRUCTURE OF THE HISTAMINE H1 RECEPTOR-BRIL, ANTI BRIL FAB COMPLEX WITH DESLORATADINE) - ligand code Y5R ; Histamine H1 receptor UNIPROT P35367 HRH1 866 ; ETONOGESTREL ; 54048-10-1 ; 2001 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (ETONOGESTREL) G03AC08 ; ; Progesterone receptor UNIPROT P06401 PGR 867 ; CETRORELIX ; 120287-85-6 ; 2000 ; ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR ; ATC (CETRORELIX) H01CC02 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 868 ; TEGASEROD ; 145158-71-0 ; 2002 ; DISCONTINUED ; TARGET 5-HYDROXYTRYPTAMINE 4 RECEPTOR ; ATC (TEGASEROD) A06AX06 ; ; 5-hydroxytryptamine receptor 4 UNIPROT Q13639 HTR4 869 ; NATEGLINIDE ; 105816-04-4 ; 2000 ; ; TARGET ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL ; ATC (NATEGLINIDE) A10BX03 ; ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 870 ; LOPINAVIR ; 192725-17-0 ; 2000 ; ; TARGET HIV-1 PROTEASE ; ATC (LOPINAVIR) J05AR10 ; PDB 2O4S (CRYSTAL STRUCTURE OF HIV-1 PROTEASE (Q7K) IN COMPLEX WITH LOPINAVIR) - ligand code AB1 ; Pol polyprotein UNIPROT Q72874 pol 871 ; NITISINONE ; 104206-65-7 ; 2002 ; ; TARGET 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE ; ATC (NITISINONE) A16AX04 ; ; 4-hydroxyphenylpyruvate dioxygenase UNIPROT P32754 HPD 872 ; TRAVOPROST ; 157283-68-6 ; 2001 ; ; TARGET FP PROSTANOID RECEPTOR ; ATC (TRAVOPROST) S01EE04 ; ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 873 ; APOMORPHINE ; 58-00-4 ; 2004 ; ; TARGET DOPAMINE D2 RECEPTOR ; ATC (APOMORPHINE) G04BE07 N04BC07 ; PDB 7JVQ (CRYO-EM STRUCTURE OF APOMORPHINE-BOUND DOPAMINE RECEPTOR 1 IN COMPLEX WITH GS PROTEIN) - ligand code OR9 ; D(2) dopamine receptor UNIPROT P14416 DRD2 874 ; VORICONAZOLE ; 137234-62-9 ; 2002 ; ; TARGET CYTOCHROME P450 CYP51 ; ATC (VORICONAZOLE) J02AC03 ; PDB 5HS1 (SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) COMPLEXED WITH VORICONAZOLE) - ligand code VOR ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 875 ; TREPROSTINIL ; 81846-19-7 ; 2002 ; ; TARGET PROSTACYCLIN RECEPTOR ; ATC (TREPROSTINIL) B01AC21 ; PDB 8X7A (TREPROSTINIL BOUND PROSTACYCLIN RECEPTOR G PROTEIN COMPLEX) - ligand code Y9J ; Prostacyclin receptor UNIPROT P43119 PTGIR 876 ; BIMATOPROST ; 155206-00-1 ; 2001 ; ; ; ATC (BIMATOPROST) S01EE03 ; PDB 2F38 (CRYSTAL STRUCTURE OF PROSTAGLANDIN F SYNATHASE CONTAINING BIMATOPROST) - ligand code 15M ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 877 ; GUAIFENESIN ; 93-14-1 ; 2002 ; ; ; ATC (GUAIFENESIN) R05CA03 ; ; UNKNOWN 878 ; OLMESARTAN MEDOXOMIL ; 144689-63-4 ; 2002 ; ; TARGET TYPE-1 ANGIOTENSIN II RECEPTOR ; ATC (OLMESARTAN MEDOXOMIL) C09CA08 C09DB02 C09DA08 C09DX03 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 879 ; ALFUZOSIN ; 81403-80-7 ; 2003 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (ALFUZOSIN) G04CA01 G04CA51 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 880 ; BOSENTAN ; 147536-97-8 ; 2001 ; ; TARGET ENDOTHELIN RECEPTOR -- ENDOTHELIN-1 RECEPTOR ; ATC (BOSENTAN) C02KX01 ; PDB 5XPR (HUMAN ENDOTHELIN RECEPTOR TYPE-B IN COMPLEX WITH ANTAGONIST BOSENTAN) - ligand code K86 ; Endothelin-1 receptor UNIPROT P25101 EDNRA -- Endothelin B receptor UNIPROT P24530 EDNRB 881 ; PIMECROLIMUS ; 137071-32-0 ; 2001 ; ; TARGET MACROPHILIN-12 (FKBP-12) ; ATC (PIMECROLIMUS) D11AH02 ; ; Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A 882 ; VALGANCICLOVIR ; 175865-60-8 ; 2001 ; ; ; ATC (VALGANCICLOVIR) J05AB14 ; PDB 6GS4 (CRYSTAL STRUCTURE OF PEPTIDE TRANSPORTER DTPA-NANOBODY IN COMPLEX WITH VALGANCICLOVIR) - ligand code F9E ; DNA polymerase catalytic subunit UNIPROT P04293 883 ; DUTASTERIDE ; 164656-23-9 ; 2001 ; ; TARGET 5 ALPHA-REDUCTASE ; ATC (DUTASTERIDE) G04CB02 G04CA52 ; ; 3-oxo-5-alpha-steroid 4-dehydrogenase 2 UNIPROT P31213 SRD5A2 -- 3-oxo-5-alpha-steroid 4-dehydrogenase 1 UNIPROT P18405 SRD5A1 884 ; ABARELIX ; 183552-38-7 ; 2003 ; DISCONTINUED ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR ; ATC (ABARELIX) L02BX01 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 885 ; ERTAPENEM ; 153832-46-3 ; 2001 ; ; TARGET PENICILLIN-BINDING PROTEIN (PBP) ; ATC (ERTAPENEM) J01DH03 ; ; D-alanyl-D-alanine carboxypeptidase DacB UNIPROT P24228 dacB -- Penicillin-binding protein 1A UNIPROT P02918 mrcA 886 ; VALDECOXIB ; 181695-72-7 ; 2001 ; DISCONTINUED ; TARGET PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (VALDECOXIB) M01AH03 ; PDB 2AW1 (CARBONIC ANHYDRASE INHIBITORS: VALDECOXIB BINDS TO A DIFFERENT ACTIVE SITE REGION OF THE HUMAN ISOFORM II AS COMPARED TO THE STRUCTURALLY RELATED CYCLOOXYGENASE II "SELECTIVE" INHIBITOR CELECOXIB) - ligand code COX ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 887 ; FULVESTRANT ; 129453-61-8 ; 2002 ; ; TARGET ESTROGEN RECEPTOR ; ATC (FULVESTRANT) L02BA03 ; PDB 4J03 (CRYSTAL STRUCTURE OF HUMAN SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH FULVESTRANT) - ligand code FVS ; Estrogen receptor UNIPROT P03372 ESR1 -- Estrogen receptor beta UNIPROT Q92731 ESR2 888 ; FONDAPARINUX ; 104993-28-4 ; 2001 ; ; TARGET ANTITHROMBIN-III ; ATC (FONDAPARINUX) B01AX05 ; PDB 4X7R (CRYSTAL STRUCTURE OF S. AUREUS TARM G117R MUTANT IN COMPLEX WITH FONDAPARINUX, ALPHA-GLCNAC-GLYCEROL AND UDP) - ligand code NTO ; Antithrombin-III UNIPROT P01008 SERPINC1 889 ; MIGLUSTAT ; 72599-27-0 ; 2003 ; ; TARGET GLUCOSYLCERAMIDE SYNTHASE ; ATC (MIGLUSTAT) A16AX06 ; PDB 2V3D (ACID-BETA-GLUCOSIDASE WITH N-BUTYL-DEOXYNOJIRIMYCIN) - ligand code NBV ; Ceramide glucosyltransferase UNIPROT Q16739 UGCG 890 ; GATIFLOXACIN ; 112811-59-3 ; 1999 ; ; TARGET DNA GYRASE -- TOPOISOMERASE 4 ; ATC (GATIFLOXACIN) J01MA16 S01AE06 ; ; DNA topoisomerase 4 UNIPROT P72525 parC -- DNA gyrase UNIPROT P0A4L9 gyrB 891 ; RIFAXIMIN ; 80621-81-4 ; 2004 ; ; TARGET DNA-DEPENDANT RNA POLYMERASE BETA CHAIN ; ATC (RIFAXIMIN) A07AA11 D06AX11 ; PDB 6BEE (CRYSTAL STRUCTURE OF VACV D13 IN COMPLEX WITH RIFAXIMIN) - ligand code RXM ; Bacterial DNA-directed RNA polymerase UNIPROT P0A7Z4 rpoA 892 ; ROSUVASTATIN ; 287714-41-4 ; 2003 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE ; ATC (ROSUVASTATIN) A10BH52 C10AA07 C10BX05 C10BX09 C10BA06 C10BA09 C10BX16 C10BA07 C10BX21 C10BX17 C10BX20 C10BX10 C10BX07 C10BX14 C10BX13 ; ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 893 ; TADALAFIL ; 171596-29-5 ; 2003 ; ; TARGET CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 5 ; ATC (TADALAFIL) C02KX52 G04CB51 C02KX54 G04BE08 G04CA54 ; PDB 1XOZ (CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH TADALAFIL) - ligand code CIA ; cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A 894 ; PALONOSETRON ; 135729-61-2 ; 2003 ; ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR ; ATC (PALONOSETRON) A04AA05 A04AA55 ; PDB 6Y1Z (MOUSE SEROTONIN 5HT3 RECEPTOR IN COMPLEX WITH PALONOSETRON) - ligand code O7B ; 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 895 ; GEFITINIB ; 184475-35-2 ; 2003 ; ; TARGET EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) ; ATC (GEFITINIB) L01EB01 ; PDB 5Y7Z (COMPLEX STRUCTURE OF CYCLIN G-ASSOCIATED KINASE WITH GEFITINIB) - ligand code IRE ; Epidermal growth factor receptor UNIPROT P00533 EGFR 896 ; VARDENAFIL ; 224785-90-4 ; 2003 ; ; TARGET PHOSPHODIESTERASE 5 ; ATC (VARDENAFIL) G04BE09 ; ; cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A 897 ; ATOMOXETINE ; 83015-26-3 ; 2002 ; ; TARGET NORADRENALINE TRANSPORTER ; ATC (ATOMOXETINE) N06BA09 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 898 ; DULOXETINE ; 116539-59-4 ; 2004 ; ; TARGET SEROTONIN TRANSPORTER -- NOREPINEPHRINE TRANSPORTER ; ATC (DULOXETINE) N06AX21 ; PDB 4MMD (CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH (S)-DULOXETINE) - ligand code 29E ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 899 ; ACAMPROSATE ; 77337-76-9 ; 2004 ; ; ; ATC (ACAMPROSATE) N07BB03 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 -- Glutamate NMDA receptor UNIPROT O15399 GRIN2D 900 ; ARIPIPRAZOLE ; 129722-12-9 ; 2002 ; ; TARGET 5-HYDROXYTRYPTAMINE 1A RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- D2 DOPAMINE RECEPTOR -- ADRENERGIC ALPHA1 RECEPTOR ; ATC (ARIPIPRAZOLE) N05AX12 ; PDB 6A7P (HUMAN SERUM ALBUMIN COMPLEXED WITH ARIPIPRAZOLE) - ligand code 9SC ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 901 ; EPLERENONE ; 107724-20-9 ; 2002 ; ; TARGET MINERALOCORTICOID RECEPTOR ; ATC (EPLERENONE) C03DA04 ; PDB 5MWY (THE STRUCTURE OF MR IN COMPLEX WITH EPLERENONE.) - ligand code YNU ; Mineralocorticoid receptor UNIPROT P08235 NR3C2 902 ; EZETIMIBE ; 163222-33-1 ; 2002 ; ; TARGET NIEMANN-PICK C1-LIKE PROTEIN 1 (NPC1L1) ; ATC (EZETIMIBE) C10BA05 C10BA10 C10AX09 C10BA11 C10BA12 C10BA06 C10BA02 ; PDB 8AXW (THE STRUCTURE OF MOUSE ASTERC (GRAMD1C) WITH EZETIMIBE) - ligand code H56 ; Niemann-Pick C1-like protein 1 UNIPROT Q9UHC9 NPC1L1 903 ; PREGABALIN ; 148553-50-8 ; 2004 ; ; TARGET ALPHA2-DELTA SITE OF VOLTAGE-GATED CALCIUM CHANNEL ; ATC (PREGABALIN) N02BF02 ; PDB 3JBR (CRYO-EM STRUCTURE OF THE RABBIT VOLTAGE-GATED CALCIUM CHANNEL CAV1.1 COMPLEX AT 4.2 ANGSTROM) ; Voltage-dependent calcium channel subunit alpha-2,delta-1 UNIPROT P54289 CACNA2D1 -- Voltage-dependent calcium channel subunit alpha-2,delta-2 UNIPROT Q9NY47 CACNA2D2 904 ; ADEFOVIR DIPIVOXIL ; 142340-99-6 ; 2002 ; ; TARGET HBV REVERSE TRANSCRIPTASE ; ATC (ADEFOVIR) J05AF08 ; ; Protein P UNIPROT Q9IF40 P 905 ; IBANDRONATE ; 114084-78-5 ; 2003 ; ; TARGET FARNESYL PYROPHOSPHATE SYNTHASE ; ATC (IBANDRONIC ACID) M05BA06 M05BB09 ; PDB 4UMJ (NATIVE STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHASE FROM PSEUDOMONAS AERUGINOSA PA01, WITH BOUND IBANDRONIC ACID MOLECULES.) - ligand code BFQ ; Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS 906 ; ESZOPICLONE ; 138729-47-2 ; 2004 ; ; TARGET GABA RECEPTOR ; ATC (ESZOPICLONE) N05CF04 ; ; Gamma-aminobutyric acid receptor subunit alpha-2 UNIPROT P47869 GABRA2 -- Gamma-aminobutyric acid receptor subunit alpha-4 UNIPROT P48169 GABRA4 907 ; MEMANTINE ; 19982-08-2 ; 2003 ; ; TARGET GLUTAMATE [NMDA] RECEPTOR SUBUNIT -- 5HT3 RECEPTOR -- NICOTINIC ACETYLCHOLINE RECEPTOR ; ATC (MEMANTINE) N06DA52 N06DA53 N06DX01 ; PDB 4TWD (X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH MEMANTINE) - ligand code 377 ; Glutamate receptor ionotropic, NMDA 3A UNIPROT Q8TCU5 GRIN3A -- Glutamate receptor ionotropic, NMDA 1 UNIPROT Q05586 GRIN1 908 ; RANOLAZINE ; 95635-55-5 ; 2006 ; ; TARGET VOLTAGE-GATED NA(+) CHANNELS (NAV) (PMID26655634) -- ALPHA1-ADRENERGIC RECEPTOR (PMID26655634) ; ATC (RANOLAZINE) C01EB18 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 909 ; GATIFLOXACIN ; 112811-59-3 ; 1999 ; ; TARGET DNA GYRASE -- TOPOISOMERASE 4 ; ATC (GATIFLOXACIN) J01MA16 S01AE06 ; PDB 5BTF (CRYSTAL STRUCTURE OF A TOPOISOMERASE II COMPLEX) - ligand code GFN ; DNA topoisomerase 4 UNIPROT P72525 parC -- DNA gyrase UNIPROT P0A4L9 gyrB 910 ; NITAZOXANIDE ; 55981-09-4 ; 2002 ; ; TARGET PYRUVATE:FERREDOXIN OXIDOREDUCTASE ; ATC (NITAZOXANIDE) P01AX11 ; PDB 3V35 (ALDOSE REDUCTASE COMPLEXED WITH A NITRO COMPOUND) - ligand code NTI ; Pyruvate dehydrogenase NADP(+) UNIPROT Q968X7 PFOR -- Pyruvate:ferredoxin oxidoreductase UNIPROT Q24982 911 ; EMTRICITABINE ; 143491-57-0 ; 2003 ; ; TARGET HIV-1 REVERSE TRANSCRIPTASE ; ATC (EMTRICITABINE) J05AF09 J05AR17 J05AR20 J05AR19 J05AR22 J05AR18 J05AR06 J05AR08 J05AR09 J05AR03 ; PDB 2NO6 (C4S DCK VARIANT OF DCK IN COMPLEX WITH FTC+ADP) - ligand code ETV ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 912 ; MICAFUNGIN ; 235114-32-6 ; 2005 ; ; TARGET BETA-1,3-GLUCAN SYNTHASE ; ATC (MICAFUNGIN) J02AX05 ; ; Beta-1,3-glucan synthase catalytic subunit 1 UNIPROT O13428 GSC1 913 ; RANOLAZINE ; 95635-55-5 ; 2006 ; ; TARGET VOLTAGE-GATED NA(+) CHANNELS (NAV) (PMID26655634) -- ALPHA1-ADRENERGIC RECEPTOR (PMID26655634) ; ATC (RANOLAZINE) C01EB18 ; PDB 8F6P (RAT CARDIAC SODIUM CHANNEL WITH RANOLAZINE BOUND) - ligand code XHO ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 914 ; FOSAMPRENAVIR ; 226700-79-4 ; 2003 ; ; TARGET HIV-1 PROTEASE ; ATC (FOSAMPRENAVIR) J05AE07 ; ; Pol polyprotein UNIPROT Q72874 pol 915 ; APREPITANT ; 170729-80-3 ; 2003 ; ; TARGET P/NEUROKININ-1 (NK1) RECEPTOR ; ATC (APREPITANT) A04AD12 ; PDB 6HLO (CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST APREPITANT) - ligand code GBQ ; Substance-P receptor UNIPROT P25103 TACR1 916 ; BISACODYL ; 603-50-9 ; 2004 ; ; ; ATC (BISACODYL) A06AB02 A06AG02 A06AB52 ; ; UNKNOWN 917 ; EPINASTINE ; 80012-43-7 ; 2003 ; ; TARGET HISTAMINE H1 RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- ALPHA-1A ADRENERGIC RECEPTOR -- ALPHA-2 ADRENERGIC RECEPTOR ; ATC (EPINASTINE) R06AX24 S01GX10 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 918 ; DAPTOMYCIN ; 103060-53-3 ; 2003 ; ; TARGET MEMBRANE ; ATC (DAPTOMYCIN) J01XX09 ; ; UNKNOWN 919 ; TROSPIUM ; 47608-32-2 ; 2004 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (TROSPIUM) G04BD09 A03DA06 ; ; Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 920 ; BORTEZOMIB ; 179324-69-7 ; 2003 ; ; TARGET 26S PROTEASOME ; ATC (BORTEZOMIB) L01XG01 ; PDB 4QW1 (YCP BETA5-A50V MUTANT IN COMPLEX WITH BORTEZOMIB) - ligand code BO2 ; Proteasome subunit alpha type-1 UNIPROT P25786 PSMA1 -- Proteasome subunit beta type-8 UNIPROT P28062 PSMB8 921 ; TINIDAZOLE ; 19387-91-8 ; 2004 ; ; ; ATC (TINIDAZOLE) J01RA11 A02BD09 J01RA13 G01AF21 J01XD02 P01AB02 ; ; UNKNOWN 922 ; ANIDULAFUNGIN ; 166663-25-8 ; 2006 ; ; TARGET BETA-1,3-GLUCAN SYNTHASE ; ATC (ANIDULAFUNGIN) J02AX06 ; ; Beta-1,3-glucan synthase catalytic subunit 1 UNIPROT O13428 GSC1 923 ; CICLESONIDE ; 126544-47-6 ; 2006 ; ; TARGET CORTICOSTEROID-BINDING GLOBULIN ; ATC (CICLESONIDE) R01AD13 R03BA08 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 924 ; BROMFENAC ; 91714-94-2 ; 2005 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (BROMFENAC) S01BC11 ; PDB 4MJQ (E. COLI SLIDING CLAMP IN COMPLEX WITH BROMFENAC) - ligand code 27R ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 925 ; CLOFARABINE ; 123318-82-1 ; 2004 ; ; TARGET DEOXYCYTIDINE KINASE ; ATC (CLOFARABINE) L01BB06 ; PDB 2A7Q (CRYSTAL STRUCTURE OF HUMAN DCK COMPLEXED WITH CLOFARABINE AND ADP) - ligand code CFB ; DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 -- Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 926 ; CINACALCET ; 226256-56-0 ; 2004 ; ; TARGET EXTRACELLULAR CALCIUM-SENSING RECEPTOR ; ATC (CINACALCET) H05BX01 ; PDB 7M3F (ASYMMETRIC ACTIVATION OF THE CALCIUM SENSING RECEPTOR HOMODIMER) - ligand code YP4 ; Extracellular calcium-sensing receptor UNIPROT P41180 CASR 927 ; CONIVAPTAN ; 210101-16-9 ; 2005 ; ; TARGET VASOPRESSIN V1A RECEPTOR -- VASOPRESSIN V2 RECEPTOR ; ATC (CONIVAPTAN) C03XA02 ; ; Vasopressin V1a receptor UNIPROT P37288 AVPR1A -- Vasopressin V2 receptor UNIPROT P30518 AVPR2 928 ; LACTIC ACID ; 50-21-5 ; 2006 ; ; TARGET AMINO-ACID OXIDASE -- BIFUNCTIONAL PROTEIN PUTA -- PROLINE DEHYDROGENASE ; ATC (LACTIC ACID) G01AD01 A07FA01 A07FA51 ; PDB 3KB6 (CRYSTAL STRUCTURE OF D-LACTATE DEHYDROGENASE FROM AQUIFEX AEOLICUS COMPLEXED WITH NAD AND LACTIC ACID) - ligand code LAC ; UNKNOWN 929 ; NEBIVOLOL ; 118457-14-0 ; 2007 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (NEBIVOLOL) C07AB12 C07FB12 C07BB12 C09DX05 C09BX07 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 930 ; ERLOTINIB ; 183321-74-6 ; 2004 ; ; TARGET EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) ; ATC (ERLOTINIB) L01EB02 ; PDB 4HJO (CRYSTAL STRUCTURE OF THE INACTIVE EGFR TYROSINE KINASE DOMAIN WITH ERLOTINIB) - ligand code AQ4 ; Epidermal growth factor receptor UNIPROT P00533 EGFR 931 ; ALVIMOPAN ; 156053-89-3 ; 2008 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (ALVIMOPAN) A06AH02 ; PDB 7UL4 (CRYOEM STRUCTURE OF INACTIVE MOR BOUND TO ALVIMOPAN AND MB6) - ligand code NG0 ; Mu-type opioid receptor UNIPROT P35372 OPRM1 932 ; ILOPROST ; 78919-13-8 ; 2004 ; ; TARGET PROSTACYCLIN RECEPTOR PGI2 ; ATC (ILOPROST) B01AC11 ; ; Prostacyclin receptor UNIPROT P43119 PTGIR 933 ; RAMELTEON ; 196597-26-9 ; 2005 ; ; TARGET MELATONIN RECEPTOR MT1 -- MELATONIN RECEPTOR MT2 ; ATC (RAMELTEON) N05CH02 ; PDB 6ME2 (XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT1 IN COMPLEX WITH RAMELTEON) - ligand code JEV ; Melatonin receptor type 1A UNIPROT P48039 MTNR1A -- Melatonin receptor type 1B UNIPROT P49286 MTNR1B 934 ; DECITABINE ; 2353-33-5 ; 2006 ; ; TARGET DEOXYCYTIDINE KINASE ; ATC (DECITABINE) L01BC08 L01BC58 ; ; DNA (cytosine-5)-methyltransferase 1 UNIPROT P26358 DNMT1 -- DNA (cytosine-5)-methyltransferase 3A UNIPROT Q9Y6K1 DNMT3A 935 ; DAPSONE ; 80-08-0 ; 1979 ; ; TARGET DIHYDROFOLATE REDUCTASE -- DIHYDROPTEROATE SYNTHASE ; ATC (DAPSONE) D10AX05 J04BA02 J04BA50 J04BA51 ; ; Dihydropteroate synthase 1 UNIPROT P0C0X1 folP1 936 ; ENTECAVIR ; 142217-69-4 ; 2005 ; ; TARGET HBV REVERSE TRANSCRIPTASE ; ATC (ENTECAVIR) J05AF10 ; ; Protein P UNIPROT Q9IF40 P 937 ; QUININE ; 130-95-0 ; 2005 ; ; TARGET HEMOZOIN ; ATC (QUININE) P01BC01 M09AA72 ; PDB 4WNV (HUMAN CYTOCHROME P450 2D6 QUININE COMPLEX) - ligand code QI9 ; UNKNOWN 938 ; TIPRANAVIR ; 174484-41-4 ; 2005 ; ; TARGET HIV-1 PROTEASE ; ATC (TIPRANAVIR) J05AE09 ; PDB 3SPK (TIPRANAVIR IN COMPLEX WITH A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE VARIANT) - ligand code TPV ; Pol polyprotein UNIPROT Q72874 pol 939 ; TIGECYCLINE ; 220620-09-7 ; 2005 ; ; TARGET 30S RIBOSOMAL PROTEIN ; ATC (TIGECYCLINE) J01AA12 ; ; UNKNOWN 940 ; NELARABINE ; 121032-29-9 ; 2005 ; ; TARGET ADENOSINE DEAMINASE ; ATC (NELARABINE) L01BB07 ; ; UNKNOWN 941 ; LENALIDOMIDE ; 191732-72-6 ; 2005 ; ; ; ATC (LENALIDOMIDE) L04AX04 ; ; Protein cereblon UNIPROT Q96SW2 CRBN 942 ; DEFERASIROX ; 201530-41-8 ; 2005 ; ; ; ATC (DEFERASIROX) V03AC03 ; ; UNKNOWN 943 ; TETRABENAZINE ; 58-46-8 ; 2008 ; ; TARGET VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) ; ATC (TETRABENAZINE) N07XX06 ; PDB 8THR (STRUCTURE OF THE HUMAN VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) BOUND TO TETRABENAZINE IN AN OCCLUDED CONFORMATION) - ligand code EBZ ; Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 944 ; LUBIPROSTONE ; 333963-40-9 ; 2006 ; ; TARGET CHLORIDE CHANNEL PROTEIN 2 (CLC-2) ; ATC (LUBIPROSTONE) A06AX03 ; ; Chloride channel protein 2 UNIPROT P51788 CLCN2 945 ; ARFORMOTEROL ; 67346-49-0 ; 2006 ; ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (ARFORMOTEROL) R03AC13 ; PDB 6IBL (ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY NB80) - ligand code H98 ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 946 ; VARENICLINE ; 249296-44-4 ; 2006 ; ; TARGET NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 BETA-2 -- 5-HT3 RECEPTOR (KI=350 NANOMOLAR) ; ATC (VARENICLINE) N07BA03 S01XA28 ; PDB 5AIN (VARENICLINE INTERACTIONS AT THE 5HT3 RECEPTOR LIGAND BINDING SITE ARE REVEALED BY 5HTBP) - ligand code QMR ; Neuronal acetylcholine receptor 947 ; DASATINIB ; 302962-49-8 ; 2006 ; ; TARGET BCR-ABL ABL1 -- SRC FAMILY (SRC, LCK, YES, FYN) -- C-KIT -- EPHA2 -- PDGFR BETA ; ATC (DASATINIB) L01EA02 ; PDB 2Y6O (CRYSTAL STRUCTURE OF EPHA4 KINASE DOMAIN IN COMPLEX WITH DASATINIB.) - ligand code 1N1 ; Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 948 ; VORINOSTAT ; 149647-78-9 ; 2006 ; ; TARGET HISTONE DEACETYLASE ; ATC (VORINOSTAT) L01XH01 ; PDB 4QA2 (CRYSTAL STRUCTURE OF I243N HDAC8 IN COMPLEX WITH SAHA) - ligand code SHH ; Histone deacetylase 2 UNIPROT Q92769 HDAC2 -- Histone deacetylase 1 UNIPROT Q13547 HDAC1 949 ; PALIPERIDONE ; 144598-75-4 ; 2006 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- D(2) DOPAMINE RECEPTOR -- ALPHA1 ADRENERGIC RECEPTOR -- ALPHA2 ADRENERGIC RECEPTOR -- H1 HISTAMINERGIC RECEPTOR ; ATC (PALIPERIDONE) N05AX13 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 950 ; POSACONAZOLE ; 171228-49-2 ; 2006 ; ; TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450 P-45014DM) ; ATC (POSACONAZOLE) J02AC04 ; PDB 2X2N (X-RAY STRUCTURE OF CYP51 FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH POSACONAZOLE IN TWO DIFFERENT CONFORMATIONS) - ligand code X2N ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 951 ; TELBIVUDINE ; 3424-98-4 ; 2006 ; DISCONTINUED ; TARGET HBV DNA POLYMERASE ; ATC (TELBIVUDINE) J05AF11 ; PDB 3QEO (S74E-R104M-D133A DCK VARIANT IN COMPLEX WITH L-DEOXYTHYMIDINE AND UDP) - ligand code LLT ; Protein P UNIPROT Q9IF40 P 952 ; MENTHOL ; 89-78-1 ; 2008 ; ; TARGET TRANSIENT RECEPTOR POTENTIAL MELASTATIN (TRPM8) ION CHANNEL (PMID25680765) ; ATC (MENTHOL) M02AX10 ; ; Transient receptor potential cation channel subfamily M member 8 UNIPROT Q7Z2W7 TRPM8 953 ; CARBENICILLIN ; 4697-36-3 ; 0 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS ; ATC (CARBENICILLIN) J01CA03 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 954 ; RETAPAMULIN ; 224452-66-8 ; 2007 ; DISCONTINUED ; TARGET 50S RIBOSOMAL PROTEIN L3 ; ATC (RETAPAMULIN) D06AX13 ; ; UNKNOWN 955 ; IXABEPILONE ; 219989-84-1 ; 2007 ; ; TARGET BETA TUBULIN ; ATC (IXABEPILONE) L01DC04 ; PDB 7DAF (IXA IN COMPLEX WITH TUBULIN) - ligand code GZX ; Tubulin beta UNIPROT P07437 TUBB 956 ; TEMSIROLIMUS ; 162635-04-3 ; 2007 ; ; TARGET FK506 BINDING PROTEIN-12 (FKBP-12)/MTOR COMPLEX ; ATC (TEMSIROLIMUS) L01EG01 ; PDB 7SQ9 (CRYO-EM STRUCTURE OF MOUSE TEMSIROLIMUS, PI(3,5)P2-BOUND TRPML1 CHANNEL AT 2.11 ANGSTROM RESOLUTION) - ligand code A4I ; Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A 957 ; DORIPENEM ; 148016-81-3 ; 2007 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (DORIPENEM) J01DH04 ; PDB 6P9C (OXA-48 CARBAPANEMASE, DORIPENEM COMPLEX) - ligand code O6P ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 958 ; MARAVIROC ; 376348-65-1 ; 2007 ; ; TARGET C-C CHEMOKINE RECEPTOR TYPE 5 ; ATC (MARAVIROC) J05AX09 ; PDB 4MBS (CRYSTAL STRUCTURE OF THE CCR5 CHEMOKINE RECEPTOR) - ligand code MRV ; C-C chemokine receptor type 5 UNIPROT P51681 CCR5 959 ; REGADENOSON ; 313348-27-5 ; 2008 ; ; TARGET A2A ADENOSINE RECEPTOR ; ATC (REGADENOSON) C01EB21 ; ; Adenosine receptor A2a UNIPROT P29274 ADORA2A 960 ; CYCLOPENTOLATE ; 204990-62-5 ; 1974 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (CYCLOPENTOLATE) S01FA04 S01FA54 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 961 ; ESTROPIPATE ; 481-97-0 ; 1977 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ESTRONE) G03CA07 G03CC04 ; ; Estrogen receptor UNIPROT P03372 ESR1 962 ; DIMENHYDRINATE ; 85-18-7 ; 1972 ; ; TARGET ADENOSINE A1 RECEPTOR ; ATC (DIPHENHYDRAMINE, COMBINATIONS) R06AA52 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 963 ; DOXYCYCLINE ; 564-25-0 ; 1967 ; ; TARGET 30S RIBOSOMAL PROTEIN -- 50S RIBOSOMAL PROTEIN ; ATC (DOXYCYCLINE) A01AB22 J01AA02 ; PDB 2XRL (TET-REPRESSOR CLASS D T103A WITH DOXYCYCLINE) - ligand code DXT ; UNKNOWN 964 ; ERYTHROMYCIN ; 114-07-8 ; 1964 ; ; TARGET 50S RIBOSOMAL PROTEIN ; ATC (ERYTHROMYCIN) D10AF02 J01FA01 S01AA17 D10AF52 ; PDB 4M83 (ENSEMBLE REFINEMENT OF PROTEIN CRYSTAL STRUCTURE (2IYF) OF MACROLIDE GLYCOSYLTRANSFERASES OLED COMPLEXED WITH UDP AND ERYTHROMYCIN A) - ligand code ERY ; UNKNOWN 965 ; ERYTHROMYCIN ESTOLATE ; 3521-62-8 ; 1967 ; DISCONTINUED ; TARGET 50S RIBOSOMAL PROTEIN ; ATC (ERYTHROMYCIN) D10AF02 J01FA01 S01AA17 D10AF52 ; ; BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIA 966 ; ERYTHROMYCIN ETHYLSUCCINATE ; 8000-15-5 ; 1965 ; ; TARGET 50S RIBOSOMAL PROTEIN ; ATC (ERYTHROMYCIN) D10AF02 J01FA01 S01AA17 D10AF52 ; ; BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIA 967 ; DICLOXACILLIN ; 3116-76-5 ; 1968 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (DICLOXACILLIN) J01CF01 ; ; Penicillin-binding protein UNIPROT P72355 pbp4 968 ; NEOMYCIN ; 1404-04-2 ; 1954 ; ; TARGET 30S RIBOSOMAL RNA ; ATC (NEOMYCIN) A01AB08 A07AA01 B05CA09 D06AX04 J01GB05 R02AB01 S01AA03 S02AA07 S03AA01 A07AA51 ; PDB 4V9C (ALLOSTERIC CONTROL OF THE RIBOSOME BY SMALL-MOLECULE ANTIBIOTICS) - ligand code NMY ; UNKNOWN 969 ; GENTAMICIN ; 1403-66-3 ; 1966 ; ; TARGET 30S RIBOSOMAL PROTEIN ; ATC (GENTAMICIN) D06AX07 J01GB03 S01AA11 S02AA14 S03AA06 ; ; UNKNOWN 970 ; GRISEOFULVIN ; 126-07-8 ; 1962 ; ; ; ATC (GRISEOFULVIN) D01AA08 D01BA01 ; ; Tubulin UNIPROT F2SG63 971 ; HETACILLIN ; 3511-16-8 ; 1971 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (HETACILLIN) J01CA18 ; ; Penicillin-binding protein UNIPROT Q54618 pbp2b 972 ; BACAMPICILLIN ; 50972-17-3 ; 1980 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (BACAMPICILLIN) J01CA06 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 973 ; AMPICILLIN ; 69-53-4 ; 1965 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (AMPICILLIN) J01CA01 S01AA19 J01CR01 J01CA51 ; PDB 3NDV (CRYSTAL STRUCTURE OF THE N-TERMINAL BETA-AMINOPEPTIDASE BAPA IN COMPLEX WITH AMPICILLIN) - ligand code AIC ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 974 ; CHLORAMPHENICOL ; 56-75-7 ; 1950 ; DISCONTINUED ; TARGET 50S RIBOSOMAL PROTEIN ; ATC (CHLORAMPHENICOL) D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08 ; PDB 4V7W (STRUCTURE OF THE THERMUS THERMOPHILUS RIBOSOME COMPLEXED WITH CHLORAMPHENICOL) - ligand code CLM ; UNKNOWN 975 ; CHLORAMPHENICOL PALMITATE ; 530-43-8 ; 0 ; DISCONTINUED ; TARGET 50S RIBOSOMAL PROTEIN ; ATC (CHLORAMPHENICOL) D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08 ; ; BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL CHEMBL2363135 BACTERIAL 70S RIBOSOME 23S RIBOSOMAL RNA BACTERIA 976 ; CAPREOMYCIN ; 11003-38-6 ; 1971 ; DISCONTINUED ; TARGET 50S RIBOSOMAL PROTEIN L10 ; ATC (CAPREOMYCIN) J04AB30 ; ; UNKNOWN 977 ; COLISTIMETHATE ; 8068-28-8 ; 1970 ; ; TARGET MEMBRANE ; ATC (COLISTIN) A07AA10 J01XB01 ; ; CELL MEMBRANE INHIBITOR CHEMBL CHEMBL2364031 CELL MEMBRANE BACTERIA 978 ; NAFCILLIN ; 147-52-4 ; 1965 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (NAFCILLIN) J01CF06 ; ; Penicillin-binding protein UNIPROT P72355 pbp4 979 ; METHICILLIN ; 61-32-5 ; 1971 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (METICILLIN) J01CF03 ; PDB 3KP4 (STAPHYLOCOCCUS EPIDERMIDIS TCAR IN COMPLEX WITH METHICILLIN) - ligand code MII ; Penicillin-binding protein UNIPROT P72355 pbp4 980 ; OXACILLIN ; 66-79-5 ; 1971 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (OXACILLIN) J01CF04 ; ; Penicillin-binding protein UNIPROT P72355 pbp4 981 ; PENICILLIN G ; 61-33-6 ; 1947 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (BENZYLPENICILLIN) J01CE01 S01AA14 ; PDB 1UOB (DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH 2-OXOGLUTARATE AND PENICILLIN G) - ligand code PNN ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 982 ; PENICILLIN V ; 87-08-1 ; 1958 ; ; TARGET BETA-LACTAMASE -- PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (PHENOXYMETHYLPENICILLIN) J01CE02 ; PDB 2Z71 (STRUCTURE OF TRUNCATED MUTANT CYS1GLY OF PENICILLIN V ACYLASE FROM BACILLUS SPHAERICUS CO-CRYSTALLIZED WITH PENICILLIN V) - ligand code PNV ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 983 ; STREPTOZOCIN ; 18883-66-4 ; 1982 ; ; TARGET DNA -- GLUCOSE TRANSPORT PROTEIN GLUT2 ; ATC (STREPTOZOCIN) L01AD04 ; ; UNKNOWN 984 ; CLINDAMYCIN ; 18323-44-9 ; 1970 ; ; TARGET 50S RIBOSOMAL SUBUNIT ; ATC (CLINDAMYCIN) D10AF01 G01AA10 J01FF01 D10AF51 ; PDB 3JZ0 (LINB COMPLEXED WITH CLINDAMYCIN AND AMPCPP) - ligand code CLY ; Large ribosomal subunit protein uL10 UNIPROT P15825 rpl10 985 ; CEFPODOXIME PROXETIL ; 87239-81-4 ; 1992 ; ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CEFPODOXIME) J01DD13 J01DD64 ; ; UNKNOWN 986 ; CLOXACILLIN ; 61-72-3 ; 1971 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B -- BETA-LACTAMASE ; ATC (CLOXACILLIN) J01CF02 ; PDB 9BIT (CRYO-EM STRUCTURE OF THE MAMMALIAN PEPTIDE TRANSPORTER PEPT2 BOUND TO CLOXACILLIN, POSE 1) - ligand code CXN ; Penicillin-binding protein UNIPROT P72355 pbp4 987 ; TETRACYCLINE ; 60-54-8 ; 1953 ; ; TARGET 30S RIBOSOMAL PROTEIN ; ATC (TETRACYCLINE) A02BD08 A02BD02 A01AB13 D06AA04 J01AA07 S01AA09 S02AA08 S03AA02 J01RA08 ; PDB 2HDN (TRYPSIN-MODIFIED ELONGATION FACTOR TU IN COMPLEX WITH TETRACYCLINE AT 2.8 ANGSTROM RESOLUTION) - ligand code TAC ; UNKNOWN 988 ; PENTOBARBITAL ; 76-74-4 ; 1973 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (PENTOBARBITAL) N05CA01 ; PDB 3RAV (HORSE SPLEEN APO-FERRITIN WITH BOUND PENTOBARBITAL) - ligand code RAV ; Gamma-aminobutyric acid receptor subunit beta-3 UNIPROT P28472 GABRB3 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 989 ; CEPHALOGLYCIN ; 3577-01-3 ; 1970 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 990 ; NYSTATIN ; 1400-61-9 ; 1964 ; ; TARGET MEMBRANE AND STEROLS ; ATC (NYSTATIN) A07AA02 D01AA01 G01AA01 G01AA51 ; ; UNKNOWN 991 ; CLIOQUINOL ; 130-26-7 ; 0 ; DISCONTINUED ; ; ATC (CLIOQUINOL) D08AH30 D09AA10 G01AC02 P01AA02 S02AA05 P01AA52 ; PDB 3KCX (FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CLIOQUINOL) - ligand code CQL ; UNKNOWN 992 ; DEMECLOCYCLINE ; 127-33-3 ; 1960 ; ; TARGET 30S RIBOSOMAL PROTEIN ; ATC (DEMECLOCYCLINE) D06AA01 J01AA01 ; ; UNKNOWN 993 ; OXYTETRACYCLINE ; 79-57-2 ; 1964 ; DISCONTINUED ; TARGET 30S RIBOSOMAL PROTEIN ; ATC (OXYTETRACYCLINE) A01AB25 D06AA03 G01AA07 J01AA06 S01AA04 J01AA56 ; PDB 2XPW (TETR(D) IN COMPLEX WITH OXYTETRACYCLINE AND MAGNESIUM.) - ligand code OTC ; UNKNOWN 994 ; CARBENICILLIN ; 4697-36-3 ; 0 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS ; ATC (CARBENICILLIN) J01CA03 ; PDB 3ZGA (PENICILLIN-BINDING PROTEIN 4 FROM LISTERIA MONOCYTOGENES) ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 995 ; TETRAHYDROZOLINE ; 84-22-0 ; 1979 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (TETRYZOLINE) R01AA06 R01AB03 S01GA02 S01GA52 ; ; Adrenergic receptor alpha UNIPROT P08913 ADRA2A 996 ; AMPHOTERICIN B ; 1397-89-3 ; 1964 ; ; TARGET MEMBRANE ; ATC (AMPHOTERICIN B) J02AA01 A01AB04 A07AA07 G01AA03 ; PDB 7SHI (CRYSTAL STRUCTURE OF CYTOCHROME P450 AMPHL FROM STREPTOMYCES NODOSUS AND THE STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN MACROLIDE METABOLIZING P450S) - ligand code 4UH ; UNKNOWN 997 ; MINOCYCLINE ; 10118-90-8 ; 1971 ; ; TARGET 30S RIBOSOMAL PROTEIN ; ATC (MINOCYCLINE) A01AB23 D10AF07 J01AA08 ; PDB 4A99 (STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE) - ligand code MIY ; UNKNOWN 998 ; LINCOMYCIN ; 154-21-2 ; 1964 ; ; TARGET 50S RIBOSOMAL PROTEIN ; ATC (LINCOMYCIN) J01FF02 ; PDB 5HKV (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LINCOMYCIN) - ligand code 3QB ; UNKNOWN 999 ; TROLEANDOMYCIN ; 2751-09-9 ; 1969 ; DISCONTINUED ; TARGET RIBOSOMAL SUBUNIT ; ATC (TROLEANDOMYCIN) J01FA08 ; PDB 3I56 (CO-CRYSTAL STRUCTURE OF TRIACETYLOLEANDOMCYIN BOUND TO THE LARGE RIBOSOMAL SUBUNIT) - ligand code TAO ; UNKNOWN 1000 ; NOVOBIOCIN ; 303-81-1 ; 1964 ; DISCONTINUED ; TARGET DNA GYRASE SUBUNIT B ; ; PDB 4URO (CRYSTAL STRUCTURE OF STAPH GYRASEB 24KDA IN COMPLEX WITH NOVOBIOCIN) - ligand code NOV ; DNA gyrase UNIPROT Q5HK03 gyrB 1001 ; SPECTINOMYCIN ; 1695-77-8 ; 1971 ; DISCONTINUED ; TARGET 30S RIBOSOMAL PROTEIN ; ATC (SPECTINOMYCIN) J01XX04 ; PDB OBSOLETE (- 2QOW CRYSTAL STRUCTURE OF THE BACTERIAL RIBOSOME FROM ESCHERICHIA COLI IN COMPLEX WITH SPECTINOMYCIN. THIS FILE CONTAINS THE 30S SUBUNIT OF THE SECOND 70S RIBOSOME, WITH SPECTINOMYCIN BOUND. THE ENTIRE CRYSTAL STRUCTURE CONTAINS TWO 70S RIBOSOMES.) - ligand code SCM ; UNKNOWN 1002 ; CHLORTETRACYCLINE ; 57-62-5 ; 1950 ; DISCONTINUED ; TARGET 30S RIBOSOMAL PROTEIN ; ATC (CHLORTETRACYCLINE) A01AB21 D06AA02 J01AA03 S01AA02 ; PDB 2TCT (THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE) - ligand code CTC ; UNKNOWN 1003 ; CEPHALEXIN ; 15686-71-2 ; 1971 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFALEXIN) J01DB01 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1004 ; RIFAMPIN ; 13292-46-1 ; 1971 ; ; TARGET DNA-DEPENDENT RNA POLYMERASE -- ADP-RIBOSYL TRANSFERASE ; ATC (RIFAMPICIN) J04BA50 J04BA51 J04AB02 J04AM02 J04AM07 J04AM05 J04AM06 ; PDB 2HW2 (CRYSTAL STRUCTURE OF RIFAMPIN ADP-RIBOSYL TRANSFERASE IN COMPLEX WITH RIFAMPIN) - ligand code RFP ; DNA-directed RNA polymerase subunit beta UNIPROT P0A8V2 rpoB 1005 ; CEPHAPIRIN ; 21593-23-7 ; 1974 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFAPIRIN) J01DB08 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1006 ; MITOMYCIN ; 50-07-7 ; 1981 ; ; TARGET DNA ; ATC (MITOMYCIN) L01DC03 ; ; UNKNOWN 1007 ; AMOXICILLIN ; 26787-78-0 ; 1974 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (AMOXICILLIN) J01CA04 J01CR02 A02BD06 A02BD07 A02BD10 A02BD03 A02BD05 A02BD01 A02BD16 A02BD04 A02BD12 A02BD13 A02BD17 A02BD14 A02BD15 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1008 ; CEFAZOLIN ; 25953-19-9 ; 1973 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFAZOLIN) J01DB04 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1009 ; DOXORUBICIN ; 23214-92-8 ; 1974 ; ; TARGET TOPOISOMERASE II -- DNA ; ATC (DOXORUBICIN) L01DB01 ; PDB 1DA9 (ANTHRACYCLINE-DNA INTERACTIONS AT UNFAVOURABLE BASE BASE-PAIR TRIPLET-BINDING SITES: STRUCTURES OF D(CGGCCG), DAUNOMYCIN AND D(TGGCCA), ADRIAMYCIN COMPL) - ligand code DM2 ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 1010 ; CEPHALOTHIN ; 153-61-7 ; 1974 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B -- D-ALANYL-D-ALANINE CARBOXYPEPTIDASE -- BETA-LACTAMASE ; ATC (CEFALOTIN) J01DB03 ; PDB 4KOX (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFALOTIN) - ligand code CLS ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1011 ; DAUNORUBICIN ; 20830-81-3 ; 1979 ; ; TARGET TOPOISOMERASE II -- DNA -- MULTIDRUG RESISTANCE PROTEIN 1 -- POLYMERASE ; ATC (DAUNORUBICIN) L01XY01 L01DB02 ; PDB 3TVB (A HIGHLY SYMMETRIC DNA G-4 QUADRUPLEX, DRUG COMPLEX) - ligand code DM1 ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 1012 ; VIDARABINE ; 5536-17-4 ; 1976 ; DISCONTINUED ; TARGET ADENOSINE DEAMINASE -- THYMIDINE KINASE -- DNA -- PURINE NUCLEOSIDE PHOSPHORYLASE -- DNA POLYMERASE ; ATC (VIDARABINE) J05AB03 S01AD06 ; PDB 1PW7 (CRYSTAL STRUCTURE OF E. COLI PURINE NUCLEOSIDE PHOSPHORYLASE COMPLEXED WITH 9-BETA-D-ARABINOFURANOSYLADENINE AND SULFATE, PHOSPHATE) - ligand code RAB ; DNA polymerase catalytic subunit UNIPROT P04293 1013 ; AMIKACIN ; 37517-28-5 ; 1981 ; ; TARGET 30S RIBOSOMAL PROTEIN S12 ; ATC (AMIKACIN) D06AX12 J01GB06 S01AA21 J01RA06 ; PDB 4P20 (CRYSTAL STRUCTURES OF THE BACTERIAL RIBOSOMAL DECODING SITE COMPLEXED WITH AMIKACIN) - ligand code AKN ; UNKNOWN 1014 ; TICARCILLIN ; 34787-01-4 ; 1976 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (TICARCILLIN) J01CA13 J01CR03 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1015 ; CEFAMANDOLE NAFATE ; 42540-40-9 ; 1978 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFAMANDOLE) J01DC03 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1016 ; CYCLACILLIN ; 3485-14-1 ; 1979 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1017 ; NATAMYCIN ; 7681-93-8 ; 1978 ; ; TARGET FUNGAL MEMBRANE TRANSPORT PROTEINS ; ATC (NATAMYCIN) A01AB10 A07AA03 D01AA02 G01AA02 S01AA10 ; ; UNKNOWN 1018 ; CEFOXITIN ; 35607-66-0 ; 1978 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B -- BETA-LACTAMASE -- BETA-LACTAMASE CTX-M-9A ; ATC (CEFOXITIN) J01DC01 ; PDB 4KOW (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFOXITIN) - ligand code CFX ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1019 ; MECLOCYCLINE ; 2013-58-3 ; 0 ; DISCONTINUED ; TARGET RIBOSOME ; ATC (MECLOCYCLINE) D10AF04 ; ; UNKNOWN 1020 ; BACAMPICILLIN ; 50972-17-3 ; 1980 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (BACAMPICILLIN) J01CA06 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1021 ; CEFACLOR ; 53994-73-3 ; 1979 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFACLOR) J01DC04 ; PDB 7Q4X (CRYSTAL STRUCTURE OF EQUINE SERUM ALBUMIN IN COMPLEX WITH CEFACLOR) - ligand code 8XI ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1022 ; CEPHRADINE ; 38821-53-3 ; 1974 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFRADINE) J01DB09 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1023 ; NETILMICIN ; 56391-56-1 ; 1983 ; DISCONTINUED ; TARGET 30S RIBOSOMAL PROTEIN S12 ; ATC (NETILMICIN) J01GB07 S01AA23 ; ; UNKNOWN 1024 ; PIPERACILLIN ; 61477-96-1 ; 1981 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (PIPERACILLIN) J01CA12 J01CR05 ; PDB 3Q07 (CTX-M-9 S70G IN COMPLEX WITH PIPERACILLIN) - ligand code WPP ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1025 ; CEFOTAXIME ; 63527-52-6 ; 1981 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B -- PENICILLIN-BINDING PROTEIN 3 ; ATC (CEFOTAXIME) J01DD01 J01DD51 ; PDB 4PM7 (CRYSTAL STRUCTURE OF CTX-M-14 S70G:S237A IN COMPLEX WITH CEFOTAXIME AT 1.29 ANGSTROMS RESOLUTION) - ligand code CE3 ; Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI -- Penicillin-binding protein 1A UNIPROT P02918 mrcA 1026 ; MOXALACTAM ; 64952-97-2 ; 0 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (LATAMOXEF) J01DD06 ; ; Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI -- Penicillin-binding protein 1A UNIPROT P02918 mrcA 1027 ; CEFOPERAZONE ; 62893-19-0 ; 1982 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFOPERAZONE) J01DD12 J01DD62 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1028 ; CEFORANIDE ; 60925-61-3 ; 1984 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFORANIDE) J01DC11 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1029 ; CEFUROXIME ; 55268-75-2 ; 1983 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFUROXIME) J01DC02 S01AA27 J01DC52 J01RA03 ; PDB 4KOV (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFUROXIME) - ligand code KOV ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1030 ; CEFUROXIME AXETIL ; 64544-07-6 ; 1987 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFUROXIME) J01DC02 S01AA27 J01DC52 J01RA03 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1031 ; CEFUROXIME AXETIL ; 64544-07-6 ; 1987 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFUROXIME) J01DC02 S01AA27 J01DC52 J01RA03 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1032 ; CEFTIZOXIME ; 68401-81-0 ; 1983 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFTIZOXIME) J01DD07 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1033 ; AZLOCILLIN ; 37091-66-0 ; 0 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (AZLOCILLIN) J01CA09 ; ; Penicillin-binding protein UNIPROT Q07806 mrcA 1034 ; CLAVULANATE ; 58001-44-8 ; 1984 ; ; TARGET BETA-LACTAMASE ; ; PDB 2XFS (STRUCTURAL AND MECHANISTIC STUDIES ON A CEPHALOSPORIN ESTERASE FROM THE CLAVULANIC ACID BIOSYNTHESIS PATHWAY) - ligand code J01 ; Beta-lactamase TEM UNIPROT P62593 bla, blaT-3, blaT-4, blaT-5, blaT-6 1035 ; AMDINOCILLIN ; 32887-01-7 ; 0 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEIN 2B ; ATC (J01CA08) PIVMECILLINAM ; PDB 6TIX (CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 2 FROM YERSINIA PESTIS IN COMPLEX WITH MECILLINAM) - ligand code DH4 ; Peptidoglycan D,D-transpeptidase MrdA UNIPROT P0AD65 mrdA 1036 ; CEFMENOXIME ; 65085-01-0 ; 1987 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFMENOXIME) J01DD05 S01AA31 S02AA18 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1037 ; STREPTOZOCIN ; 18883-66-4 ; 1982 ; ; TARGET DNA ; ATC (STREPTOZOCIN) L01AD04 ; PDB 2W4X (BTGH84 IN COMPLEX WITH STZ) - ligand code STZ ; UNKNOWN 1038 ; CEFTAZIDIME ; 72558-82-8 ; 1985 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFTAZIDIME) J01DD02 J01DD52 ; ; Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI -- Penicillin-binding protein 1A UNIPROT P02918 mrcA 1039 ; CEFONICID ; 61270-58-4 ; 1993 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFONICID) J01DC06 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1040 ; AZTREONAM ; 78110-38-0 ; 1986 ; ; TARGET PENICILLIN-BINDING PROTEIN 3 -- BETA-LACTAMASE ; ATC (AZTREONAM) J01DF01 ; PDB 1FR6 (BETA-LACTAMASE FROM CITROBACTER FREUNDII) ; Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI -- Penicillin-binding protein 1A UNIPROT P02918 mrcA 1041 ; CEFTRIAXONE ; 73384-59-5 ; 1984 ; ; TARGET GAMMA-GLUTAMYLTRANSPEPTIDASE ; ATC (CEFTRIAXONE) J01DD04 J01DD63 J01DD54 ; PDB 5NZX (CRYSTAL STRUCTURE OF DNA CROSS-LINK REPAIR PROTEIN 1A IN COMPLEX WITH CEFTRIAXONE (ALTERNATIVE SITE)) - ligand code 9F2 ; Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI -- Penicillin-binding protein 1A UNIPROT P02918 mrcA 1042 ; CILASTATIN ; 82009-34-5 ; 1985 ; ; TARGET DIPEPTIDASE 1 -- DEHYDROPEPTIDASE I ; ATC (CILASTATIN) J01DH51 J01DH56 ; PDB 1ITU (HUMAN RENAL DIPEPTIDASE) ; Dipeptidase 1 UNIPROT P16444 DPEP1 1043 ; IMIPENEM ; 64221-86-9 ; 1985 ; ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (IMIPENEM) J01DH51 J01DH56 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1044 ; MUPIROCIN ; 12650-69-0 ; 1987 ; ; TARGET ISOLEUCYL-TRNA SYNTHETASE ; ATC (MUPIROCIN) D06AX09 R01AX06 ; PDB 1FFY (INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN) - ligand code MRC ; Isoleucine--tRNA ligase UNIPROT P41972 ileS -- Isoleucine--tRNA ligase UNIPROT Q99YW3 ileS 1045 ; CEFOTIAM ; 61622-34-2 ; 1988 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFOTIAM) J01DC07 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1046 ; VANCOMYCIN ; 1404-90-6 ; 1964 ; ; TARGET DNA ; ATC (VANCOMYCIN) A07AA09 J01XA01 S01AA28 ; PDB 1PNV (TDP-EPI-VANCOSAMINYLTRANSFERASE GTFA FROM AMYCOLATOPSIS ORIENTALIS) ; UNKNOWN 1047 ; CEFIXIME ; 79350-37-1 ; 1989 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFIXIME) J01DD08 J01RA16 J01DD58 J01RA15 ; PDB 4KOU (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFIXIME) - ligand code C04 ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1048 ; CEFPIRAMIDE ; 70797-11-4 ; 1989 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFPIRAMIDE) J01DD11 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1049 ; CEFMETAZOLE ; 56796-20-4 ; 1989 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFMETAZOLE) J01DC09 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1050 ; IDARUBICIN ; 58957-92-9 ; 1990 ; ; TARGET DNA TOPOISOMERASE 2-ALPHA ; ATC (IDARUBICIN) L01DB06 ; PDB 4LB2 (X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH IDARUBICIN) - ligand code DM5 ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 1051 ; CLARITHROMYCIN ; 81103-11-9 ; 1991 ; ; TARGET 50S RIBOSOMAL PROTEIN ; ATC (CLARITHROMYCIN) J01FA09 A02BD06 A02BD07 A02BD09 A02BD05 A02BD04 A02BD11 A02BD12 A02BD14 ; PDB 5IGW (MACROLIDE 2'-PHOSPHOTRANSFERASE TYPE II - COMPLEX WITH GDP AND CLARITHROMYCIN) - ligand code CTY ; UNKNOWN 1052 ; CEFPROZIL ; 92665-29-7 ; 1991 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFPROZIL) J01DC10 ; ; UNKNOWN 1053 ; LORACARBEF ; 76470-66-1 ; 1991 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (LORACARBEF) J01DC08 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1054 ; AZITHROMYCIN ; 83905-01-5 ; 1991 ; ; TARGET 50S RIBOSOMAL PROTEIN ; ATC (AZITHROMYCIN) J01FA10 S01AA26 J01RA07 J01RA16 ; PDB 5UXD (CRYSTAL STRUCTURE OF MACROLIDE 2'-PHOSPHOTRANSFERASE MPHH FROM BRACHYBACTERIUM FAECIUM IN COMPLEX WITH AZITHROMYCIN) - ligand code ZIT ; UNKNOWN 1055 ; CEFPODOXIME PROXETIL ; 87239-81-4 ; 1992 ; ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CEFPODOXIME) J01DD13 J01DD64 ; ; UNKNOWN 1056 ; DIRITHROMYCIN ; 62013-04-1 ; 1995 ; DISCONTINUED ; TARGET RIBOSOME ; ATC (DIRITHROMYCIN) J01FA13 ; ; UNKNOWN 1057 ; CEFEPIME ; 88040-23-7 ; 1996 ; ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CEFEPIME) J01DE01 J01RA06 J01DE51 ; PDB 5OJ0 (PENICILLIN-BINDING PROTEIN 2X (PBP2X) FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH CEFEPIME) - ligand code 9WT ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1058 ; DACTINOMYCIN ; 50-76-0 ; 1964 ; ; TARGET DNA ; ATC (DACTINOMYCIN) L01DA01 ; ; UNKNOWN 1059 ; TAZOBACTAM ; 89786-04-9 ; 1993 ; ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (TAZOBACTAM) J01CG02 ; PDB 1VM1 (STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM) - ligand code TAZ ; Beta-lactamase TEM UNIPROT P62593 bla 1060 ; CEFTIBUTEN ; 97519-39-6 ; 1995 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CEFTIBUTEN) J01DD14 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1061 ; RIFABUTIN ; 72559-06-9 ; 1992 ; ; TARGET DNA-DIRECTED RNA POLYMERASE ; ATC (RIFABUTIN) A02BD16 J04AB04 ; PDB 4CP3 (THE STRUCTURE OF BCL6 BTB (POZ) DOMAIN IN COMPLEX WITH THE ANSAMYCIN ANTIBIOTIC RIFABUTIN.) - ligand code RBT ; Bacterial DNA-directed RNA polymerase UNIPROT P0A7Z4 rpoA 1062 ; PYRAZINAMIDE ; 98-96-4 ; 1971 ; ; TARGET MYCOBACTERIAL PYRAZINAMIDASE (PNCA) ; ATC (PYRAZINAMIDE) J04AK01 J04AM05 ; PDB 5FPD (STRUCTURE OF HEAT SHOCK-RELATED 70KDA PROTEIN 2 WITH SMALL-MOLECULE LIGAND PYRAZINE-2-CARBOXAMIDE (AT513) IN AN ALTERNATE BINDING SITE.) - ligand code PZA ; 3-oxoacyl-ACP synthase 1063 ; MEROPENEM ; 96036-03-2 ; 1996 ; ; TARGET PENICILLIN-BINDING PROTEIN (PBP) ; ATC (MEROPENEM) J01DH02 J01DH52 ; PDB 4EUZ (CRYSTAL STRUCTURE OF SERRATIA FONTICOLA CARBAPENEMASE SFC-1 S70A-MEROPENEM COMPLEX) - ligand code MEM ; D-alanyl-D-alanine carboxypeptidase DacB UNIPROT P24228 dacB 1064 ; TACROLIMUS ; 104987-11-3 ; 1994 ; ; TARGET FKBP-12 ; ATC (TACROLIMUS) D11AH01 L04AD02 ; PDB 3O5R (COMPLEX OF FK506 WITH THE FK1 DOMAIN MUTANT A19T OF FKBP51) - ligand code FK5 ; Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A 1065 ; FOSFOMYCIN ; 23155-02-4 ; 1996 ; ; TARGET ENOLPYRUVYL TRANSFERASE ; ATC (FOSFOMYCIN) J01XX01 S02AA17 ; PDB 4IR0 (CRYSTAL STRUCTURE OF METALLOTHIOL TRANSFERASE FOSB 2 FROM BACILLUS ANTHRACIS STR. AMES) - ligand code FCN ; UDP-N-acetylglucosamine 1-carboxyvinyltransferase UNIPROT P0A749 murA 1066 ; MYCOPHENOLATE MOFETIL ; 128794-94-5 ; 1995 ; ; TARGET INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) ; ATC (MYCOPHENOLIC ACID) L04AA06 ; ; Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1 -- Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2 1067 ; CEFDINIR ; 91832-40-5 ; 1997 ; ; TARGET PENICILLIN-BINDING PROTEINS (PBPS) ; ATC (CEFDINIR) J01DD15 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1068 ; IVERMECTIN ; 70288-86-7 ; 1996 ; ; TARGET GLYCINE RECEPTOR (GLYR) -- GLUTAMATE-GATED CHLORIDE CHANNEL -- GABA RECEPTOR -- NS3 HELICASE (PMID22535622) ; ATC (IVERMECTIN) D11AX22 P02CF01 ; PDB 3JAF (DANIO RERIO ALPHA-1 GLYCINE RECEPTOR BY CRYO-EM) - ligand code IVM ; Glutamate-gated chloride channel UNIPROT P91730 -- Glutamate-gated chloride channel UNIPROT Q25634 GluClX 1069 ; QUINUPRISTIN ; 120138-50-3 ; 1999 ; ; TARGET RIBOSOME -- STAPHYLOCOCCUS AUREUS VIRGINIAMYCIN B LYASE ; ATC (QUINUPRISTIN) J01FG02 ; PDB 2Z2P (CATALYTICALLY INACTIVE H270A VIRGINIAMYCIN B LYASE FROM STAPHYLOCOCCUS AUREUS) ; UNKNOWN 1070 ; DALFOPRISTIN ; 112362-50-2 ; 1999 ; ; TARGET VIRGINIAMYCIN ACETYLTRANSFERASE D (VATD) -- RIBOSOME ; ATC (DALFOPRISTIN) J01FG02 ; PDB 4U26 (CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO DALFOPRISTIN AND QUINUPRISTIN.) - ligand code DOL ; UNKNOWN 1071 ; EPIRUBICIN ; 56420-45-2 ; 1999 ; ; TARGET DNA -- DNA HELICASE ; ATC (EPIRUBICIN) L01DB03 ; PDB 2DR6 (CRYSTAL STRUCTURE OF A MULTIDRUG TRANSPORTER REVEAL A FUNCTIONALLY ROTATING MECHANISM) - ligand code DM2_2DR6 ; UNKNOWN 1072 ; MYCOPHENOLIC ACID ; 24280-93-1 ; 2004 ; ; TARGET INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) ; ATC (MYCOPHENOLIC ACID) L04AA06 ; PDB 4FXS (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE FROM VIBRIO CHOLERAE COMPLEXED WITH IMP AND MYCOPHENOLIC ACID) - ligand code MOA ; Inosine-5-monophosphate dehydrogenase (IMPDH) UNIPROT P12268 IMPDH2 1073 ; AZACITIDINE ; 320-67-2 ; 2004 ; ; TARGET URIDINE-CYTIDINE KINASE 2 (UCK2) ; ATC (AZACITIDINE) L01BC07 ; PDB 4QD3 (CRYSTAL STRUCTURE OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH 5-AZACYTIDINE AT 1.89 ANGSTROM RESOLUTION) - ligand code 5AE ; DNA (cytosine-5)-methyltransferase 1 UNIPROT P26358 DNMT1 -- DNA (cytosine-5)-methyltransferase 3A UNIPROT Q9Y6K1 DNMT3A 1074 ; STREPTOMYCIN ; 57-92-1 ; 1946 ; ; TARGET RIBOSOMAL PROTEIN ; ATC (STREPTOMYCIN) A07AA04 J01GA01 J04AM01 A07AA54 ; PDB 1NTA (2.9 A CRYSTAL STRUCTURE OF STREPTOMYCIN RNA-APTAMER) - ligand code SRY ; UNKNOWN 1075 ; GRAMICIDIN ; 1405-97-6 ; 1968 ; ; TARGET MEMBRANES ; ATC (GRAMICIDIN) R02AB30 ; ; UNKNOWN 1076 ; PAROMOMYCIN ; 7542-37-2 ; 1969 ; ; TARGET RIBOSOMAL DECODING A-SITE BACTERIAL 16S RRNA ; ATC (PAROMOMYCIN) A07AA06 ; PDB 5BR8 (AMBIENT-TEMPERATURE CRYSTAL STRUCTURE OF 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH PAROMOMYCIN) - ligand code PAR ; UNKNOWN 1077 ; CYCLOSERINE ; 68-41-7 ; 1964 ; ; TARGET NMDA RECEPTOR -- D-ALANINE-D-ALANINE LIGASE -- ALANINE RACEMASE ; ATC (CYCLOSERINE) J04AB01 ; PDB 1PB9 (CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-CYCLOSERINE AT 1.60 ANGSTROMS RESOLUTION) - ligand code 4AX ; D-alanine--D-alanine ligase UNIPROT P9WP31 ddl -- Alanine racemase UNIPROT P9WQA9 alr 1078 ; METHACYCLINE ; 914-00-1 ; 0 ; DISCONTINUED ; TARGET RIBOSOME ; ATC (METACYCLINE) J01AA05 ; ; BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL CHEMBL2363135 BACTERIAL 70S RIBOSOME 16S RIBOSOMAL RNA BACTERIA 1079 ; CANDICIDIN ; 1403-17-4 ; 0 ; DISCONTINUED ; TARGET MEMBRANE ; ATC (CANDICIDIN) G01AA04 ; ; UNKNOWN 1080 ; PRAMOXINE ; 140-65-8 ; 1973 ; ; ; ATC (PRAMOCAINE) C05AD07 D04AB07 ; PDB 4Y0Q (BOVINE BETA-LACTOGLOBULIN COMPLEX WITH PRAMOCAINE CRYSTALLIZED FROM SODIUM CITRATE (BLG-PRM1)) - ligand code PX9 ; Sigma non-opioid intracellular receptor 1 UNIPROT Q99720 SIGMAR1 1081 ; PENTOBARBITAL ; 76-74-4 ; 1973 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (PENTOBARBITAL) N05CA01 ; ; Gamma-aminobutyric acid receptor subunit beta-3 UNIPROT P28472 GABRB3 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 1082 ; GENTIAN VIOLET ; 548-62-9 ; 1977 ; DISCONTINUED ; TARGET NADPH OXIDASE IN MAMMALIAN CELLS AND THIOREDOXIN REDUCTASE 2 IN BACTERIAL, FUNGAL AND PARASITIC CELLS ; ATC (METHYLROSANILINE) D01AE02 G01AX09 ; PDB 5OV9 (CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE IN COMPLEX WITH CRYSTAL VIOLET) - ligand code CVI ; UNKNOWN 1083 ; DIGITOXIN ; 71-63-6 ; 1978 ; DISCONTINUED ; TARGET SODIUM-POTASSIUM ATPASE ; ATC (DIGITOXIN) C01AA04 ; PDB 7DDI (CRYSTAL STRUCTURES OF NA+,K+-ATPASE IN COMPLEX WITH DIGITOXIN) - ligand code F9R ; Sodium,potassium-transporting ATPase subunit alpha-1 UNIPROT P05023 ATP1A1 1084 ; BENZYL BENZOATE ; 120-51-4 ; 1976 ; DISCONTINUED ; ; ATC (BENZYL BENZOATE) P03AX01 ; PDB 1DZM (PORCINE ODORANT BINDING PROTEIN COMPLEXED WITH BENZOIC ACID PHENYLMETHYLESTER) - ligand code BZM ; Beta-lactamase UNIPROT P00811 ampC 1085 ; TETRAHYDROZOLINE ; 84-22-0 ; 1979 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (TETRYZOLINE) R01AA06 R01AB03 S01GA02 S01GA52 ; ; Adrenergic receptor alpha UNIPROT P08913 ADRA2A 1086 ; DRONEDARONE ; 141626-36-0 ; 2009 ; ; TARGET IONIC CHANNELS ; ATC (DRONEDARONE) C01BD07 ; ; Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 UNIPROT O60741 HCN1 -- Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 UNIPROT Q9UL51 HCN2 1087 ; ARTEMETHER ; 71963-77-4 ; 2009 ; ; ; ATC (ARTEMETHER) P01BE02 P01BF01 ; PDB 6FGD (CRYSTAL STRUCTURE OF GEPHYRIN E DOMAIN IN COMPLEX WITH ARTEMETHER) - ligand code D8Z ; UNKNOWN 1088 ; CHLOROQUINE ; 54-05-7 ; 1949 ; ; TARGET DNA -- LACTATE DEHYDROGENASE ; ATC (CHLOROQUINE) P01BA01 P01BB52 ; PDB 4FGK (OXIDIZED QUINONE REDUCTASE 2 IN COMPLEX WITH CHLOROQUINE) - ligand code 0TX ; UNKNOWN 1089 ; MEPHENYTOIN ; 50-12-4 ; 1946 ; DISCONTINUED ; TARGET NA+ CHANNELS (NAV) ; ATC (MEPHENYTOIN) N03AB04 N03AB54 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 1090 ; METHADONE ; 76-99-3 ; 1947 ; ; TARGET MU-TYPE OPIOID RECEPTOR -- N-METHYL-D-ASPARTATE RECEPTOR (NMDA) ; ATC (METHADONE) N07BC02 N02AC52 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1091 ; DOXYLAMINE ; 469-21-6 ; 1948 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DOXYLAMINE) R06AA09 R06AA59 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1092 ; DIHYDROARTEMISININ ; 71939-50-9 ; 0 ; ; ; ATC (ARTEMISININ) P01BE01 P01BF08 P01BF07 ; ; UNKNOWN 1093 ; BETHANECHOL ; 590-63-6 ; 1948 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (BETHANECHOL) N07AB02 ; ; Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1094 ; TRIHEXYPHENIDYL ; 144-11-6 ; 1949 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (TRIHEXYPHENIDYL) N04AA01 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 1095 ; PARAMETHADIONE ; 115-67-3 ; 1949 ; DISCONTINUED ; ; ATC (PARAMETHADIONE) N03AC01 ; ; Voltage-gated T-type calcium channel UNIPROT O43497 CACNA1G 1096 ; SECOBARBITAL ; 76-73-3 ; 1950 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (SECOBARBITAL) N05CA06 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 1097 ; DYPHYLLINE ; 479-18-5 ; 1951 ; DISCONTINUED ; TARGET PHOSPHODIESTERASE ; ATC (DIPROPHYLLINE) R03DA01 R03DB01 R03DA51 ; ; cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A -- cAMP-specific 3,5-cyclic phosphodiesterase 4B UNIPROT Q07343 PDE4B 1098 ; PROMETHAZINE ; 60-87-7 ; 1951 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (PROMETHAZINE) V03AB05 D04AA10 R06AD02 R06AD52 ; PDB 7MQU (THE HADDOCK MODEL OF GDP KRAS IN COMPLEX WITH PROMETHAZINE USING NMR CHEMICAL SHIFT PERTURBATIONS) - ligand code ZM7 ; Histamine H1 receptor UNIPROT P35367 HRH1 1099 ; BROMODIPHENHYDRAMINE ; 1808-12-4 ; 1954 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DIPHENHYDRAMINE) D04AA32 R06AA02 D04AA33 R06AA52 M01AE57 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1100 ; CYCRIMINE ; 77-39-4 ; 1953 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 1101 ; ETHOPROPAZINE ; 522-00-9 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (PROFENAMINE) N04AA05 ; PDB 6EQP (HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH ETHOPROPAZINE) - ligand code BUW ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 1102 ; WARFARIN ; 81-81-2 ; 1954 ; ; TARGET VITAMIN K EPOXIDE REDUCTASE COMPLEX ; ATC (WARFARIN) B01AA03 ; ; Vitamin K epoxide reductase complex subunit 1 UNIPROT Q9BQB6 VKORC1 1103 ; GLUTETHIMIDE ; 77-21-4 ; 1957 ; DISCONTINUED ; ; ATC (GLUTETHIMIDE) N05CE01 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 1104 ; PROCYCLIDINE ; 77-37-2 ; 1955 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (PROCYCLIDINE) N04AA04 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 1105 ; ETHCHLORVYNOL ; 113-18-8 ; 1961 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (ETHCHLORVYNOL) N05CM08 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 1106 ; AMPHETAMINE ; 300-62-9 ; 1955 ; ; TARGET NORADRENALINE TRANSPORTER (NAT) -- DOPAMINE TRANSPORTER (DAT) ; ATC (AMFETAMINE) N06BA01 ; PDB 2AOI (CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P1-P6) - ligand code FRD ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1107 ; MECAMYLAMINE ; 60-40-2 ; 1956 ; ; TARGET ACETYLCHOLINE RECEPTORS ; ATC (MECAMYLAMINE) C02BB01 ; ; Neuronal acetylcholine receptor 1108 ; CLIDINIUM ; 3485-62-9 ; 1966 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (CLIDINIUM) A03CA02 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1109 ; HYDROXYZINE ; 68-88-2 ; 1956 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (HYDROXYZINE) N05BB01 N05BB51 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1110 ; BROMPHENIRAMINE ; 86-22-6 ; 1957 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (BROMPHENIRAMINE) R06AB01 R06AB51 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1111 ; ETHOTOIN ; 86-35-1 ; 1957 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ATC (ETHOTOIN) N03AB01 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 1112 ; BUCLIZINE ; 82-95-1 ; 1957 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 -- HISTAMINE H1 RECEPTOR ; ATC (BUCLIZINE) R06AE01 R06AE51 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1113 ; METHOCARBAMOL ; 532-03-6 ; 1957 ; ; ; ATC (METHOCARBAMOL) M03BA03 M03BA53 M03BA73 ; ; Carbonic anhydrase 1 UNIPROT P00915 CA1 1114 ; PHENPROCOUMON ; 435-97-2 ; 1957 ; DISCONTINUED ; TARGET VITAMIN K EPOXIDE REDUCTASE ; ATC (PHENPROCOUMON) B01AA04 ; ; Vitamin K epoxide reductase complex subunit 1 UNIPROT Q9BQB6 VKORC1 1115 ; TRIMEPRAZINE ; 84-96-8 ; 0 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (ALIMEMAZINE) R06AD01 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1116 ; LUMEFANTRINE ; 82186-77-4 ; 2009 ; ; ; ATC (LUMEFANTRINE) P01BF01 ; ; UNKNOWN 1117 ; METHOHEXITAL ; 151-83-7 ; 1960 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 ; ATC (METHOHEXITAL) N01AF01 N05CA15 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 1118 ; OXYPHENCYCLIMINE ; 125-53-1 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (OXYPHENCYCLIMINE) A03AA01 A03CA03 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1119 ; DIETHYLPROPION ; 90-84-6 ; 1959 ; ; TARGET NORADRENALINE TRANSPORTER -- DOPAMINE TRANSPORTER ; ATC (AMFEPRAMONE) A08AA03 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1120 ; THIORIDAZINE ; 50-52-2 ; 1962 ; ; TARGET DOPAMINE RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- ALPHA-1A ADRENERGIC RECEPTOR ; ATC (THIORIDAZINE) N05AC02 ; PDB 4I1R (HUMAN MALT1 (CASPASE-IG3) IN COMPLEX WITH THIORIDAZINE) - ligand code LZU ; D(2) dopamine receptor UNIPROT P14416 DRD2 1121 ; BIPERIDEN ; 514-65-8 ; 1959 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (BIPERIDEN) N04AA02 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 1122 ; TROPICAMIDE ; 1508-75-4 ; 1960 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (TROPICAMIDE) S01FA06 S01FA56 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1123 ; MEPIVACAINE ; 96-88-8 ; 1960 ; ; TARGET SODIUM CHANNEL PROTEIN ; ATC (MEPIVACAINE) N01BB03 N01BB53 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A 1124 ; CHLOPHEDIANOL ; 791-35-5 ; 0 ; DISCONTINUED ; ; ATC (CLOFEDANOL) R05DB10 ; ; UNKNOWN 1125 ; BENDROFLUMETHIAZIDE ; 73-48-3 ; 1959 ; DISCONTINUED ; TARGET SODIUM CHLORIDE SYMPORTER -- CARBONIC ANHYDRASE ; ATC (BENDROFLUMETHIAZIDE) C03AA01 C03AB01 C03EA13 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1126 ; TRICHLORMETHIAZIDE ; 133-67-5 ; 1960 ; DISCONTINUED ; TARGET SODIUM CHLORIDE SYMPORTER ; ATC (TRICHLORMETHIAZIDE) C03AA06 C03AB06 C03EA02 ; PDB 3ILT (CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, TRICHLORMETHIAZIDE) - ligand code TRU ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1127 ; CHLORTHALIDONE ; 77-36-1 ; 1960 ; ; TARGET SODIUM CHLORIDE SYMPORTER ; ATC (CHLORTALIDONE) C03BA04 C03BB04 C03EA06 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1128 ; ETHOSUXIMIDE ; 77-67-8 ; 1960 ; ; TARGET VOLTAGE-DEPENDENT CHANNEL ; ATC (ETHOSUXIMIDE) N03AD01 N03AD51 ; PDB 5OH3 (CEREBLON ISOFORM 4 FROM MAGNETOSPIRILLUM GRYPHISWALDENSE IN COMPLEX WITH ETHOSUXIMIDE) - ligand code 9V2 ; Voltage-dependent T-type calcium channel subunit alpha-1G UNIPROT O43497 CACNA1G 1129 ; PROPIOMAZINE ; 362-29-8 ; 1960 ; DISCONTINUED ; TARGET DOPAMINE RECEPTOR -- MUSCARINIC ACETYLCHOLINE RECEPTOR -- HISTAMINE H1 RECEPTOR ; ATC (PROPIOMAZINE) N05CM06 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1130 ; ACRISORCIN ; 7527-91-5 ; 0 ; DISCONTINUED ; ; ATC (HEXYLRESORCINOL) R02AA12 ; PDB 1FN2 (9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CGTACG)2) - ligand code 8AD ; UNKNOWN 1131 ; METHYCLOTHIAZIDE ; 135-07-9 ; 1960 ; DISCONTINUED ; TARGET SODIUM CHLORIDE SYMPORTER ; ATC (METHYCLOTHIAZIDE) C03AA08 C03AB08 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1132 ; OXYPHENBUTAZONE ; 129-20-4 ; 1960 ; DISCONTINUED ; ; ATC (OXYPHENBUTAZONE) M01AA03 M02AA04 S01BC02 ; PDB 2BXB (HUMAN SERUM ALBUMIN COMPLEXED WITH OXYPHENBUTAZONE) - ligand code OPB_2BXB ; Cyclooxygenase UNIPROT P23219 PTGS1 1133 ; POLYTHIAZIDE ; 346-18-9 ; 1961 ; DISCONTINUED ; TARGET SODIUM CHLORIDE SYMPORTER ; ATC (POLYTHIAZIDE) C03AA05 C03AB05 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1134 ; METAXALONE ; 1665-48-1 ; 1962 ; ; ; ; ; UNKNOWN 1135 ; QUINETHAZONE ; 73-49-4 ; 1963 ; DISCONTINUED ; TARGET CARBONIC ANHYDRASE ; ATC (QUINETHAZONE) C03BA02 C03BB02 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1136 ; PRILOCAINE ; 721-50-6 ; 1965 ; ; TARGET SODIUM CHANNEL ; ATC (PRILOCAINE) N01BB04 N01BB54 ; ; Sodium channel alpha subunits 1137 ; DOXAPRAM ; 309-29-5 ; 1965 ; ; ; ATC (DOXAPRAM) R07AB01 ; ; Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 -- Potassium channel subfamily K member 9 UNIPROT Q9NPC2 KCNK9 1138 ; OXAZEPAM ; 604-75-1 ; 1965 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (OXAZEPAM) N05BA04 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 1139 ; PROPRANOLOL ; 525-66-6 ; 1967 ; ; TARGET BETA ADRENERGIC RECEPTOR ; ATC (PROPRANOLOL) C07AA05 C07FX01 C07BA05 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1140 ; TRIMIPRAMINE ; 739-71-9 ; 1979 ; ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (TRIMIPRAMINE) N06AA06 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1141 ; KETAMINE ; 6740-88-1 ; 1970 ; ; TARGET GLUTAMATE [NMDA] RECEPTOR -- AMPA RECEPTOR ; ATC (KETAMINE) N01AX03 ; PDB 4F8H (X-RAY STRUCTURE OF THE ANESTHETIC KETAMINE BOUND TO THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL) - ligand code RKE ; Glutamate NMDA receptor UNIPROT O15399 GRIN2D -- Glutamate receptor ionotropic AMPA UNIPROT P42261 GRIA1 1142 ; BENZQUINAMIDE ; 63-12-7 ; 1974 ; DISCONTINUED ; TARGET P-GLYCOPROTEIN (PMID1362504) ; ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 1143 ; PEMOLINE ; 2152-34-3 ; 1975 ; DISCONTINUED ; ; ATC (PEMOLINE) N06BA05 ; ; Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1144 ; MITOTANE ; 53-19-0 ; 1970 ; ; TARGET SXR RECEPTOR ; ATC (MITOTANE) L01XX23 ; ; Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1 -- Cholesterol side-chain cleavage enzyme, mitochondrial UNIPROT P05108 CYP11A1 1145 ; BUPIVACAINE ; 2180-92-9 ; 1972 ; ; TARGET ACETYLCHOLINE RECEPTOR -- NMDA RECEPTOR -- 5HT3 ; ATC (BUPIVACAINE) N01BB01 N01BB59 N01BB51 ; ; Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A 1146 ; ENFLURANE ; 13838-16-9 ; 1972 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR -- GLYCINE RECEPTOR ; ATC (ENFLURANE) N01AB04 ; ; Glycine receptor subunit alpha-1 UNIPROT P23415 GLRA1 -- Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 1147 ; MOLINDONE ; 7416-34-4 ; 1974 ; ; TARGET D(2) DOPAMINE RECEPTOR ; ATC (MOLINDONE) N05AE02 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1148 ; MAZINDOL ; 22232-71-9 ; 1973 ; DISCONTINUED ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT DOPAMINE TRANSPORTER ; ATC (MAZINDOL) A08AA05 ; PDB 4MME (CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH MAZINDOL) - ligand code 29Q ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1149 ; METOLAZONE ; 17560-51-9 ; 1973 ; ; TARGET NA-CL COTRANSPORTER (NCC) ; ATC (METOLAZONE) C03BA08 C03EA12 ; ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1150 ; DISOPYRAMIDE ; 3737-09-5 ; 1977 ; ; TARGET VOLTAGE GATED SODIUM CHANNEL -- KV1.5 ; ATC (DISOPYRAMIDE) C01BA03 ; PDB 3APW (CRYSTAL STRUCTURE OF THE A VARIANT OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND DISOPYRAMIDE COMPLEX) - ligand code DP0 ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 1151 ; MICONAZOLE ; 22916-47-8 ; 1974 ; ; TARGET CYTOCHROME P450 14ALPHA-DEMETHYLASE ; ATC (MICONAZOLE) A01AB09 A07AC01 D01AC02 G01AF04 J02AB01 S02AA13 D01AC52 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 1152 ; IBUPROFEN ; 15687-27-1 ; 1974 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (IBUPROFEN) N02AJ08 N02AJ23 C01EB16 G02CC01 M01AE01 M02AA13 R02AX02 M01AE51 N02AJ19 ; PDB 4RS0 (CRYSTAL STRUCTURE OF MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH S-IBUPROFEN) - ligand code IBP ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1153 ; LUMEFANTRINE ; 82186-77-4 ; 2009 ; ; ; ATC (LUMEFANTRINE) P01BF01 ; ; UNKNOWN 1154 ; LORAZEPAM ; 846-49-1 ; 1977 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (LORAZEPAM) N05BA06 N05BA56 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 1155 ; DOBUTAMINE ; 34368-04-2 ; 1978 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- CATECHOL O-METHYLTRANSFERASE (COMT) ; ATC (DOBUTAMINE) C01CA07 ; PDB 2Y00 (TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92)) - ligand code Y00 ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1156 ; BACLOFEN ; 1134-47-0 ; 1977 ; ; TARGET GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR ; ATC (BACLOFEN) M03BX01 ; PDB 4MS4 (CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GABA(B) RECEPTOR BOUND TO THE AGONIST BACLOFEN) - ligand code 2C0 ; GABA-B receptor UNIPROT O75899 GABBR2 1157 ; TEMAZEPAM ; 846-50-4 ; 1981 ; ; TARGET GABA RECEPTOR ; ATC (TEMAZEPAM) N05CD07 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 1158 ; OXPRENOLOL ; 6452-71-7 ; 0 ; DISCONTINUED ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (OXPRENOLOL) C07AA02 C07CA02 C07BA02 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1159 ; AMINOGLUTETHIMIDE ; 125-84-8 ; 1980 ; DISCONTINUED ; TARGET CYTOCHROME P450 ; ATC (AMINOGLUTETHIMIDE) L02BG01 ; ; Aromatase UNIPROT P11511 CYP19A1 -- Cholesterol side-chain cleavage enzyme, mitochondrial UNIPROT P05108 CYP11A1 1160 ; DIPIVEFRIN ; 52365-63-6 ; 1980 ; DISCONTINUED ; TARGET ALPHA-2A ADRENERGIC RECEPTOR ; ATC (DIPIVEFRIN) S01EA02 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B -- Alpha-2C adrenergic receptor UNIPROT P18825 ADRA2C 1161 ; ATENOLOL ; 29122-68-7 ; 1981 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ATENOLOL) C07AB03 C07FB03 C07CB03 C07CB53 C07BB03 C07DB01 ; PDB 2NUV (CRYSTAL STRUCTURE OF THE COMPLEX OF C-TERMINAL LOBE OF BOVINE LACTOFERRIN WITH ATENOLOL AT 2.25 A RESOLUTION) - ligand code 2TN ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 1162 ; TOCAINIDE ; 41708-72-9 ; 1984 ; DISCONTINUED ; TARGET SODIUM CHANNEL PROTEIN ; ATC (TOCAINIDE) C01BB03 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 1163 ; PINDOLOL ; 13523-86-9 ; 1982 ; ; TARGET BETA ADRENERGIC RECEPTOR ; ATC (PINDOLOL) C07AA03 C07CA03 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1164 ; CARPROFEN ; 53716-49-7 ; 1987 ; DISCONTINUED ; TARGET PROSTAGLANDIN G/H SYNTHASE 2 ; ; PDB 4MJR (E. COLI SLIDING CLAMP IN COMPLEX WITH (S)-CARPROFEN) - ligand code 0LA ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 1165 ; SULCONAZOLE ; 61318-90-9 ; 1985 ; ; TARGET CYTOCHROME P450 ; ATC (SULCONAZOLE) D01AC09 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 1166 ; ECONAZOLE ; 27220-47-9 ; 1982 ; ; TARGET CYTOCHROME P450 ; ATC (ECONAZOLE) D01AC03 G01AF05 G01AF55 ; PDB 6B5V (STRUCTURE OF TRPV5 IN COMPLEX WITH ECONAZOLE) - ligand code ECL ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 1167 ; KETOPROFEN ; 22071-15-4 ; 1986 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (KETOPROFEN) M01AE03 M02AA10 M01AE53 ; PDB 7JWN (CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN IN COMPLEX WITH KETOPROFEN) - ligand code JGE ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1168 ; FLURBIPROFEN ; 5104-49-4 ; 1986 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (FLURBIPROFEN) M01AE09 M02AA19 R02AX01 S01BC04 ; PDB 3RR3 (STRUCTURE OF (R)-FLURBIPROFEN BOUND TO MCOX-2) - ligand code FLR ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1169 ; FLECAINIDE ; 54143-55-4 ; 1985 ; ; TARGET SODIUM CHANNEL NAV1.5 ; ATC (FLECAINIDE) C01BC04 ; PDB 6MVX (NAVAB VOLTAGE-GATED SODIUM CHANNEL, I217C, IN COMPLEX WITH CLASS 1C ANTI-ARRHYTHMIC FLECAINIDE) - ligand code K4D ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 1170 ; NIMODIPINE ; 66085-59-4 ; 1988 ; ; TARGET CALCIUM CHANNEL ; ATC (NIMODIPINE) C08CA06 ; ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 1171 ; MEXILETINE ; 31828-71-4 ; 1985 ; ; TARGET SODIUM CHANNEL ; ATC (MEXILETINE) C01BB02 ; PDB 2VIN (FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR) - ligand code 505 ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A 1172 ; ACEBUTOLOL ; 37517-30-9 ; 1984 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ACEBUTOLOL) C07AB04 C07BB04 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 1173 ; ETODOLAC ; 41340-25-4 ; 1991 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (ETODOLAC) M01AB08 ; PDB 5V0V (CRYSTAL STRUCTURE OF EQUINE SERUM ALBUMIN COMPLEX WITH ETODOLAC) - ligand code 8QP ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 1174 ; FLUOXETINE ; 54910-89-3 ; 1987 ; ; TARGET SODIUM-DEPENDENT SEROTONIN TRANSPORTER -- POTASSIUM CHANNEL TREKS ; ATC (FLUOXETINE) N06AB03 N06CA03 ; PDB 3GWW (LEUCINE TRANSPORTER LEUT IN COMPLEX WITH S-FLUOXETINE) - ligand code SFX ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1175 ; BEPRIDIL ; 64706-54-3 ; 1990 ; DISCONTINUED ; TARGET CALCIUM CHANNEL ; ATC (BEPRIDIL) C08EA02 ; PDB 6F5U (CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH BEPRIDIL) - ligand code CQN ; Voltage-dependent T-type calcium channel subunit alpha-1H UNIPROT O95180 CACNA1H -- Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C 1176 ; TERAZOSIN ; 63590-64-7 ; 1987 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR ; ATC (TERAZOSIN) G04CA03 ; PDB 4O33 (CRYSTAL STRUCTURE OF HUMAN PGK1 3PG AND TERAZOSIN(TZN) TERNARY COMPLEX) - ligand code TZN ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 1177 ; IPRATROPIUM ; 60205-81-4 ; 1986 ; ; TARGET MUSCARINIC RECEPTOR ; ATC (IPRATROPIUM BROMIDE) R03AL01 R01AX03 R03BB01 R03AL02 ; PDB 2X8M (CRYSTAL STRUCTURE OF CBPF IN COMPLEX WITH IPRATROPIUM BY SOAKING) - ligand code X8M ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1178 ; PROPAFENONE ; 54063-53-5 ; 1989 ; ; TARGET POTASSIUM VOLTAGE-GATED CHANNEL -- SODIUM CHANNEL ; ATC (PROPAFENONE) C01BC03 ; PDB 7FBS (STRUCTURE OF A CHANNEL) - ligand code 4Y4 ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 1179 ; METHACHOLINE ; 55-92-5 ; 1986 ; ; ; ATC (METHACHOLINE) V04CX03 ; PDB 7ECQ (CRYSTAL STRUCTURE OF FAM3A) - ligand code J0R ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1180 ; CARTEOLOL ; 51781-06-7 ; 1988 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (CARTEOLOL) C07AA15 S01ED05 S01ED55 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1181 ; BETAXOLOL ; 63659-18-7 ; 1985 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (BETAXOLOL) C07AB05 S01ED02 S01ED52 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 1182 ; ESMOLOL ; 81147-92-4 ; 1986 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ESMOLOL) C07AB09 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 1183 ; SUPROFEN ; 40828-46-4 ; 1988 ; DISCONTINUED ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (SUPROFEN) M01AE07 ; PDB 6OCL (CRYSTAL STRUCTURE OF LEPORINE SERUM ALBUMIN IN COMPLEX WITH SUPROFEN) - ligand code M5A ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1184 ; RIMANTADINE ; 13392-28-4 ; 1993 ; ; TARGET PROTON TRANSPORTER M2 (PMID23480101) ; ATC (RIMANTADINE) J05AC02 ; PDB 2BOC (INFLUENZA A M2 TRANSMEMBRANE DOMAIN BOUND TO RIMANTADINE IN THE INWARD(OPEN) CONFORMATION) - ligand code EU7 ; Matrix protein 2 UNIPROT P63231 M 1185 ; EVEROLIMUS ; 159351-69-6 ; 2009 ; ; TARGET FK506 BINDING PROTEIN-12 (FKBP-12)/MTOR COMPLEX ; ATC (EVEROLIMUS) L01EG02 L04AH02 ; ; Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A 1186 ; AMLODIPINE ; 88150-42-9 ; 1992 ; ; TARGET CALCIUM CHANNEL ; ATC (AMLODIPINE) C09XA53 C09XA54 C08CA01 C08CA51 C08GA02 C10BX03 C10BX19 C10BX11 C10BX18 C09BB13 C07FB07 C09DB07 C09DX06 C09DB09 C09DB05 C09DX07 C09BB03 C09DB06 C07FB13 C07FB12 C09DB02 C09DX03 C09BB04 C09BX01 C09BX04 C09BX06 C09BB07 C09BX03 C10BX09 C10BX07 C10BX14 C09DB04 C09DX08 C09DB01 C09DX01 ; PDB 3TMZ (CRYSTAL STRUCTURE OF P450 2B4(H226Y) IN COMPLEX WITH AMLODIPINE) - ligand code 06X ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 1187 ; MIDODRINE ; 42794-76-3 ; 1996 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (MIDODRINE) C01CA17 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 1188 ; FELODIPINE ; 72509-76-3 ; 1991 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM L-CHANNEL ; ATC (FELODIPINE) C08CA02 C07FB02 C09BB05 ; PDB 2NNJ (CYP2C8DH COMPLEXED WITH FELODIPINE) - ligand code 225 ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 1189 ; LEVOCETIRIZINE ; 83881-52-1 ; 1995 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (CETIRIZINE) R06AE07 S01GX12 ; PDB 5DQF (HORSE SERUM ALBUMIN (ESA) IN COMPLEX WITH CETIRIZINE) - ligand code LCR ; Histamine H1 receptor UNIPROT P35367 HRH1 1190 ; METIPRANOLOL ; 22664-55-7 ; 1989 ; DISCONTINUED ; TARGET BETA ADRENERGIC RECEPTOR ; ATC (METIPRANOLOL) S01ED04 C07BA68 S01ED54 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1191 ; BISOPROLOL ; 66722-44-9 ; 1992 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR -- ADRENERGIC BETA-2 RECEPTOR ; ATC (BISOPROLOL) C07AB07 C07FX04 C07FB07 C07BB07 C09BX02 C09BX04 C09BX05 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 1192 ; ONDANSETRON ; 99614-02-5 ; 1991 ; ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR ; ATC (ONDANSETRON) A04AA01 ; PDB 6W1M (CRYO-EM STRUCTURE OF 5HT3A RECEPTOR IN PRESENCE OF ONDANSETRON) - ligand code S87 ; 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 1193 ; LOMEFLOXACIN ; 98079-51-7 ; 1992 ; DISCONTINUED ; TARGET DNA GYRASE -- DNA TOPOISOMERASE ; ATC (LOMEFLOXACIN) J01MA07 S01AE04 ; ; DNA gyrase UNIPROT P0AES4 gyrA 1194 ; DESFLURANE ; 57041-67-5 ; 1992 ; ; TARGET ION CHANNEL ; ATC (DESFLURANE) N01AB07 ; PDB 3P4W (STRUCTURE OF DESFLURANE BOUND TO A PENTAMERIC LIGAND-GATED ION CHANNEL, GLIC) - ligand code DSF ; Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 -- Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 1195 ; HALOFANTRINE ; 69756-53-2 ; 1992 ; DISCONTINUED ; TARGET FERRIPROTOPORPHYRIN IX (FE(III)PPIX) (PMID18508124) ; ATC (HALOFANTRINE) P01BX01 ; ; UNKNOWN 1196 ; CARVEDILOL ; 72956-09-3 ; 1995 ; ; TARGET BETA ADRENERGIC RECEPTOR -- ALPHA-1A ADRENERGIC RECEPTOR ; ATC (CARVEDILOL) C07AG02 C07FX06 ; PDB 4AMJ (TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND BIASED AGONIST CARVEDILOL) - ligand code CVD ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1197 ; BICALUTAMIDE ; 90357-06-5 ; 1995 ; ; TARGET ANDROGEN RECEPTOR ; ATC (BICALUTAMIDE) L02BB03 L02AE51 ; PDB 4OKT (CRYSTAL STRUCTURE OF W741L-AR-LBD BOUND WITH CO-REGULATOR PEPTIDE) - ligand code 198 ; Androgen receptor UNIPROT P10275 AR 1198 ; DONEPEZIL ; 120014-06-4 ; 1996 ; ; TARGET ACETYLCHOLINESTERASE ; ATC (DONEPEZIL) N06DA02 N06DA52 N06DA53 ; PDB 4EY7 (CRYSTAL STRUCTURE OF RECOMBINANT HUMAN ACETYLCHOLINESTERASE IN COMPLEX WITH DONEPEZIL) - ligand code E20 ; Acetylcholinesterase UNIPROT P22303 ACHE 1199 ; GREPAFLOXACIN ; 119914-60-2 ; 1997 ; DISCONTINUED ; TARGET DNA TOPOISOMERASE II (DNA GYRASE) -- DNA TOPOISOMERASE IV ; ATC (GREPAFLOXACIN) J01MA11 ; ; DNA topoisomerase 4 UNIPROT P72525 parC -- DNA gyrase UNIPROT P0A4L9 gyrB 1200 ; THALIDOMIDE ; 50-35-1 ; 1998 ; ; ; ATC (THALIDOMIDE) L04AX02 ; PDB 5YJ1 (MOUSE CEREBLON THALIDOMIDE BINDING DOMAIN COMPLEXED WITH R-FORM THALIDOMIDE) - ligand code 6EL ; Protein cereblon UNIPROT Q96SW2 CRBN 1201 ; EPINASTINE ; 80012-43-7 ; 2003 ; ; TARGET HISTAMINE H1 RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- ALPHA-1A ADRENERGIC RECEPTOR -- ALPHA-2 ADRENERGIC RECEPTOR ; ATC (EPINASTINE) R06AX24 S01GX10 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1202 ; LACTIC ACID ; 50-21-5 ; 2006 ; ; TARGET AMINO-ACID OXIDASE -- BIFUNCTIONAL PROTEIN PUTA -- PROLINE DEHYDROGENASE ; ATC (LACTIC ACID) G01AD01 A07FA01 A07FA51 ; PDB 2W11 (STRUCTURE OF THE L-2-HALOACID DEHALOGENASE FROM SULFOLOBUS TOKODAII) - ligand code 2OP ; UNKNOWN 1203 ; ILOPROST ; 78919-13-8 ; 2004 ; ; TARGET PROSTACYCLIN RECEPTOR PGI2 ; ATC (ILOPROST) B01AC11 ; PDB 3SP6 (STRUCTURAL BASIS FOR ILOPROST AS A DUAL PPARALPHA, DELTA AGONIST) - ligand code IL2 ; Prostacyclin receptor UNIPROT P43119 PTGIR 1204 ; LENALIDOMIDE ; 191732-72-6 ; 2005 ; ; ; ATC (LENALIDOMIDE) L04AX04 ; PDB 5FQD (STRUCTURAL BASIS OF LENALIDOMIDE INDUCED CK1A DEGRADATION BY THE CRL4CRBN UBIQUITIN LIGASE) - ligand code LVY ; Protein cereblon UNIPROT Q96SW2 CRBN 1205 ; PALIPERIDONE ; 144598-75-4 ; 2006 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- D(2) DOPAMINE RECEPTOR -- ALPHA1 ADRENERGIC RECEPTOR -- ALPHA2 ADRENERGIC RECEPTOR -- H1 HISTAMINERGIC RECEPTOR ; ATC (PALIPERIDONE) N05AX13 ; PDB 8GSQ (STRUCTURE BASED STUDIES REVEAL AN ATYPICAL ANTIPSYCHOTIC DRUG CANDIDATE - PALIPERIDONE AS A POTENT HSOD1 MODULATOR WITH IMPLICATIONS IN ALS TREATMENT) - ligand code K4I ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1206 ; METHANTHELINE ; 5818-17-7 ; 1951 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (METHANTHELINE) A03AB07 ; ; Muscarinic acetylcholine receptor UNIPROT P08172 CHRM2 1207 ; NOREPINEPHRINE ; 51-41-2 ; 1950 ; ; TARGET ADRENERGIC RECEPTORS ; ATC (NOREPINEPHRINE) C01CA03 ; PDB 3HCD (CRYSTAL STRUCTURE OF HPNMT IN COMPLEX WITH NORADRENALINE AND ADOHCY) - ligand code LNR ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1208 ; PHENTOLAMINE ; 50-60-2 ; 1952 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (PHENTOLAMINE) C04AB01 V03AB36 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A 1209 ; PRIMAQUINE ; 90-34-6 ; 1952 ; ; ; ATC (PRIMAQUINE) P01BA03 ; ; UNKNOWN 1210 ; PRIMAQUINE ; 90-34-6 ; 1952 ; ; ; ATC (PRIMAQUINE) P01BA03 ; PDB 4FGJ (OXIDIZED QUINONE REDUCTASE 2 IN COMPLEX WITH PRIMAQUINE) - ligand code 1PQ ; UNKNOWN 1211 ; OXYPHENONIUM ; 14214-84-7 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (OXYPHENONIUM) A03AB03 A03AB53 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1212 ; OXYPHENONIUM ; 14214-84-7 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1 ; ATC (OXYPHENONIUM) A03AB03 A03AB53 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1213 ; ERGOLOID ; 8067-24-1 ; 1953 ; ; TARGET ALPHA ADRENERGIC RECEPTOR ; ATC (ERGOLOID MESYLATES) C04AE01 C04AE51 ; ; UNKNOWN 1214 ; BENZTROPINE ; 86-13-5 ; 1954 ; ; TARGET DOPAMINE TRANSPORTER -- MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (BENZATROPINE) N04AC01 ; PDB 6F6S (CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH BENZTROPINE) - ligand code CXQ ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 1215 ; CYCLIZINE ; 82-92-8 ; 1954 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR -- MUSCARINIC ACETYLCHOLINE RECEPTOR M3 -- MUSCARINIC ACETYLCHOLINE RECEPTOR M1 -- -- MUSCARINIC ACETYLCHOLINE RECEPTOR M2 ; ATC (CYCLIZINE) R06AE03 R06AE53 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1216 ; DIHYDROCODEINE ; 125-28-0 ; 1958 ; ; TARGET OPIOID RECEPTOR ; ATC (DIHYDROCODEINE) N02AA08 N02AJ02 N02AJ03 N02AJ01 N02AA58 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1217 ; ACETOPHENAZINE ; 2751-68-0 ; 1961 ; DISCONTINUED ; TARGET D(1A) DOPAMINE RECEPTOR -- D(2) DOPAMINE RECEPTOR ; ATC (ACETOPHENAZINE) N05AB07 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 1218 ; GUANETHIDINE ; 55-65-2 ; 1960 ; DISCONTINUED ; TARGET NITRIC OXIDE SYNTHASE (PMID10889350) ; ATC (GUANETHIDINE) C02CC02 S01EX01 C02LF01 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1219 ; METHYSERGIDE ; 361-37-5 ; 1962 ; DISCONTINUED ; TARGET 5-HYDROXYTRYPTAMINE 1A RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- 5-HYDROXYTRYPTAMINE 2C RECEPTOR -- 5-HYDROXYTRYPTAMINE 7 RECEPTOR ; ATC (METHYSERGIDE) N02CA04 ; PDB 6DRZ (STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR) - ligand code H8J ; 5-hydroxytryptamine receptor 2B UNIPROT P41595 HTR2B -- 5-hydroxytryptamine receptor 2C UNIPROT P28335 HTR2C 1220 ; CARPHENAZINE ; 2622-30-2 ; 1963 ; DISCONTINUED ; TARGET D(1A) DOPAMINE RECEPTOR -- D(1B) DOPAMINE RECEPTOR -- D(2) DOPAMINE RECEPTOR ; ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1221 ; METAPROTERENOL ; 586-06-1 ; 1973 ; ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (ORCIPRENALINE) R03AB03 R03CB03 R03CB53 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1222 ; METAPROTERENOL ; 586-06-1 ; 1973 ; ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (ORCIPRENALINE) R03AB03 R03CB03 R03CB53 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1223 ; MAFENIDE ; 138-39-6 ; 1969 ; ; TARGET CARBONIC ANHYDRASE (SECONDARY TARGET) ; ATC (MAFENIDE) D06BA03 ; PDB 5JNC (CRYSTAL STRUCTURE FOR THE COMPLEX OF HUMAN CARBONIC ANHYDRASE IV AND 4-AMINOMETHYLBENZENE SULFONAMIDE) - ligand code 6LH ; Dihydropteroate synthase UNIPROT P0AC13 folP 1224 ; MESORIDAZINE ; 5588-33-0 ; 1970 ; DISCONTINUED ; TARGET D(2) DOPAMINE RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR ; ATC (MESORIDAZINE) N05AC03 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1225 ; MESORIDAZINE ; 5588-33-0 ; 1970 ; DISCONTINUED ; TARGET D(2) DOPAMINE RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- ; ATC (MESORIDAZINE) N05AC03 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1226 ; CLORAZEPATE ; 23887-31-2 ; 1972 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA) ; ATC (POTASSIUM CLORAZEPATE) N05BA05 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 1227 ; TERBUTALINE ; 23031-25-6 ; 1974 ; ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (TERBUTALINE) R03AC03 R03CC03 R03CC53 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1228 ; CLORAZEPATE ; 23887-31-2 ; 1972 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA) ; ATC (POTASSIUM CLORAZEPATE) N05BA05 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2 1229 ; TERBUTALINE ; 23031-25-6 ; 1974 ; ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (TERBUTALINE) R03AC03 R03CC03 R03CC53 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1230 ; AZATADINE ; 3964-81-6 ; 1977 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR ; ATC (AZATADINE) R06AX09 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1231 ; CLEMASTINE ; 15686-51-8 ; 1977 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (CLEMASTINE) D04AA14 R06AA04 R06AA54 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1232 ; BETHANIDINE ; 55-73-2 ; 1981 ; DISCONTINUED ; ; ATC (BETANIDINE) C02CC01 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1233 ; CHLORHEXIDINE ; 55-56-1 ; 1976 ; ; ; ATC (CHLORHEXIDINE) A01AB03 B05CA02 D08AC02 D09AA12 R02AA05 S01AX09 S02AA09 S03AA04 A01AB53 D08AC52 ; ; UNKNOWN 1234 ; DESMOPRESSIN ; 16679-58-6 ; 1978 ; ; TARGET VASOPRESSIN V1A RECEPTOR -- VASOPRESSIN V1B RECEPTOR ; ATC (DESMOPRESSIN) H01BA02 ; ; Vasopressin V2 receptor UNIPROT P30518 AVPR2 1235 ; CERULETIDE ; 17650-98-5 ; 0 ; DISCONTINUED ; TARGET CHOLECYSTOKININ TYPE A RECEPTOR ; ATC (CERULETIDE) V04CC04 ; ; Cholecystokinin receptor type A UNIPROT P32238 CCKAR 1236 ; MORPHINE ; 57-27-2 ; 1984 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (MORPHINE) N02AA01 N02AG01 A07DA52 N02AA51 ; PDB 1Q0Y (ANTI-MORPHINE ANTIBODY 9B1 COMPLEXED WITH MORPHINE) - ligand code MOI ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1237 ; NICOTINE ; 54-11-5 ; 1984 ; ; TARGET ACETYLCHOLINE RECEPTOR ; ATC (NICOTINE) N07BA01 ; PDB 5KXI (X-RAY STRUCTURE OF THE HUMAN ALPHA4BETA2 NICOTINIC RECEPTOR) - ligand code NCT ; Neuronal acetylcholine receptor 1238 ; BITOLTEROL ; 30392-40-6 ; 1984 ; DISCONTINUED ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (BITOLTEROL) R03AC17 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1239 ; BITOLTEROL ; 30392-40-6 ; 1984 ; DISCONTINUED ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (BITOLTEROL) R03AC17 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1240 ; PENBUTOLOL ; 38363-40-5 ; 1987 ; DISCONTINUED ; TARGET BETA-1 ADRENERGIC RECEPTOR -- BETA-2 ADRENERGIC RECEPTOR ; ATC (PENBUTOLOL) C07AA23 C07CA23 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1241 ; PIRBUTEROL ; 38677-81-5 ; 1986 ; DISCONTINUED ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (PIRBUTEROL) R03AC08 R03CC07 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1242 ; PIRBUTEROL ; 38677-81-5 ; 1986 ; DISCONTINUED ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (PIRBUTEROL) R03AC08 R03CC07 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1243 ; SUFENTANIL ; 56030-54-7 ; 1984 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (SUFENTANIL) N01AH03 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1244 ; BUTOCONAZOLE ; 64872-76-0 ; 1995 ; ; TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE ; ATC (BUTOCONAZOLE) G01AF15 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 1245 ; BUTOCONAZOLE ; 64872-76-0 ; 1995 ; ; TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE ; ATC (BUTOCONAZOLE) G01AF15 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 1246 ; PENTAMIDINE ; 100-33-4 ; 1984 ; ; TARGET DNA-BINDING -- PROTEIN S100-B -- TRANSCRIPTIONAL REGULATOR QACR ; ATC (PENTAMIDINE ISETHIONATE) P01CX01 ; PDB 1RKW (CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO PENTAMADINE) - ligand code PNT ; UNKNOWN 1247 ; MILRINONE ; 78415-72-2 ; 1987 ; ; TARGET CAMP 3',5'-CYCLIC PHOSPHODIESTERASE 3 ; ATC (MILRINONE) C01CE02 ; PDB 1TLM (STRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX) - ligand code MIL ; cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A 1248 ; PIPECURONIUM ; 68399-58-6 ; 1990 ; DISCONTINUED ; TARGET NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2 ; ATC (PIPECURONIUM BROMIDE) M03AC06 ; ; Acetylcholine receptor UNIPROT P02708 CHRNA1 1249 ; OCTREOTIDE ; 83150-76-9 ; 1988 ; ; TARGET SOMATOSTATIN RECEPTOR TYPE 1 -- SOMATOSTATIN RECEPTOR TYPE 5 -- SUBSTANCE-K RECEPTOR ; ATC (OCTREOTIDE) H01CB02 ; ; Somatostatin receptor type 2 UNIPROT P30874 SSTR2 -- Somatostatin receptor type 3 UNIPROT P32745 SSTR3 1250 ; DOXAZOSIN ; 74191-85-8 ; 1990 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR ; ATC (DOXAZOSIN) C02CA04 G04CA55 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 1251 ; DOXAZOSIN ; 74191-85-8 ; 1990 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR ; ATC (DOXAZOSIN) C02CA04 G04CA55 ; ; Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D 1252 ; GOSERELIN ; 65807-02-5 ; 1989 ; ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR ; ATC (GOSERELIN) L02AE03 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 1253 ; NAFARELIN ; 76932-56-4 ; 1990 ; ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR -- GONADOTROPIN-RELEASING HORMONE II RECEPTOR ; ATC (NAFARELIN) H01CA02 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 1254 ; FENOLDOPAM ; 67227-56-9 ; 1997 ; DISCONTINUED ; TARGET D1 DOPAMINE RECEPTOR ; ATC (FENOLDOPAM) C01CA19 ; ; D(1A) dopamine receptor UNIPROT P21728 DRD1 1255 ; FENOLDOPAM ; 67227-56-9 ; 1997 ; DISCONTINUED ; TARGET D1 DOPAMINE RECEPTOR ; ATC (FENOLDOPAM) C01CA19 ; PDB 7CKW (CRYO-EM STRUCTURE OF FENOLDOPAM BOUND DOPAMINE RECEPTOR DRD1-GS SIGNALING COMPLEX) - ligand code G3C ; D(1A) dopamine receptor UNIPROT P21728 DRD1 1256 ; PAMIDRONATE ; 57248-88-1 ; 1991 ; ; TARGET FARNESYL PYROPHOSPHATE SYNTHASE ; ATC (PAMIDRONIC ACID) M05BA03 ; PDB 5ERO (CRYSTAL STRUCTURE OF ELONGATION DOMAIN OF PHOMOPSIS AMYGDALI FUSICOCCADIENE SYNTHASE COMPLEXED WITH COBALT IONS AND PAMIDRONATE) - ligand code 210 ; Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS 1257 ; SUMATRIPTAN ; 103628-46-2 ; 1992 ; ; TARGET 5-HYDROXYTRYPTAMINE 1D RECEPTOR -- 5-HYDROXYTRYPTAMINE 1B RECEPTOR ; ATC (SUMATRIPTAN) N02CC01 N02CC51 ; ; 5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B -- 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 1258 ; PENTOSAN POLYSULFATE ; 9014-63-5 ; 1996 ; ; TARGET FIBROBLAST GROWTH FACTOR 4 -- HEPARIN-BINDING GROWTH FACTOR 1 -- HEPARIN-BINDING GROWTH FACTOR 2 ; ATC (PENTOSAN POLYSULFATE SODIUM) C05BA04 G04BX15 ; ; UNKNOWN 1259 ; ROCURONIUM ; 143558-00-3 ; 1994 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M2 -- NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2 ; ATC (ROCURONIUM BROMIDE) M03AC09 ; PDB 8F2S (CRYO-EM STRUCTURE OF TORPEDO NICOTINIC ACETYLCHOLINE RECEPTOR IN COMPLEX WITH ROCURONIUM, PORE-BLOCKED STATE) - ligand code RBR ; Acetylcholine receptor UNIPROT P02708 CHRNA1 1260 ; LEVOMETHADYL ACETATE ; 1477-40-3 ; 1993 ; DISCONTINUED ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (LEVACETYLMETHADOL) N07BC03 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1261 ; CYSTEAMINE ; 60-23-1 ; 1994 ; ; ; ATC (MERCAPTAMINE) A16AA04 S01XA21 ; PDB 4CG4 (CRYSTAL STRUCTURE OF THE CHS-B30.2 DOMAINS OF TRIM20) - ligand code DHL ; UNKNOWN 1262 ; IBUTILIDE ; 122647-31-8 ; 1995 ; ; TARGET POTASSIUM CHANNEL ; ATC (IBUTILIDE) C01BD05 ; ; UNKNOWN 1263 ; IBUTILIDE ; 122647-31-8 ; 1995 ; ; TARGET POTASSIUM CHANNEL ; ATC (IBUTILIDE) C01BD05 ; ; UNKNOWN 1264 ; TOREMIFENE ; 89778-26-7 ; 1997 ; ; TARGET ESTROGEN RECEPTOR ; ATC (TOREMIFENE) L02BA02 ; PDB 5JQ7 (CRYSTAL STRUCTURE OF EBOLA GLYCOPROTEIN IN COMPLEX WITH TOREMIFENE) - ligand code T0R ; Estrogen receptor UNIPROT P03372 ESR1 1265 ; ROPIVACAINE ; 84057-95-4 ; 1996 ; ; TARGET SODIUM CHANNEL ; ATC (ROPIVACAINE) N01BB09 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A 1266 ; BALSALAZIDE ; 80573-04-2 ; 2000 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 -- BACTERIAL NADPH AZOREDUCTASE ; ATC (BALSALAZIDE) A07EC04 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1267 ; DOLASETRON ; 115956-12-2 ; 1997 ; DISCONTINUED ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR ; ATC (DOLASETRON) A04AA04 ; ; 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 1268 ; SAQUINAVIR ; 127779-20-8 ; 1995 ; DISCONTINUED ; TARGET HIV-1 PROTEASE (IC50= 37 NANOMOLAR) ; ATC (SAQUINAVIR) J05AE01 ; PDB 3D1Y (CRYSTAL STRUCTURE OF HIV-1 MUTANT I54V AND INHIBITOR SAQUINA) - ligand code ROC ; Pol polyprotein UNIPROT Q72874 pol 1269 ; QUETIAPINE ; 111974-69-7 ; 1997 ; ; TARGET 5-HYDROXYTRYPTAMINE 2 RECEPTOR -- D2 DOPAMINE RECEPTOR ; ATC (QUETIAPINE) N05AH04 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1270 ; PRAMIPEXOLE ; 104632-26-0 ; 1997 ; ; TARGET D3 DOPAMINE RECEPTOR ; ATC (PRAMIPEXOLE) N04BC05 ; PDB 7CMU (DOPAMINE RECEPTOR D3R-GI-PRAMIPEXOLE COMPLEX) - ligand code G6L ; D(2) dopamine receptor UNIPROT P14416 DRD2 1271 ; INDINAVIR ; 150378-17-9 ; 1996 ; DISCONTINUED ; TARGET HIV-1 PROTEASE ; ATC (INDINAVIR) J05AE02 ; PDB 1SGU (COMPARING THE ACCUMULATION OF ACTIVE SITE AND NON-ACTIVE SITE MUTATIONS IN THE HIV-1 PROTEASE) - ligand code MK1 ; Pol polyprotein UNIPROT Q72874 pol 1272 ; DELAVIRDINE ; 136817-59-9 ; 1997 ; DISCONTINUED ; TARGET NON-NUCLEOSIDE REVERSE TRANSCRIPTASE (IC50=38 NANOMOLAR) -- GAG-POL POLYPROTEIN ; ATC (DELAVIRDINE) J05AG02 ; PDB 1KLM (HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152) - ligand code SPP ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1273 ; EMEDASTINE ; 87233-61-2 ; 1997 ; DISCONTINUED ; TARGET HISTAMINE H1 RECEPTOR (KI=1.3 NANOMOLAR) ; ATC (EMEDASTINE) S01GX06 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1274 ; TILUDRONATE ; 89987-06-4 ; 1997 ; DISCONTINUED ; TARGET TYROSINE-PROTEIN PHOSPHATASE ; ATC (TILUDRONIC ACID) M05BA05 ; ; Tyrosine-protein phosphatase non-receptor type 1 UNIPROT P18031 PTPN1 1275 ; EPROSARTAN ; 133040-01-4 ; 1997 ; DISCONTINUED ; TARGET TYPE-1 ANGIOTENSIN II RECEPTOR (AT1) ; ATC (EPROSARTAN) C09CA02 C09DA02 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1276 ; TROVAFLOXACIN ; 147059-72-1 ; 1997 ; DISCONTINUED ; TARGET DNA GYRASE SUBUNIT A -- DNA TOPOISOMERASE 4 SUBUNIT A -- DNA TOPOISOMERASE 2-ALPHA ; ATC (TROVAFLOXACIN) J01MA13 ; PDB 4Z53 (QUINOLONE(TROVAFLOXACIN)-DNA CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM S. PNEUMONIAE) - ligand code TR6 ; Topoisomerase IV UNIPROT P0AFI2 parC -- DNA gyrase UNIPROT P0AES4 gyrA 1277 ; NELFINAVIR ; 159989-64-7 ; 1997 ; ; TARGET HIV-1 PROTEASE ; ATC (NELFINAVIR) J05AE04 ; PDB 3EKX (CRYSTAL STRUCTURE OF THE WILD-TYPE HIV-1 PROTEASE WITH THE INHIBITOR, NELFINAVIR) - ligand code 1UN ; Pol polyprotein UNIPROT Q72874 pol 1278 ; CITALOPRAM ; 59729-33-8 ; 1998 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (CITALOPRAM) N06AB04 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1279 ; ESCITALOPRAM ; 128196-01-0 ; 2002 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (ESCITALOPRAM) N06AB10 ; PDB 5I75 (X-RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH S-CITALOPRAM AT THE CENTRAL SITE AND BR-CITALOPRAM AT THE ALLOSTERIC SITE) - ligand code 68P ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1280 ; CLOPIDOGREL ; 113665-84-2 ; 1997 ; ; TARGET P2Y PURINOCEPTOR 12 ; ATC (CLOPIDOGREL) B01AC04 ; PDB 3ME6 (CRYSTAL STRUCTURE OF CYTOCHROME 2B4 IN COMPLEX WITH THE ANTI-PLATELET DRUG CLOPIDOGREL) - ligand code CGE ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1281 ; RIZATRIPTAN ; 144034-80-0 ; 1998 ; ; TARGET 5-HYDROXYTRYPTAMINE 1D RECEPTOR -- 5-HYDROXYTRYPTAMINE 1B -- MONOAMINE OXIDASE TYPE A (MAO-A) ; ATC (RIZATRIPTAN) N02CC04 ; ; 5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B -- 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 1282 ; SILDENAFIL ; 139755-83-2 ; 1998 ; ; TARGET PHOSPHODIESTERASE TYPE 5 (PDE5) ; ATC (SILDENAFIL) G04BE03 ; ; cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A 1283 ; ABACAVIR ; 136470-78-5 ; 1998 ; ; TARGET GLUCURONOSYLTRANSFERASE -- ALCOHOL DEHYDROGENASE -- GAG-POL POLYPROTEIN ; ATC (ABACAVIR) J05AF06 J05AR02 J05AR13 J05AR04 ; PDB 5U98 (THE CRYSTAL STRUCTURE OF A SELF-PEPTIDE COMPLEXED TO ABACAVIR AND HLA-B*57:01) - ligand code 1KX ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1284 ; RAPACURONIUM ; 465499-11-0 ; 1999 ; DISCONTINUED ; TARGET CHOLINERGIC RECEPTOR ; ; ; Muscle-type nicotinic acetylcholine receptor UNIPROT P02708 CHRNA1 1285 ; ALMOTRIPTAN ; 154323-57-6 ; 2001 ; ; TARGET 5-HYDROXYTRYPTAMINE 1D RECEPTOR -- 5-HYDROXYTRYPTAMINE 1B RECEPTOR -- 5-HYDROXYTRYPTAMINE 1F RECEPTOR ; ATC (ALMOTRIPTAN) N02CC05 ; ; 5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B -- 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 1286 ; FROVATRIPTAN ; 158747-02-5 ; 2001 ; ; TARGET 5-HYDROXYTRYPTAMINE 1D RECEPTOR -- 5-HYDROXYTRYPTAMINE 1B RECEPTOR ; ATC (FROVATRIPTAN) N02CC07 ; ; 5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B -- 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D 1287 ; ROSIGLITAZONE ; 122320-73-4 ; 1999 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA ; ATC (ROSIGLITAZONE) A10BD04 A10BD03 A10BG02 ; PDB 1ZGY (STRUCTURAL AND BIOCHEMICAL BASIS FOR SELECTIVE REPRESSION OF THE ORPHAN NUCLEAR RECEPTOR LRH-1 BY SHP) - ligand code BRL ; Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 1288 ; ROSIGLITAZONE ; 122320-73-4 ; 1999 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA ; ATC (ROSIGLITAZONE) A10BD04 A10BD03 A10BG02 ; ; Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 1289 ; OSELTAMIVIR ; 196618-13-0 ; 1999 ; ; TARGET NEURAMINIDASE ; ATC (OSELTAMIVIR) J05AH02 ; ; Neuraminidase UNIPROT P03468 -- Neuraminidase UNIPROT P03474 1290 ; GALANTAMINE ; 357-70-0 ; 2001 ; ; TARGET CHOLINESTERASE ; ATC (GALANTAMINE) N06DA04 ; PDB 1QTI (ACETYLCHOLINESTERASE (E.C.3.1.1.7)) - ligand code GNT ; Acetylcholinesterase UNIPROT P22303 ACHE 1291 ; CASPOFUNGIN ; 162808-62-0 ; 2001 ; ; TARGET BETA-1,3-GLUCAN SYNTHASE ; ATC (CASPOFUNGIN) J02AX04 ; ; Beta-1,3-glucan synthase catalytic subunit 1 UNIPROT O13428 GSC1 -- 1,3-beta-glucan synthase catalytic subunit FksP UNIPROT Q4WLT4 1292 ; IMATINIB ; 152459-95-5 ; 2001 ; ; TARGET BCR-ABL TYROSINE KINASE -- PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGF) -- STEM CELL FACTOR (SCF) -- C-KIT ; ATC (IMATINIB) L01EA01 ; PDB 3MSS (ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE) - ligand code STI ; Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 1293 ; SERTACONAZOLE ; 99592-32-2 ; 2003 ; ; TARGET CYTOCHROME P450 ; ATC (SERTACONAZOLE) D01AC14 G01AF19 ; PDB 1TQN (HUMAN MICROSOMAL P450 3A4) ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 1294 ; SERTACONAZOLE ; 99592-32-2 ; 2003 ; ; TARGET CYTOCHROME P450 ; ATC (SERTACONAZOLE) D01AC14 G01AF19 ; PDB 1TQN (HUMAN MICROSOMAL P450 3A4) ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 1295 ; TIOTROPIUM ; 186691-13-4 ; 2004 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR (M1-M5) ; ATC (TIOTROPIUM BROMIDE) R03AL10 R03AL06 R03BB04 R03BB54 ; PDB 4DAJ (STRUCTURE OF THE M3 MUSCARINIC ACETYLCHOLINE RECEPTOR) - ligand code 0HK ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1296 ; METHYL AMINOLEVULINATE ; 33320-16-0 ; 2004 ; DISCONTINUED ; ; ATC (METHYL AMINOLEVULINATE) L01XD03 ; ; UNKNOWN 1297 ; PEMETREXED ; 137281-23-3 ; 2004 ; ; TARGET THYMIDYLATE SYNTHASE (TS) -- DIHYDROFOLATE REDUCTASE (DHFR) -- GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE (GARFT) ; ATC (PEMETREXED) L01BA04 ; PDB 1JUJ (HUMAN THYMIDYLATE SYNTHASE BOUND TO DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE) - ligand code LYA ; Thymidylate synthase UNIPROT P04818 TYMS -- Dihydrofolate reductase UNIPROT P00374 DHFR 1298 ; DARIFENACIN ; 133099-04-4 ; 2004 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M3 ; ATC (DARIFENACIN) G04BD10 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1299 ; SOLIFENACIN ; 242478-37-1 ; 2004 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (SOLIFENACIN) G04BD08 G04CA53 ; ; Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1300 ; ATAZANAVIR ; 198904-31-3 ; 2003 ; ; TARGET HIV-1 PROTEASE ; ATC (ATAZANAVIR) J05AE08 J05AR15 J05AR23 ; PDB 3EKW (CRYSTAL STRUCTURE OF THE INHIBITOR ATAZANAVIR (ATV) IN COMPLEX WITH A MULTI-DRUG RESISTANCE HIV-1 PROTEASE VARIANT (L10I, G48V, I54V, V64I, V82A) REFER: FLAP+ IN CITATION) - ligand code DR7 ; Pol polyprotein UNIPROT Q72874 pol 1301 ; TETRACAINE ; 94-24-6 ; 2005 ; ; TARGET SODIUM CHANNEL ; ATC (TETRACAINE) C05AD02 D04AB06 N01BA03 S01HA03 N01BA53 ; PDB 4OMW (CRYSTAL STRUCTURE OF GOAT BETA-LACTOGLOBULIN (ORTHORHOMBIC FORM)) - ligand code TE4 ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A 1302 ; RASAGILINE ; 136236-51-6 ; 2006 ; ; TARGET MONOAMINE OXIDASE TYPE A (MAO-A) -- MONOAMINE OXIDASE TYPE B (MAO-B) -- APOPTOSIS REGULATOR BCL-2 -- AMINE OXIDASE [FLAVIN-CONTAINING] B ; ATC (RASAGILINE) N04BD02 ; PDB 2C75 (FUNCTIONAL ROLE OF THE AROMATIC CAGE IN HUMAN MONOAMINE OXIDASE B: STRUCTURES AND CATALYTIC PROPERTIES OF TYR435 MUTANT PROTEINS) - ligand code RSA ; Amine oxidase flavin-containing B UNIPROT P27338 MAOB 1303 ; SORAFENIB ; 284461-73-0 ; 2005 ; ; TARGET CRAF -- BRAF -- MUTANT BRAF -- KIT -- FLT-3 -- RET -- VEGFR-1 -- VEGFR-2 -- VEGFR-3 -- PDGFR-BETA ; ATC (SORAFENIB) L01EX02 ; PDB 1UWJ (THE COMPLEX OF MUTANT V599E B-RAF AND BAY439006.) - ligand code BAX ; Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT 1304 ; SUNITINIB ; 557795-19-4 ; 2006 ; ; TARGET OF PLATELET-DERIVED GROWTH FACTOR RECEPTORS (PDGFRALPHA AND PDGFRBETA) -- VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS (VEGFR1, VEGFR2 AND VEGFR3) -- STEM CELL FACTOR RECEPTOR (KIT) -- FMS-LIKE TYROSINE KINASE-3 (FLT3) -- COLONY STIMULATING FACTOR RECEPTOR TYPE 1 (CSF-1R) -- GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR (RET) ; ATC (SUNITINIB) L01EX01 ; PDB 2Y7J (STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2) - ligand code B49 ; Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT 1305 ; DARUNAVIR ; 206361-99-1 ; 2006 ; ; TARGET HIV-1 PROTEASE ; ATC (DARUNAVIR) J05AE10 J05AR14 J05AR26 J05AR22 ; PDB 4Q1W (MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE) - ligand code 017 ; Pol polyprotein UNIPROT Q72874 pol 1306 ; LISDEXAMFETAMINE ; 608137-32-2 ; 2007 ; ; TARGET MONOAMINE TRANSPORTER ; ATC (DEXAMFETAMINE) N06BA02 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1307 ; ALISKIREN ; 173334-57-1 ; 2007 ; ; TARGET RENIN ; ATC (ALISKIREN) C09XA02 C09XA53 C09XA52 C09XA54 C09DX02 ; PDB 2V0Z (CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 10 (ALISKIREN)) - ligand code C41 ; Renin UNIPROT P00797 REN 1308 ; SITAGLIPTIN ; 486460-32-6 ; 2006 ; ; TARGET DIPEPTIDYL PEPTIDASE 4 (DPP-4) ; ATC (SITAGLIPTIN) A10BD07 A10BD12 A10BH01 A10BD29 A10BD24 A10BH51 ; PDB 4FFW (CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPP4, DPP-IV, CD26) IN COMPLEX WITH FAB + SITAGLIPTIN) - ligand code 715 ; Dipeptidyl peptidase 4 UNIPROT P27487 DPP4 1309 ; LAPATINIB ; 231277-92-2 ; 2007 ; ; TARGET HUMAN EPIDERMAL RECEPTOR TYPE 2 (RECEPTOR TYROSINE-PROTEIN KINASE HER2 ERBB-2 KI = 3 NANOMOLAR) -- EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR KI = 13 NANOMOLAR) ; ATC (LAPATINIB) L01EH01 ; PDB 1XKK (EGFR KINASE DOMAIN COMPLEXED WITH A QUINAZOLINE INHIBITOR- GW572016) - ligand code FMM ; Epidermal growth factor receptor UNIPROT P00533 EGFR -- Receptor tyrosine-protein kinase erbB-2 UNIPROT P04626 ERBB2 1310 ; NILOTINIB ; 641571-10-0 ; 2007 ; ; TARGET BCR-ABL TYROSINE KINASE ; ATC (NILOTINIB) L01EA03 ; PDB 3CS9 (HUMAN ABL KINASE IN COMPLEX WITH NILOTINIB) - ligand code NIL ; Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 1311 ; BACITRACIN ; 1405-87-4 ; 1948 ; ; TARGET UNDECAPRENYL PYROPHOSPHATE (C55-PP) ; ATC (BACITRACIN) D06AX05 J01XX10 R02AB04 S01AA32 ; ; UNKNOWN 1312 ; COLISTIN ; 1066-17-7 ; 1962 ; ; TARGET MEMBRANE ; ATC (COLISTIN) A07AA10 J01XB01 ; ; UNKNOWN 1313 ; BLEOMYCIN ; 11056-06-7 ; 1973 ; ; TARGET DNA ; ATC (BLEOMYCIN) L01DC01 ; PDB 1JIE (BLEOMYCIN-BINDING PROTEIN FROM BLEOMYCIN-PRODUCING STREPTOMYCES VERTICILLUS) - ligand code BLM ; UNKNOWN 1314 ; TOBRAMYCIN ; 32986-56-4 ; 1975 ; ; TARGET 30S RIBOSOMAL PROTEIN S12 -- 16S RRNA ; ATC (TOBRAMYCIN) J01GB01 S01AA12 ; PDB 4LFC (CRYSTAL STRUCTURE OF 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS) - ligand code TOY ; UNKNOWN 1315 ; MEZLOCILLIN ; 51481-65-3 ; 1981 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (MEZLOCILLIN) J01CA10 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1316 ; BENZOYL PEROXIDE ; 94-36-0 ; 1984 ; ; ; ATC (BENZOYL PEROXIDE) D10AE01 D10AE51 ; ; UNKNOWN 1317 ; CEFOTETAN ; 69712-56-7 ; 1985 ; ; TARGET PENICILLIN BINDING PROTEINS (PBPS) ; ATC (CEFOTETAN) J01DC05 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1318 ; KANAMYCIN ; 59-01-8 ; 1973 ; DISCONTINUED ; TARGET AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB -- KANAMYCIN NUCLEOTIDYLTRANSFERASE ; ATC (KANAMYCIN) A07AA08 J01GB04 S01AA24 ; PDB 4FEX (CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR TYRPHOSTIN AG1478) - ligand code KAN ; UNKNOWN 1319 ; HYDROXYAMPHETAMINE ; 103-86-6 ; 1969 ; DISCONTINUED ; TARGET MONOAMINE TRANSPORTER ; ATC (AMFETAMINE) N06BA01 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1320 ; METHYLTESTOSTERONE ; 58-18-4 ; 1971 ; ; TARGET ANDROGEN RECEPTOR (AR) ; ATC (METHYLTESTOSTERONE) G03BA02 G03EK01 G03EA01 ; ; Androgen receptor UNIPROT P10275 AR 1321 ; MENADIOL ; 481-85-6 ; 1941 ; DISCONTINUED ; ; ; PDB 4HQM (THE CRYSTAL STRUCTURE OF QSRR-MENADIONE COMPLEX) - ligand code 17Z ; UNKNOWN 1322 ; EQUILIN ; 474-86-2 ; 1942 ; ; TARGET ESTROGEN RECEPTOR (ER) -- ESTRADIOL 17-BETA-DEHYDROGENASE 1 ; ATC (CONJUGATED ESTROGENS) G03CA57 G03CC07 ; PDB 1EQU (TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EQUILIN COMPLEXED WITH NADP+) - ligand code EQI ; Estrogen receptor UNIPROT P03372 ESR1 -- Estrogen receptor beta UNIPROT Q92731 ESR2 1323 ; DEXPANTHENOL ; 81-13-0 ; 1947 ; ; ; ATC (DEXPANTHENOL) A11HA30 D03AX03 S01XA12 ; ; UNKNOWN 1324 ; RIBOFLAVIN PHOSPHATE ; 146-17-8 ; 1947 ; ; TARGET CYTOCHROME B2 MITOCHONDRIAL ; ATC (RIBOFLAVIN) S01XA26 A11HA04 ; PDB 6CNY (2.3 ANGSTROM STRUCTURE OF PHOSPHODIESTERASE TREATED VIVID (COMPLEX WITH FMN)) - ligand code FMN ; UNKNOWN 1325 ; VITAMIN A PALMITATE ; 79-81-2 ; 1947 ; ; ; ATC (RETINOL ; ; Retinol-binding protein 4 UNIPROT P02753 RBP4 1326 ; ABAMETAPIR ; 1762-34-1 ; 2020 ; DISCONTINUED ; TARGET METALLOPROTEINASE ; ATC (ABAMETAPIR) P03AX07 ; PDB 5ARC (COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE) - ligand code EL3 ; UNKNOWN 1327 ; HYDROCORTISONE CYPIONATE ; 508-99-6 ; 1955 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (HYDROCORTISONE) A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01 D07AC16 D07CA01 S01CA03 S02CA03 S03CA04 D07BA04 S01BB01 D07AB11 D07AB02 D07BB04 R01AD60 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1328 ; HYDROCORTISONE PROBUTATE ; 72590-77-3 ; 1997 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (HYDROCORTISONE BUTEPRATE) D07AB11 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1329 ; TYROSINE ; 60-18-4 ; 0 ; DISCONTINUED ; TARGET TYROSYL-TRNA SYNTHETASE ; ; PDB 4P6R (CRYSTAL STRUCTURE OF TYROSINASE FROM BACILLUS MEGATERIUM WITH TYROSINE IN THE ACTIVE SITE) - ligand code TYR ; Large neutral amino acids transporter small subunit 1 UNIPROT Q01650 SLC7A5 1330 ; PROPOXYCAINE ; 86-43-1 ; 0 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ; ; Sodium channel alpha subunits 1331 ; PROTOKYLOL ; 912804-63-8 ; 0 ; DISCONTINUED ; TARGET BETA2-ADRENERGIC RECEPTOR -- BETA 1-ADRENERGIC RECEPTOR ; ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1332 ; DEXTROAMPHETAMINE ; 51-64-9 ; 1955 ; ; TARGET NORADRENALINE TRANSPORTER (NAT) -- DOPAMINE TRANSPORTER (DAT) ; ATC (DEXAMFETAMINE) N06BA02 ; PDB 4XP9 (X-RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO PSYCHOSTIMULANT D-AMPHETAMINE) - ligand code 1WE ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1333 ; TRIMETHAPHAN ; 7187-66-8 ; 1954 ; DISCONTINUED ; TARGET NICOTINIC ACETYLCHOLINE RECEPTOR ; ATC (TRIMETAPHAN) C02BA01 ; ; Neuronal acetylcholine receptor 1334 ; TESTOSTERONE ENANTHATE ; 315-37-7 ; 1953 ; ; TARGET ANDROGEN RECEPTOR ; ATC (TESTOSTERONE) G03BA03 G03EA02 ; ; Androgen receptor UNIPROT P10275 AR 1335 ; TESTOSTERONE CYPIONATE ; 58-20-8 ; 1978 ; ; TARGET ANDROGEN RECEPTOR ; ATC (TESTOSTERONE) G03BA03 G03EA02 ; ; Androgen receptor UNIPROT P10275 AR 1336 ; HEXAFLUORENIUM ; 4844-10-4 ; 0 ; DISCONTINUED ; TARGET CHOLINESTERASE (CHE) (PMID948350) ; ; ; Acetylcholinesterase UNIPROT P22303 ACHE 1337 ; PREDNISOLONE TEBUTATE ; 7681-14-3 ; 1956 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (PREDNISOLONE) L02BX53 A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02 D07CA03 S01CA02 S02CA01 S03CA02 D07BA01 S01BB02 V03AB05 A01AC54 R01AD52 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1338 ; HEXOCYCLIUM ; 6004-98-4 ; 1957 ; DISCONTINUED ; TARGET MUSCARINIC RECEPTOR ; ATC (HEXOCYCLIUM) A03AB10 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1339 ; HEXOCYCLIUM ; 6004-98-4 ; 1957 ; DISCONTINUED ; TARGET MUSCARINIC RECEPTOR ; ATC (HEXOCYCLIUM) A03AB10 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1340 ; METHYLPREDNISOLONE ACETATE ; 53-36-1 ; 1959 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (METHYLPREDNISOLONE) D07AA01 D10AA02 H02AB04 D07AC14 D07CA02 S01CA08 S03CA07 H02BX01 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1341 ; TRIAMCINOLONE HEXACETONIDE ; 5611-51-8 ; 1969 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (TRIAMCINOLONE) A01AC01 C05AA12 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05 D07CB01 S02CA04 D07BB03 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1342 ; TROLAMINE ; 102-71-6 ; 1958 ; DISCONTINUED ; ; ATC (TROLAMINE) D03AX12 ; PDB 2HMP (UNCOMPLEXED ACTIN CLEAVED WITH PROTEASE ECP32) - ligand code 211 ; UNKNOWN 1343 ; FLUPHENAZINE ENANTHATE ; 2746-81-8 ; 1967 ; DISCONTINUED ; TARGET DOPAMINE D2 RECEPTOR ; ATC (FLUPHENAZINE) N05AB02 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- D(2) dopamine receptor UNIPROT P14416 DRD2 1344 ; FLUPHENAZINE DECANOATE ; 5002-47-1 ; 1972 ; ; TARGET D2 DOPAMINE RECEPTOR ; ATC (FLUPHENAZINE) N05AB02 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- D(2) dopamine receptor UNIPROT P14416 DRD2 1345 ; NANDROLONE PHENPROPIONATE ; 62-90-8 ; 1959 ; DISCONTINUED ; TARGET ANDROGEN RECEPTOR (AR) ; ATC (NANDROLONE) A14AB01 S01XA11 ; ; Androgen receptor UNIPROT P10275 AR 1346 ; NANDROLONE DECANOATE ; 360-70-3 ; 1962 ; DISCONTINUED ; TARGET ANDROGEN RECEPTOR (AR) ; ATC (NANDROLONE) A14AB01 S01XA11 ; ; Androgen receptor UNIPROT P10275 AR 1347 ; FLUPREDNISOLONE ; 53-34-9 ; 1978 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1348 ; BETAMETHASONE BENZOATE ; 22298-29-9 ; 1974 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BETAMETHASONE) A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03 D07CC01 S01CA05 S03CA06 D07BC01 S01BB04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1349 ; BETAMETHASONE DIPROPIONATE ; 5593-20-4 ; 1975 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BETAMETHASONE) A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03 D07CC01 S01CA05 S03CA06 D07BC01 S01BB04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1350 ; PARAMETHASONE ACETATE ; 1597-82-6 ; 1961 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (PARAMETHASONE) H02AB05 ; ; UNKNOWN 1351 ; STANOZOLOL ; 10418-03-8 ; 1962 ; DISCONTINUED ; TARGET ESTROGEN RECEPTOR (PMID22906881) -- ANDROGEN RECEPTOR ; ATC (STANOZOLOL) A14AA02 ; ; Androgen receptor UNIPROT P10275 AR 1352 ; LEVOPROPOXYPHENE ; 2338-37-6 ; 1962 ; DISCONTINUED ; TARGET SODIUM CHANNEL -- HERG -- OPIOID RECEPTOR ; ATC (DEXTROPROPOXYPHENE) N02AC04 N02AC54 N02AC74 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1353 ; DROMOSTANOLONE PROPIONATE ; 521-12-0 ; 0 ; DISCONTINUED ; TARGET ANDROGEN RECEPTOR ; ; ; Androgen receptor UNIPROT P10275 AR 1354 ; SULFAPHENAZOLE ; 526-08-9 ; 1974 ; DISCONTINUED ; TARGET CYTOCHROME P450 (PMID22674719) ; ATC (SULFAPHENAZOLE) J01ED08 ; ; Dihydropteroate synthase UNIPROT P0AC13 folP 1355 ; METHIXENE ; 4969-02-2 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (METIXENE) N04AA03 ; ; 5-hydroxytryptamine receptor 2C UNIPROT P28335 HTR2C -- Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 1356 ; METHIXENE ; 4969-02-2 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (METIXENE) N04AA03 ; ; 5-hydroxytryptamine receptor 2C UNIPROT P28335 HTR2C -- Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 1357 ; PIPERACETAZINE ; 3819-00-9 ; 1969 ; DISCONTINUED ; ; ; ; UNKNOWN 1358 ; CHLORPHENESIN CARBAMATE ; 886-74-8 ; 1965 ; DISCONTINUED ; ; ATC (CHLORPHENESIN) D01AE07 ; ; UNKNOWN 1359 ; CHLORPHENESIN CARBAMATE ; 886-74-8 ; 1965 ; DISCONTINUED ; ; ATC (CHLORPHENESIN) D01AE07 ; ; UNKNOWN 1360 ; LEVOMEPROMAZINE ; 60-99-1 ; 0 ; DISCONTINUED ; TARGET MUSCARINIC CHOLINERGIC RECEPTORS (PMID2899826) -- HISTAMINE H1 RECEPTOR (PMID2899826) -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR ; ATC (LEVOMEPROMAZINE) N05AA02 ; ; UNKNOWN 1361 ; HALOPERIDOL LACTATE ; 75478-79-4 ; 1967 ; ; TARGET D(1A) DOPAMINE RECEPTOR -- D(2) DOPAMINE RECEPTOR ; ATC (HALOPERIDOL) N05AD01 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 1362 ; HALOPERIDOL DECANOATE ; 74050-97-8 ; 1986 ; ; TARGET DOPAMINE D2 RECEPTOR ; ATC (HALOPERIDOL) N05AD01 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- D(2) dopamine receptor UNIPROT P14416 DRD2 1363 ; MEPREDNISONE ; 1247-42-3 ; 1978 ; DISCONTINUED ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (MEPREDNISONE) H02AB15 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1364 ; ETHACRYNATE ; 6463-21-4 ; 1967 ; ; ; ATC (ETACRYNIC ACID) C03CC01 ; PDB 11GS (GLUTATHIONE S-TRANSFERASE COMPLEXED WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE (FORM II)) - ligand code EAA ; Solute carrier family 12 member 1 UNIPROT Q13621 SLC12A1 1365 ; METHENAMINE ; 100-97-0 ; 1967 ; ; ; ATC (METHENAMINE) J01XX05 G04BX17 ; ; UNKNOWN 1366 ; HIPPURATE ; 495-69-2 ; 1967 ; ; ; ; ; UNKNOWN 1367 ; LYPRESSIN ; 50-57-7 ; 0 ; DISCONTINUED ; TARGET VASOPRESSIN V1 RECEPTOR -- VASOPRESSIN V2 RECEPTOR ; ATC (LYPRESSIN) H01BA03 ; ; Vasopressin receptor UNIPROT P30518 AVPR2 1368 ; TRICLOFOS ; 306-52-5 ; 0 ; DISCONTINUED ; ; ATC (TRICLOFOS) N05CM07 ; ; GABA-A receptor 1369 ; OXYMETHOLONE ; 434-07-1 ; 1972 ; DISCONTINUED ; TARGET ANDROGEN RECEPTOR ; ATC (OXYMETHOLONE) A14AA05 ; ; Androgen receptor UNIPROT P10275 AR 1370 ; THONZONIUM ; 553-08-2 ; 1962 ; ; ; ; ; Insulin-degrading enzyme UNIPROT P14735 IDE 1371 ; CEFADROXIL ; 50370-12-2 ; 1978 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B -- OLIGOPEPTIDE TRANSPORTER, SMALL INTESTINE ISOFORM -- OLIGOPEPTIDE TRANSPORTER, KIDNEY ISOFORM ; ATC (CEFADROXIL) J01DB05 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1372 ; SULBACTAM ; 68373-14-8 ; 1986 ; ; TARGET BETA-LACTAMASE ; ATC (SULBACTAM) J01CG01 ; PDB 4FH2 (STRUCTURE OF S70C BETA-LACTAMASE BOUND TO SULBACTAM) - ligand code 0RN ; Beta-lactamase TEM UNIPROT P62593 bla 1373 ; VIOMYCIN ; 32988-50-4 ; 0 ; DISCONTINUED ; TARGET 70S RIBOSOME ; ; PDB 4V7L (THE STRUCTURES OF VIOMYCIN BOUND TO THE 70S RIBOSOME) ; UNKNOWN 1374 ; PROTOKYLOL ; 912804-64-9 ; 0 ; DISCONTINUED ; TARGET BETA2-ADRENERGIC RECEPTOR -- BETA 1-ADRENERGIC RECEPTOR ; ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1375 ; BENOXINATE ; 99-43-4 ; 1975 ; ; ; ATC (OXYBUPROCAINE) D04AB03 S01HA02 ; ; Sodium channel protein type 10 subunit alpha UNIPROT Q9Y5Y9 SCN10A -- Sodium channel alpha subunits 1376 ; MEBUTAMATE ; 64-55-1 ; 0 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR (GABA) ; ATC (MEBUTAMATE) N05BC04 ; ; UNKNOWN 1377 ; MEBUTAMATE ; 64-55-1 ; 0 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR (GABA) ; ATC (MEBUTAMATE) N05BC04 ; ; UNKNOWN 1378 ; GLYBURIDE ; 10238-21-8 ; 1984 ; ; TARGET ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL ; ATC (GLIBENCLAMIDE) A10BB01 ; PDB 5IFU (CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE (PRORS, PROLINE--TRNA LIGASE) FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH GLYBURIDE) - ligand code GBM ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 1379 ; ALBUTEROL ; 18559-94-9 ; 1981 ; ; TARGET BETA2-ADRENERGIC ; ATC (SALBUTAMOL) R03AC02 R03CC02 R03AK13 R03AK15 R03AL02 R03AK04 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1380 ; BETA CAROTENE ; 7235-40-7 ; 0 ; DISCONTINUED ; TARGET BETA,BETA-CAROTENE 15,15PRIME-MONOOXYGENASE ; ATC (BETACAROTENE) A11CA02 D02BB01 ; PDB 5MX2 (PHOTOSYSTEM II DEPLETED OF THE MN4CAO5 CLUSTER AT 2.55 A RESOLUTION) - ligand code BCR ; UNKNOWN 1381 ; PROTIRELIN ; 24305-27-9 ; 1976 ; DISCONTINUED ; ; ATC (PROTIRELIN) V04CJ02 ; ; Thyrotropin-releasing hormone receptor UNIPROT P34981 TRHR 1382 ; SINCALIDE ; 25126-32-3 ; 1976 ; ; ; ATC (SINCALIDE) V04CC03 ; ; Cholecystokinin receptor type A UNIPROT P32238 CCKAR 1383 ; DIFLORASONE DIACETATE ; 33564-31-7 ; 1977 ; ; TARGET GLUCOCORTICOID RECEPTORS ; ATC (DIFLORASONE) D07AC10 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1384 ; ETIDOCAINE ; 36637-18-0 ; 1976 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ATC (ETIDOCAINE) N01BB07 N01BB57 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A 1385 ; ETIDOCAINE ; 36637-18-0 ; 1976 ; DISCONTINUED ; TARGET SODIUM CHANNEL ; ATC (ETIDOCAINE) N01BB07 N01BB57 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A 1386 ; CLOCORTOLONE PIVALATE ; 34097-16-0 ; 1977 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (CLOCORTOLONE) D07AB21 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1387 ; BRETYLIUM ; 59-41-6 ; 1986 ; DISCONTINUED ; TARGET SODIUM/POTASSIUM-TRANSPORTING ATPASE ; ATC (BRETYLIUM TOSYLATE) C01BD02 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1388 ; SARALASIN ; 34273-10-4 ; 0 ; DISCONTINUED ; TARGET ANGIOTENSIN II RECEPTOR ; ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1389 ; ESTRAMUSTINE PHOSPHATE ; 4891-15-0 ; 1981 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ESTRAMUSTINE) L01XX11 ; ; Estrogen receptor beta UNIPROT Q92731 ESR2 1390 ; CALCIFEDIOL ; 19356-17-3 ; 1980 ; ; TARGET 25(OH)D-1ALPHA-HYDROXYLASE ; ATC (CALCIFEDIOL) A11CC06 H05BX05 ; PDB 1J78 (CRYSTALLOGRAPHIC ANALYSIS OF THE HUMAN VITAMIN D BINDING PROTEIN) - ligand code VDY ; Vitamin D3 receptor UNIPROT P11473 VDR 1391 ; GLUTATHIONE DISULFIDE ; 27025-41-8 ; 1981 ; ; TARGET GLUTATHIONE S-TRANSFERASE MU 2 ; ATC (GLUTATHIONE) V03AB32 ; PDB 4ZB6 (CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE URE2P4 FROM PHANEROCHAETE CHRYSOSPORIUM IN COMPLEX WITH OXIDIZED GLUTATHIONE.) - ligand code GDS ; GLUTATHIONE REDUCTASE CHEMBL CHEMBL2755 GLUTATHIONE REDUCTASE UNIPROT P00390 GLUTATHIONE REDUCTASE, MITOCHONDRIAL HOMO SAPIENS ENZYME REDUCTASE 1392 ; DRONABINOL ; 1972-08-3 ; 1985 ; ; TARGET CANNABINOID RECEPTOR ; ATC (DRONABINOL) A04AD10 ; PDB 7M6M (FULL LENGTH ALPHA1 GLYCINE RECEPTOR IN PRESENCE OF 32UM TETRAHYDROCANNABINOL) - ligand code TCI ; Cannabinoid receptor 1 UNIPROT P21554 CNR1 1393 ; INAMRINONE ; 60719-84-8 ; 1984 ; ; TARGET PHOSPHODIESTERASE 3 ; ATC (AMRINONE) C01CE01 ; ; cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A 1394 ; ALCLOMETASONE DIPROPIONATE ; 66734-13-2 ; 1982 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (ALCLOMETASONE) D07AB10 S01BA10 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1395 ; ETOPOSIDE PHOSPHATE ; 117091-64-2 ; 1996 ; ; TARGET DNA TOPOISOMERASE 2 ; ATC (ETOPOSIDE) L01CB01 ; ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 1396 ; ENALAPRILAT ; 76420-72-9 ; 1988 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME (ACE) ; ATC (ENALAPRILAT) C09AA02 ; PDB 1UZE (COMPLEX OF THE ANTI-HYPERTENSIVE DRUG ENALAPRILAT AND THE HUMAN TESTICULAR ANGIOTENSIN I-CONVERTING ENZYME) - ligand code EAL ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1397 ; TIOPRONIN ; 1953-02-2 ; 1988 ; ; ; ATC (TIOPRONIN) G04BX16 ; ; UNKNOWN 1398 ; TIOPRONIN ; 1953-02-2 ; 1988 ; ; ; ATC (TIOPRONIN) G04BX16 ; PDB 5A5Z (APPROVED DRUGS CONTAINING THIOLS AS INHIBITORS OF METALLO-BETA- LACTAMASES: STRATEGY TO COMBAT MULTIDRUG-RESISTANT BACTERIA) - ligand code WJZ ; UNKNOWN 1399 ; MESALAMINE ; 89-57-6 ; 1987 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (MESALAZINE) A07EC02 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1400 ; ACRIVASTINE ; 87848-99-5 ; 1994 ; DISCONTINUED ; TARGET HISTAMINE H1-RECEPTOR (PMID1715267) ; ATC (ACRIVASTINE) R06AX18 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1401 ; HISTRELIN ; 76712-82-8 ; 1991 ; ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR ; ATC (HISTRELIN) L02AE05 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 1402 ; EFLORNITHINE ; 70052-12-9 ; 1990 ; DISCONTINUED ; TARGET ORNITHINE DECARBOXYLASE (ODC) ; ATC (EFLORNITHINE) D11AX16 L01XX79 P01CX03 ; PDB 3GN0 (CRYSTAL STRUCTURE OF HUMAN ARGINASE I IN COMPLEX WITH DIFLUOROMETHYLORNITHINE (DFMO)) - ligand code DMO ; Ornithine decarboxylase UNIPROT P11926 ODC1 -- Ornithine decarboxylase UNIPROT Q9TZZ6 1403 ; FLUTICASONE FUROATE ; 397864-44-7 ; 2007 ; ; TARGET HUMAN GLUCOCORTICOID RECEPTOR ; ATC (FLUTICASONE FUROATE) R01AD12 R03BA09 R03AK10 R03AL08 ; PDB 3CLD (LIGAND BINDING DOMAIN OF THE GLUCOCORTICOID RECEPTOR COMPLEXED WITH FLUTICAZONE FUROATE) - ligand code GW6 ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1404 ; COLFOSCERIL PALMITATE ; 63-89-8 ; 1990 ; DISCONTINUED ; ; ATC (COLFOSCERIL PALMITATE) R07AA01 ; PDB 2YGO (WIF DOMAIN-EGF-LIKE DOMAIN 1 OF HUMAN WNT INHIBITORY FACTOR 1 IN COMPLEX WITH 1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE) - ligand code PCF ; UNKNOWN 1405 ; OCTINOXATE ; 5466-77-3 ; 1992 ; DISCONTINUED ; ; ATC (OCTINOXATE) D02BA02 ; ; UNKNOWN 1406 ; OCTINOXATE ; 5466-77-3 ; 1992 ; DISCONTINUED ; ; ATC (OCTINOXATE) D02BA02 ; ; UNKNOWN 1407 ; TORSEMIDE ; 56211-40-6 ; 1993 ; ; TARGET NA+/K+/2CL- CARRIER SYSTEM ; ATC (TORASEMIDE) C03CA04 ; ; Solute carrier family 12 member 1 UNIPROT Q13621 SLC12A1 1408 ; PANTOTHENIC ACID ; 79-83-4 ; 1993 ; DISCONTINUED ; ; ATC (CALCIUM PANTOTHENATE) A11HA31 D03AX04 ; PDB 3BF1 (TYPE III PANTOTHENATE KINASE FROM THERMOTOGA MARITIMA COMPLEXED WITH PANTOTHENATE AND ADP) - ligand code PAU ; UNKNOWN 1409 ; LODOXAMIDE ; 53882-12-5 ; 1993 ; ; TARGET G PROTEIN-COUPLED RECEPTOR GPR35 (PMID24113750) ; ATC (LODOXAMIDE) S01GX05 ; PDB 8H8J (LODOXAMIDE-BOUND GPR35 IN COMPLEX WITH G13) - ligand code WYB ; G-protein coupled receptor 35 UNIPROT Q9HC97 GPR35 1410 ; SALMETEROL ; 89365-50-4 ; 1994 ; ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (SALMETEROL) R03AC12 R03AK12 R03AK06 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1411 ; SALMETEROL ; 89365-50-4 ; 1994 ; ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (SALMETEROL) R03AC12 R03AK12 R03AK06 ; PDB 6MXT (CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71) - ligand code K5Y ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1412 ; CALCIPOTRIENE ; 112965-21-6 ; 1993 ; ; TARGET VITAMIN D3 RECEPTOR ; ATC (CALCIPOTRIOL) D05AX02 D05AX52 ; PDB 1S19 (CRYSTAL STRUCTURE OF VDR LIGAND BINDING DOMAIN COMPLEXED TO CALCIPOTRIOL.) - ligand code MC9 ; Vitamin D3 receptor UNIPROT P11473 VDR 1413 ; TRIMETREXATE ; 52128-35-5 ; 1993 ; DISCONTINUED ; TARGET DIHYDROFOLATE REDUCTASE (DHFR) ; ATC (TRIMETREXATE) P01AX07 ; PDB 1BZF (NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE) - ligand code TMQ ; Dihydrofolate reductase UNIPROT P16184 1414 ; CANDESARTAN CILEXETIL ; 145040-37-5 ; 1998 ; ; TARGET ANGIOTENSIN II RECEPTOR AT1 ; ATC (CANDESARTAN) C10BX19 C09CA06 C09DB07 C09DA06 C09DX06 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1415 ; NALMEFENE ; 55096-26-9 ; 1995 ; ; TARGET OPIOID RECEPTOR ; ATC (NALMEFENE) N07BB05 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 1416 ; PHENYLBUTYRATE ; 1716-12-7 ; 1996 ; ; TARGET PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE ; ATC (SODIUM PHENYLBUTYRATE) A16AX03 N07XX19 ; PDB 3TZ2 (CRYSTAL STRUCTURE OF BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE, PHENYLBUTYRATE COMPLEX) - ligand code CLT ; UNKNOWN 1417 ; DOXERCALCIFEROL ; 54573-75-0 ; 1999 ; ; TARGET VITAMIN D3 RECEPTOR ; ATC (DOXERCALCIFEROL) H05BX03 ; PDB 3DL9 (CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITH 1-ALPHA-HYDROXY-VITAMIN D2) - ligand code V2H ; Vitamin D3 receptor UNIPROT P11473 VDR 1418 ; MEQUINOL ; 150-76-5 ; 1999 ; DISCONTINUED ; TARGET TYROSINASE ; ATC (MEQUINOL) D11AX06 ; PDB 5K1M (CRYSTAL STRUCTURE OF OXIDIZED SHEWANELLA YELLOW ENZYME 4 (SYE4) IN COMPLEX WITH P-METHOXYPHENOL) - ligand code 4KS ; Tyrosinase UNIPROT P14679 TYR 1419 ; ALPHA-TOCOPHEROL ACETATE ; 58-95-7 ; 2000 ; ; TARGET ALPHA-TOCOPHEROL TRANSFER PROTEIN (ALPHA-TTP) (PMID24231105) ; ATC (TOCOPHEROL) A11HA03 ; ; UNKNOWN 1420 ; ARTICAINE ; 23964-58-1 ; 2000 ; ; TARGET SODIUM CHANNEL ; ATC (ARTICAINE) N01BB08 N01BB58 ; ; Sodium channel alpha subunits 1421 ; PIPERONYL BUTOXIDE ; 51-03-6 ; 2000 ; DISCONTINUED ; TARGET MONO-OXYGENASE -- ESTERASE ; ; ; Cytochrome P450 UNIPROT E0V9R7 1422 ; GANIRELIX ; 124904-93-4 ; 1999 ; ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR ; ATC (GANIRELIX) H01CC01 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 1423 ; NORELGESTROMIN ; 53016-31-2 ; 2001 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (NORELGESTROMIN AND ESTROGEN) G03AA13 ; ; Progesterone receptor UNIPROT P06401 PGR 1424 ; UNOPROSTONE ISOPROPYL ; 120373-24-2 ; 2000 ; DISCONTINUED ; TARGET BK (KCA1.1) CHANNEL (PMID26277265) ; ATC (UNOPROSTONE) S01EE02 ; ; UNKNOWN 1425 ; CEFDITOREN PIVOXIL ; 117467-28-4 ; 2001 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CEFDITOREN) J01DD16 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1426 ; ZOLEDRONIC ACID ; 118072-93-8 ; 2001 ; ; ; ATC (ZOLEDRONIC ACID) M05BA08 M05BB08 ; PDB 4KQ5 (CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG AND ZOLEDRONATE) - ligand code ZOL ; Farnesyl pyrophosphate synthase UNIPROT P14324 FDPS 1427 ; DEXMETHYLPHENIDATE ; 1072298-18-0 ; 1955 ; ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT DOPAMINE TRANSPORTER -- SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (METHYLPHENIDATE) N06BA04 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1428 ; TENOFOVIR DISOPROXIL ; 201341-05-1 ; 2001 ; ; TARGET HIV REVERSE TRANSCRIPTASE ; ATC (TENOFOVIR DISOPROXIL) J05AR06 J05AR08 J05AR12 J05AR27 J05AR24 J05AR11 J05AF07 J05AR03 ; ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1429 ; ROTIGOTINE ; 99755-59-6 ; 2007 ; ; TARGET DOPAMINE RECEPTOR ; ATC (ROTIGOTINE) N04BC09 ; PDB 8IRT (DOPAMINE RECEPTOR D3R-GI-ROTIGOTINE COMPLEX) - ligand code R5F ; D(2) dopamine receptor UNIPROT P14416 DRD2 1430 ; NEPAFENAC ; 78281-72-8 ; 2005 ; ; TARGET PROSTAGLANDIN H SYNTHASE (CYCLOOXYGENASE) ; ATC (NEPAFENAC) S01BC10 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1431 ; METHYLNALTREXONE ; 73232-52-7 ; 2008 ; ; TARGET DELTA-TYPE OPIOID RECEPTOR -- KAPPA-TYPE OPIOID RECEPTOR -- MU-TYPE OPIOID RECEPTOR ; ATC (NALTREXONE) A08AA62 N07BB04 N02AA56 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Kappa-type opioid receptor UNIPROT P41145 OPRK1 1432 ; DESVENLAFAXINE ; 93413-62-8 ; 2008 ; ; TARGET SEROTONIN AND NOREPINEPHRINE REUPTAKE ; ATC (DESVENLAFAXINE) N06AX23 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1433 ; DESVENLAFAXINE ; 93413-62-8 ; 2008 ; ; TARGET SEROTONIN AND NOREPINEPHRINE REUPTAKE ; ATC (DESVENLAFAXINE) N06AX23 ; PDB 4MMC (CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH DESVENLAFAXINE) - ligand code 29J ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1434 ; FOSAPREPITANT ; 172673-20-0 ; 2008 ; ; TARGET P/NEUROKININ-1 (NK1) RECEPTOR ; ATC (APREPITANT) A04AD12 ; ; Substance-P receptor UNIPROT P25103 TACR1 1435 ; METHYL SALICYLATE ; 119-36-8 ; 2008 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (ACETYLSALICYLIC ACID) A01AD05 B01AC06 N02BA01 M01BA03 N02BA51 B01AC56 N02BA71 C10BX08 C10BX12 C10BX06 C07FX04 N02AJ07 N02AJ02 C07FX03 N02AJ18 C10BX02 B01AF51 C10BX05 C10BX01 C10BX04 C07FX02 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1436 ; LANREOTIDE ; 108736-35-2 ; 2007 ; ; TARGET SOMATOSTATIN RECEPTORS (SSTR) 2 AND 5 -- REDUCED BINDING AFFINITY FOR HUMAN SSTR1, 3, AND 4 ; ATC (LANREOTIDE) H01CB03 ; ; Somatostatin receptor type 2 UNIPROT P30874 SSTR2 -- Somatostatin receptor type 5 UNIPROT P35346 SSTR5 1437 ; AMBRISENTAN ; 177036-94-1 ; 2007 ; ; TARGET ENDOTHELIN TYPE-A RECEPTOR (ETA) (KI = 0.011 NANOMOLAR) ; ATC (AMBRISENTAN) C02KX02 C02KX52 ; ; Endothelin-1 receptor UNIPROT P25101 EDNRA 1438 ; RALTEGRAVIR ; 518048-05-0 ; 2007 ; ; TARGET INTEGRASE ; ATC (RALTEGRAVIR) J05AR16 J05AJ01 ; PDB 4MDB (STRUCTURE OF MOS1 TRANSPOSASE CATALYTIC DOMAIN AND RALTEGRAVIR WITH MG) - ligand code RLT ; Integrase UNIPROT Q7ZJM1 pol 1439 ; CLEVIDIPINE ; 167221-71-8 ; 2008 ; ; TARGET L-TYPE CALCIUM CHANNEL BLOCKER ; ATC (CLEVIDIPINE) C08CA16 ; ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 1440 ; SAPROPTERIN ; 62989-33-7 ; 2007 ; ; TARGET PHENYLALANINE HYDROXYLASE ; ATC (SAPROPTERIN) A16AX07 ; ; Phenylalanine-4-hydroxylase UNIPROT P00439 PAH 1441 ; ETRAVIRINE ; 269055-15-4 ; 2008 ; ; TARGET REVERSE TRANSCRIPTASE ; ATC (ETRAVIRINE) J05AG04 ; PDB 3MED (HIV-1 K103N REVERSE TRANSCRIPTASE IN COMPLEX WITH TMC125) - ligand code 65B ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1442 ; DIFLUPREDNATE ; 23674-86-4 ; 2008 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DIFLUPREDNATE) D07AC19 S01BA16 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1443 ; BENDAMUSTINE ; 16506-27-7 ; 2008 ; ; TARGET DNA ; ATC (BENDAMUSTINE) L01AA09 ; ; UNKNOWN 1444 ; PLICAMYCIN ; 18378-89-7 ; 1970 ; DISCONTINUED ; TARGET DNA ; ATC (PLICAMYCIN) L01DC02 ; PDB 6VGG (CRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN TRANSCRIPTION FACTOR ERG, HUMAN RUNX2 BOUND TO CORE BINDING FACTOR BETA (CBFB), AND MITHRAMYCIN, IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC) - ligand code QWP ; UNKNOWN 1445 ; CLINDAMYCIN PHOSPHATE ; 24729-96-2 ; 1972 ; ; TARGET 50S RIBOSOMAL SUBUNIT ; ATC (CLINDAMYCIN) D10AF01 G01AA10 J01FF01 D10AF51 ; ; Large ribosomal subunit protein uL10 UNIPROT P15825 rpl10 1446 ; CLINDAMYCIN PALMITATE ; 36688-78-5 ; 1986 ; ; TARGET 50S RIBOSOMAL SUBUNIT ; ATC (CLINDAMYCIN) D10AF01 G01AA10 J01FF01 D10AF51 ; ; Large ribosomal subunit protein uL10 UNIPROT P15825 rpl10 1447 ; CARBENICILLIN INDANYL ; 35531-88-5 ; 1972 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CARBENICILLIN) J01CA03 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1448 ; CARBENICILLIN INDANYL ; 35531-88-5 ; 1972 ; DISCONTINUED ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CARBENICILLIN) J01CA03 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1449 ; PLERIXAFOR ; 110078-46-1 ; 2008 ; ; TARGET ALPHA-CHEMOKINE RECEPTOR CXCR4 ; ATC (PLERIXAFOR) L03AX16 ; PDB 8U4P (STRUCTURE OF AMD3100-BOUND CXCR4, GI COMPLEX) - ligand code VH6 ; C-X-C chemokine receptor type 4 UNIPROT P61073 CXCR4 1450 ; ELTROMBOPAG ; 496775-61-2 ; 2008 ; ; TARGET THROMBOPOIETIN ; ATC (ELTROMBOPAG) B02BX05 ; ; Thrombopoietin receptor UNIPROT P40238 MPL 1451 ; DEGARELIX ; 214766-78-6 ; 2008 ; ; TARGET GONADOTROPIN-RELEASING HORMONE ; ATC (DEGARELIX) L02BX02 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 1452 ; FESOTERODINE ; 286930-02-7 ; 2008 ; ; TARGET MUSCARINIC RECEPTOR ANTAGONIST ; ATC (FESOTERODINE) G04BD11 ; ; Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1453 ; RUFINAMIDE ; 106308-44-5 ; 2008 ; ; TARGET SODIUM CHANNELS (EC50 = 3.8 MICROMOLAR) ; ATC (RUFINAMIDE) N03AF03 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 1454 ; FOSPROPOFOL ; 258516-89-1 ; 2008 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA(A)) -- BETA-ADRENOCEPTOR (BETA-AR) (PMID21793316) ; ATC (PROPOFOL) N01AX10 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 -- GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 1455 ; LACOSAMIDE ; 175481-36-4 ; 2008 ; ; TARGET VOLTAGE GATED SODIUM CHANNELS -- COLLAPSIN RESPONSE MEDIATOR PROTEIN-2 (CRMP-2) ; ATC (LACOSAMIDE) N03AX18 ; PDB 8S9B (CRYO-EM STRUCTURE OF NAV1.7 WITH LCM) - ligand code LQO ; Sodium channel protein type 9 subunit alpha UNIPROT Q15858 SCN9A 1456 ; ISOSORBIDE ; 652-67-5 ; 1974 ; DISCONTINUED ; ; ATC (ISOSORBIDE) C01DA08 C05AE02 C01DA58 C01DA14 ; ; UNKNOWN 1457 ; BETAMETHASONE PHOSPHATE ; 360-63-4 ; 1965 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BETAMETHASONE) A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03 D07CC01 S01CA05 S03CA06 D07BC01 S01BB04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1458 ; BENZYL ALCOHOL ; 100-51-6 ; 2009 ; DISCONTINUED ; ; ATC (BENZYL ALCOHOL) P03AX06 ; PDB 5EB5 (THE CRYSTAL STRUCTURE OF ALMOND HNL, PAHNL5 V317A, IN COMPLEX WITH BENZYL ALCOHOL) - ligand code 010 ; UNKNOWN 1459 ; TROGLITAZONE ; 97322-87-7 ; 1997 ; DISCONTINUED ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR) ; ATC (TROGLITAZONE) A10BG01 ; ; Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 1460 ; BENZQUINAMIDE ; 63-12-7 ; 1974 ; DISCONTINUED ; TARGET P-GLYCOPROTEIN (PMID1362504) ; ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 1461 ; CYCLOTHIAZIDE ; 159405-29-5 ; 1963 ; DISCONTINUED ; TARGET GLUTAMATE RECEPTOR 2 ; ATC (CYCLOTHIAZIDE) C03AA09 C03AB09 ; PDB 1LBC (GLUTAMATE RECEPTOR LIGAND BINDING CORE GLUR2 RATTUS NORVEGICUS) ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1462 ; CYCLOTHIAZIDE ; 159405-28-4 ; 1963 ; DISCONTINUED ; TARGET GLUTAMATE RECEPTOR 2 ; ATC (CYCLOTHIAZIDE) C03AA09 C03AB09 ; PDB 1LBC (GLUTAMATE RECEPTOR LIGAND BINDING CORE GLUR2 RATTUS NORVEGICUS) ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1463 ; CYCLOTHIAZIDE ; 134077-75-1 ; 1963 ; DISCONTINUED ; TARGET GLUTAMATE RECEPTOR 2 ; ATC (CYCLOTHIAZIDE) C03AA09 C03AB09 ; PDB 1LBC (GLUTAMATE RECEPTOR LIGAND BINDING CORE GLUR2 RATTUS NORVEGICUS) ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1464 ; CYCLOTHIAZIDE ; 134077-79-5 ; 1963 ; DISCONTINUED ; TARGET GLUTAMATE RECEPTOR 2 ; ATC (CYCLOTHIAZIDE) C03AA09 C03AB09 ; PDB 1LBC (GLUTAMATE RECEPTOR LIGAND BINDING CORE GLUR2 RATTUS NORVEGICUS) ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1465 ; CYCLOTHIAZIDE ; 134077-78-4 ; 1963 ; DISCONTINUED ; TARGET GLUTAMATE RECEPTOR 2 ; ATC (CYCLOTHIAZIDE) C03AA09 C03AB09 ; PDB 1LBC (GLUTAMATE RECEPTOR LIGAND BINDING CORE GLUR2 RATTUS NORVEGICUS) ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1466 ; CYCLOTHIAZIDE ; 134077-81-9 ; 1963 ; DISCONTINUED ; TARGET GLUTAMATE RECEPTOR 2 -- ; ATC (CYCLOTHIAZIDE) C03AA09 C03AB09 ; PDB 1LBC (GLUTAMATE RECEPTOR LIGAND BINDING CORE GLUR2 RATTUS NORVEGICUS) ; Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 1467 ; ISOETHARINE ; 79490-84-9 ; 1978 ; DISCONTINUED ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (ISOETARINE) R03AC07 R03CC06 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1468 ; ISOETHARINE ; 52553-26-1 ; 1978 ; DISCONTINUED ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (ISOETARINE) R03AC07 R03CC06 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1469 ; METHYLPHENIDATE ; 29419-96-3 ; 1955 ; ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT DOPAMINE TRANSPORTER -- SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (METHYLPHENIDATE) N06BA04 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1470 ; METHYLPHENIDATE ; 29419-97-4 ; 1955 ; ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT DOPAMINE TRANSPORTER -- SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (METHYLPHENIDATE) N06BA04 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1471 ; ILOPERIDONE ; 133454-47-4 ; 2009 ; ; TARGET DOPAMINE D2 (KI = 6.3 NANOMOLAR) -- SEROTONIN 5-HT2A (KI = 5.6 NANOMOLAR) -- DOPAMINE D3 (KI = 7.1 NANOMOLAR) ; ATC (ILOPERIDONE) N05AX14 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1472 ; TOLVAPTAN ; 150683-30-0 ; 2009 ; ; TARGET ARGININE VASOPRESSIN RECEPTOR 2 ; ATC (TOLVAPTAN) C03XA01 ; ; Vasopressin V2 receptor UNIPROT P30518 AVPR2 1473 ; BESIFLOXACIN ; 141388-76-3 ; 2009 ; ; TARGET DNA GYRASE -- TOPOISOMERASE IV ; ATC (BESIFLOXACIN) S01AE08 ; ; Topoisomerase IV UNIPROT P0AFI2 parC -- DNA gyrase UNIPROT P0AES4 gyrA 1474 ; PRASUGREL ; 150322-43-3 ; 2009 ; ; TARGET P2Y12 ADP RECEPTOR ; ATC (PRASUGREL) B01AC22 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1475 ; PITAVASTATIN ; 147511-69-1 ; 2009 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA) ; ATC (PITAVASTATIN) C10AA08 ; PDB 7ULM (COMPLEX OF HMG1 WITH PITAVASTATIN) - ligand code PV9 ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 1476 ; SAXAGLIPTIN ; 361442-04-8 ; 2009 ; ; TARGET DIPEPTIDYL PEPTIDASE-4 (DPP-4) ; ATC (SAXAGLIPTIN) A10BD10 A10BD25 A10BH03 A10BD21 ; ; Dipeptidyl peptidase 4 UNIPROT P27487 DPP4 1477 ; ASENAPINE ; 65576-45-6 ; 2009 ; ; TARGET 5-HT2A RECEPTOR (KI = 0.06 NANOMOLAR) -- D2 RECEPTOR (KI = 1.3 NANOMOLAR) ; ATC (ASENAPINE) N05AH05 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1478 ; VIGABATRIN ; 68506-86-5 ; 2009 ; ; TARGET 4-AMINOBUTYRATE AMINOTRANSFERASE MITOCHONDRIAL ; ATC (VIGABATRIN) N03AG04 ; ; 4-aminobutyrate aminotransferase, mitochondrial UNIPROT P80404 ABAT 1479 ; BEPOTASTINE ; 125602-71-3 ; 2009 ; ; TARGET HISTAMINE H1 RECEPTOR ; ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1480 ; TELAVANCIN ; 372151-71-8 ; 2009 ; ; ; ATC (TELAVANCIN HYDROCHLORIDE) J01XA03 ; ; UNKNOWN 1481 ; PRALATREXATE ; 146464-95-1 ; 2009 ; ; TARGET DIHYDROFOLATE REDUCTASE -- FOLYLPOLYGLUTAMYL SYNTHETASE ; ATC (PRALATREXATE) L01BA05 ; ; Dihydrofolate reductase UNIPROT P00374 DHFR 1482 ; PAZOPANIB ; 444731-52-6 ; 2009 ; ; TARGET VEGFR-1 -- VEGFR-2 -- VEGFR-3 -- PDGFR-ALPHA -- PDGRF-BETA -- FGFR-1 -- FGFR-3 -- KIT -- ITK -- LCK -- TRANSMEMBRANE GLYCOPROTEIN RECEPTOR TYROSINE KINASE (C-FMS) ; ATC (PAZOPANIB) L01EX03 ; ; Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT 1483 ; ROMIDEPSIN ; 128517-07-7 ; 2009 ; ; TARGET HISTONE DEACETYLASE (IC50 NANOMOLAR RANGE) ; ATC (ROMIDEPSIN) L01XH02 ; ; Histone deacetylase UNIPROT O15379 HDAC3 1484 ; DALFAMPRIDINE ; 504-24-5 ; 2010 ; ; TARGET SHAKER -- KCNA ; ATC (FAMPRIDINE) N07XX07 ; ; Voltage-gated potassium channel UNIPROT O43525 KCNQ3 1485 ; CARGLUMIC ACID ; 1188-38-1 ; 2010 ; ; TARGET CARBAMOYL PHOSPHATE SYNTHETASE 1 (CPS 1) ; ATC (CARGLUMIC ACID) A16AA05 ; ; Carbamoyl-phosphate synthase ammonia, mitochondrial UNIPROT P31327 CPS1 1486 ; FENOFIBRIC ACID ; 42017-89-0 ; 2008 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA ; ATC (FENOFIBRATE) C10AB05 C10BA03 C10BA12 C10BA09 C10BA04 ; PDB 7BQ0 (X-RAY STRUCTURE OF HUMAN PPARALPHA LIGAND BINDING DOMAIN-FENOFIBRIC ACID-SRC1 COACTIVATOR PEPTIDE CO-CRYSTALS OBTAINED BY DELIPIDATION AND CO-CRYSTALLIZATION) - ligand code F5A ; Peroxisome proliferator-activated receptor alpha UNIPROT Q07869 PPARA 1487 ; PALIPERIDONE PALMITATE ; 199739-10-1 ; 2009 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- D(2) DOPAMINE RECEPTOR -- ALPHA1 ADRENERGIC RECEPTOR -- ALPHA2 ADRENERGIC RECEPTOR -- H1 HISTAMINERGIC RECEPTOR ; ATC (PALIPERIDONE) N05AX13 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1488 ; PALIPERIDONE PALMITATE ; 199739-10-1 ; 2009 ; ; TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- D(2) DOPAMINE RECEPTOR -- ALPHA1 ADRENERGIC RECEPTOR -- ALPHA2 ADRENERGIC RECEPTOR -- H1 HISTAMINERGIC RECEPTOR ; ATC (PALIPERIDONE) N05AX13 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1489 ; ABIRATERONE ; 154229-19-3 ; 0 ; ; TARGET 17 ALPHA-HYDROXYLASE/C17,20-LYASE (CYP17) ; ATC (ABIRATERONE) L02BX03 L02BX53 L01XK52 ; PDB 4NKV (HUMAN STEROIDOGENIC CYTOCHROME P450 17A1 MUTANT A105L WITH INHIBITOR ABIRATERONE) - ligand code AER ; Steroid 17-alpha-hydroxylase,17,20 lyase UNIPROT P05093 CYP17A1 1490 ; CAPSAICIN ; 404-86-4 ; 2009 ; ; TARGET TRPV1 CATION CHANNEL ; ATC (CAPSAICIN) M02AB01 N01BX04 ; PDB 2N27 (COMPETITIVE INHIBITION OF TRPV1 CALMODULIN INTERACTION BY VANILLOIDS) - ligand code 4DY ; Transient receptor potential cation channel subfamily V member 1 UNIPROT Q8NER1 TRPV1 1491 ; TENOFOVIR ; 147127-20-6 ; 0 ; ; TARGET HIV REVERSE TRANSCRIPTASE ; ATC (TENOFOVIR DISOPROXIL) J05AR06 J05AR08 J05AR12 J05AR27 J05AR24 J05AR11 J05AF07 J05AR03 ; PDB 8BVS (CRYO-EM STRUCTURE OF RAT SLC22A6 BOUND TO TENOFOVIR) - ligand code TFO ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1492 ; TOLVAPTAN ; 150683-30-0 ; 2009 ; ; TARGET ARGININE VASOPRESSIN RECEPTOR 2 ; ATC (TOLVAPTAN) C03XA01 ; ; Vasopressin V2 receptor UNIPROT P30518 AVPR2 1493 ; PRASUGREL ; 150322-43-3 ; 2009 ; ; TARGET P2Y12 ADP RECEPTOR ; ATC (PRASUGREL) B01AC22 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1494 ; VIGABATRIN ; 68506-86-5 ; 2009 ; ; TARGET 4-AMINOBUTYRATE AMINOTRANSFERASE MITOCHONDRIAL ; ATC (VIGABATRIN) N03AG04 ; ; 4-aminobutyrate aminotransferase, mitochondrial UNIPROT P80404 ABAT 1495 ; PRALATREXATE ; 146464-95-1 ; 2009 ; ; TARGET DIHYDROFOLATE REDUCTASE -- FOLYLPOLYGLUTAMYL SYNTHETASE ; ATC (PRALATREXATE) L01BA05 ; ; Dihydrofolate reductase UNIPROT P00374 DHFR 1496 ; ALCAFTADINE ; 147084-10-4 ; 2010 ; ; TARGET H1 HISTAMINE RECEPTOR ; ATC (ALCAFTADINE) S01GX11 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1497 ; DIENOGEST ; 65928-58-7 ; 2010 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (DIENOGEST AND ESTROGEN) G03FA15 ; ; Progesterone receptor UNIPROT P06401 PGR 1498 ; ULIPRISTAL ACETATE ; 126784-99-4 ; 2010 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (ULIPRISTAL) G03AD02 G03XB02 ; PDB 4OAR (PROGESTERONE RECEPTOR WITH BOUND ULIPRISTAL ACETATE AND A PEPTIDE FROM THE CO-REPRESSOR SMRT) - ligand code 2S0 ; Progesterone receptor UNIPROT P06401 PGR 1499 ; DABIGATRAN ETEXILATE ; 211915-06-9 ; 2010 ; ; TARGET PROTHROMBIN ; ATC (DABIGATRAN ETEXILATE) B01AE07 ; ; Prothrombin UNIPROT P00734 F2 1500 ; FINGOLIMOD ; 162359-55-9 ; 2010 ; ; TARGET SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P1) ; ATC (FINGOLIMOD) L04AE01 ; ; Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 1501 ; LEVOMEFOLATE ; 151533-22-1 ; 2010 ; ; ; ; ; Thymidylate synthase UNIPROT P04818 TYMS 1502 ; CEFTAROLINE ; 402741-13-3 ; 2010 ; ; TARGET PENICILLIN-BINDING PROTEIN 1B -- PENICILLIN-BINDING PROTEIN 1A -- PENICILLIN-BINDING PROTEIN 2A ; ATC (CEFTAROLINE) J01DI02 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1503 ; LURASIDONE ; 367514-87-2 ; 2010 ; ; TARGET DOPAMINE D2 ANTAGONIST (KI=0.994 NANOMOLAR) -- 5-HT2A ANTAGONIST (KI=0.47 NANOMOLAR) -- 5-HT7 ANTAGONIST (KI=0.495 NANOMOLAR) -- ALPHA2C-ADRENERGIC RECEPTOR ANTAGONIST (KI=10.8 NANOMOLAR) -- 5-HT1A RECEPTOR PARTIAL AGONIST (KI=6.38 NANOMOLAR) -- ALPHA2A ADRENERGIC RECEPTORS ANTAGONIST (KI=40.7 NM) ; ATC (LURASIDONE) N05AE05 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1504 ; CABAZITAXEL ; 183133-96-2 ; 2010 ; ; TARGET MICROTUBULE -- BINDS TO TUBULIN AND PROMOTES ITS ASSEMBLY INTO MICROTUBULES WHILE SIMULTANEOUSLY INHIBITING DISASSEMBLY ; ATC (CABAZITAXEL) L01CD04 ; ; Tubulin beta UNIPROT P07437 TUBB 1505 ; ERIBULIN ; 253128-41-5 ; 2010 ; ; TARGET MICROTUBULES -- G2/M CELL-CYCLE BLOCK ; ATC (ERIBULIN) L01XX41 ; PDB 5JH7 (TUBULIN-ERIBULIN COMPLEX) - ligand code 6K9 ; Tubulin beta UNIPROT P07437 TUBB 1506 ; EZOGABINE ; 150812-12-7 ; 2011 ; DISCONTINUED ; TARGET KCNQ ION CHANNELS (KV7.2 TO 7.5) ; ATC (RETIGABINE) N03AX21 ; PDB 7CR7 (HUMAN KCNQ2-CAM IN COMPLEX WITH RETIGABINE) - ligand code FBX ; Potassium voltage-gated channel subfamily KQT member 2 UNIPROT O43526 KCNQ2 -- Potassium voltage-gated channel subfamily KQT member 3 UNIPROT O43525 KCNQ3 1507 ; GABAPENTIN ENACARBIL ; 478296-72-9 ; 2011 ; ; TARGET VOLTAGE-GATED CALCIUM CHANNEL (PMID26680202) ; ATC (GABAPENTIN) N02BF01 ; ; Voltage-dependent calcium channel subunit alpha-2,delta-1 UNIPROT P54289 CACNA2D1 -- Voltage-dependent calcium channel subunit alpha-2,delta-2 UNIPROT Q9NY47 CACNA2D2 1508 ; GABAPENTIN ENACARBIL ; 478296-72-9 ; 2011 ; ; TARGET VOLTAGE-GATED CALCIUM CHANNEL (PMID26680202) ; ATC (GABAPENTIN) N02BF01 ; ; Voltage-dependent calcium channel subunit alpha-2,delta-1 UNIPROT P54289 CACNA2D1 -- Voltage-dependent calcium channel subunit alpha-2,delta-2 UNIPROT Q9NY47 CACNA2D2 1509 ; VANDETANIB ; 443913-73-3 ; 2011 ; ; TARGET EGFR -- VEGF -- PROTEIN TYROSINE KINASE 6 (BRK) -- TIE2 -- EPH RECEPTORS KINASE FAMILY -- SRC FAMILY ; ATC (VANDETANIB) L01EX04 ; PDB 2IVU (CRYSTAL STRUCTURE OF PHOSPHORYLATED RET TYROSINE KINASE DOMAIN COMPLEXED WITH THE INHIBITOR ZD6474) - ligand code ZD6 ; Epidermal growth factor receptor UNIPROT P00533 EGFR -- Proto-oncogene tyrosine-protein kinase receptor Ret UNIPROT P07949 RET 1510 ; ROFLUMILAST ; 162401-32-3 ; 2011 ; ; TARGET PDE4 -- PHOSPHODIESTERASE 4 ; ATC (ROFLUMILAST) D05AX06 R03DX07 ; PDB 1XMU (CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH ROFLUMILAST) - ligand code ROF ; Phosphodiesterase 4 UNIPROT P27815 PDE4A 1511 ; VILAZODONE ; 163521-12-8 ; 2011 ; ; TARGET SEROTONIN REUPTAKE ; ATC (VILAZODONE) N06AX24 ; PDB 8FYL (VILAZODONE-BOUND SEROTONIN 1A (5-HT1A) RECEPTOR-GI1 PROTEIN COMPLEX) - ligand code YG7 ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 1512 ; AZILSARTAN KAMEDOXOMIL ; 863031-21-4 ; 2011 ; ; TARGET AT1 RECEPTOR ; ATC (AZILSARTAN MEDOXOMIL) C09CA09 C09DA09 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1513 ; LINAGLIPTIN ; 668270-12-0 ; 2011 ; ; TARGET DPP-4 -- DIPEPTIDYL PEPTIDASE-4 ; ATC (LINAGLIPTIN) A10BH05 A10BD19 A10BD11 A10BD27 ; PDB 2RGU (CRYSTAL STRUCTURE OF COMPLEX OF HUMAN DPP4 AND INHIBITOR) - ligand code 356 ; Dipeptidyl peptidase 4 UNIPROT P27487 DPP4 1514 ; FIDAXOMICIN ; 873857-62-6 ; 2011 ; ; TARGET BETA SUBUNIT OF RNA POLYMERASE ; ATC (FIDAXOMICIN) A07AA12 ; PDB 6BZO (MTB RNAP HOLO, RBPA, FIDAXOMICIN, UPSTREAM FORK DNA) - ligand code FI8 ; DNA-directed RNA polymerase UNIPROT Q182S6 rpoZ 1515 ; TELAPREVIR ; 402957-28-2 ; 2011 ; DISCONTINUED ; TARGET NS3/4A PROTEASE ; ATC (TELAPREVIR) J05AP02 ; ; Hepatitis C virus serine protease, NS3,NS4A UNIPROT A3EZI9 NS3 1516 ; RILPIVIRINE ; 500287-72-9 ; 2011 ; ; TARGET HIV-1 REVERSE TRANSCRIPTASE (EC50(HIV-1IIIB) = 0.73 NM) ; ATC (RILPIVIRINE) J05AR21 J05AR19 J05AR08 J05AG05 ; PDB 2ZE2 (CRYSTAL STRUCTURE OF L100I, K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH TMC278 (RILPIVIRINE), A NON-NUCLEOSIDE RT INHIBITOR) - ligand code T27 ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1517 ; BOCEPREVIR ; 394730-60-0 ; 2011 ; DISCONTINUED ; TARGET HCV NON-STRUCTURAL PROTEIN 3 (NS3) SERINE PROTEASE ; ATC (BOCEPREVIR) J05AP03 ; PDB 2OC8 (STRUCTURE OF HEPATITIS C VIRAL NS3 PROTEASE DOMAIN COMPLEXED WITH NS4A PEPTIDE AND KETOAMIDE SCH503034) - ligand code HU5 ; Hepatitis C virus serine protease, NS3,NS4A UNIPROT A3EZI9 NS3 1518 ; BOCEPREVIR ; 394730-60-0 ; 2011 ; DISCONTINUED ; TARGET HCV NON-STRUCTURAL PROTEIN 3 (NS3) SERINE PROTEASE ; ATC (BOCEPREVIR) J05AP03 ; ; Hepatitis C virus serine protease, NS3,NS4A UNIPROT A3EZI9 NS3 1519 ; ABIRATERONE ACETATE ; 154229-18-2 ; 2011 ; ; TARGET 17 ALPHA-HYDROXYLASE/C17,20-LYASE (CYP17) ; ATC (ABIRATERONE) L02BX03 L02BX53 L01XK52 ; ; Steroid 17-alpha-hydroxylase,17,20 lyase UNIPROT P05093 CYP17A1 1520 ; DEFERIPRONE ; 30652-11-0 ; 2011 ; ; TARGET FERRIC ION (IRON III) ; ATC (DEFERIPRONE) V03AC02 ; ; UNKNOWN 1521 ; ICATIBANT ; 130308-48-4 ; 2011 ; ; TARGET BRADYKININ B2 RECEPTOR ; ATC (ICATIBANT ACETATE) B06AC02 ; ; B2 bradykinin receptor UNIPROT P30411 BDKRB2 1522 ; INDACATEROL ; 312753-06-3 ; 2011 ; DISCONTINUED ; TARGET BETA-2-ADRENORECEPTOR ; ATC (INDACATEROL) R03AC18 R03AL04 R03AK14 R03AL12 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1523 ; RIVAROXABAN ; 366789-02-8 ; 2011 ; ; TARGET XA FACTOR ; ATC (RIVAROXABAN) B01AF01 B01AF51 ; PDB 2W26 (FACTOR XA IN COMPLEX WITH BAY59-7939) - ligand code RIV ; Coagulation factor X UNIPROT P00742 F10 1524 ; TICAGRELOR ; 274693-27-5 ; 2011 ; ; TARGET P2Y12 ADP-RECEPTOR ; ATC (TRICAGRELOR) B01AC24 ; PDB 5ALC (TICAGRELOR ANTIDOTE CANDIDATE FAB 72 IN COMPLEX WITH TICAGRELOR) - ligand code TIQ ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1525 ; CLOBAZAM ; 22316-47-8 ; 2011 ; ; TARGET GABAA RECEPTOR ; ATC (CLOBAZAM) N05BA09 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 1526 ; RUXOLITINIB ; 941678-49-5 ; 2011 ; ; TARGET JANUS ASSOCIATED KINASES -- JAK1 -- JAK2 ; ATC (RUXOLITINIB) D11AH09 L01EJ01 ; PDB 4U5J (C-SRC IN COMPLEX WITH RUXOLITINIB) - ligand code RXT ; Tyrosine-protein kinase JAK1 UNIPROT P23458 JAK1 -- Tyrosine-protein kinase JAK2 UNIPROT O60674 JAK2 1527 ; AXITINIB ; 319460-85-0 ; 2012 ; ; TARGET RECEPTOR TYROSINE KINASES -- VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS -- VEGFR-1 -- VEGFR-2 -- VEGFR-3 ; ATC (AXITINIB) L01EK01 ; PDB 4WA9 (THE CRYSTAL STRUCTURE OF HUMAN ABL1 WILD TYPE KINASE DOMAIN IN COMPLEX WITH AXITINIB) - ligand code AXI ; Vascular endothelial growth factor receptor 1 UNIPROT P17948 FLT1 -- Vascular endothelial growth factor receptor 2 UNIPROT P35968 KDR 1528 ; VEMURAFENIB ; 918504-65-1 ; 2011 ; ; TARGET BRAF SERINE-THREONINE KINASE -- CRAF -- ARAF -- SRMS -- ACK1 -- MAP4K5 -- FGR ; ATC (VEMURAFENIB) L01EC01 ; PDB 5HES (HUMAN LEUCINE ZIPPER- AND STERILE ALPHA MOTIF-CONTAINING KINASE (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) IN COMPLEX WITH VEMURAFENIB) - ligand code 032 ; Serine,threonine-protein kinase B-raf UNIPROT P15056 BRAF 1529 ; TAFLUPROST ; 209860-87-7 ; 2012 ; ; TARGET FP PROSTANOID RECEPTOR ; ATC (TAFLUPROST) S01EE05 ; ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 1530 ; CRIZOTINIB ; 877399-52-5 ; 2011 ; ; TARGET TYROSINE KINASES -- ALK (IC50=24 NANOMOLAR) PMID22162641 -- C-MET ; ATC (CRIZOTINIB) L01ED01 ; PDB 5AAB (STRUCTURE OF C1156Y,L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB) - ligand code VGH ; Hepatocyte growth factor receptor UNIPROT P08581 MET -- ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK 1531 ; INGENOL MEBUTATE ; 75567-37-2 ; 2012 ; ; ; ATC (INGENOL MEBUTATE) D06BX02 ; ; Protein kinase C delta type UNIPROT Q05655 PRKCD 1532 ; IVACAFTOR ; 873054-44-5 ; 2012 ; ; TARGET G551D-CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR ; ATC (IVACAFTOR) R07AX02 R07AX30 R07AX31 R07AX32 ; PDB 6O2P (COMPLEX OF IVACAFTOR WITH CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)) - ligand code VX7 ; Cystic fibrosis transmembrane conductance regulator UNIPROT P13569 CFTR 1533 ; VISMODEGIB ; 879085-55-9 ; 2012 ; ; TARGET SMOOTHENED TRANSMEMBRANE PROTEIN (IC50 = 7 NANOMOLAR) PMID22268551 ; ATC (VISMODEGIB) L01XJ01 ; PDB 5L7I (STRUCTURE OF HUMAN SMOOTHENED IN COMPLEX WITH VISMODEGIB) - ligand code VIS ; Smoothened homolog UNIPROT Q99835 SMO 1534 ; M TAFLUPROST ; 209860-88-8 ; 0 ; ; TARGET FP PROSTANOID RECEPTOR ; ATC (TAFLUPROST) S01EE05 ; PDB 8IUM (CRYO-EM STRUCTURE OF THE TAFLUPROST ACID-BOUND HUMAN PTGFR-GQ COMPLEX) - ligand code S2F ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 1535 ; M FIDAXOMICIN ; 1030825-28-5 ; 0 ; ; TARGET BETA SUBUNIT OF RNA POLYMERASE ; ATC (FIDAXOMICIN) A07AA12 ; ; DNA-directed RNA polymerase UNIPROT Q182S6 rpoZ 1536 ; M AZILSARTAN KAMEDOXOMIL ; 147403-03-0 ; 0 ; ; TARGET AT1 RECEPTOR ; ATC (AZILSARTAN MEDOXOMIL) C09CA09 C09DA09 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1537 ; M ROFLUMILAST ; 1026258-58-1 ; 0 ; ; TARGET PDE4 -- PHOSPHODIESTERASE 4 ; ATC (ROFLUMILAST) D05AX06 R03DX07 ; ; Phosphodiesterase 4 UNIPROT P27815 PDE4A 1538 ; M FINGOLIMOD ; 402616-26-6 ; 0 ; ; TARGET SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P1) ; ATC (FINGOLIMOD) L04AE01 ; PDB 7VIF (CRYO-EM STRUCTURE OF GI COUPLED SPHINGOSINE 1-PHOSPHATE RECEPTOR BOUND WITH (S)-FTY720-P) - ligand code J89 ; Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 1539 ; DABIGATRAN ; 211914-51-1 ; 0 ; ; TARGET PROTHROMBIN ; ATC (DABIGATRAN ETEXILATE) B01AE07 ; PDB 4JN2 (AN ANTIDOTE FOR DABIGATRAN) - ligand code 4CC ; Prothrombin UNIPROT P00734 F2 1540 ; M ULIPRISTAL ACETATE ; 159681-66-0 ; 0 ; ; TARGET PROGESTERONE RECEPTOR ; ATC (ULIPRISTAL) G03AD02 G03XB02 ; ; Progesterone receptor UNIPROT P06401 PGR 1541 ; M ALCAFTADINE ; 147083-93-0 ; 0 ; ; TARGET H1 HISTAMINE RECEPTOR ; ATC (ALCAFTADINE) S01GX11 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1542 ; M PRASUGREL ; 204204-73-9 ; 0 ; ; TARGET P2Y12 ADP RECEPTOR ; ATC (PRASUGREL) B01AC22 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1543 ; M PRASUGREL ; 204204-73-9 ; 0 ; ; TARGET P2Y12 ADP RECEPTOR ; ATC (PRASUGREL) B01AC22 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1544 ; M PRASUGREL ; 204204-73-9 ; 0 ; ; TARGET P2Y12 ADP RECEPTOR ; ATC (PRASUGREL) B01AC22 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1545 ; M PRASUGREL ; 204204-73-9 ; 0 ; ; TARGET P2Y12 ADP RECEPTOR ; ATC (PRASUGREL) B01AC22 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1546 ; M SAXAGLIPTIN ; 841302-24-7 ; 0 ; ; TARGET DIPEPTIDYL PEPTIDASE-4 (DPP-4) ; ATC (SAXAGLIPTIN) A10BD10 A10BD25 A10BH03 A10BD21 ; ; Dipeptidyl peptidase 4 UNIPROT P27487 DPP4 1547 ; TROGLITAZONE ; 97322-87-7 ; 1997 ; DISCONTINUED ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR) ; ATC (TROGLITAZONE) A10BG01 ; PDB 6DGO (CRYSTAL STRUCTURE OF HUMAN PPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH TROGLITAZONE) - ligand code GD4 ; Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 1548 ; TROGLITAZONE ; 97322-87-7 ; 1997 ; DISCONTINUED ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR) ; ATC (TROGLITAZONE) A10BG01 ; PDB 2VN0 (CYP2C8DH COMPLEXED WITH TROGLITAZONE) - ligand code TDZ ; Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG 1549 ; M FESOTERODINE ; 207679-81-0 ; 0 ; ; TARGET MUSCARINIC RECEPTOR ; ATC (FESOTERODINE) G04BD11 ; ; Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 -- Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1550 ; M DIFLUPREDNATE ; 23640-96-2 ; 0 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DIFLUPREDNATE) D07AC19 S01BA16 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1551 ; CLEVIDIPINE ; 167221-71-8 ; 2008 ; ; TARGET L-TYPE CALCIUM CHANNEL BLOCKER ; ATC (CLEVIDIPINE) C08CA16 ; ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 1552 ; AMFENAC ; 51579-82-9 ; 0 ; ; TARGET PROSTAGLANDIN H SYNTHASE (CYCLOOXYGENASE) ; ATC (NEPAFENAC) S01BC10 ; ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1553 ; CEFDITOREN ; 104145-95-1 ; 0 ; ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CEFDITOREN) J01DD16 ; ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1554 ; UNOPROSTONE ; 120373-36-6 ; 0 ; ; TARGET BK (KCA1.1) CHANNEL (PMID26277265) ; ATC (UNOPROSTONE) S01EE02 ; ; UNKNOWN 1555 ; ARTICAINE ; 23964-58-1 ; 2000 ; ; TARGET SODIUM CHANNEL ; ATC (ARTICAINE) N01BB08 N01BB58 ; ; Sodium channel alpha subunits 1556 ; M DOXERCALCIFEROL ; 100496-04-6 ; 0 ; ; TARGET VITAMIN D3 RECEPTOR ; ATC (DOXERCALCIFEROL) H05BX03 ; ; Vitamin D3 receptor UNIPROT P11473 VDR 1557 ; CANDESARTAN ; 139481-59-7 ; 0 ; ; TARGET ANGIOTENSIN II RECEPTOR AT1 ; ATC (CANDESARTAN) C10BX19 C09CA06 C09DB07 C09DA06 C09DX06 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1558 ; EFLORNITHINE ; 70052-12-9 ; 1990 ; DISCONTINUED ; TARGET ORNITHINE DECARBOXYLASE (ODC) ; ATC (EFLORNITHINE) D11AX16 L01XX79 P01CX03 ; ; Ornithine decarboxylase UNIPROT P11926 ODC1 -- Ornithine decarboxylase UNIPROT Q9TZZ6 1559 ; ESTRAMUSTINE ; 4891-15-0 ; 0 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ESTRAMUSTINE) L01XX11 ; ; UNKNOWN 1560 ; NORPROPOXYPHENE ; 66796-40-5 ; 0 ; ; TARGET SODIUM CHANNEL -- HERG -- OPIOID RECEPTOR ; ATC (DEXTROPROPOXYPHENE) N02AC04 N02AC54 N02AC74 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1561 ; M OSELTAMIVIR ; 187227-45-8 ; 0 ; ; TARGET NEURAMINIDASE ; ATC (OSELTAMIVIR) J05AH02 ; PDB 4QN7 (CRYSTAL STRUCTURE OF NEURAMNIDASE N7 COMPLEXED WITH OSELTAMIVIR) - ligand code G39 ; Neuraminidase UNIPROT P03468 -- Neuraminidase UNIPROT P03474 1562 ; M RAPACURONIUM ; 736123-17-4 ; 0 ; ; TARGET CHOLINERGIC RECEPTOR ; ; ; Muscle-type nicotinic acetylcholine receptor UNIPROT P02708 CHRNA1 1563 ; M SILDENAFIL ; 139755-82-1 ; 0 ; ; TARGET PHOSPHODIESTERASE TYPE 5 (PDE5) ; ATC (SILDENAFIL) G04BE03 ; ; cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A 1564 ; M CLOPIDOGREL ; 767612-34-0 ; 0 ; ; TARGET P2Y PURINOCEPTOR 12 ; ATC (CLOPIDOGREL) B01AC04 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1565 ; M CLOPIDOGREL ; 767612-34-0 ; 0 ; ; TARGET P2Y PURINOCEPTOR 12 ; ATC (CLOPIDOGREL) B01AC04 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1566 ; M CEFTAROLINE ; 700803-62-9 ; 0 ; ; TARGET PENICILLIN-BINDING PROTEIN 1B -- PENICILLIN-BINDING PROTEIN 1A -- PENICILLIN-BINDING PROTEIN 2A ; ATC (CEFTAROLINE) J01DI02 ; PDB 3ZG0 (CRYSTAL STRUCTURE OF CEFTAROLINE ACYL-PBP2A FROM MRSA WITH NON- COVALENTLY BOUND CEFTAROLINE AND MURAMIC ACID AT ALLOSTERIC SITE OBTAINED BY COCRYSTALLIZATION) - ligand code 1W8 ; Bacterial penicillin-binding protein UNIPROT P02918 mrcA 1567 ; M QUETIAPINE ; 5747-48-8 ; 0 ; ; TARGET 5-HYDROXYTRYPTAMINE 2 RECEPTOR -- D2 DOPAMINE RECEPTOR ; ATC (QUETIAPINE) N05AH04 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1568 ; M DOLASETRON ; 127951-99-9 ; 0 ; ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR ; ATC (DOLASETRON) A04AA04 ; ; 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 1569 ; M DOLASETRON ; 127951-99-9 ; 0 ; ; TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR ; ATC (DOLASETRON) A04AA04 ; ; 5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A 1570 ; M BECLOMETHASONE DIPROPIONATE ; 5534-18-9 ; 0 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (BECLOMETASONE) A07EA07 D07AC15 R01AD01 R03BA01 D07CC04 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1571 ; APIXABAN ; 503612-47-3 ; 2012 ; ; TARGET FACTOR XA ; ATC (APIXABAN) B01AF02 ; PDB 2P16 (FACTOR XA IN COMPLEX WITH THE INHIBITOR APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE) - ligand code GG2 ; Coagulation factor X UNIPROT P00742 F10 1572 ; LOMITAPIDE ; 182431-12-5 ; 2012 ; ; TARGET MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN ; ATC (LOMITAPIDE) C10AX12 ; ; Microsomal triglyceride transfer protein large subunit UNIPROT P55157 MTTP 1573 ; ICOSAPENT ETHYL ; 86227-47-6 ; 2012 ; ; ; ; ; Diacylglycerol O-acyltransferase 1 UNIPROT O75907 DGAT1 1574 ; ICOSAPENT ; 10417-94-4 ; 0 ; ; ; ; PDB 1IGX (CRYSTAL STRUCTURE OF EICOSAPENTANOIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.) - ligand code EPA ; UNKNOWN 1575 ; LORCASERIN ; 616202-92-7 ; 2012 ; ; TARGET SEROTONIN 2C RECEPTOR (5-HT2C) ; ATC (LORCASERIN) A08AA11 ; ; 5-hydroxytryptamine receptor 2C UNIPROT P28335 HTR2C 1576 ; CABOZANTINIB ; 849217-68-1 ; 2012 ; ; TARGET RET -- MET -- VEGFR-1 -- VEGFR-2 -- VEGFR-3 -- KIT -- TRKB -- FLT-3 -- AXL -- TIE-2 ; ATC (CABOZANTINIB) L01EX07 ; ; Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 1577 ; PASIREOTIDE ; 396091-73-9 ; 2012 ; ; TARGET SOMATOSTATIN RECEPTORS (SST) ; ATC (PASIREOTIDE) H01CB05 ; ; Somatostatin receptor type 2 UNIPROT P30874 SSTR2 -- Somatostatin receptor type 3 UNIPROT P32745 SSTR3 1578 ; TERIFLUNOMIDE ; 163451-81-8 ; 2012 ; ; TARGET DIHYDROOROTATE DEHYDROGENASE ; ATC (LEFLUNOMIDE) L04AK01 ; PDB 1TV5 (PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE WITH A BOUND INHIBITOR) - ligand code A26 ; Dihydroorotate dehydrogenase (quinone), mitochondrial UNIPROT Q02127 DHODH -- Dihydroorotate dehydrogenase (quinone), mitochondrial UNIPROT Q02127 DHODH 1579 ; PERAMPANEL ; 380917-97-5 ; 2012 ; ; TARGET AMPA GLUTAMATE RECEPTOR ; ATC (PERAMPANEL) N03AX22 ; PDB 5L1F (AMPA SUBTYPE IONOTROPIC GLUTAMATE RECEPTOR GLUA2 IN COMPLEX WITH NONCOMPETITIVE INHIBITOR PERAMPANEL) - ligand code 6ZP ; Glutamate receptor ionotropic AMPA UNIPROT P42261 GRIA1 1580 ; CARFILZOMIB ; 868540-17-4 ; 2012 ; ; TARGET 20S PROTEASOME ; ATC (CARFILZOMIB) L01XG02 ; ; Proteasome subunit beta type-5 UNIPROT P28074 PSMB5 1581 ; LINACLOTIDE ; 851199-59-2 ; 2012 ; ; TARGET GUANYLATE CYCLASE-C (GC-C) ; ATC (LINACLOTIDE) A06AX04 ; ; Heat-stable enterotoxin receptor UNIPROT P25092 GUCY2C 1582 ; M LINACLOTIDE ; 851199-59-2 ; 0 ; ; TARGET GUANYLATE CYCLASE-C (GC-C) ; ATC (LINACLOTIDE) A06AX04 ; ; Heat-stable enterotoxin receptor UNIPROT P25092 GUCY2C 1583 ; MIRABEGRON ; 223673-61-8 ; 2012 ; ; TARGET BETA-3 ADRENERGIC RECEPTOR ; ATC (MIRABEGRON) G04BD12 ; PDB 7DH5 (DOG BETA3 ADRENERGIC RECEPTOR BOUND TO MIRABEGRON IN COMPLEX WITH A MINIGS HETEROTRIMER) - ligand code H6U ; Beta-3 adrenergic receptor UNIPROT P13945 ADRB3 1584 ; AVANAFIL ; 330784-47-9 ; 2012 ; ; TARGET PHOSPHODIESTERASE 5 (PDE5) ; ATC (AVANAFIL) G04BE10 ; PDB 6L6E (HUMAN PDE5 CATALYTIC CORE IN COMPLEX WITH AVANAFIL) - ligand code E6L ; cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A 1585 ; REGORAFENIB ; 755037-03-7 ; 2012 ; ; TARGET RET -- VEGFR1 -- VEGFR2 -- VEGFR3 -- KIT -- PDGFR-ALPHA -- PDGFR-BETA -- FGFR1 -- FGFR2 -- TIE2 -- DDR2 -- TRKA -- RAF-1 -- BRAF -- BRAF(V600E) -- SAPK2 -- PTK5 -- ABL ; ATC (REGORAFENIB) L01EX05 ; ; Serine,threonine-protein kinase B-raf UNIPROT P15056 BRAF -- Vascular endothelial growth factor receptor 2 UNIPROT P35968 KDR 1586 ; ELVITEGRAVIR ; 697761-98-1 ; 2012 ; ; TARGET VIRAL INTEGRASE ; ATC (ELVITEGRAVIR) J05AJ02 J05AR18 J05AR09 ; PDB 3L2U (CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) INTASOME IN COMPLEX WITH MAGNESIUM AND GS9137 (ELVITEGRAVIR)) - ligand code ELV ; Integrase UNIPROT Q7ZJM1 pol 1587 ; COBICISTAT ; 1004316-88-4 ; 2012 ; ; TARGET CYTOCHROME P450 3A ; ATC (COBICISTAT) J05AR15 V03AX03 J05AR14 J05AR22 J05AR18 J05AR09 ; ; Cytochrome P450 3A UNIPROT P08684 CYP3A4 1588 ; ACLIDINIUM ; 727649-81-2 ; 2012 ; ; TARGET MUSCARINIC RECEPTORS (M1 TO M5) ; ATC (ACLIDINIUM BROMIDE) R03BB05 R03AL05 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1589 ; TOFACITINIB ; 477600-75-2 ; 2012 ; ; TARGET JANUS KINASES (JAK) ; ATC (TOFACITINIB) L04AF01 ; PDB 3LXK (STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION OF THE TYK2 AND JAK3 KINASE DOMAINS IN COMPLEX WITH CP-690550 AND CMP-6) - ligand code MI1 ; JAK1,TYK2 UNIPROT P23458 JAK1 -- JAK2,TYK2 UNIPROT O60674 JAK2 1590 ; ENZALUTAMIDE ; 915087-33-1 ; 2012 ; ; TARGET ANDROGEN RECEPTOR (AR) ; ATC (ENZALUTAMIDE) L02BB04 ; ; Androgen receptor UNIPROT P10275 AR 1591 ; M ENZALUTAMIDE ; 1242137-16-1 ; 0 ; ; TARGET ANDROGEN RECEPTOR (AR) ; ATC (ENZALUTAMIDE) L02BB04 ; ; Androgen receptor UNIPROT P10275 AR 1592 ; BOSUTINIB ; 380843-75-4 ; 2012 ; ; TARGET BCR-ABL ; ATC (BOSUTINIB) L01EA04 ; PDB 4OTW (HER3 PSEUDOKINASE DOMAIN BOUND TO BOSUTINIB) - ligand code DB8 ; Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 -- Proto-oncogene tyrosine-protein kinase Src UNIPROT P12931 SRC 1593 ; PONATINIB ; 943319-70-8 ; 2012 ; ; TARGET ABL ; ATC (PONATINIB) L01EA05 ; PDB 3ZOS (STRUCTURE OF THE DDR1 KINASE DOMAIN IN COMPLEX WITH PONATINIB) - ligand code 0LI ; Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 -- Breakpoint cluster region protein UNIPROT P11274 BCR 1594 ; OMACETAXINE MEPESUCCINATE ; 26833-87-4 ; 2012 ; DISCONTINUED ; TARGET RIBOSOME ; ATC (OMACETAXINE MEPESUCCINATE) L01XX40 ; PDB OBSOLETE (- 4UL7 CRYSTAL STRUCTURE OF HOMOHARRINGTONINE BOUND TO THE YEAST 80S RIBOSOME) - ligand code HMT ; UNKNOWN 1595 ; BEDAQUILINE ; 843663-66-1 ; 2012 ; ; TARGET ATP (ADENOSINE 5PRIME-TRIPHOSPHATE) SYNTHASE ; ATC (BEDAQUILINE) J04AK05 ; PDB 4V1F (CRYSTAL STRUCTURE OF A MYCOBACTERIAL ATP SYNTHASE ROTOR RING IN COMPLEX WITH BEDAQUILINE) - ligand code BQ1 ; ATP synthase UNIPROT P9WPS1 atpE 1596 ; POMALIDOMIDE ; 19171-19-8 ; 2013 ; ; ; ATC (POMALIDOMIDE) L04AX06 ; PDB 4CI3 (STRUCTURE OF THE DDB1-CRBN E3 UBIQUITIN LIGASE BOUND TO POMALIDOMIDE) - ligand code Y70 ; Protein cereblon UNIPROT Q96SW2 CRBN 1597 ; OSPEMIFENE ; 128607-22-7 ; 2013 ; ; TARGET ESTROGEN RECEPTOR ; ATC (OSPEMIFENE) G03XC05 ; ; Estrogen receptor UNIPROT P03372 ESR1 1598 ; DABRAFENIB ; 1195765-45-7 ; 2013 ; ; TARGET BRAF V600E KINASE (IC50=0.65 NANOMOLAR) -- BRAF V600K (IC50=0.5 NANOMOLAR) -- BRAF V600D (IC50=1.84 NANOMOLAR) -- WILD-TYPE BRAF (3.2 NANOMOLAR) -- CRAF KINASE (5 NANOMOLAR) ; ATC (DABRAFENIB) L01EC02 ; PDB 5CSW (B-RAF IN COMPLEX WITH DABRAFENIB) - ligand code P06 ; Serine,threonine-protein kinase B-raf UNIPROT P15056 BRAF 1599 ; POMALIDOMIDE ; 19171-19-8 ; 2013 ; ; ; ATC (POMALIDOMIDE) L04AX06 ; PDB 7SZA (CRYSTAL STRUCTURE ANALYSIS OF HUMAN PRPK COMPLEX WITH A COMPOUND) - ligand code DUI ; Protein cereblon UNIPROT Q96SW2 CRBN 1600 ; TRAMETINIB ; 871700-17-3 ; 2013 ; ; TARGET MEK1 -- MEK2 ; ATC (TRAMETINIB) L01EE01 ; PDB 7JUR (CRYSTAL STRUCTURE OF KSR2:MEK1 IN COMPLEX WITH AMP-PNP AND ALLOSTERIC MEK INHIBITOR TRAMETINIB) - ligand code QOM ; Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 -- Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2 1601 ; PICOSULFATE ; 10040-45-6 ; 2012 ; ; ; ATC (SODIUM PICOSULFATE) A06AB08 A06AB58 ; ; UNKNOWN 1602 ; ALOGLIPTIN ; 850649-61-5 ; 2013 ; ; TARGET DIPEPTIDYL PEPTIDASE-4 (DPP-4) ; ATC (ALOGLIPTIN) A10BH04 A10BD13 A10BD09 ; PDB 3G0B (CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH TAK-322) - ligand code T22 ; Dipeptidyl peptidase 4 UNIPROT P27487 DPP4 1603 ; CANAGLIFLOZIN ; 842133-18-0 ; 2013 ; ; TARGET SODIUM-GLUCOSE CO-TRANSPORTER 2 (SGLT2) ; ATC (CANAGLIFLOZIN) A10BK02 A10BD16 ; PDB 8HDH (STRUCTURE OF HUMAN SGLT2-MAP17 COMPLEX WITH CANAGLIFLOZIN) - ligand code L3R ; Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 1604 ; GLYCEROL PHENYLBUTYRATE ; 611168-24-2 ; 2013 ; ; TARGET PANCREATIC TRIGLYCERIDE LIPASE -- CARBOXYL ESTER LIPASE -- PANCREATIC LIPASE–RELATED PROTEIN 2 -- HUMAN ESTERASES ; ATC (GLYCEROL PHENYLBUTYRATE) A16AX09 ; ; UNKNOWN 1605 ; VILANTEROL ; 503068-34-6 ; 2013 ; ; TARGET BETA2-ADRENERGIC RECEPTOR ; ATC (VILANTEROL) R03AK10 R03AL03 R03AL08 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1606 ; NEOSTIGMINE ; 59-99-4 ; 2013 ; ; TARGET CHOLINESTERASE ; ATC (NEOSTIGMINE) N07AA01 S01EB06 N07AA51 ; ; Acetylcholinesterase UNIPROT P22303 ACHE 1607 ; PHENYLACETATE ; 7631-42-7 ; 0 ; ; TARGET PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE ; ATC (GLYCEROL PHENYLBUTYRATE) A16AX09 ; PDB 2ISF (CRYSTAL STRUCTURE OF C298A W219Y ALDOSE REDUCTASE COMPLEXED WITH PHENYLACETIC ACID) - ligand code PAC ; UNKNOWN 1608 ; M PICOSULFATE ; 603-41-8 ; 0 ; ; ; ATC (SODIUM PICOSULFATE) A06AB08 A06AB58 ; ; UNKNOWN 1609 ; NORFLUOXETINE ; 83891-03-6 ; 0 ; ; TARGET SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (FLUOXETINE) N06AB03 N06CA03 ; PDB 4XDK (CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH NORFLUOXETINE) - ligand code 405 ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1610 ; NORFLUOXETINE ; 83891-03-6 ; 0 ; ; TARGET SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (FLUOXETINE) N06AB03 N06CA03 ; PDB 4XDK (CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH NORFLUOXETINE) - ligand code 408 ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1611 ; DIACETOLOL ; 22568-64-5 ; 0 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ACEBUTOLOL) C07AB04 C07BB04 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 1612 ; DIACETOLOL ; 22568-64-5 ; 0 ; ; TARGET BETA-1 ADRENERGIC RECEPTOR ; ATC (ACEBUTOLOL) C07AB04 C07BB04 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 1613 ; PYRAZINOIC ACID ; 98-97-5 ; 0 ; ; TARGET MYCOBACTERIAL PYRAZINAMIDASE (PNCA) -- XANTHINE OXYDASE ; ATC (PYRAZINAMIDE) J04AK01 J04AM05 ; PDB 4NNI (STRUCTURAL BASIS FOR TARGETING THE RIBOSOMAL PROTEIN S1 OF MYCOBACTERIUM TUBERCULOSIS BY PYRAZINAMIDE) - ligand code VGL ; 3-oxoacyl-ACP synthase 1614 ; RIOCIGUAT ; 625115-55-1 ; 2013 ; ; TARGET SOLUBLE GUANYLATE CYCLASE ; ATC (RIOCIGUAT) C02KX05 ; PDB 8HBF (STRUCTURE OF HUMAN SOLUBLE GUANYLATE CYCLASE IN THE NO+RIO STATE AT 3.1 ANGSTROM) - ligand code GZO ; Guanylate cyclase soluble subunit beta-1 UNIPROT Q02153 GUCY1B3 1615 ; MACITENTAN ; 441798-33-0 ; 2013 ; ; TARGET ENDOTHELIN RECEPTOR ET-1 ; ATC (MACITENTAN) C02KX04 C02KX54 ; ; Endothelin-1 receptor UNIPROT P25101 EDNRA -- Endothelin B receptor UNIPROT P24530 EDNRB 1616 ; APROCITENTAN ; 1103522-45-7 ; 2024 ; ; TARGET ENDOTHELIN RECEPTOR ET-1 ; ATC (APROCITENTAN) C02KN01 ; ; 1617 ; VORTIOXETINE ; 508233-74-7 ; 2013 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (VORTIOXETINE) N06AX26 ; PDB 8BLA (HUMAN SEROTONIN 5-HT3A RECEPTOR IN COMPLEX WITH VORTIOXETINE (DETERGENT, ECD ONLY, ACTIVE, DISTORTED CONFORMATION)) - ligand code VTX ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 1618 ; AFATINIB ; 850140-72-6 ; 2013 ; ; TARGET EGFR (ERBB1) -- HER2 (ERBB2) -- HER4 (ERBB4) ; ATC (AFATINIB) L01EB03 ; PDB 4G5J (CRYSTAL STRUCTURE OF EGFR KINASE IN COMPLEX WITH BIBW2992) - ligand code 0WM ; Epidermal growth factor receptor UNIPROT P00533 EGFR -- Receptor tyrosine-protein kinase erbB-2 UNIPROT P04626 ERBB2 1619 ; LEVOMILNACIPRAN ; 96847-54-0 ; 2013 ; ; TARGET SEROTONIN TRANSPORTER -- NOREPINEPHRINE TRANSPORTER ; ATC (MILNACIPRAN) N06AX17 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1620 ; ESLICARBAZEPINE ; 104746-04-5 ; 0 ; ; TARGET VOLTAGE-GATED SODIUM CHANNELS ; ATC (ESLICARBAZEPINE) N03AF04 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 1621 ; ESLICARBAZEPINE ACETATE ; 236395-14-5 ; 2013 ; ; TARGET VOLTAGE-GATED SODIUM CHANNELS ; ATC (ESLICARBAZEPINE) N03AF04 ; ; Sodium channel alpha subunit UNIPROT P35498 SCN1A 1622 ; DOLUTEGRAVIR ; 1051375-16-6 ; 2013 ; ; TARGET HIV-1 INTEGRASE ; ATC (DOLUTEGRAVIR) J05AJ03 J05AR21 J05AR25 J05AR13 J05AR27 ; PDB 3S3O (CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) N224H MUTANT INTASOME IN COMPLEX WITH MAGNESIUM AND DOLUTEGRAVIR (S, GSK1349572)) - ligand code DLU ; Integrase UNIPROT Q7ZJM1 pol 1623 ; IBRUTINIB ; 936563-96-1 ; 2013 ; ; TARGET BRUTON TYROSINE KINASE (BTK) ; ATC (IBRUTINIB) L01EL01 ; PDB 4IFG (CRYSTAL STRUCTURE OF TGCDPK1 WITH INHIBITOR BOUND) - ligand code 1E8 ; Tyrosine-protein kinase BTK UNIPROT Q06187 BTK 1624 ; MONOMETHYL FUMARATE ; 2756-87-8 ; 2020 ; ; TARGET NICOTINIC ACID RECEPTOR (NIACR) ; ATC (DIMETHYL FUMARATE) L04AX07 ; PDB 8JHN (STRUCTURE OF MMF-GPR109A-G PROTEIN COMPLEX) - ligand code UR9 ; Kelch-like ECH-associated protein 1 UNIPROT Q14145 KEAP1 1625 ; DIMETHYL FUMARATE ; 624-49-7 ; 2013 ; ; TARGET NICOTINIC ACID RECEPTOR (NIACR) ; ATC (DIMETHYL FUMARATE) L04AX07 ; PDB 6LRZ (CRYSTAL STRUCTURE OF KEAP1 IN COMPLEX WITH DIMETHYL FUMARATE (DMF)) - ligand code EOU ; Kelch-like ECH-associated protein 1 UNIPROT Q14145 KEAP1 1626 ; SOFOSBUVIR ; 1190307-88-0 ; 2013 ; ; TARGET HEPATITIS C VIRUS (HCV) NUCLEOTIDE ANALOG NS5B POLYMERASE ; ATC (SOFOSBUVIR) J05AP08 J05AP51 J05AP55 J05AP56 ; PDB 8FHS (HUMAN L-TYPE VOLTAGE-GATED CALCIUM CHANNEL CAV1.2 IN THE PRESENCE OF AMIODARONE AND SOFOSBUVIR AT 3.3 ANGSTROM RESOLUTION) - ligand code WG6 ; NS5B protein UNIPROT Q8JXU8 NS5B -- Genome polyprotein UNIPROT P27958 1627 ; M SOFOSBUVIR ; 1015073-42-3 ; 0 ; ; TARGET HEPATITIS C VIRUS (HCV) NUCLEOTIDE ANALOG NS5B POLYMERASE ; ATC (SOFOSBUVIR) J05AP08 J05AP51 J05AP55 J05AP56 ; ; NS5B protein UNIPROT Q8JXU8 NS5B -- Genome polyprotein UNIPROT P27958 1628 ; SIMEPREVIR ; 923604-59-5 ; 2013 ; DISCONTINUED ; TARGET HEPATITIS C VIRUS (HCV) NS3/4A PROTEASE ; ATC (SIMEPREVIR) J05AP05 ; PDB 3KEE (HCV NS3, NS4A COMPLEXED WITH NON-COVALENT MACROCYCLIC COMPOUND TMC435) - ligand code 30B ; Hepatitis C virus serine protease, NS3,NS4A UNIPROT A3EZI9 NS3 -- Genome polyprotein UNIPROT P27958 1629 ; UMECLIDINIUM ; 869113-09-7 ; 2013 ; ; TARGET MUSCARINIC RECEPTORS M1 TO M5 ; ATC (VILANTEROL AND UMECLIDINIUM BROMIDE) R03AL03 ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 1630 ; BAZEDOXIFENE ; 198481-32-2 ; 2013 ; ; TARGET ESTROGEN RECEPTOR ALPHA -- ESTROGEN RECEPTOR BETA ; ATC (BAZEDOXIFENE) G03XC02 G03CC07 ; PDB 4XI3 (ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH BAZEDOXIFENE) - ligand code 29S ; Estrogen receptor UNIPROT P03372 ESR1 -- Estrogen receptor beta UNIPROT Q92731 ESR2 1631 ; LULICONAZOLE ; 187164-19-8 ; 2013 ; ; TARGET LANOSTEROL DEMETHYLASE ; ATC (LULICONAZOLE) D01AC18 ; ; Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11 1632 ; POLIDOCANOL ; 9002-92-0 ; 2010 ; ; TARGET MEMBRANE ; ATC (POLIDOCANOL) C05BB02 ; ; UNKNOWN 1633 ; CEFPODOXIME ; 80210-62-4 ; 0 ; ; TARGET PENICILLIN-BINDING PROTEIN ; ATC (CEFPODOXIME) J01DD13 J01DD64 ; ; UNKNOWN 1634 ; CEFPROZIL ; 92665-29-7 ; 1991 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFPROZIL) J01DC10 ; ; UNKNOWN 1635 ; CEFAMANDOLE ; 34444-01-4 ; 0 ; ; TARGET PENICILLIN-BINDING PROTEINS 1A/1B ; ATC (CEFAMANDOLE) J01DC03 ; PDB 3NY4 (CRYSTAL STRUCTURE OF BLAC-K73A BOUND WITH CEFAMANDOLE) - ligand code SMX ; UNKNOWN 1636 ; DAUNORUBICINOL ; 28008-55-1 ; 0 ; ; TARGET TOPOISOMERASE II -- DNA -- MULTIDRUG RESISTANCE PROTEIN 1 -- POLYMERASE ; ATC (DAUNORUBICIN) L01XY01 L01DB02 ; ; DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A 1637 ; M TETRABENAZINE ; 85081-18-1 ; 0 ; ; TARGET VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) ; ATC (TETRABENAZINE) N07XX06 ; ; Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 1638 ; M TETRABENAZINE ; 164104-49-8 ; 0 ; ; TARGET VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) ; ATC (TETRABENAZINE) N07XX06 ; ; Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 1639 ; M NELARABINE ; 72490-81-4 ; 0 ; ; TARGET DNA ; ATC (NELARABINE) L01BB07 ; ; UNKNOWN 1640 ; M ENTECAVIR ; 336608-44-7 ; 0 ; ; TARGET HBV REVERSE TRANSCRIPTASE ; ATC (ENTECAVIR) J05AF10 ; ; Protein P UNIPROT Q9IF40 P 1641 ; M CLOFARABINE ; 134646-41-6 ; 0 ; ; TARGET RIBONUCLEOTIDE REDUCTASE ; ATC (CLOFARABINE) L01BB06 ; ; DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 -- Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 1642 ; M CICLESONIDE ; 161115-59-9 ; 0 ; ; TARGET CORTICOSTEROID-BINDING GLOBULIN ; ATC (CICLESONIDE) R01AD13 R03BA08 ; PDB 4UDD (GR IN COMPLEX WITH DESISOBUTYRYLCICLESONIDE) - ligand code CV7 ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1643 ; TIZOXANIDE ; 173903-47-4 ; 0 ; ; TARGET PYRUVATE:FERREDOXIN OXIDOREDUCTASE ; ATC (NITAZOXANIDE) P01AX11 ; ; Pyruvate dehydrogenase NADP(+) UNIPROT Q968X7 PFOR -- Pyruvate:ferredoxin oxidoreductase UNIPROT Q24982 1644 ; ADEFOVIR ; 106941-25-7 ; 0 ; ; TARGET HBV REVERSE TRANSCRIPTASE ; ATC (ADEFOVIR) J05AF08 ; PDB 2G1A (CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN APHA CLASS B ACID PHOSPHATASE, PHOSPHOTRANSFERASE) - ligand code 5HG ; Protein P UNIPROT Q9IF40 P 1645 ; M GANCICLOVIR ; 86761-38-8 ; 0 ; ; ; ATC (GANCICLOVIR) J05AB06 S01AD09 ; ; DNA polymerase catalytic subunit UNIPROT P04293 1646 ; M GANCICLOVIR ; 86761-38-8 ; 0 ; ; ; ATC (GANCICLOVIR) J05AB06 S01AD09 ; PDB 7AOM (STRUCTURE OF NUDT15 IN COMPLEX WITH GANCICLOVIR TRIPHOSPHATE) - ligand code RQ2 ; DNA polymerase catalytic subunit UNIPROT P04293 1647 ; OLMESARTAN ; 144689-24-7 ; 0 ; ; TARGET TYPE-1 ANGIOTENSIN II RECEPTOR ; ATC (OLMESARTAN MEDOXOMIL) C09CA08 C09DB02 C09DA08 C09DX03 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1648 ; M TRAVOPROST ; 54276-17-4 ; 0 ; ; TARGET FP PROSTANOID RECEPTOR ; ATC (TRAVOPROST) S01EE04 ; ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 1649 ; M DESLORATADINE ; 119410-08-1 ; 0 ; ; TARGET HISTAMINE H1 RECEPTOR ; ATC (DESLORATADINE) R06AX27 ; ; Histamine H1 receptor UNIPROT P35367 HRH1 1650 ; CYCLOGUANIL ; 516-21-2 ; 0 ; ; TARGET DIHYDROFOLATE REDUCTASE ; ATC (PROGUANIL) P01BB52 P01BB01 P01BB51 ; PDB 3UM8 (WILD-TYPE PLASMODIUM FALCIPARUM DHFR-TS COMPLEXED WITH CYCLOGUANIL AND NADPH) - ligand code 1CY ; Bifunctional dihydrofolate reductase-thymidylate synthase UNIPROT P13922 1651 ; M TEMOZOLOMIDE ; 3413-72-7 ; 0 ; ; TARGET DNA ; ATC (TEMOZOLOMIDE) L01AX03 ; ; UNKNOWN 1652 ; M RIFAPENTINE ; 79039-56-8 ; 0 ; ; TARGET DNA-DIRECTED RNA POLYMERASE ; ATC (RIFAPENTINE) J04AB05 ; ; Bacterial DNA-directed RNA polymerase UNIPROT P0A7Z4 rpoA 1653 ; M OXCARBAZEPINE ; 104746-03-4 ; 0 ; ; TARGET VOLTAGE SENSITIVE SODIUM CHANNEL ; ATC (OXCARBAZEPINE) N03AF02 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A 1654 ; M FLUOROURACIL ; 134-46-3 ; 0 ; ; TARGET THYMIDYLATE SYNTHASE (TS) ; ATC (FLUOROURACIL) L01BC02 L01BC52 ; PDB 3H9K (STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY) - ligand code UFP ; Thymidylate synthase UNIPROT P04818 TYMS 1655 ; M FLUOROURACIL ; 2710-64-7 ; 0 ; ; TARGET DNA ; ATC (FLUOROURACIL) L01BC02 L01BC52 ; PDB 5WNY (DNA POLYMERASE BETA SUBSTRATE COMPLEX WITH INCOMING 5-FDUTP) - ligand code B7P ; Thymidylate synthase UNIPROT P04818 TYMS 1656 ; M ALBENDAZOLE ; 54029-12-8 ; 0 ; ; TARGET TUBULIN ; ATC (ALBENDAZOLE) P02CA03 ; ; Tubulin UNIPROT C4PKY4 -- Tubulin UNIPROT F1L005 1657 ; M SIBUTRAMINE ; 168835-59-4 ; 0 ; ; TARGET MONOAMINE REUPTAKE ; ATC (SIBUTRAMINE) A08AA10 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1658 ; M SIBUTRAMINE ; 168835-59-4 ; 0 ; ; TARGET MONOAMINE REUPTAKE ; ATC (SIBUTRAMINE) A08AA10 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1659 ; M SIBUTRAMINE ; 84467-54-9 ; 0 ; ; TARGET MONOAMINE REUPTAKE ; ATC (SIBUTRAMINE) A08AA10 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1660 ; M SIBUTRAMINE ; 84467-54-9 ; 0 ; ; TARGET MONOAMINE REUPTAKE ; ATC (SIBUTRAMINE) A08AA10 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1661 ; M PENCICLOVIR ; 145839-78-7 ; 0 ; ; TARGET HSV POLYMERASE ; ATC (PENCICLOVIR) D06BB06 J05AB13 ; ; DNA polymerase catalytic subunit UNIPROT P04293 1662 ; M PENCICLOVIR ; 145839-78-7 ; 0 ; ; TARGET HSV POLYMERASE ; ATC (PENCICLOVIR) D06BB06 J05AB13 ; ; DNA polymerase catalytic subunit UNIPROT P04293 1663 ; M CIDOFOVIR ; 142276-30-0 ; 0 ; ; TARGET DNA POLYMERASE ; ATC (CIDOFOVIR) J05AB12 ; ; DNA polymerase catalytic subunit UNIPROT P04293 1664 ; M TAZAROTENE ; 118292-41-4 ; 0 ; ; TARGET RETINOIC ACID RECEPTOR GAMMA -- RETINOIC ACID RECEPTOR BETA -- RETINOIC ACID RECEPTOR ALPHA ; ATC (TAZAROTENE) D05AX05 D05AX55 ; ; Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor beta UNIPROT P10826 RARB 1665 ; M LATANOPROST ; 41639-83-2 ; 0 ; ; TARGET PROSTAGLANDIN F2-ALPHA RECEPTOR ; ATC (LATANOPROST) S01EE01 S01EE51 ; PDB 8XJM (LATANOPROST ACID BOUND PROSTAGLANDIN F2-ALPHA RECEPTOR-GQ PROTEIN COMPLEX) - ligand code 7WT ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 1666 ; M LAMIVUDINE ; 143188-53-8 ; 0 ; ; TARGET REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) ; ATC (LAMIVUDINE) J05AF05 J05AR02 J05AR25 J05AR16 J05AR12 J05AR13 J05AR27 J05AR24 J05AR11 J05AR28 J05AR07 J05AR01 J05AR04 J05AR05 ; PDB 4K4H (TERNARY CRYSTAL STRUCTURES OF A HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)3TC-TP.) - ligand code 1RZ ; Protein P UNIPROT Q9IF40 P -- Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1667 ; TRANDOLAPRILAT ; 87679-71-8 ; 0 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (TRANDOLAPRIL) C09AA10 C09BB10 ; PDB 2X93 (CRYSTAL STRUCTURE OF ANCE-TRANDOLAPRILAT COMPLEX) - ligand code X93 ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1668 ; M GEMCITABINE ; 116371-66-5 ; 0 ; ; TARGET DEOXYCYTIDINE KINASE ; ATC (GEMCITABINE) L01BC05 ; PDB 2EUD (STRUCTURES OF YEAST RIBONUCLEOTIDE REDUCTASE I COMPLEXED WITH LIGANDS AND SUBUNIT PEPTIDES) - ligand code GCQ ; Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 -- Ribonucleoside-diphosphate reductase subunit M2 UNIPROT P31350 RRM2 1669 ; M GEMCITABINE ; 110988-86-8 ; 0 ; ; TARGET DEOXYCYTIDINE KINASE ; ATC (GEMCITABINE) L01BC05 ; PDB 3MDC (DNA POLYMERASE LAMBDA IN COMPLEX WITH DFDCTP) - ligand code GTF ; Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 -- Ribonucleoside-diphosphate reductase subunit M2 UNIPROT P31350 RRM2 1670 ; M ACYCLOVIR ; 66341-18-2 ; 0 ; ; TARGET DNA POLYMERASE ; ATC (ACYCLOVIR) D06BB03 ; ; DNA polymerase catalytic subunit UNIPROT P04293 -- DNA polymerase catalytic subunit UNIPROT P09252 1671 ; M LOSARTAN ; 124750-92-1 ; 0 ; ; TARGET TYPE-1 ANGIOTENSIN II RECEPTOR ; ATC (LOSARTAN) C09CA01 C09DB06 C09DA01 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1672 ; NISOLDIPINE ; 63675-72-9 ; 1995 ; ; TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL ; ATC (NISOLDIPINE) C08CA07 ; ; Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C -- Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D 1673 ; MOEXIPRILAT ; 103775-14-0 ; 0 ; ; TARGET ANGIOTENSIN CONVERTING ENZYME (ACE) -- KININASE II ; ATC (MOEXIPRIL) C09AA13 C09BA13 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1674 ; M TRAMADOL ; 144830-14-8 ; 0 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (TRAMADOL) N02AX02 N02AJ16 N02AJ14 N02AJ15 N02AJ13 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1675 ; TRAMADOL ; 152538-36-8 ; 1995 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (TRAMADOL) N02AX02 N02AJ16 N02AJ14 N02AJ15 N02AJ13 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1676 ; M TRAMADOL ; 330999-27-4 ; 0 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (TRAMADOL) N02AX02 N02AJ16 N02AJ14 N02AJ15 N02AJ13 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1677 ; TRAMADOL ; 123134-25-8 ; 1995 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (TRAMADOL) N02AX02 N02AJ16 N02AJ14 N02AJ15 N02AJ13 ; PDB 6M47 (X-RAY STRUCTURE OF A DROSOPHILA DOPAMINE TRANSPORTER WITH NET-LIKE MUTATIONS (D121G, S426M, F471L) IN TRAMADOL BOUND FORM) - ligand code F1U ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1678 ; M TRAMADOL ; 144830-15-9 ; 0 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (TRAMADOL) N02AX02 N02AJ16 N02AJ14 N02AJ15 N02AJ13 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1679 ; TRAMADOL ; 27203-92-5 ; 1995 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (TRAMADOL) N02AX02 N02AJ16 N02AJ14 N02AJ15 N02AJ13 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1680 ; M TRAMADOL ; 144830-14-8 ; 0 ; ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (TRAMADOL) N02AX02 N02AJ16 N02AJ14 N02AJ15 N02AJ13 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1681 ; SPIRAPRILAT ; 83602-05-5 ; 0 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME (ACE) ; ATC (SPIRAPRIL) C09AA11 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1682 ; M CLADRIBINE ; 106867-30-5 ; 0 ; ; TARGET DNA ; ATC (CLADRIBINE) L01BB04 L04AA40 ; ; UNKNOWN 1683 ; M AMIFOSTINE ; 31098-42-7 ; 0 ; ; TARGET ALKALINE PHOSPHATASE ; ATC (AMIFOSTINE) V03AF05 ; PDB 7NIZ (HUMAN 14-3-3 SIGMA IN COMPLEX WITH HUMAN ESTROGEN RECEPTOR ALPHA PEPTIDE AND LIGANDS FUSICOCCIN-A AND WR-1065) - ligand code UGH ; UNKNOWN 1684 ; M ZALCITABINE ; 66004-77-1 ; 0 ; ; TARGET HIV REVERSE TRANSCRIPTASE (GAG-POL) -- DNA POLYMERASE-BETA -- MITOCHONDRIAL DNA POLYMERASE-GAMMA ; ATC (ZALCITABINE) J05AF03 ; PDB 4DQP (TERNARY COMPLEX OF BACILLUS DNA POLYMERASE I LARGE FRAGMENT, DNA DUPLEX, AND DDCTP (PAIRED WITH DG OF TEMPLATE)) - ligand code DCT ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1685 ; PERINDOPRILAT ; 95153-31-4 ; 0 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (PERINDOPRIL) C10BX15 C10BX12 C10BX11 C09AA04 C09BB04 C09BX02 C09BA04 C09BX01 C09BX04 C09BX06 C10BX21 C10BX14 C10BX13 ; PDB 2X94 (CRYSTAL STRUCTURE OF ANCE-PERINDOPRILAT COMPLEX) - ligand code X94 ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1686 ; M DIDANOSINE ; 122406-02-4 ; 0 ; ; TARGET REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) ; ATC (DIDANOSINE) J05AF02 ; ; Reverse transcriptase,RNaseH UNIPROT Q72549 pol 1687 ; M FLUDARABINE ; 74832-57-8 ; 0 ; ; TARGET DNA POLYMERASE ALPHA, GAMMA AND DELTA -- RIBONUCLEOTIDE DIPHOSPHATE REDUCTASE -- DNA PRIMASE -- DNA LIGASE I ; ATC (FLUDARABINE) L01BB05 ; PDB 6DWK (SAMHD1 BOUND TO FLUDARABINE-TP IN THE CATALYTIC POCKET) - ligand code HFD ; DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 1688 ; FLUDARABINE ; 21679-14-1 ; 0 ; ; TARGET DEOXYCYTIDINE KINASE ; ATC (FLUDARABINE) L01BB05 ; ; DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1 1689 ; M TICLOPIDINE ; 750643-90-4 ; 0 ; ; TARGET P2Y PURINOCEPTOR 12 ; ATC (TICLOPIDINE) B01AC05 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1690 ; M TICLOPIDINE ; 750643-90-4 ; 0 ; ; TARGET P2Y PURINOCEPTOR 12 ; ATC (TICLOPIDINE) B01AC05 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1691 ; HALOBETASOL ; 98651-66-2 ; 0 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (ULOBETASOL) D05AX55 D07AC21 ; ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1692 ; FOSINOPRILAT ; 95399-71-6 ; 0 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (FOSINOPRIL) C09AA09 C09BA09 ; PDB 7Z6Z (CRYSTAL STRUCTURE OF ANGIOTENSIN-1 CONVERTING ENZYME N-DOMAIN IN COMPLEX WITH FOSINOPRILAT) - ligand code KS8 ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1693 ; M CLOMIPRAMINE ; 303-48-0 ; 0 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (CLOMIPRAMINE) N06AA04 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1694 ; RAMIPRILAT ; 87269-97-4 ; 0 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (RAMIPRIL) C10BX06 C10BX18 C09AA05 C09BB07 C09BX05 C09BA05 C09BB05 C09BX03 C10BX17 C10BX04 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1695 ; QUINAPRILAT ; 82768-85-2 ; 0 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (QUINAPRIL) C09AA06 C09BA06 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1696 ; BENAZEPRILAT ; 86541-78-8 ; 0 ; ; TARGET ANGIOTENSIN-CONVERTING ENZYME ; ATC (BENAZEPRIL) C09AA07 C09BB13 C09BA07 ; ; Angiotensin-converting enzyme UNIPROT P12821 ACE 1697 ; M SIMVASTATIN ; 121009-77-6 ; 0 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA) ; ATC (SIMVASTATIN) C10AA01 C10BX01 C10BA02 C10BA04 C10BX04 A10BH51 ; PDB 1HW9 (COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH SIMVASTATIN) - ligand code SIM ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 1698 ; DIMESNA ; 16208-51-8 ; 0 ; ; TARGET METABOLITES ACROLEIN AND 4-HYDROXY-IFOSFAMIDE ; ATC (MESNA) R05CB05 V03AF01 ; ; 1699 ; M LOVASTATIN ; 75225-51-3 ; 0 ; ; TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE ; ATC (LOVASTATIN) C10AA02 C10BA01 ; PDB 3HLG (SIMVASTATIN SYNTHASE (LOVD), FROM ASPERGILLUS TERREUS, S5 MUTANT, S76A MUTANT, COMPLEX WITH LOVASTATIN) - ligand code LVA ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR 1700 ; M NABUMETONE ; 23981-47-7 ; 0 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (NABUMETONE) M01AX01 ; PDB 6U5A (CRYSTAL STRUCTURE OF EQUINE SERUM ALBUMIN COMPLEX WITH 6-MNA) - ligand code PWY ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 1701 ; M MISOPROSTOL ; 259218-79-6 ; 0 ; ; TARGET PROSTAGLANDIN RECEPTOR ; ATC (MISOPROSTOL) A02BB01 G02AD06 M01AE56 ; PDB 6M9T (CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA) - ligand code J9P ; Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3 1702 ; LABETALOL ; 36894-69-6 ; 1984 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR -- BETA ADRENERGIC RECEPTOR ; ATC (LABETALOL) C07AG01 C07CG01 C07BG01 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1703 ; LABETALOL ; 36894-69-6 ; 1984 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR -- BETA ADRENERGIC RECEPTOR ; ATC (LABETALOL) C07AG01 C07CG01 C07BG01 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1704 ; LABETALOL ; 36894-69-6 ; 1984 ; ; TARGET ALPHA-1 ADRENERGIC RECEPTOR -- BETA ADRENERGIC RECEPTOR ; ATC (LABETALOL) C07AG01 C07CG01 C07BG01 ; ; Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1705 ; M FLUTAMIDE ; 52806-53-8 ; 0 ; ; TARGET ANDROGEN RECEPTOR ; ATC (FLUTAMIDE) L02BB01 ; PDB 4OH6 (CRYSTAL STRUCTURE OF T877A-AR-LBD BOUND WITH CO-REGULATOR PEPTIDE) - ligand code HFT ; Androgen receptor UNIPROT P10275 AR 1706 ; M MINOXIDIL ; 83701-22-8 ; 0 ; ; TARGET ADENOSINE TRIPHOSPHATE-SENSITIVE POTASSIUM CHANNEL (PMID15133413) ; ATC (MINOXIDIL) C02DC01 D11AX01 ; ; Sulfonylurea receptor 2, Kir6.2 UNIPROT O60706 ABCC9 1707 ; M TAMOXIFEN ; 31750-48-8 ; 0 ; ; TARGET ESTROGEN RECEPTOR ; ATC (TAMOXIFEN) L02BA01 ; PDB 6Z8C (CRYSTAL STRUCTURE OF THE VOLTAGE-GATED SODIUM CHANNEL NAVMS (F208L) IN COMPLEX WITH N-DESMETHYLTAMOXIFEN (3.2 A RESOLUTION)) - ligand code QBN ; Estrogen receptor UNIPROT P03372 ESR1 1708 ; M SULINDAC ; 49627-27-2 ; 0 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (SULINDAC) M01AB02 ; PDB 4XUH (PPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH SULINDAC SULFIDE) - ligand code SFI ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 1709 ; M DIAZEPAM ; 1088-11-5 ; 0 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (DIAZEPAM) N05BA01 ; ; GABA A receptor alpha-5,beta-2,gamma-3 UNIPROT P31644 GABRA5 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 1710 ; VORAPAXAR ; 618385-01-6 ; 2014 ; DISCONTINUED ; TARGET PROTEASE-ACTIVATED RECEPTOR-1 (PAR-1) ; ATC (VORAPAXAR) B01AC26 ; PDB 3VW7 (CRYSTAL STRUCTURE OF HUMAN PROTEASE-ACTIVATED RECEPTOR 1 (PAR1) BOUND WITH ANTAGONIST VORAPAXAR AT 2.2 ANGSTROM) - ligand code VPX ; Proteinase-activated receptor 1 UNIPROT P25116 F2R 1711 ; DALBAVANCIN ; 171500-79-1 ; 2014 ; ; TARGET PEPTIDOGLYCAN PRECURSORS ; ATC (DALBAVANCIN) J01XA04 ; PDB 3RUL (A CARRIER PROTEIN STRATEGY YIELDS THE STRUCTURE OF DALBAVANCIN) ; UNKNOWN 1712 ; EFINACONAZOLE ; 164650-44-6 ; 2014 ; ; TARGET LANOSTEROL 14 ALPHA DEMETHYLASE ; ATC (EFINACONAZOLE) D01AC19 ; ; Lanosterol 14-alpha demethylase UNIPROT F2SHH3 1713 ; TAVABOROLE ; 174671-46-6 ; 2014 ; ; TARGET LEUCYL-TRNA SYNTHETASE (AARS) ; ATC (TAVABOROLE) D01AE24 ; ; Leucine-tRNA ligase UNIPROT F2SF18 1714 ; ORITAVANCIN ; 171099-57-3 ; 2014 ; ; TARGET PEPTIDOGLYCAN PRECURSORS ; ATC (ORITAVANCIN) J01XA05 ; ; UNKNOWN 1715 ; APREMILAST ; 608141-41-9 ; 2014 ; ; TARGET PHOSPHODIEASTERASE 4 (PDE4) ; ATC (APREMILAST) L04AA32 ; PDB 7CBQ (CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN IN COMPLEX WITH APREMILAST) - ligand code A9L ; cAMP-specific 3,5-cyclic phosphodiesterase 4D UNIPROT Q08499 PDE4D 1716 ; TEDIZOLID ; 856866-72-3 ; 0 ; ; TARGET RIBOSOME 50S SUBUNIT ; ATC (TEDIZOLID) J01XX11 ; PDB 6WRS (STRUCTURE OF THE 50S SUBUNIT OF THE RIBOSOME FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN COMPLEX WITH THE ANTIBIOTIC, TEDIZOLID) - ligand code U7V ; UNKNOWN 1717 ; TEDIZOLID PHOSPHATE ; 856867-55-5 ; 2014 ; ; TARGET RIBOSOME 50S SUBUNIT ; ATC (TEDIZOLID) J01XX11 ; ; UNKNOWN 1718 ; TESTOSTERONE UNDECANOATE ; 5949-44-0 ; 2014 ; ; TARGET ANDROGEN RECEPTOR ; ATC (TESTOSTERONE) G03BA03 G03EA02 ; ; Androgen receptor UNIPROT P10275 AR 1719 ; DAPAGLIFLOZIN ; 461432-26-8 ; 2014 ; ; TARGET SODIUM-GLUCOSE COTRANSPORTER 2 (SGLT2) ; ATC (DAPAGLIFLOZIN) A10BK01 A10BD15 A10BD25 A10BD21 A10BD29 ; PDB 8HEZ (STRUCTURE OF HUMAN SGLT2-MAP17 COMPLEX WITH DAPAGLIFLOZIN) - ligand code LE6 ; Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 1720 ; EMPAGLIFLOZIN ; 864070-44-0 ; 2014 ; ; TARGET SODIUM-GLUCOSE CO-TRANSPORTER2 (SGLT2) ; ATC (EMPAGLIFLOZIN) A10BK03 A10BD19 A10BD20 A10BD27 ; PDB 7Y0B (CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL-COA DEHYDROGENASE) - ligand code 7R3 ; Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 1721 ; SUVOREXANT ; 1030377-33-3 ; 2014 ; ; TARGET OREXIN RECEPTOR OX1R -- OREXIN RECEPTOR OX2R ; ATC (SUVOREXANT) N05CJ01 ; PDB OBSOLETE (- 4RNB CRYSTAL STRUCTURE OF THE HUMAN OX2 OREXIN RECEPTOR BOUND TO THE INSOMNIA DRUG SUVOREXANT) - ligand code SUV ; Orexin receptor type 1 UNIPROT O43613 HCRTR1 -- Orexin receptor type 2 UNIPROT O43614 HCRTR2 1722 ; DROXIDOPA ; 23651-95-8 ; 2014 ; ; TARGET DOPA-DECARBOXYLASE ; ATC (DROXIDOPA) C01CA27 ; ; Adrenergic receptor UNIPROT P07550 ADRB2 1723 ; PERAMIVIR ; 330600-85-6 ; 2014 ; ; TARGET NEURAMINIDASE ; ATC (PERAMIVIR) J05AH03 ; PDB 3K39 (CRYSTAL STRUCTURE OF B, PERTH NEURAMINIDASE D197E MUTANT IN COMPLEX WITH PERAMIVIR) - ligand code BCZ ; Neuraminidase UNIPROT P03468 -- Neuraminidase UNIPROT P03474 1724 ; FINAFLOXACIN ; 209342-40-5 ; 2014 ; DISCONTINUED ; TARGET DNA GYRASE -- TOPOISOMERASE IV ; ; ; UNKNOWN 1725 ; CEFTOLOZANE ; 689293-68-3 ; 2014 ; ; TARGET PENICILLIN-BINDING PROTEINS (PBPS) ; ATC (CEFTOLOZANE) J01DI54 ; ; UNKNOWN 1726 ; NETUPITANT ; 290297-26-6 ; 2014 ; ; TARGET SUBSTANCE P/NEUROKININ 1 (NK1) RECEPTOR ; ; PDB 6HLP (CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST NETUPITANT) - ligand code GAW ; Substance-P receptor UNIPROT P25103 TACR1 1727 ; NALOXEGOL ; 854601-70-0 ; 2014 ; ; TARGET MU-OPIOID RECEPTOR ; ATC (NALOXEGOL) A06AH03 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1728 ; ELIGLUSTAT ; 491833-29-5 ; 2014 ; ; TARGET GLUCOSYLCERAMIDE SYNTHASE ; ATC (ELIGLUSTAT) A16AX10 ; ; Ceramide glucosyltransferase UNIPROT Q16739 UGCG 1729 ; BELINOSTAT ; 414864-00-9 ; 2014 ; ; TARGET HISTONE DEACETYLASE (HDAC) ; ATC (BELINOSTAT) L01XH04 ; PDB 5EEN (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 2 IN COMPLEX WITH BELINOSTAT) - ligand code 5OG ; Histone deacetylase 5 UNIPROT Q9UQL6 HDAC5 -- Histone deacetylase 2 UNIPROT Q92769 HDAC2 1730 ; IDELALISIB ; 870281-82-6 ; 2014 ; ; TARGET PHOSPHOINOSITIDE 3-KINASE DELTA ; ATC (IDELALISIB) L01EM01 ; PDB 4XE0 (IDELALISIB BOUND TO THE P110 SUBUNIT OF PI3K DELTA) - ligand code 40L ; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD 1731 ; LEDIPASVIR ; 1256388-51-8 ; 2014 ; ; TARGET HCV NS5A ; ATC (LEDIPASVIR) J05AP51 ; ; Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT P27958 1732 ; MILTEFOSINE ; 58066-85-6 ; 2014 ; ; TARGET MEMBRANE ; ATC (MILTEFOSINE) P01CX04 ; ; UNKNOWN 1733 ; OMBITASVIR ; 1258226-87-7 ; 2014 ; ; TARGET HCV NS5A ; ATC (OMBITASVIR) J05AP53 ; ; Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT P27958 1734 ; PARITAPREVIR ; 1216941-48-8 ; 2014 ; ; TARGET HCV NS3/4A PROTEASE ; ATC (PARITAPREVIR) J05AP52 J05AP53 ; ; UNKNOWN 1735 ; DASABUVIR ; 1132935-63-7 ; 2014 ; DISCONTINUED ; TARGET HCV NON-NUCLEOSIDE NS5B PALM POLYMERASE ; ATC (DASABUVIR) J05AP09 J05AP52 ; ; UNKNOWN 1736 ; TASIMELTEON ; 609799-22-6 ; 2014 ; ; TARGET MELATONIN MT1 RECEPTOR -- MELATONIN MT2 RECEPTOR ; ATC (TASIMELTEON) N05CH03 ; ; Melatonin receptor type 1A UNIPROT P48039 MTNR1A -- Melatonin receptor type 1B UNIPROT P49286 MTNR1B 1737 ; OLAPARIB ; 763113-22-0 ; 2014 ; ; TARGET POLY (ADP-RIBOSE) POLYMERASE (PARP) -- PARP-1 -- PARP-2 -- PARP-3 ; ATC (OLAPARIB) L01XK01 ; PDB 5DS3 (CRYSTAL STRUCTURE OF CONSTITUTIVELY ACTIVE PARP-1) - ligand code 09L ; Poly ADP-ribose polymerase 2 UNIPROT Q9UGN5 PARP2 -- Poly ADP-ribose polymerase 1 UNIPROT P09874 PARP1 1738 ; CERITINIB ; 1032900-25-6 ; 2014 ; ; TARGET ALK TYROSINE KINASE ; ATC (CERITINIB) L01ED02 ; PDB 4MKC (CRYSTAL STRUCTURE OF ANAPLASTIC LYMPHOMA KINASE COMPLEXED WITH LDK378) - ligand code 4MK ; ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK 1739 ; PIRFENIDONE ; 53179-13-8 ; 2014 ; ; ; ATC (PIRFENIDONE) L04AX05 ; ; UNKNOWN 1740 ; NINTEDANIB ; 656247-17-5 ; 2014 ; ; TARGET VEGFR -- PDGFR -- FGFR ; ATC (NINTEDANIB) L01EX09 ; PDB 5MAF (CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR) - ligand code XIN ; Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Fibroblast growth factor receptor 3 UNIPROT P22607 FGFR3 1741 ; OLODATEROL ; 868049-49-4 ; 2014 ; ; TARGET BETA2 ADRENERGIC RECEPTOR ; ATC (OLODATEROL) R03AC19 R03AL06 ; PDB 8JJL (CRYO-EM STRUCTURE OF THE BETA2-AR-MBRIL, 1B3 FAB, GLUE COMPLEX WITH A FULL AGONIST) - ligand code DZQ ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1742 ; EDOXABAN ; 480449-70-5 ; 2015 ; ; TARGET FACTOR XA ; ATC (EDOXABAN) B01AF03 ; ; Coagulation factor X UNIPROT P00742 F10 1743 ; AVIBACTAM ; 1192500-31-4 ; 2015 ; ; TARGET BETA LACTAMASE ; ; PDB 4S2N (OXA-48) - ligand code FYG ; Beta-lactamase UNIPROT P05364 ampC -- Beta-lactamase UNIPROT P24735 ampC 1744 ; PANOBINOSTAT ; 404950-80-7 ; 2015 ; DISCONTINUED ; TARGET HISTONE DEACETYLASE ; ATC (PANOBINOSTAT) L01XH03 ; PDB 5EF8 (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 2 IN COMPLEX WITH PANOBINOSTAT) - ligand code LBH ; Histone deacetylase 5 UNIPROT Q9UQL6 HDAC5 -- Histone deacetylase 2 UNIPROT Q92769 HDAC2 1745 ; PALBOCICLIB ; 571190-30-2 ; 2015 ; ; TARGET CYCLIN-DEPENDENT KINASE (CDK) 4 -- CYCLIN-DEPENDENT KINASE (CDK) 6 ; ATC (PALBOCICLIB) L01EF01 ; PDB 2EUF (X-RAY STRUCTURE OF HUMAN CDK6-VCYCLIN IN COMPLEX WITH THE INHIBITOR PD0332991) - ligand code LQQ ; Cyclin-dependent kinase 6 UNIPROT Q00534 CDK6 -- Cyclin-dependent kinase 4 UNIPROT P11802 CDK4 1746 ; LENVATINIB ; 417716-92-8 ; 2015 ; ; TARGET VEGFR RECEPTORS ; ATC (LENVATINIB) L01EX08 ; PDB 3WZD (KDR IN COMPLEX WITH LIGAND LENVATINIB) - ligand code LEV ; Proto-oncogene tyrosine-protein kinase receptor Ret UNIPROT P07949 RET -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT 1747 ; M DOXEPIN ; 67035-76-1 ; 0 ; ; TARGET HISTAMINE H2 RECEPTOR -- HISTAMINE H1 RECEPTOR ; ATC (DOXEPIN) D04AX01 N06AA12 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Histamine H1 receptor UNIPROT P35367 HRH1 1748 ; M DOXEPIN ; 58534-46-6 ; 0 ; ; TARGET HISTAMINE H2 RECEPTOR -- HISTAMINE H1 RECEPTOR ; ATC (DOXEPIN) D04AX01 N06AA12 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Histamine H1 receptor UNIPROT P35367 HRH1 1749 ; DOXEPIN ; 1668-19-5 ; 1969 ; ; TARGET HISTAMINE H2 RECEPTOR -- HISTAMINE H1 RECEPTOR ; ATC (DOXEPIN) D04AX01 N06AA12 ; PDB 3RZE (STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR IN COMPLEX WITH DOXEPIN) - ligand code 5EH ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Histamine H1 receptor UNIPROT P35367 HRH1 1750 ; M CYTARABINE ; 13191-15-6 ; 0 ; ; TARGET DNA POLYMERASE ; ATC (CYTARABINE) L01BC01 L01XY01 ; PDB 6DW3 (SAMHD1 BOUND TO CYTARABINE-TP IN THE CATALYTIC POCKET) - ligand code HF4 ; DNA polymerase (alpha,delta,epsilon) UNIPROT P09884 POLA1 1751 ; M FLURAZEPAM ; 2886-65-9 ; 0 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (FLURAZEPAM) N05CD01 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 1752 ; M CARBAMAZEPINE ; 36507-30-9 ; 0 ; ; TARGET VOLTAGE-GATED SODIUM CHANNELS ; ATC (CARBAMAZEPINE) N03AF01 ; ; Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A 1753 ; CLOMIPHENE ; 911-45-5 ; 1967 ; ; TARGET ESTROGEN RECEPTOR ; ATC (CLOMIFENE) G03GB02 ; PDB 6VPF (ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH THE SELECTIVE ESTROGEN RECEPTOR MODULATOR CLOMIPHENE) - ligand code 53Q ; Estrogen receptor UNIPROT P03372 ESR1 1754 ; M CLOFIBRATE ; 882-09-7 ; 0 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ; ATC (CLOFIBRATE) C10AB01 ; PDB 7BPY (X-RAY STRUCTURE OF HUMAN PPARALPHA LIGAND BINDING DOMAIN-CLOFIBRIC ACID-SRC1 COACTIVATOR PEPTIDE CO-CRYSTALS OBTAINED BY DELIPIDATION AND CO-CRYSTALLIZATION) - ligand code E0O ; Peroxisome proliferator-activated receptor alpha UNIPROT Q07869 PPARA 1755 ; M ALLOPURINOL ; 2465-59-0 ; 0 ; ; TARGET XANTHINE OXIDASE ; ATC (ALLOPURINOL) M04AA01 M04AA51 ; ; Xanthine dehydrogenase,oxidase UNIPROT P47989 XDH 1756 ; M NALIDIXIC ACID ; 3759-18-0 ; 0 ; ; TARGET DNA GYRASE ; ATC (NALIDIXIC ACID) J01MB02 ; ; DNA gyrase UNIPROT P0AES4 gyrA 1757 ; M ACETOHEXAMIDE ; 968-80-9 ; 0 ; ; TARGET ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL ; ATC (ACETOHEXAMIDE) A10BB31 ; ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 1758 ; M ACETOHEXAMIDE ; 220948-25-4 ; 0 ; ; TARGET ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL ; ATC (ACETOHEXAMIDE) A10BB31 ; ; Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 1759 ; M THIOGUANINE ; 15867-02-4 ; 0 ; ; TARGET IMP DEHYDROGENASE -- GLUTAMINE-5-PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE ; ATC (TIOGUANINE) L01BB03 ; ; Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1 -- Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2 1760 ; THIOPENTAL ; 76-75-5 ; 1959 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR ; ATC (THIOPENTAL) N01AF03 N05CA19 ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 1761 ; HALOTHANE ; 151-67-7 ; 1958 ; DISCONTINUED ; TARGET POLYPHARMACOLOGY (VOLTAGE-DEPENDENT ANION CHANNEL, GABA, PMID24563623) ; ATC (HALOTHANE) N01AB01 ; PDB 1XZ1 (COMPLEX OF HALOTHANE WITH APOFERRITIN) - ligand code HLT_1XZ1 ; Potassium channel subfamily K member 2 UNIPROT O95069 KCNK2 -- Potassium channel subfamily K member 3 UNIPROT O14649 KCNK3 1762 ; M METHSUXIMIDE ; 39122-10-6 ; 0 ; ; ; ATC (MESUXIMIDE) N03AD03 ; ; Voltage-gated T-type calcium channel UNIPROT O43497 CACNA1G 1763 ; M METHSUXIMIDE ; 39122-11-7 ; 0 ; ; ; ATC (MESUXIMIDE) N03AD03 ; ; Voltage-gated T-type calcium channel UNIPROT O43497 CACNA1G 1764 ; PHENMETRAZINE ; 134-49-6 ; 0 ; DISCONTINUED ; TARGET NORADRENALINE TRANSPORTER -- DOPAMINE TRANSPORTER ; ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1765 ; PHENMETRAZINE ; 134-49-6 ; 0 ; DISCONTINUED ; TARGET NORADRENALINE TRANSPORTER -- DOPAMINE TRANSPORTER ; ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1766 ; PHENMETRAZINE ; 134-49-6 ; 0 ; DISCONTINUED ; TARGET NORADRENALINE TRANSPORTER -- DOPAMINE TRANSPORTER ; ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1767 ; METHYPRYLON ; 125-64-4 ; 1955 ; DISCONTINUED ; ; ATC (METHYPRYLON) N05CE02 ; ; GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1 1768 ; TALBUTAL ; 115-44-6 ; 1954 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA) ; ATC (TALBUTAL) N05CA07 ; ; GABA-A receptor 1769 ; PHENSUXIMIDE ; 86-34-0 ; 1953 ; DISCONTINUED ; ; ATC (PHENSUXIMIDE) N03AD02 ; ; Voltage-gated T-type calcium channel UNIPROT O43497 CACNA1G 1770 ; M ASPIRIN ; 69-72-7 ; 0 ; ; TARGET PROSTAGLANDIN G/H SYNTHASE 1 -- PROSTAGLANDIN G/H SYNTHASE 2 ; ATC (ACETYLSALICYLIC ACID) A01AD05 B01AC06 N02BA01 M01BA03 N02BA51 B01AC56 N02BA71 C10BX08 C10BX12 C10BX06 C07FX04 N02AJ07 N02AJ02 C07FX03 N02AJ18 C10BX02 B01AF51 C10BX05 C10BX01 C10BX04 C07FX02 ; PDB 2FN1 (CRYSTAL STRUCTURES OF YERSINIA ENTEROCOLITICA SALICYLATE SYNTHASE (IRP9) IN COMPLEX WITH THE REACTION PRODUCTS SALICYLATE AND PYRUVATE) - ligand code SAL ; Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 1771 ; CORTISONE ; 53-06-5 ; 0 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (CORTISONE) H02AB10 S01BA03 ; PDB 8CC0 (CRYSTAL STRUCTURE OF ANTI-CORTISOL FAB IN COMPLEX WITH CORTISONE) - ligand code UQC ; Glucocorticoid receptor UNIPROT P04150 NR3C1 1772 ; M AMODIAQUINE ; 79352-78-6 ; 0 ; ; ; ATC (AMODIAQUINE) P01BA06 P01BF03 ; ; UNKNOWN 1773 ; M TRIMETHADIONE ; 695-53-4 ; 0 ; ; TARGET VOLTAGE DEPENDENT CALCIUM CHANNEL (PMID24846538) ; ATC (TRIMETHADIONE) N03AC02 ; ; Voltage-dependent T-type calcium channel subunit alpha-1G UNIPROT O43497 CACNA1G 1774 ; BUTABARBITAL ; 125-40-6 ; 1939 ; DISCONTINUED ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA) ; ; ; GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1 1775 ; FLORBETAPIR ; 956103-76-7 ; 2012 ; ; TARGET BETA-AMYLOID PLAQUE ; ATC (FLORBETAPIR (18F)) V09AX05 ; ; Amyloid-beta precursor protein UNIPROT P05067 APP 1776 ; FLUTEMETAMOL ; 765922-62-1 ; 2013 ; ; TARGET BETA-AMYLOID PLAQUE ; ATC (FLUTEMETAMOL 18F) V09AX04 ; ; Amyloid-beta precursor protein UNIPROT P05067 1777 ; FLORBETABEN ; 902143-01-5 ; 2014 ; ; TARGET BETA-AMYLOID PLAQUE ; ATC (FLORBETABEN (18F)) V09AX06 ; ; Amyloid-beta precursor protein UNIPROT P05067 APP 1778 ; CANGRELOR ; 163706-06-7 ; 2015 ; ; TARGET P2Y12 PLATELET RECEPTOR ; ATC (CANGRELOR) B01AC25 ; ; P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12 1779 ; SONIDEGIB ; 956697-53-3 ; 2015 ; ; TARGET SMOOTHENED (SMO) ; ATC (SONIDEGIB) L01XJ02 ; ; Smoothened homolog UNIPROT Q99835 SMO 1780 ; BREXPIPRAZOLE ; 913611-97-9 ; 2015 ; ; TARGET 5-HT1A RECEPTORS -- DOPAMINE D2 RECEPTOR -- 5-HT2A RECEPTOR ; ATC (BREXPIPRAZOLE) N05AX16 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 1781 ; CHOLIC ACID ; 81-25-4 ; 2015 ; ; TARGET FXR ; ATC (CHOLIC ACID) A05AA03 ; ; G-protein coupled bile acid receptor 1 UNIPROT Q8TDU6 GPBAR1 1782 ; LUMACAFTOR ; 936727-05-8 ; 2015 ; ; TARGET CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR ; ATC (LUMACAFTOR) R07AX30 ; PDB 7SVD (THE COMPLEX OF PHOSPHORYLATED HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH ATP, MG AND LUMACAFTOR (VX-809)) - ligand code VX8 ; Cystic fibrosis transmembrane conductance regulator UNIPROT P13569 CFTR 1783 ; IVABRADINE ; 155974-00-8 ; 2015 ; ; TARGET HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNEL ; ATC (IVABRADINE) C07FX06 C01EB17 C07FX05 ; ; Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 UNIPROT O60741 HCN1 -- Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 UNIPROT Q9UL51 HCN2 1784 ; DEOXYCHOLIC ACID ; 83-44-3 ; 2015 ; ; ; ATC (DEOXYCHOLIC ACID) D11AX24 ; PDB OBSOLETE (- 1WB2 CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS, APO FORM) - ligand code DXC ; UNKNOWN 1785 ; DACLATASVIR ; 1009119-64-5 ; 2015 ; DISCONTINUED ; TARGET NS5A ; ATC (DACLATASVIR) J05AP07 J05AP58 ; ; Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT P27958 1786 ; ELUXADOLINE ; 864821-90-9 ; 2015 ; ; TARGET MU-OPIOID RECEPTOR ; ATC (ELUXADOLINE) A07DA06 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 -- Delta-type opioid receptor UNIPROT P41143 OPRD1 1787 ; ISAVUCONAZONIUM ; 742049-41-8 ; 2015 ; ; TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450 P-45014DM PMID26598096) ; ATC (ISAVUCONAZOLE) J02AC05 ; ; UNKNOWN 1788 ; ISAVUCONAZOLE ; 241479-67-4 ; 0 ; ; TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450 P-45014DM PMID26598096) ; ATC (ISAVUCONAZOLE) J02AC05 ; PDB 6UX0 (ISAVUCONAZOLE BOUND COMPLEX OF ACANTHAMOEBA CASTELLANII CYP51) - ligand code QKM ; UNKNOWN 1789 ; SACUBITRIL ; 149709-62-6 ; 2015 ; ; TARGET NEPRILYSIN ; ATC (SACUBITRIL) C09DX04 ; ; Neprilysin UNIPROT P08473 MME 1790 ; M SACUBITRIL ; 149709-44-4 ; 0 ; ; TARGET NEPRILYSIN ; ATC (SACUBITRIL) C09DX04 ; PDB 5JMY (NEPRILYSIN COMPLEXED WITH LBQ657) - ligand code 6LD ; Neprilysin UNIPROT P08473 MME 1791 ; DESOXYCORTICOSTERONE ; 64-85-7 ; 0 ; ; TARGET ALDOSTERONE SYNTHASE ; ATC (DESOXYCORTONE) H02AA03 ; PDB 2AA7 (MINERALOCORTICOID RECEPTOR WITH BOUND DEOXYCORTICOSTERONE) - ligand code 1CA ; Mineralocorticoid receptor UNIPROT P08235 NR3C2 1792 ; SUGAMMADEX ; 343306-71-8 ; 2015 ; ; ; ATC (SUGAMMADEX) V03AB35 ; ; UNKNOWN 1793 ; FLIBANSERIN ; 167933-07-5 ; 2015 ; ; TARGET 5-HT1A RECEPTOR -- 5-HT2A RECEPTOR ; ATC (FLIBANSERIN) G02CX02 ; ; 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1794 ; CARIPRAZINE ; 839712-12-8 ; 2015 ; ; TARGET DOPAMINE D2 RECEPTOR -- 5-HT1A RECEPTOR ; ATC (CARIPRAZINE) N05AX15 ; PDB 7VOD (CRYSTAL STRUCTURE OF 5-HT2AR IN COMPLEX WITH CARIPRAZINE) - ligand code 7RU ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 1795 ; M CARIPRAZINE ; 839712-15-1 ; 0 ; ; TARGET DOPAMINE D2 RECEPTOR -- 5-HT1A RECEPTOR ; ATC (CARIPRAZINE) N05AX15 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 1796 ; M CARIPRAZINE ; 839712-25-3 ; 0 ; ; TARGET DOPAMINE D2 RECEPTOR -- 5-HT1A RECEPTOR ; ATC (CARIPRAZINE) N05AX15 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 1797 ; METHYLENE BLUE ; 61-73-4 ; 2016 ; ; TARGET NADPH REDUCTASE ; ATC (METHYLTHIONINIUM CHLORIDE) V03AB17 V04CG05 ; PDB 5DLP (ACETYCHOLINESTERASE METHYLENE BLUE NO PEG) - ligand code MBT ; Thioredoxin reductase 1, cytoplasmic UNIPROT Q16881 1798 ; LEUCOMETHYLENE BLUE ; 613-11-6 ; 0 ; ; TARGET HEMOGLOBIN IRON ; ATC (METHYLTHIONINIUM CHLORIDE) V03AB17 V04CG05 ; ; 1799 ; BRIVARACETAM ; 357336-20-0 ; 2016 ; ; TARGET SYNAPTIC VESICLE GLYCOPROTEIN 2A (SV2A) ; ATC (BRIVARACETAM) N03AX23 ; PDB 8K77 (CRYO-EM STRUCTURE OF SV2A IN COMPLEX WITH BONT, A2 HC AND BRIVARACETAM) - ligand code VLX ; Synaptic vesicle glycoprotein 2A UNIPROT Q7L0J3 SV2A 1800 ; COBIMETINIB ; 934660-93-2 ; 2015 ; ; TARGET MAPK -- MEK1 -- MEK2 ; ATC (COBIMETINIB) L01EE02 ; PDB 4AN2 (CRYSTAL STRUCTURES OF HUMAN MEK1 WITH CARBOXAMIDE-BASED ALLOSTERIC INHIBITOR XL518 (GDC-0973), OR RELATED ANALOGS.) - ligand code EUI ; Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 1801 ; ROLAPITANT ; 552292-08-7 ; 2015 ; ; TARGET P/NEUROKININ-1 (NK1) RECEPTOR ; ATC (ROLAPITANT) A04AD14 ; ; Substance-P receptor UNIPROT P25103 TACR1 1802 ; PIMAVANSERIN ; 706779-91-1 ; 2016 ; ; TARGET 5-HT2A RECEPTOR -- 5-HT2C RECEPTOR ; ATC (PIMAVANSERIN) N05AX17 ; ; 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1803 ; M PIMAVANSERIN ; 639863-77-7 ; 0 ; ; TARGET 5-HT2A RECEPTOR -- 5-HT2C RECEPTOR ; ATC (PIMAVANSERIN) N05AX17 ; ; 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1804 ; ARIPIPRAZOLE LAUROXIL ; 1259305-29-7 ; 2015 ; ; TARGET 5-HYDROXYTRYPTAMINE 1A RECEPTOR -- 5-HYDROXYTRYPTAMINE 2A RECEPTOR -- D2 DOPAMINE RECEPTOR -- ADRENERGIC ALPHA1 RECEPTOR ; ATC (ARIPIPRAZOLE) N05AX12 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1805 ; TENOFOVIR ALAFENAMIDE ; 379270-37-8 ; 2015 ; ; TARGET HIV REVERSE TRANSCRIPTASE ; ATC (TENOFOVIR ALAFENAMIDE) J05AR17 J05AR20 J05AR19 J05AF13 ; ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1806 ; SELEXIPAG ; 475086-01-2 ; 2015 ; ; TARGET IP PROSTACYCLIN RECEPTOR ; ATC (SELEXIPAG) B01AC27 ; ; Prostacyclin receptor UNIPROT P43119 PTGIR 1807 ; M SELEXIPAG ; 475086-28-3 ; 0 ; ; TARGET IP PROSTACYCLIN RECEPTOR ; ATC (SELEXIPAG) B01AC27 ; ; Prostacyclin receptor UNIPROT P43119 PTGIR 1808 ; TRABECTEDIN ; 114899-77-3 ; 2015 ; ; TARGET DNA ; ATC (TRABECTEDIN) L01CX01 ; ; UNKNOWN 1809 ; TIPIRACIL ; 183204-74-2 ; 2015 ; ; TARGET THYMIDINE PHOSPHORYLASE ; ; PDB 1UOU (CRYSTAL STRUCTURE OF HUMAN THYMIDINE PHOSPHORYLASE IN COMPLEX WITH A SMALL MOLECULE INHIBITOR) - ligand code CMU ; Thymidine phosphorylase UNIPROT P19971 TYMP 1810 ; LESINURAD ; 878672-00-5 ; 2015 ; DISCONTINUED ; TARGET URIC ACID TRANSPORTER 1 (URAT1) -- ORGANIC ANION TRANSPORTER 4 (OAT4) ; ATC (LESINURAD) M04AB05 ; ; Solute carrier family 22 member 12 UNIPROT Q96S37 SLC22A12 1811 ; OBETICHOLIC ACID ; 459789-99-2 ; 2016 ; ; TARGET FARNESOID X RECEPTOR (FXR) ; ATC (OBETICHOLIC ACID) A05AA04 ; PDB 1OT7 (STRUCTURAL BASIS FOR 3-DEOXY-CDCA BINDING AND ACTIVATION OF FXR) - ligand code CHC ; Bile acid receptor UNIPROT Q96RI1 NR1H4 1812 ; OSIMERTINIB ; 1421373-65-0 ; 2015 ; ; TARGET EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) ; ATC (OSIMERTINIB) L01EB04 ; PDB 4ZAU (AZD9291 COMPLEX WITH WILD TYPE EGFR) - ligand code YY3 ; Epidermal growth factor receptor UNIPROT P00533 EGFR 1813 ; URIDINE TRIACETATE ; 4105-38-8 ; 2015 ; ; TARGET ESTERASES ; ATC (URIDINE TRIACETATE) A16AX13 ; ; UNKNOWN 1814 ; URIDINE ; 58-96-8 ; 0 ; ; TARGET RNA ; ATC (URIDINE) A16AX13 ; PDB 5M2T (X-RAY STRUCTURE OF URIDINE PHOSPHORYLASE FROM VIBRIO CHOLERAE IN COMPLEX WITH URIDINE AT 1.03 A RESOLUTION) - ligand code URI ; P2Y purinoceptor 2 UNIPROT P41231 P2RY2 1815 ; ELBASVIR ; 1370468-36-2 ; 2016 ; ; TARGET NS5A ; ATC (ELBASVIR) J05AP10 J05AP54 ; ; Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT P27958 1816 ; GRAZOPREVIR ; 1350514-68-9 ; 2016 ; ; TARGET NS3/4A PROTEASE ; ATC (GRAZOPREVIR) J05AP54 J05AP11 ; PDB 3SUF (CRYSTAL STRUCTURE OF NS3, 4A PROTEASE VARIANT D168A IN COMPLEX WITH MK-5172) - ligand code SUE ; Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT P27958 1817 ; EPHEDRINE ; 299-42-3 ; 2016 ; ; TARGET ALPHA ADRENERGIC RECEPTOR -- BETA ADRENERGIC RECEPTOR ; ATC (EPHEDRINE) C01CA26 R01AA03 R01AB05 R03CA02 S01FB02 A08AA56 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 1818 ; VELPATASVIR ; 1377049-84-7 ; 2016 ; ; TARGET NS5A ; ATC (VELPATASVIR) J05AP55 J05AP56 ; ; Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT P27958 1819 ; ALECTINIB ; 1256580-46-7 ; 2015 ; ; TARGET ALK KINASE -- RET KINASE ; ATC (ALECTINIB) L01ED03 ; PDB 3AOX (X-RAY CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CH5424802) - ligand code EMH ; ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK -- Proto-oncogene tyrosine-protein kinase receptor Ret UNIPROT P07949 RET 1820 ; IXAZOMIB ; 1072833-77-2 ; 0 ; ; TARGET 20S PROTEASOME ; ATC (IXAZOMIB) L01XG03 ; PDB 5LF7 (HUMAN 20S PROTEASOME COMPLEX WITH IXAZOMIB AT 2.0 ANGSTROM) - ligand code 6V8 ; Proteasome subunit beta type-5 UNIPROT P28074 PSMB5 1821 ; IXAZOMIB CITRATE ; 1239908-20-3 ; 2015 ; ; TARGET 20S PROTEASOME ; ATC (IXAZOMIB) L01XG03 ; ; Proteasome subunit beta type-5 UNIPROT P28074 PSMB5 1822 ; VENETOCLAX ; 1257044-40-8 ; 2016 ; ; TARGET BCL-2 ; ATC (VENETOCLAX) L01XX52 ; PDB 6O0K (CRYSTAL STRUCTURE OF BCL-2 WITH VENETOCLAX) - ligand code LBM ; Apoptosis regulator Bcl-2 UNIPROT P10415 BCL2 1823 ; CRISABOROLE ; 906673-24-3 ; 2016 ; ; TARGET PHOSPHODIESTERASE 4 ; ATC (CRISABOROLE) D11AH06 ; ; Phosphodiesterase 4 UNIPROT P27815 PDE4A 1824 ; LIFITEGRAST ; 1025967-78-5 ; 2016 ; ; TARGET LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1) ; ATC (LIFITEGRAST) S01XA25 ; ; Integrin alpha-L,beta-2 UNIPROT P20701 ITGAL 1825 ; PRASTERONE ; 53-43-0 ; 2016 ; ; TARGET HYDROXYSTEROID DEHYDROGENASES -- 5ALPHA-REDUCTASES -- AROMATASES ; ATC (PRASTERONE) A14AA07 G03XX01 G03EA03 ; PDB 1Q22 (CRYSTAL STRUCTURE OF HUMAN CHOLESTEROL SULFOTRANSFERASE (SULT2B1B) IN THE PRESENCE OF DHEA AND PAP) - ligand code AND ; UNKNOWN 1826 ; RUCAPARIB ; 283173-50-2 ; 2016 ; ; TARGET POLY (ADP-RIBOSE) POLYMERASE (PARP) -- PARP-1 -- PARP-2 -- PARP-3 ; ATC (RUCAPARIB) L01XK03 ; PDB 4BJC (CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH RUCAPARIB) - ligand code RPB ; Poly ADP-ribose polymerase 2 UNIPROT Q9UGN5 PARP2 -- Poly ADP-ribose polymerase 1 UNIPROT P09874 PARP1 1827 ; SAFINAMIDE ; 133865-89-1 ; 2017 ; ; TARGET MONOAMINE OXIDASE TYPE B (MAO-B) ; ATC (SAFINAMIDE) N04BD03 ; ; Amine oxidase flavin-containing B UNIPROT P27338 MAOB 1828 ; MIDOSTAURIN ; 120685-11-2 ; 2017 ; ; TARGET FLT3 KINASE -- FLT3 MUTANT KINASES -- KIT -- PDGFR -- VEGFR2 -- SERINE/THREONINE KINASE PKC ; ATC (MIDOSTAURIN) L01EX10 ; PDB 4NCT (HUMAN DYRK1A IN COMPLEX WITH PKC412) - ligand code 2K2 ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 1829 ; M MIDOSTAURIN ; 740816-86-8 ; 0 ; ; TARGET FLT3 KINASE -- FLT3 MUTANT KINASES -- KIT -- PDGFR -- VEGFR2 -- SERINE/THREONINE KINASE PKC ; ATC (MIDOSTAURIN) L01EX10 ; ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 1830 ; M MIDOSTAURIN ; 179237-49-1 ; 0 ; ; TARGET FLT3 KINASE -- FLT3 MUTANT KINASES -- KIT -- PDGFR -- VEGFR2 -- SERINE/THREONINE KINASE PKC ; ATC (MIDOSTAURIN) L01EX10 ; ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 1831 ; NERATINIB ; 698387-09-6 ; 2017 ; ; TARGET EGFR -- HER2 -- HER4 ; ATC (NERATINIB) L01EH02 ; ; Receptor tyrosine-protein kinase erbB-4 UNIPROT Q15303 ERBB4 -- Epidermal growth factor receptor UNIPROT P00533 EGFR 1832 ; BETRIXABAN ; 330942-05-7 ; 2017 ; DISCONTINUED ; TARGET FACTOR XA (FXA) ; ATC (BETRIXABAN) B01AF04 ; ; Coagulation factor X UNIPROT P00742 F10 1833 ; ETELCALCETIDE ; 1262780-97-1 ; 2017 ; ; TARGET CALCIUM-SENSING RECEPTOR (CASR) ; ATC (ETELCALCETIDE) H05BX04 ; ; Extracellular calcium-sensing receptor UNIPROT P41180 CASR 1834 ; NIRAPARIB ; 1038915-60-4 ; 2017 ; ; TARGET POLY(ADP-RIBOSE) POLYMERASE (PARP) -- PARP-1 -- PARP-2 ; ATC (NIRAPARIB) L01XK02 L01XK52 ; PDB 4R6E (HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR NIRAPARIB) - ligand code 3JD ; Poly ADP-ribose polymerase 2 UNIPROT Q9UGN5 PARP2 -- Poly ADP-ribose polymerase 1 UNIPROT P09874 PARP1 1835 ; L-GLUTAMINE ; 56-85-9 ; 2004 ; ; ; ATC (GLUTAMINE) A16AA03 ; PDB 2F2A (STRUCTURE OF TRNA-DEPENDENT AMIDOTRANSFERASE GATCAB COMPLEXED WITH GLN) - ligand code GLN ; Amino acid transporter UNIPROT Q9Z1J7 1836 ; DELAFLOXACIN ; 189279-58-1 ; 2017 ; ; TARGET DNA GYRASE (TOPOISOMERASE II)-- BACTERIAL TOPOISOMERASE IV ; ATC (DELAFLOXACIN) J01MA23 ; PDB 8C41 (HIGH RESOLUTION STRUCTURE OF THE STREPTOCOCCUS PNEUMONIAE TOPOISOMERASE IV-DNA COMPLEX WITH THE NOVEL FLUOROQUINOLONE DELAFLOXACIN) - ligand code TE9 ; UNKNOWN 1837 ; ENASIDENIB ; 1446502-11-9 ; 2017 ; ; TARGET ISOCITRATE DEHYDROGENASE-2 (IDH2) ; ATC (ENASIDENIB) L01XX59 ; PDB 5I96 (CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ISOCITRATE DEHYDROGENASE (IDH2) R140Q MUTANT HOMODIMER IN COMPLEX WITH AG-221 (ENASIDENIB) INHIBITOR.) - ligand code 69Q ; Isocitrate dehydrogenase NADP, mitochondrial UNIPROT P48735 IDH2 1838 ; DEFLAZACORT ; 14484-47-0 ; 2017 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DEFLAZACORT) H02AB13 ; ; UNKNOWN 1839 ; M DEFLAZACORT ; 13649-57-5 ; 0 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (DEFLAZACORT) H02AB13 ; PDB 6W9L (STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH DEACETYLATED DEFLAZACORT AND PGC1A COREGULATOR FRAGMENT) - ligand code TUS ; UNKNOWN 1840 ; PLECANATIDE ; 467426-54-6 ; 2017 ; ; TARGET GUANYLATE CYCLASE-C ; ATC (PLECANATIDE) A06AX07 ; ; Heat-stable enterotoxin receptor UNIPROT P25092 GUCY2C 1841 ; BRIGATINIB ; 1197953-54-0 ; 2017 ; ; TARGET ALK KINASE -- ROS1 -- IGF-1R -- FLT-3 -- EGFR ; ATC (BRIGATINIB) L01ED04 ; PDB 5J7H (CRYSTAL STRUCTURE OF ANAPLASTIC LYMPHOMA KINASE (ALK) BOUND BY BRIGATINIB) - ligand code 6GY ; ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK 1842 ; TELOTRISTAT ; 1033805-28-5 ; 0 ; ; TARGET TRYPTOPHAN HYDROXYLASE ; ATC (TELOTRISTAT) A16AX15 ; ; ENZYME TPH1_HUMAN INHIBITOR UNIPROT P17752 1843 ; TELOTRISTAT ETHYL ; 1033805-22-9 ; 2017 ; ; TARGET TRYPTOPHAN HYDROXYLASE ; ATC (TELOTRISTAT) A16AX15 ; ; Tryptophan 5-hydroxylase 1 UNIPROT P17752 TPH1 1844 ; NALDEMEDINE ; 916072-89-4 ; 2017 ; ; TARGET MU OPIOID RECEPTOR -- DELTA OPIOID RECEPTOR -- KAPPA OPIOID RECEPTOR ; ATC (NALDEMEDINE) A06AH05 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1845 ; RIBOCICLIB ; 1211441-98-3 ; 2017 ; ; TARGET CDK-4 -- CDK-6 ; ATC (RIBOCICLIB) L01EF02 ; PDB 5L2T (THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND RIBOCICLIB.) - ligand code 6ZZ ; Cyclin-dependent kinase 6 UNIPROT Q00534 CDK6 -- Cyclin-dependent kinase 4 UNIPROT P11802 CDK4 1846 ; EDARAVONE ; 89-25-8 ; 2017 ; ; ; ATC (EDARAVONE) N07XX14 ; PDB 5S52 (TUBULIN-Z50145861-COMPLEX) - ligand code W1P ; UNKNOWN 1847 ; VOXILAPREVIR ; 1535212-07-7 ; 2017 ; ; TARGET NS3/4A PROTEASE ; ATC (VOXILAPREVIR) J05AP56 ; PDB 6NZT (CRYSTAL STRUCTURE OF HCV NS3, 4A PROTEASE IN COMPLEX WITH VOXILAPREVIR) - ligand code L9P ; Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT Q81495 1848 ; VALBENAZINE ; 1025504-45-3 ; 2017 ; ; TARGET VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) ; ATC (VALBENAZINE) N07XX13 ; ; Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 1849 ; M VALBENAZINE ; 3466-75-9 ; 0 ; ; TARGET VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) ; ATC (VALBENAZINE) N07XX13 ; ; Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2 1850 ; GLECAPREVIR ; 1365970-03-1 ; 2017 ; ; TARGET NS3/4A PROTEASE INHIBITOR ; ATC (GLECAPREVIR) J05AP57 ; PDB 6P6T (HCV NS3,4A PROTEASE DOMAIN OF GENOTYPE 4A IN COMPLEX WITH GLECAPREVIR) - ligand code O31 ; UNKNOWN 1851 ; PIBRENTASVIR ; 1353900-92-1 ; 2017 ; ; TARGET NS5A PROTEASE ; ATC (PIBRENTASVIR) J05AP57 ; ; UNKNOWN 1852 ; M MIDOSTAURIN ; 179237-49-1 ; 0 ; ; TARGET FLT3 KINASE -- FLT3 MUTANT KINASES -- KIT -- PDGFR -- VEGFR2 -- SERINE/THREONINE KINASE PKC ; ATC (MIDOSTAURIN) L01EX10 ; ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 1853 ; LEVOLEUCOVORIN ; 68538-85-2 ; 1952 ; ; ; ATC (FOLIC ACID) B03AD04 B03AD01 B03AD02 B03AD05 B03AD03 B03BB01 V04CX02 B03BB51 B03AE02 B03AE01 ; PDB 3UWL (CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE) - ligand code FOZ ; UNKNOWN 1854 ; CALICHEAMICIN ; 108212-76-6 ; 2000 ; ; TARGET DNA ; ATC (INOTUZUMAB OZOGAMICIN) L01FB01 ; ; B-cell receptor CD22 UNIPROT P20273 1855 ; MAYTANSINE ; 139504-50-0 ; 2013 ; ; TARGET TUBULIN ; ATC (TRASTUZUMAB EMTANSINE) L01FD03 ; ; TUBULIN TBB1_HUMAN INHIBITOR UNIPROT P04350 1856 ; MMAE ; 474645-27-7 ; 2011 ; ; TARGET TUBULIN ; ATC (BRENTUXIMAB VEDOTIN) L01FX05 ; PDB 5IYZ (TUBULIN-MMAE COMPLEX) - ligand code 4Q5 ; TUBULIN TBB1_HUMAN INHIBITOR UNIPROT P04350 1857 ; MACIMORELIN ; 381231-18-1 ; 2017 ; DISCONTINUED ; TARGET GROWTH HORMONE SECRETAGOGUE RECEPTOR (GHS-R) ; ATC (MACIMORELIN) V04CD06 ; ; Growth hormone secretagogue receptor type 1 UNIPROT Q92847 GHSR 1858 ; LATANOPROSTENE BUNOD ; 860005-21-6 ; 2017 ; ; ; ATC (LATANOPROSTENE BUNOD) S01EE06 ; ; Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR 1859 ; BARICITINIB ; 1187594-09-7 ; 2018 ; ; TARGET JANUS KINASES (JAK) ; ATC (BARICITINIB) L04AF02 ; PDB 4W9X (CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH BARICITINIB) - ligand code 3JW ; Tyrosine-protein kinase JAK1 UNIPROT P23458 JAK1 -- Tyrosine-protein kinase JAK2 UNIPROT O60674 JAK2 1860 ; NETARSUDIL ; 1254032-66-0 ; 2017 ; ; TARGET RHO KINASE ; ATC (NETARSUDIL) S01EE51 S01EX05 ; ; Rho-associated protein kinase 2 UNIPROT O75116 ROCK2 1861 ; M NETARSUDIL ; 1254032-16-0 ; 0 ; ; TARGET RHO KINASE ; ATC (NETARSUDIL) S01EE51 S01EX05 ; ; Rho-associated protein kinase 2 UNIPROT O75116 ROCK2 1862 ; BENZHYDROCODONE ; 1259440-61-3 ; 2018 ; DISCONTINUED ; TARGET MU-TYPE OPIOID RECEPTOR ; ATC (HYDROMORPHONE) N02AA03 N02AG04 N02AA53 ; ; 1863 ; ABEMACICLIB ; 1231929-97-7 ; 2017 ; ; TARGET CYCLIN-DEPENDENT KINASES 4 AND 6 (CDK4 AND CDK6) ; ATC (ABEMACICLIB) L01EF03 ; PDB 5L2S (THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND ABEMACICLIB) - ligand code 6ZV ; Cyclin-dependent kinase 6 UNIPROT Q00534 CDK6 -- Cyclin-dependent kinase 4 UNIPROT P11802 CDK4 1864 ; OZENOXACIN ; 245765-41-7 ; 2017 ; ; TARGET DNA GYRASE A -- TOPOISOMERASE IV ; ATC (OZENOXACIN) D06AX14 ; ; UNKNOWN 1865 ; LOFEXIDINE ; 31036-80-3 ; 2018 ; ; TARGET ALPHA-2 ADRENERGIC RECEPTOR ; ATC (LOFEXIDINE) N07BC04 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A 1866 ; LOFEXIDINE ; 31036-80-3 ; 2018 ; ; TARGET ALPHA-2 ADRENERGIC RECEPTOR ; ATC (LOFEXIDINE) N07BC04 ; ; Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A 1867 ; FOSTAMATINIB ; 901119-35-5 ; 2018 ; ; TARGET PHOSPHATASE ; ATC (FOSTAMATINIB) B02BX09 ; PDB 4O75 (CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH FOSTAMATINIB) - ligand code 2RC ; Tyrosine-protein kinase SYK UNIPROT P43405 SYK 1868 ; M FOSTAMATINIB ; 841290-80-0 ; 0 ; ; TARGET TYROSINE KINASE SYK ; ATC (FOSTAMATINIB) B02BX09 ; PDB 3FQS (CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE COMPLEXED WITH R406) - ligand code 585 ; Tyrosine-protein kinase SYK UNIPROT P43405 SYK 1869 ; ANGIOTENSIN II ; 4474-91-3 ; 2017 ; ; TARGET G-PROTEIN-COUPLED ANGIOTENSIN II RECEPTOR TYPE 1 ; ATC (ANGIOTENSIN II) C01CX09 ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 1870 ; SECNIDAZOLE ; 3366-95-8 ; 2017 ; ; TARGET DNA ; ATC (SECNIDAZOLE) J01RA07 P01AB07 ; ; UNKNOWN 1871 ; SECNIDAZOLE ; 3366-95-8 ; 2017 ; ; TARGET DNA ; ATC (SECNIDAZOLE) J01RA07 P01AB07 ; ; UNKNOWN 1872 ; BENZNIDAZOLE ; 22994-85-0 ; 2017 ; ; TARGET DNA ; ATC (BENZNIDAZOLE) P01CA02 ; ; UNKNOWN 1873 ; VABORBACTAM ; 1360457-46-0 ; 2017 ; ; TARGET BETA-LACTAMASE ; ATC (VABORBACTAM) J01DH52 ; PDB 4XUZ (STRUCTURE OF CTX-M-15 BOUND TO RPX-7009 AT 1.5 A) - ligand code 4D6 ; beta-lactamase UNIPROT A8DS27 1874 ; ERTUGLIFLOZIN ; 1210344-57-2 ; 2017 ; ; TARGET SODIUM-GLUCOSE CO-TRANSPORTER 2 (SGLT2) ; ATC (ERTUGLIFLOZIN) A10BK04 A10BD23 A10BD24 ; ; Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 1875 ; COPANLISIB ; 1032568-63-0 ; 2017 ; DISCONTINUED ; TARGET PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) ; ATC (COPANLISIB) L01EM02 ; PDB 5G2N (X-RAY STRUCTURE OF PI3KINASE GAMMA IN COMPLEX WITH COPANLISIB) - ligand code 6E2 ; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD -- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform UNIPROT P42336 PIK3CA 1876 ; LETERMOVIR ; 917389-32-3 ; 2017 ; ; TARGET DNA TERMINASE COMPLEX ; ATC (LETERMOVIR) J05AX18 ; ; DNA terminase complex UNIPROT F5HC79 TRM1 1877 ; COCAINE ; 50-36-2 ; 2017 ; ; TARGET SODIUM CHANNELS ; ATC (COCAINE) N01BC01 R02AD03 S01HA01 S02DA02 ; PDB 1Q72 (ANTI-COCAINE ANTIBODY M82G2 COMPLEXED WITH COCAINE) - ligand code COC ; Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 1878 ; AVATROMBOPAG ; 570406-98-3 ; 2018 ; ; TARGET THROMBOPOIETIN RECEPTOR ; ATC (AVATROMBOPAG) B02BX08 ; ; Thrombopoietin receptor UNIPROT P40238 MPL 1879 ; BICTEGRAVIR ; 1611493-60-7 ; 2018 ; ; TARGET INTEGRASE STRAND TRANSFER ; ATC (BICTEGRAVIR) J05AR20 ; PDB 6PUW (STRUCTURE OF HIV CLEAVED SYNAPTIC COMPLEX (CSC) INTASOME BOUND WITH MAGNESIUM AND BICTEGRAVIR (BIC)) - ligand code KLQ ; Integrase UNIPROT Q7ZJM1 pol 1880 ; ACALABRUTINIB ; 1420477-60-6 ; 2017 ; ; TARGET BRUTON TYROSINE KINASE (BTK) ; ATC (ACALABRUTINIB) L01EL02 ; ; Tyrosine-protein kinase BTK UNIPROT Q06187 BTK 1881 ; TEZACAFTOR ; 1152311-62-0 ; 2018 ; ; TARGET CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR ; ATC (TEZACAFTOR) R07AX31 R07AX32 ; PDB 7SV7 (THE COMPLEX OF PHOSPHORYLATED HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH ATP, MG AND TEZACAFTOR (VX-661)) - ligand code CV6 ; Cystic fibrosis transmembrane conductance regulator UNIPROT P13569 CFTR 1882 ; FOSNETUPITANT ; 1703748-89-3 ; 2018 ; ; ; ; ; Substance-P receptor UNIPROT P25103 TACR1 1883 ; APALUTAMIDE ; 956104-40-8 ; 2018 ; ; TARGET ANDROGEN RECEPTOR ; ATC (APALUTAMIDE) L02BB05 ; ; Androgen receptor UNIPROT P10275 AR 1884 ; M APALUTAMIDE ; 1332391-11-3 ; 0 ; ; TARGET ANDROGEN RECEPTOR ; ATC (APALUTAMIDE) L02BB05 ; ; Androgen receptor UNIPROT P10275 AR 1885 ; STIRIPENTOL ; 137767-55-6 ; 2018 ; ; ; ATC (STIRIPENTOL) N03AX17 ; ; UNKNOWN 1886 ; STIRIPENTOL ; 137767-55-6 ; 2018 ; ; ; ATC (STIRIPENTOL) N03AX17 ; ; UNKNOWN 1887 ; AMIFAMPRIDINE ; 54-96-6 ; 2018 ; ; TARGET POTASSIUM CHANNELS ; ATC (AMIFAMPRIDINE) N07XX05 ; PDB 5NOW (STRUCTURE OF CYCLOPHILIN A IN COMPLEX WITH PYRIDINE-3,4-DIAMINE) - ligand code L89 ; Voltage-gated potassium channel UNIPROT O43525 KCNQ3 1888 ; MIGALASTAT ; 108147-54-2 ; 2018 ; ; TARGET ALPHA-GALACTOSIDASE A ; ATC (MIGALASTAT) A16AX14 ; PDB 4D1J (THE STRUCTURE OF THE GH35 BETA-GALACTOSIDASE BGL35A FROM CELLVIBRIO JAPONICAS IN COMPLEX WITH 1-DEOXYGALACTONOJIRIMYCIN) - ligand code DGJ ; Alpha-galactosidase A UNIPROT P06280 GLA 1889 ; TECOVIRIMAT ; 869572-92-9 ; 2018 ; ; TARGET VP37 PROTEIN ; ATC (TECOVIRIMAT) J05AX24 ; ; Envelope protein F13 UNIPROT P33815 C17L 1890 ; TRICLABENDAZOLE ; 68786-66-3 ; 2019 ; ; ; ATC (TRICLABENDAZOLE) P02BX04 ; PDB 7ERI (CRYSTAL STRUCTURE OF V30M-TTR IN COMPLEX WITH TRICLABENDAZOLE) - ligand code JA9 ; UNKNOWN 1891 ; M TRICLABENDAZOLE ; 100648-13-3 ; 0 ; ; ; ATC (TRICLABENDAZOLE) P02BX04 ; ; UNKNOWN 1892 ; M TRICLABENDAZOLE ; 106791-37-1 ; 0 ; ; ; ATC (TRICLABENDAZOLE) P02BX04 ; ; UNKNOWN 1893 ; SARECYCLINE ; 1035654-66-0 ; 2018 ; ; ; ATC (SARECYCLINE) J01AA14 ; PDB 6XQD (CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH SARECYCLINE, UUC-MRNA, AND DEACYLATED P-SITE TRNA AT 2.80A RESOLUTION) - ligand code V7A ; UNKNOWN 1894 ; SEGESTERONE ACETATE ; 7759-35-5 ; 2018 ; ; TARGET PROGESTERONE RECEPTOR ; ; ; 1895 ; OMADACYCLINE ; 389139-89-3 ; 2018 ; ; TARGET 30S RIBOSOMAL SUBUNIT ; ATC (OMADACYCLINE) J01AA15 ; ; UNKNOWN 1896 ; SIPONIMOD ; 1230487-00-9 ; 2019 ; ; TARGET SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P) ; ATC (SIPONIMOD) L04AE03 ; PDB 7EVY (CRYO-EM STRUCTURE OF SIPONIMOD -BOUND SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 IN COMPLEX WITH GI PROTEIN) - ligand code J8C ; Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 1897 ; PRUCALOPRIDE ; 179474-81-8 ; 2018 ; ; TARGET SEROTONIN-4 (5-HT4) ; ATC (PRUCALOPRIDE) A06AX05 ; ; 5-hydroxytryptamine receptor 4 UNIPROT Q13639 HTR4 1898 ; PLAZOMICIN ; 1154757-24-0 ; 2018 ; ; TARGET 30S RIBOSOMAL SUBUNIT ; ATC (PLAZOMICIN) J01GB14 ; PDB 6CD7 (CRYSTAL STRUCTURE OF APH(2)-IVA) - ligand code EDS ; UNKNOWN 1899 ; GLYCOPYRRONIUM ; 596-51-0 ; 2018 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (GLYCOPYRRONIUM) R03AL07 R03AL09 R03AL11 D11AA01 A03AB02 R03BB06 A03CA05 R03AL04 R03AL12 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 1900 ; GLYCOPYRRONIUM ; 596-51-0 ; 2018 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (GLYCOPYRRONIUM) R03AL07 R03AL09 R03AL11 D11AA01 A03AB02 R03BB06 A03CA05 R03AL04 R03AL12 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 1901 ; GLYCOPYRRONIUM ; 596-51-0 ; 2018 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR ; ATC (GLYCOPYRRONIUM) R03AL07 R03AL09 R03AL11 D11AA01 A03AB02 R03BB06 A03CA05 R03AL04 R03AL12 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 1902 ; CANNABIDIOL ; 13956-29-1 ; 2018 ; ; TARGET CANNABINOID RECEPTOR ; ATC (CANNABIDIOL) N03AX24 ; PDB 6U8A (CBD-BOUND FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 1) - ligand code P0T ; Transient receptor potential cation channel subfamily V member 1 UNIPROT Q8NER1 TRPV1 -- G-protein coupled receptor 55 UNIPROT Q9Y2T6 GPR55 1903 ; M CANNABIDIOL ; 50725-17-2 ; 0 ; ; TARGET CANNABINOID RECEPTOR ; ATC (CANNABIDIOL) N03AX24 ; ; Transient receptor potential cation channel subfamily V member 1 UNIPROT Q8NER1 TRPV1 -- G-protein coupled receptor 55 UNIPROT Q9Y2T6 GPR55 1904 ; ELAGOLIX ; 834153-87-6 ; 2018 ; ; TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR ; ATC (ELAGOLIX) H01CC03 H01CC53 ; PDB 7BR3 (CRYSTAL STRUCTURE OF THE PROTEIN 1) - ligand code F5O ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 1905 ; ENCORAFENIB ; 1269440-17-6 ; 2018 ; ; TARGET BRAF ; ATC (ENCORAFENIB) L01EC03 ; ; RAF proto-oncogene serine,threonine-protein kinase UNIPROT P04049 RAF1 -- Serine,threonine-protein kinase B-raf UNIPROT P15056 BRAF 1906 ; BINIMETINIB ; 606143-89-9 ; 2018 ; ; TARGET MEK1 AND MEK2 ; ATC (BINIMETINIB) L01EE03 ; PDB 7M0U (CRYSTAL STRUCTURE OF THE BRAF:MEK1 KINASES IN COMPLEX WITH AMPPNP AND BINIMETINIB) - ligand code QO7 ; Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 -- Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2 1907 ; TAFENOQUINE ; 106635-80-7 ; 2018 ; ; ; ATC (TAFENOQUINE) P01BA07 ; ; UNKNOWN 1908 ; TAFENOQUINE ; 106635-80-7 ; 2018 ; ; ; ATC (TAFENOQUINE) P01BA07 ; PDB 7DDC (CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE IN COMPLEX WITH TAFENOQUINE) - ligand code H3F ; UNKNOWN 1909 ; REVEFENACIN ; 864750-70-9 ; 2018 ; ; TARGET MUSCARINIC RECEPTORS M1 TO M5 ; ATC (REVEFENACIN) R03BB08 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 1910 ; M REVEFENACIN ; 909800-36-8 ; 0 ; ; TARGET MUSCARINIC RECEPTORS M1 TO M5 ; ATC (REVEFENACIN) R03BB08 ; ; Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 -- Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2 1911 ; GLASDEGIB ; 1095173-27-5 ; 2018 ; ; TARGET SMOOTHENED (SMO) ; ATC (GLASDEGIB) L01XJ03 ; ; Smoothened homolog UNIPROT Q99835 SMO 1912 ; DORAVIRINE ; 1338225-97-0 ; 2018 ; ; TARGET HIV-1 REVERSE TRANSCRIPTASE ; ATC (DORAVIRINE) J05AG06 J05AR24 ; PDB 4NCG (HIV NON-NUCLEOSIDE REVERSE TRANSCRIPTASE) - ligand code 2KW ; Reverse transcriptase,RNaseH UNIPROT Q72547 pol 1913 ; BALOXAVIR MARBOXIL ; 1985606-14-1 ; 2018 ; ; TARGET POLYMERASE ACIDIC PROTEIN ; ATC (BALOXAVIR MARBOXIL) J05AX25 ; ; Polymerase acidic protein UNIPROT P03433 PA 1914 ; BALOXAVIR ; 1985605-59-1 ; 0 ; ; TARGET POLYMERASE ACIDIC PROTEIN ; ATC (BALOXAVIR) J05AX25 ; PDB 6FS6 (INFLUENZA A, CALIFORNIA 04 2009 (PH1N1) ENDONUCLEASE) - ligand code E4Z ; Polymerase acidic protein UNIPROT P03433 1915 ; LAROTRECTINIB ; 1223403-58-4 ; 2018 ; ; TARGET TROPOMYOSIN RECEPTOR KINASE ; ATC (LAROTRECTINIB) L01EX12 ; ; High affinity nerve growth factor receptor UNIPROT P04629 NTRK1 -- BDNF,NT-3 growth factors receptor UNIPROT Q16620 NTRK2 1916 ; MOXIDECTIN ; 113507-06-5 ; 2018 ; ; TARGET GLUTAMATE-GATED CHLORIDE CHANNELS (GLUCL) ; ATC (MOXIDECTIN) P02CX03 ; ; Glutamate-gated chloride channel UNIPROT Q25634 GluClX 1917 ; LORLATINIB ; 1454846-35-5 ; 2018 ; ; TARGET ALK -- ROS1 ; ATC (LORLATINIB) L01ED05 ; PDB 5A9U (HUMAN ANAPLASTIC LYMPHOMA KINASE) - ligand code 5P8 ; ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK -- Proto-oncogene tyrosine-protein kinase ROS UNIPROT P08922 ROS1 1918 ; RIFAMYCIN ; 6998-60-3 ; 2018 ; ; TARGET BETA-SUBUNIT DNA-DEPENDENT RNA POLYMERASE ; ATC (RIFAMYCIN) A07AA13 D06AX15 J04AB03 S01AA16 S02AA12 ; PDB 6BEB (CRYSTAL STRUCTURE OF VACV D13) - ligand code RFV ; DNA-directed RNA polymerase subunit beta UNIPROT P0A8V2 rpoB 1919 ; LUSUTROMBOPAG ; 1110766-97-6 ; 2018 ; ; TARGET THROMBOPOIETIN RECEPTOR ; ATC (LUSUTROMBOPAG) B02BX07 ; ; Thrombopoietin receptor UNIPROT P40238 MPL 1920 ; ERAVACYCLINE ; 1207283-85-9 ; 2018 ; ; TARGET 30S RIBOSOMAL SUBUNIT ; ATC (ERAVACYCLINE) J01AA13 ; ; UNKNOWN 1921 ; DUVELISIB ; 1201438-56-3 ; 2018 ; ; TARGET PI3K ; ATC (DUVELISIB) L01EM04 ; ; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD -- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform UNIPROT P48736 PIK3CG 1922 ; IVOSIDENIB ; 1448347-49-6 ; 2018 ; ; TARGET ISOCITRATE DEHYDROGENASE-1 (IDH1) ; ATC (IVOSIDENIB) L01XX62 ; ; Isocitrate dehydrogenase NADP cytoplasmic UNIPROT O75874 IDH1 1923 ; SOLRIAMFETOL ; 178429-62-4 ; 2019 ; ; TARGET DOPAMINE TRANSPORTER -- NOREPINEPHRINE TRANSPORTER ; ATC (SOLRIAMFETOL) N06BA14 ; ; UNKNOWN 1924 ; DACOMITINIB ; 1110813-31-4 ; 2018 ; ; TARGET EGFR KINASE ; ATC (DACOMITINIB) L01EB07 ; ; Epidermal growth factor receptor UNIPROT P00533 EGFR -- Receptor tyrosine-protein kinase erbB-2 UNIPROT P04626 ERBB2 1925 ; GILTERITINIB ; 1254053-43-4 ; 2018 ; ; TARGET FMS-LIKE TYROSINE KINASE 3 (FLT3) ; ATC (GILTERITINIB) L01EX13 ; PDB 6JQR (CRYSTAL STRUCTURE OF FLT3 IN COMPLEX WITH GILTERITINIB) - ligand code C6F ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 1926 ; BREXANOLONE ; 516-54-1 ; 2019 ; ; TARGET GAMMA-AMINOBUTYRIC ACID (GABA) A RECEPTOR ; ATC (BREXANOLONE) N06AX29 ; PDB 8G4N (NATIVE GABA-A RECEPTOR FROM THE MOUSE BRAIN, ALPHA1-BETA2-GAMMA2 SUBTYPE, IN COMPLEX WITH GABA, ZOLPIDEM, AND ENDOGENOUS NEUROSTEROIDS) - ligand code Y4B ; Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 GABRA1 1927 ; TALAZOPARIB ; 1207456-01-6 ; 2018 ; ; TARGET POLYADENOSINE 5-DIPHOSPHORIBOSE POLYMERASE (PARP) ; ATC (TALAZOPARIB) L01XK04 ; PDB 4UND (HUMAN ARTD1 (PARP1)) - ligand code 2YQ ; Poly ADP-ribose polymerase 1 UNIPROT P09874 PARP1 -- Poly ADP-ribose polymerase 2 UNIPROT Q9UGN5 PARP2 1928 ; TAFAMIDIS ; 594839-88-0 ; 2019 ; ; TARGET TRANSTHYRETIN ; ATC (TAFAMIDIS) N07XX08 ; PDB 3TCT (STRUCTURE OF WILD-TYPE TTR) - ligand code 3MI ; Transthyretin UNIPROT P02766 TTR 1929 ; ERDAFITINIB ; 1346242-81-6 ; 2019 ; ; TARGET FGFR1 -- FGFR2 -- FGFR3 -- FGFR4 ; ATC (ERDAFITINIB) L01EN01 ; PDB 5EW8 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH JNJ-4275693) - ligand code 5SF ; Vascular endothelial growth factor receptor 2 UNIPROT P35968 KDR -- Fibroblast growth factor receptor 3 UNIPROT P22607 FGFR3 1930 ; ALPELISIB ; 1217486-61-7 ; 2019 ; ; TARGET PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) ; ATC (ALPELISIB) L01EM03 ; PDB 4JPS (CO-CRYSTAL STRUCTURES OF THE LIPID KINASE PI3K ALPHA WITH PAN AND ISOFORM SELECTIVE INHIBITORS) - ligand code 1LT ; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform UNIPROT P42336 PIK3CA 1931 ; ISTRADEFYLLINE ; 155270-99-8 ; 2019 ; ; TARGET ADENOSINE RECEPTOR A2A ; ATC (ISTRADEFYLLINE) N04CX01 ; PDB 8GNG (CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR IN COMPLEX WITH ISTRADEFYLLINE) - ligand code JQ9 ; Adenosine receptor A2a UNIPROT P29274 ADORA2A 1932 ; CEFIDEROCOL ; 1225208-94-5 ; 2019 ; ; TARGET PENICILLIN-BINDING PROTEINS (PBPS) ; ATC (CEFIDEROCOL) J01DI04 ; ; Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI -- Penicillin-binding protein 1A UNIPROT Q07806 mrcA 1933 ; LUMATEPERONE ; 313368-91-1 ; 2019 ; ; TARGET 5-HT2A RECEPTORS -- DOPAMINE D2 RECEPTORS ; ATC (LUMATEPERONE) N05AD10 ; PDB 7WC8 (CRYSTAL STRUCTURE OF SEROTONIN 2A RECEPTOR IN COMPLEX WITH LUMATEPERONE) - ligand code 92S ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A 1934 ; AMISULPRIDE ; 71675-85-9 ; 2020 ; ; TARGET DOPAMINE-2 (D2) RECEPTOR -- DOPAMINE-3 (D3) RECEPTOR ; ATC (AMISULPRIDE) N05AL05 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- D(3) dopamine receptor UNIPROT P35462 DRD3 1935 ; AMISULPRIDE ; 71675-85-9 ; 2020 ; ; TARGET DOPAMINE-2 (D2) RECEPTOR -- DOPAMINE-3 (D3) RECEPTOR ; ATC (AMISULPRIDE) N05AL05 ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 -- D(3) dopamine receptor UNIPROT P35462 DRD3 1936 ; OZANIMOD ; 1306760-87-1 ; 2020 ; ; TARGET SPHINGOSINE 1- PHOSPHATE RECEPTORS S1P 1 AND 5 ; ATC (OZANIMOD) L04AE02 ; PDB 7EW0 (CRYO-EM STRUCTURE OF OZANIMOD -BOUND SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 IN COMPLEX WITH GI PROTEIN) - ligand code JEU ; Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 1937 ; M OZANIMOD ; 2251699-84-8 ; 0 ; ; TARGET SPHINGOSINE 1- PHOSPHATE RECEPTORS S1P 1 AND 5 ; ATC (OZANIMOD) L04AE02 ; ; Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 1938 ; M OZANIMOD ; 1306760-61-1 ; 0 ; ; TARGET SPHINGOSINE 1- PHOSPHATE RECEPTORS S1P 1 AND 5 ; ATC (OZANIMOD) L04AE02 ; ; Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 1939 ; M OZANIMOD ; 1306760-60-0 ; 0 ; ; TARGET SPHINGOSINE 1- PHOSPHATE RECEPTORS S1P 1 AND 5 ; ATC (OZANIMOD) L04AE02 ; ; Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 1940 ; BREMELANOTIDE ; 189691-06-3 ; 2019 ; ; TARGET MELANOCORTIN RECEPTOR (MCR) MC1R, MC4R, MC3R, MC5R, MC2R ; ATC (BREMELANOTIDE) G02CX05 ; ; Melanocortin receptor 4 UNIPROT P32245 MC4R 1941 ; AFAMELANOTIDE ; 75921-69-6 ; 2019 ; ; TARGET MELANOCORTIN 1 RECEPTOR (MC1-R) ; ATC (AFAMELANOTIDE) D02BB02 ; ; Melanocyte-stimulating hormone receptor UNIPROT Q01726 MC1R 1942 ; PITOLISANT ; 362665-56-3 ; 2019 ; ; TARGET HISTAMINE-3 (H3) RECEPTOR ; ATC (PITOLISANT) N07XX11 ; ; Histamine H3 receptor UNIPROT Q9Y5N1 HRH3 1943 ; LASMIDITAN ; 439239-90-4 ; 2020 ; ; TARGET SEROTONIN (5-HT) 1F RECEPTOR ; ATC (LASMIDITAN) N02CC08 ; PDB 7EXD (LASMIDITAN-BOUND SEROTONIN 1F (5-HT1F) RECEPTOR-GI PROTEIN COMPLEX) - ligand code 05X ; 5-hydroxytryptamine receptor 1F UNIPROT P30939 HTR1F 1944 ; TRIFAROTENE ; 895542-09-3 ; 2019 ; ; TARGET RETINOIC ACID RECEPTOR (RAR) GAMMA ; ATC (TRIFAROTENE) D10AD06 ; ; Retinoic acid receptor gamma UNIPROT P13631 RARG 1945 ; BEMPEDOIC ACID ; 738606-46-7 ; 2020 ; ; TARGET ADENOSINE TRIPHOSPHATE-CITRATE LYASE (ACL) ; ATC (BEMPEDOIC ACID) C10AX15 C10BA10 ; ; ATP-citrate synthase UNIPROT P53396 ACLY 1946 ; LEFAMULIN ; 1061337-51-6 ; 2019 ; ; TARGET RIBOSOMAL SUBUNIT 50S ; ATC (LEFAMULIN) J01XX12 ; PDB 5HL7 (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LEFAMULIN) - ligand code 62B ; UNKNOWN 1947 ; UPADACITINIB ; 1310726-60-3 ; 2019 ; ; TARGET JANUS KINASE (JAK) ; ATC (UPADACITINIB) L04AF03 ; ; Tyrosine-protein kinase JAK3 UNIPROT P52333 JAK3 -- Tyrosine-protein kinase JAK1 UNIPROT P23458 JAK1 1948 ; TAZEMETOSTAT ; 1403254-99-8 ; 2020 ; ; TARGET METHYLTRANSFERASE EZH2 ; ATC (TAZEMETOSTAT) L01XX72 ; ; Histone-lysine N-methyltransferase EZH2 UNIPROT Q15910 EZH2 1949 ; UBROGEPANT ; 1374248-77-7 ; 2019 ; ; TARGET CALCITONIN GENE-RELATED PEPTIDE (CGRP) RECEPTOR ; ATC (UBROGEPANT) N02CD04 ; ; Calcitonin gene-related peptide type 1 receptor UNIPROT Q16602 CALCRL 1950 ; TENAPANOR ; 1234423-95-0 ; 2019 ; ; TARGET SODIUM/HYDROGEN EXCHANGER 3 (NHE3) ; ATC (TENAPANOR) A06AX08 ; ; Sodium,hydrogen exchanger 3 UNIPROT P48764 SLC9A3 1951 ; PEXIDARTINIB ; 1029044-16-3 ; 2019 ; ; TARGET COLONY STIMULATING ACTOR 1 RECEPTOR (CSF1R) ; ATC (PEXIDARTINIB) L01EX15 ; PDB 4R7H (CRYSTAL STRUCTURE OF FMS KINASE DOMAIN WITH A SMALL MOLECULAR INHIBITOR, PLX3397) - ligand code P31 ; Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 1952 ; DIROXIMEL ; 1577222-14-0 ; 2019 ; ; ; ATC (DIMETHYL FUMARATE) L04AX07 ; ; Kelch-like ECH-associated protein 1 UNIPROT Q14145 KEAP1 1953 ; LEMBOREXANT ; 1369764-02-2 ; 2020 ; ; TARGET OREXIN-1 RECEPTOR (IC50=6.1 NM) -- OREXIN-2 RECEPTOR (IC50=2.6 NM) ; ATC (LEMBOREXANT) N05CJ02 ; PDB 6TOT (CRYSTAL STRUCTURE OF THE OREXIN-1 RECEPTOR IN COMPLEX WITH LEMBOREXANT) - ligand code NRK ; Orexin receptor type 1 UNIPROT O43613 HCRTR1 -- Orexin receptor type 2 UNIPROT O43614 HCRTR2 1954 ; DAROLUTAMIDE ; 1297538-32-9 ; 2019 ; ; TARGET ANDROGEN RECEPTOR (AR) ; ATC (DAROLUTAMIDE) L02BB06 ; ; Androgen receptor UNIPROT P10275 AR 1955 ; DAROLUTAMIDE ; 1297538-32-9 ; 2019 ; ; TARGET ANDROGEN RECEPTOR (AR) ; ATC (DAROLUTAMIDE) L02BB06 ; ; Androgen receptor UNIPROT P10275 AR 1956 ; M DAROLUTAMIDE ; 1297537-33-7 ; 0 ; ; TARGET ANDROGEN RECEPTOR (AR) ; ATC (DAROLUTAMIDE) L02BB06 ; ; Androgen receptor UNIPROT P10275 AR 1957 ; FENFLURAMINE ; 458-24-2 ; 2020 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (FENFLURAMINE) A08AA02 N03AX26 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1958 ; FENFLURAMINE ; 458-24-2 ; 2020 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (FENFLURAMINE) A08AA02 N03AX26 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1959 ; M FENFLURAMINE ; 1886-26-6 ; 0 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (FENFLURAMINE) A08AA02 N03AX26 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1960 ; M FENFLURAMINE ; 1886-26-6 ; 0 ; ; TARGET SEROTONIN TRANSPORTER ; ATC (FENFLURAMINE) A08AA02 N03AX26 ; ; Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 1961 ; FLORTAUCIPIR ; 1522051-90-6 ; 2020 ; ; TARGET AGGREGATED TAU NEUROFIBRILLARY TANGLES ; ATC (FLORTAUCIPIR) V09AX07 ; PDB 8BYN (CHRONIC TRAUMATIC ENCEPHALOPATHY TAU FILAMENTS WITH PET LIGAND FLORTAUCIPIR) - ligand code S9C ; Microtubule-associated protein tau UNIPROT P10636 1962 ; ELEXACAFTOR ; 2216712-66-0 ; 2019 ; ; TARGET CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR ; ATC (ELEXACAFTOR) R07AX32 ; PDB 8EIQ (THE COMPLEX OF PHOSPHORYLATED HUMAN DELTA F508 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH TRIKAFTA [ELEXACAFTOR (VX-445), TEZACAFTOR (VX-661), IVACAFTOR (VX-770)] AND ATP, MG) - ligand code WJX ; Cystic fibrosis transmembrane conductance regulator UNIPROT P13569 CFTR 1963 ; REMIMAZOLAM ; 308242-62-8 ; 2020 ; ; TARGET GAMMA AMINO BUTYRIC ACID TYPE A [GABAA] RECEPTOR ; ATC (REMIMAZOLAM) N05CD14 ; ; GABA-A receptor 1964 ; SELINEXOR ; 1393477-72-9 ; 2019 ; ; TARGET EXPORTIN 1 (XPO1) ; ATC (SELINEXOR) L01XX66 ; ; Exportin-1 UNIPROT O14980 XPO1 1965 ; FEDRATINIB ; 936091-26-8 ; 2019 ; ; TARGET JANUS ASSOCIATED KINASE 2 INHIBITOR (JAK2) -- FMS-LIKE TYROSINE KINASE 3 (FLT3) ; ATC (FEDRATINIB) L01EJ02 ; PDB 4PS5 (CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH TG101348) - ligand code 2TA ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 -- Tyrosine-protein kinase JAK2 UNIPROT O60674 JAK2 1966 ; OPICAPONE ; 923287-50-7 ; 2020 ; ; TARGET CATECHOL-O-METHYLTRANSFERASE (COMT) ; ATC (OPICAPONE) N04BX04 ; PDB 7XJB (RAT-COMT, OPICAPONE,SAM AND MG BOND) - ligand code DNI ; Catechol O-methyltransferase UNIPROT P21964 COMT 1967 ; CEDAZURIDINE ; 1141397-80-9 ; 2020 ; ; TARGET CYTIDINE DEAMINASE (CDA) ; ; ; Cytidine deaminase UNIPROT P32320 1968 ; AVAPRITINIB ; 1703793-34-3 ; 2020 ; ; TARGET PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGFRA) -- MAST STEM CELL GROWTH FACTOR RECEPTOR (KIT) ; ATC (AVAPRITINIB) L01EX18 ; PDB 8PQG (C-KIT T670I MUTATED KINASE DOMAIN IN COMPLEX WITH AVAPRITINIB) - ligand code 9JI ; Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Platelet-derived growth factor receptor alpha UNIPROT P16234 PDGFRA 1969 ; ENTRECTINIB ; 1108743-60-7 ; 2019 ; ; TARGET TROPOMYOSIN RECEPTOR TYROSINE KINASES INHIBITOR (TRK) TRKA TRKB AND TRKC -- PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS1 -- ANAPLASTIC LYMPHOMA KINASE (ALK) ; ATC (ENTRECTINIB) L01EX14 ; PDB 5FTO (CRYSTAL STRUCTURE OF THE ALK KINASE DOMAIN IN COMPLEX WITH ENTRECTINIB) - ligand code YMX ; High affinity nerve growth factor receptor UNIPROT P04629 NTRK1 -- ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK 1970 ; M ENTRECTINIB ; 1108743-80-1 ; 0 ; ; TARGET TROPOMYOSIN RECEPTOR TYROSINE KINASES INHIBITOR (TRK) TRKA TRKB AND TRKC -- PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS1 -- ANAPLASTIC LYMPHOMA KINASE (ALK) ; ATC (ENTRECTINIB) L01EX14 ; ; High affinity nerve growth factor receptor UNIPROT P04629 NTRK1 -- ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK 1971 ; RIMEGEPANT ; 1289023-67-1 ; 2020 ; ; TARGET CALCITONIN GENE-RELATED PEPTIDE RECEPTOR ; ATC (RIMEGEPANT) N02CD06 ; ; Calcitonin gene-related peptide type 1 receptor UNIPROT Q16602 CALCRL 1972 ; OSILODROSTAT ; 928134-65-0 ; 2020 ; ; TARGET 11 BETA-HYDROXYLASE (CYP11B1) ; ATC (OSILODROSTAT) H02CA02 ; PDB 7M8V (HUMAN CYP11B2 IN COMPLEX WITH LCI699) - ligand code YSY ; Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1 1973 ; RELEBACTAM ; 1174018-99-5 ; 2019 ; ; TARGET BETA-LACTAMASE ; ATC (RELEBACTAM) J01DH56 ; ; Beta-lactamase UNIPROT Q2PUH3 blaCTX-M-15 -- Beta-lactamase UNIPROT Q9X5A7 L2camp 1974 ; CENOBAMATE ; 913088-80-9 ; 2020 ; ; ; ATC (CENOBAMATE) N03AX25 ; ; Gamma-aminobutyric acid receptor subunit alpha-4 UNIPROT P48169 GABRA4 1975 ; PRETOMANID ; 187235-37-6 ; 2019 ; ; ; ATC (PRETOMANID) J04AK08 ; ; UNKNOWN 1976 ; FOSTEMSAVIR ; 864953-29-7 ; 2020 ; ; TARGET HIV-1 GP120 ; ATC (FOSTEMSAVIR) J05AX29 ; ; Envelope glycoprotein gp160 UNIPROT Q75760 env 1977 ; TEMSAVIR ; 701213-36-7 ; 0 ; ; TARGET HIV-1 GP120 ; ATC (FOSTEMSAVIR) J05AX29 ; PDB 5U7O (CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-626529 IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 3.8 ANGSTROM) - ligand code 83J ; Envelope glycoprotein gp160 UNIPROT Q75760 env 1978 ; ARTESUNATE ; 88495-63-0 ; 2020 ; ; ; ATC (ARTESUNATE) P01BE03 P01BF03 P01BF02 P01BF06 P01BF09 P01BF04 ; PDB 6FGC (CRYSTAL STRUCTURE OF GEPHYRIN E DOMAIN IN COMPLEX WITH ARTESUNATE) - ligand code D95 ; UNKNOWN 1979 ; VOXELOTOR ; 1446321-46-5 ; 2019 ; ; TARGET HEMOGLOBIN (HBS) ; ATC (VOXELOTOR) B06AX03 ; ; hemoglobin subunit alpha UNIPROT P69905 HBA1 1980 ; ZANUBRUTINIB ; 1691249-45-2 ; 2019 ; ; TARGET BRUTON TYROSINE KINASE (BTK) ; ATC (ZANUBRUTINIB) L01EL03 ; PDB 6J6M (CO-CRYSTAL STRUCTURE OF BTK KINASE DOMAIN WITH ZANUBRUTINIB) - ligand code BA0 ; Tyrosine-protein kinase BTK UNIPROT Q06187 BTK 1981 ; SELPERCATINIB ; 2152628-33-4 ; 2020 ; ; TARGET RET -- VEGFR1 -- VEGFR3 -- FGFR1 -- FGFR2 -- FGFR3 ; ATC (SELPERCATINIB) L01EX22 ; PDB 7JU6 (STRUCTURE OF RET PROTEIN TYROSINE KINASE IN COMPLEX WITH SELPERCATINIB) - ligand code Q6G ; Proto-oncogene tyrosine-protein kinase receptor Ret UNIPROT P07949 RET 1982 ; TUCATINIB ; 937263-43-9 ; 2020 ; ; TARGET HER2 ; ATC (TUCATINIB) L01EH03 ; ; ERBB2,ERBB3 UNIPROT P04626 ERBB2 1983 ; CAPMATINIB ; 1029712-80-8 ; 2020 ; ; TARGET MET ; ATC (CAPMATINIB) L01EX17 ; ; Hepatocyte growth factor receptor UNIPROT P08581 MET 1984 ; TRIHEPTANOIN ; 620-67-7 ; 2020 ; ; ; ATC (TRIHEPTANOIN) A16AX17 ; ; UNKNOWN 1985 ; M TRIHEPTANOIN ; 7563-37-3 ; 0 ; ; ; ATC (TRIHEPTANOIN) A16AX17 ; PDB 6JYD (STRUCTURE OF LIGHT-STATE MARINE BACTERIAL CHLORIDE IMPORTER, NM-R3, WITH CW LASER (ND-30PERCENT) AT 95K) - ligand code OLA ; UNKNOWN 1986 ; LURBINECTEDIN ; 497871-47-3 ; 2020 ; ; TARGET DNA ; ATC (LURBINECTEDIN) L01XX69 ; ; UNKNOWN 1987 ; PEMIGATINIB ; 1513857-77-6 ; 2020 ; ; TARGET FGFR1 -- FGFR2 -- FGFR3 ; ATC (PEMIGATINIB) L01EN02 ; PDB 7WCL (CRYSTAL STRUCTURE OF FGFR1 KINASE DOMAIN WITH PEMIGATINIB) - ligand code 8ZF ; Fibroblast growth factor receptor 3 UNIPROT P22607 FGFR3 -- Fibroblast growth factor receptor 1 UNIPROT P11362 FGFR1 1988 ; SELUMETINIB ; 606143-52-6 ; 2020 ; ; TARGET MEK1 -- MEK2 ; ATC (SELUMETINIB) L01EE04 ; PDB 4U7Z (MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK1) BOUND TO G805) - ligand code 3EW ; Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 -- Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2 1989 ; M SELUMETINIB ; 606143-88-8 ; 0 ; ; TARGET MEK1 -- MEK2 ; ATC (SELUMETINIB) L01EE04 ; ; Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 -- Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2 1990 ; RIPRETINIB ; 1442472-39-0 ; 2020 ; ; TARGET PROTO-ONCOGENE RECEPTOR TYROSINE KINASE (KIT) ; ATC (RIPRETINIB) L01EX19 ; ; Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Platelet-derived growth factor receptor alpha UNIPROT P16234 PDGFRA 1991 ; M RIPRETINIB ; 1442473-09-7 ; 0 ; ; TARGET PROTO-ONCOGENE RECEPTOR TYROSINE KINASE (KIT) ; ATC (RIPRETINIB) L01EX19 ; ; Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Platelet-derived growth factor receptor alpha UNIPROT P16234 PDGFRA 1992 ; SN38 ; 86639-52-3 ; 2020 ; ; TARGET TOPOISOMERASE ; ATC (SACITUZUMAB GOVITECAN) L01FX17 ; PDB 6VXJ (STRUCTURE OF ABCG2 BOUND TO SN38) - ligand code RS4 ; DNA topoisomerase 1 UNIPROT P11387 TOP1 -- Tumor-associated calcium signal transducer 2 UNIPROT P09758 TACSTD2 1993 ; EXATECAN ; 171335-80-1 ; 2019 ; ; TARGET TOPOISOMERASE ; ATC (TRASTUZUMAB DERUXTECAN) L01FD04 ; ; Receptor tyrosine-protein kinase erbB-2 UNIPROT P04626 ERBB2 -- DNA topoisomerase 1 UNIPROT P11387 TOP1 1994 ; OLICERIDINE ; 1401028-24-7 ; 2021 ; ; TARGET MU-OPIOID RECEPTOR ; ATC (OLICERIDINE) N02AX07 ; PDB 8EFB (OLICERIDINE-BOUND MU-OPIOID RECEPTOR-GI COMPLEX) - ligand code WH2 ; Mu-type opioid receptor UNIPROT P35372 OPRM1 1995 ; VILOXAZINE ; 46817-91-8 ; 2021 ; ; TARGET NOREPINEPHRINE TRANSPORTER (NET KI=0.63 MICROMOLAR) ; ATC (VILOXAZINE) N06AX09 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1996 ; VILOXAZINE ; 46817-91-8 ; 2021 ; ; TARGET NOREPINEPHRINE TRANSPORTER (NET KI=0.63 MICROMOLAR) ; ATC (VILOXAZINE) N06AX09 ; ; Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 1997 ; CABOTEGRAVIR ; 1051375-10-0 ; 2021 ; ; TARGET HIV-1 INTEGRASE ; ATC (CABOTEGRAVIR) J05AJ04 ; ; Integrase UNIPROT Q7ZJM1 pol 1998 ; TIVOZANIB ; 475108-18-0 ; 2021 ; ; TARGET VEGFR-1 VEGFR-2 VEGFR-3 PDGFR-BETA ; ATC (TIVOZANIB) L01EK03 ; PDB 4ASE (CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH TIVOZANIB (AV-951)) - ligand code AV9 ; Vascular endothelial growth factor receptor 1 UNIPROT P17948 FLT1 -- Vascular endothelial growth factor receptor 2 UNIPROT P35968 KDR 1999 ; SERDEXMETHYLPHENIDATE ; 1996626-29-9 ; 2021 ; ; TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER -- SODIUM-DEPENDENT DOPAMINE TRANSPORTER -- SODIUM-DEPENDENT SEROTONIN TRANSPORTER ; ATC (SERDEXMETHYLPHENIDATE) N06BA15 ; ; UNKNOWN 2000 ; VIBEGRON ; 1190389-15-1 ; 2020 ; ; TARGET BETA-3 ADRENERGIC RECEPTOR ; ATC (VIBEGRON) G04BD15 ; ; Beta-3 adrenergic receptor UNIPROT P13945 ADRB3 2001 ; UMBRALISIB ; 1532533-67-7 ; 2021 ; DISCONTINUED ; TARGET PI3K-DELTA -- CASEIN KINASE CK1-EPSILON ; ATC (UMBRALISIB) L01EX25 ; ; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD -- Casein kinase I isoform epsilon UNIPROT P49674 CSNK1E 2002 ; TIRBANIBULIN ; 897016-82-9 ; 2020 ; ; TARGET TUBULIN ; ATC (TIRBANIBULIN) D06BX03 ; PDB 6KNZ (CRYSTAL STRUCTURE OF T2R-TTL-KXO1 COMPLEX) - ligand code DN0 ; Tubulin beta chain UNIPROT P07437 TUBB 2003 ; SAMIDORPHAN ; 852626-89-2 ; 2021 ; ; TARGET MU-OPIOID RECEPTOR (KI=0.052 NANOMOLAR) -- KAPPA-OPIOID RECEPTOR (KI=0.23 NANOMOLAR) -- DELTA-OPIOID RECEPTOR (KI=2.7 NANOMOLAR) ; ATC (SAMIDORPHAN) N05AH53 ; ; Mu-type opioid receptor UNIPROT P35372 OPRM1 2004 ; CLASCOTERONE ; 19608-29-8 ; 2020 ; ; TARGET ANDROGEN RECEPTOR ; ATC (CLASCOTERONE) D10AX06 ; ; Androgen receptor UNIPROT P10275 AR 2005 ; NIFURTIMOX ; 23256-30-6 ; 2020 ; ; TARGET DNA ; ATC (NIFURTIMOX) P01CC01 ; ; UNKNOWN 2006 ; NIFURTIMOX ; 23256-30-6 ; 2020 ; ; TARGET DNA ; ATC (NIFURTIMOX) P01CC01 ; ; UNKNOWN 2007 ; PONESIMOD ; 854107-55-4 ; 2021 ; ; TARGET SPHINGOSINE1-PHOSPHATE (S1P) RECEPTOR 1 ; ATC (PONESIMOD) L04AE04 ; ; Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 2008 ; RISDIPLAM ; 1825352-65-5 ; 2020 ; ; TARGET MRNA ; ATC (RISDIPLAM) M09AX10 ; ; UNKNOWN 2009 ; VOCLOSPORIN ; 515814-01-4 ; 2021 ; ; TARGET CYCLOPHILIN A ; ATC (VOCLOSPORIN) L04AD03 ; PDB 3ODI (CRYSTAL STRUCTURE OF CYCLOPHILIN A IN COMPLEX WITH VOCLOSPORIN E-ISA247) - ligand code VOCLOSPORIN ; Peptidyl-prolyl cis-trans isomerase A UNIPROT P62937 PPIA 2010 ; PRALSETINIB ; 2097132-94-8 ; 2020 ; ; TARGET RET PROTEIN TYROSINE KINASE (IC50 LESS THAN 0.5 NANOMOLAR) ; ATC (PRALSETINIB) L01EX23 ; PDB 7JU5 (STRUCTURE OF RET PROTEIN TYROSINE KINASE IN COMPLEX WITH PRALSETINIB) - ligand code Q4J ; Proto-oncogene tyrosine-protein kinase receptor Ret UNIPROT P07949 RET 2011 ; SETMELANOTIDE ; 920014-72-8 ; 2020 ; ; TARGET MELANOCORTIN 4 (MC4) RECEPTOR ; ATC (SETMELANOTIDE) A08AA12 ; ; Melanocortin receptor 4 UNIPROT P32245 MC4R 2012 ; LONAFARNIB ; 193275-84-2 ; 2020 ; ; TARGET FARNESYL PROTEIN TRANSFERASE ; ATC (LONAFARNIB) A16AX20 ; PDB 1O5M (STRUCTURE OF FPT BOUND TO THE INHIBITOR SCH66336) - ligand code 336 ; Protein farnesyltransferase UNIPROT P49354 FNTA 2013 ; FOSDENOPTERIN ; 150829-29-1 ; 2021 ; ; ; ATC (FOSDENOPTERIN) A16AX19 ; ; Molybdenum cofactor biosynthesis protein 1 UNIPROT Q9NZB8 MOCS1 2014 ; BEROTRALSTAT ; 1809010-50-1 ; 2020 ; ; TARGET KALLIKREIN ; ATC (BEROTRALSTAT) B06AC06 ; PDB 7N7X (CRYSTAL STRUCTURE OF BCX7353(ORLADEYO) IN COMPLEX WITH HUMAN PLASMA KALLIKREIN SERINE PROTEASE DOMAIN AT 2.1 ANGSTROM RESOLUTION) - ligand code 0RI ; Plasma kallikrein UNIPROT P03952 KLKB1 2015 ; TEPOTINIB ; 1100598-32-0 ; 2021 ; ; TARGET MET KINASE ; ATC (TEPOTINIB) L01EX21 ; PDB 4R1V (IDENTIFICATION AND OPTIMIZATION OF PYRIDAZINONES AS POTENT AND SELECTIVE C-MET KINASE INHIBITORS) - ligand code 3E8 ; Hepatocyte growth factor receptor UNIPROT P08581 MET 2016 ; ESTETROL ; 15183-37-6 ; 2021 ; ; TARGET ESTROGEN RECEPTOR ; ATC (ESTETROL) G03AA18 ; PDB 3L03 (CRYSTAL STRUCTURE OF HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE AND ESTETROL) - ligand code 4OH ; Estrogen receptor UNIPROT P03372 ESR1 -- Estrogen receptor beta UNIPROT Q92731 ESR2 2017 ; TRILACICLIB ; 1374743-00-6 ; 2021 ; ; TARGET CDK4 -- CDK6 ; ATC (TRILACICLIB) V03AF12 ; ; Cyclin-dependent kinase 6 UNIPROT Q00534 CDK6 -- Cyclin-dependent kinase 4 UNIPROT P11802 CDK4 2018 ; VERICIGUAT ; 1350653-20-1 ; 2021 ; ; ; ATC (VERICIGUAT) C01DX22 ; ; Guanylate cyclase soluble subunit beta-1 UNIPROT Q02153 GUCY1B3 2019 ; MELPHALAN FLUFENAMIDE ; 380449-51-4 ; 2021 ; DISCONTINUED ; TARGET DNA ; ATC (MELPHALAN) L01AA03 L01AA10 ; ; UNKNOWN 2020 ; BRINCIDOFOVIR ; 444805-28-1 ; 2021 ; ; TARGET DNA POLYMERASE ; ATC (CIDOFOVIR) J05AB12 ; ; 2021 ; RELUGOLIX ; 737789-87-6 ; 2020 ; ; TARGET GONADOTROPIN-RELEASING HORMONE (GNRH) RECEPTOR ; ATC (RELUGOLIX) L02BX04 H01CC54 ; ; Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR 2022 ; INFIGRATINIB ; 872511-34-7 ; 2021 ; DISCONTINUED ; TARGET FGFR KINASE 1, 2, 3 AND 4 (IC50=1.1, 1, 2 AND 61 NANOMOLAR RESPECTIVELY) ; ATC (INFIGRATINIB) L01EN03 ; PDB 3TT0 (CO-STRUCTURE OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE DOMAIN WITH 3-(2,6-DICHLORO-3,5-DIMETHOXY-PHENYL)-1-{6-[4-(4-ETHYL-PIPERAZIN-1-YL)-PHENYLAMINO]-PYRIMIDIN-4-YL}-1-METHYL-UREA (BGJ398)) - ligand code 07J ; Fibroblast growth factor receptor 1 UNIPROT P11362 FGFR1 2023 ; SOTORASIB ; 2296729-00-3 ; 2021 ; ; TARGET KRAS(G12C) ; ATC (SOTORASIB) L01XX73 ; ; GTPase KRas UNIPROT P01116 KRAS 2024 ; REMDESIVIR ; 1809249-37-3 ; 2020 ; ; TARGET RNA POLYMERASE ; ATC (REMDESIVIR) J05AB16 ; ; Replicase polyprotein 1ab UNIPROT P0DTD1 REP 2025 ; M REMDESIVIR ; 1191237-69-0 ; 0 ; ; TARGET RNA POLYMERASE ; ATC (REMDESIVIR) J05AB16 ; PDB 7BF6 (CRYSTAL STRUCTURE OF SARS-COV-2 MACRODOMAIN IN COMPLEX WITH REMDESIVIR METABOLITE GS-441524) - ligand code U08 ; Replicase polyprotein 1ab UNIPROT P0DTD1 REP 2026 ; IBREXAFUNGERP ; 1207753-03-4 ; 2021 ; ; TARGET GLUCAN SYNTHASE ; ATC (IBREXAFUNGERP) J02AX07 ; ; Beta-1,3-glucan synthase catalytic subunit 1 UNIPROT O13428 GSC1 -- 1,3-Beta-D-glucan-UDP glucosyltransferase UNIPROT Q6FTN8 FKS1 2027 ; MAFODOTIN ; 863971-19-1 ; 2020 ; DISCONTINUED ; TARGET TUBULIN ; ATC (BELANTAMAB MAFODOTIN) L01FX15 ; ; IgG receptor FcRn large subunit p51 UNIPROT P55899 FCGRT -- High affinity immunoglobulin gamma Fc receptor I UNIPROT P12314 FCGR1A 2028 ; SG3199 ; 1595275-71-0 ; 2021 ; ; TARGET DNA ; ATC (LONCASTUXIMAB TESIRINE) L01FX22 ; ; B-lymphocyte antigen CD19 UNIPROT P15391 CD19 2029 ; PACRITINIB ; 937272-79-2 ; 2022 ; ; TARGET JAK2 -- FLT3 ; ATC (PACRITINIB) L01EJ03 ; PDB 5LBZ (STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH PACRITINIB) - ligand code 6T3 ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 -- Tyrosine-protein kinase JAK2 UNIPROT O60674 JAK2 2030 ; ABROCITINIB ; 1622902-68-4 ; 2022 ; ; TARGET JAK1 KINASE ; ATC (ABROCITINIB) D11AH08 ; PDB 6BBU (CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH COMPOUND 25) - ligand code D7D ; Tyrosine-protein kinase JAK1 UNIPROT P23458 2031 ; M ABROCITINIB ; 2744171-53-5 ; 0 ; ; TARGET JAK1 KINASE ; ATC (ABROCITINIB) D11AH08 ; ; Tyrosine-protein kinase JAK1 UNIPROT P23458 2032 ; M ABROCITINIB ; 2744171-52-4 ; 0 ; ; TARGET JAK1 KINASE ; ATC (ABROCITINIB) D11AH08 ; ; Tyrosine-protein kinase JAK1 UNIPROT P23458 2033 ; LEVOKETOCONAZOLE ; 142128-57-2 ; 2021 ; ; TARGET CYP11B1 -- CYP11A1 -- CYP17A1 ; ATC (LEVOKETOCONAZOLE) H02CA04 ; PDB 3OZW (THE CRYSTAL STRUCTURE OF FLAVOHEMOGLOBIN FROM R. EUTROPHUS IN COMPLEX WITH KETOCONAZOLE) - ligand code KKK_3OZW ; Steroid 17-alpha-hydroxylase 17,20 lyase UNIPROT P05093 CYP17A1 -- Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1 2034 ; FEXINIDAZOLE ; 59729-37-2 ; 2021 ; ; ; ATC (FEXINIDAZOLE) P01CA03 ; ; UNKNOWN 2035 ; M FEXINIDAZOLE ; 62351-99-9 ; 0 ; ; ; ATC (FEXINIDAZOLE) P01CA03 ; ; UNKNOWN 2036 ; M FEXINIDAZOLE ; 64570-18-9 ; 0 ; ; ; ATC (FEXINIDAZOLE) P01CA03 ; ; UNKNOWN 2037 ; AVACOPAN ; 1346623-17-3 ; 2021 ; ; TARGET C5AR ; ATC (AVACOPAN) L04AJ05 ; PDB 6C1R (CRYSTAL STRUCTURE OF HUMAN C5A RECEPTOR IN COMPLEX WITH AN ORTHOSTERIC ANTAGONIST PMX53 AND AN ALLOSTERIC ANTAGONIST AVACOPAN) - ligand code EFD ; C5a anaphylatoxin chemotactic receptor 1 UNIPROT P21730 2038 ; MARALIXIBAT ; 716313-53-0 ; 2021 ; ; TARGET IBAT TRANSPORTER ; ATC (MARALIXIBAT) A05AX04 ; ; Ileal sodium bile acid cotransporter UNIPROT Q12908 2039 ; BELUMOSUDIL ; 911417-87-3 ; 2021 ; ; TARGET ROCK2 KINASE ; ATC (BELUMOSUDIL) L04AA48 ; PDB 7Z39 (STRUCTURE OF BELUMOSUDIL BOUND TO CK2ALPHA) - ligand code ICQ ; Rho-associated protein kinase 1 UNIPROT Q13464 ROCK1 -- Rho-associated protein kinase 2 UNIPROT O75116 ROCK2 2040 ; DIFELIKEFALIN ; 1024828-77-0 ; 2021 ; ; TARGET KAPPA OPIOID RECEPTOR ; ATC (DIFELIKEFALIN) V03AX04 ; ; Kappa-type opioid receptor UNIPROT P41145 2041 ; DARIDOREXANT ; 1505484-82-1 ; 2022 ; ; TARGET OREXIN-1 RECEPTOR (OX1R) -- OREXIN-2 RECEPTOR (OX2R) ; ATC (DARIDOREXANT) N05CJ03 ; PDB 6TP3 (CRYSTAL STRUCTURE OF THE OREXIN-1 RECEPTOR IN COMPLEX WITH DARIDOREXANT) - ligand code NS2 ; Orexin Hypocretin receptor type 1 UNIPROT O43613 HCRTR1 -- Orexin receptor type 2 UNIPROT O43614 HCRTR2 2042 ; MAVACAMTEN ; 1642288-47-8 ; 2022 ; ; TARGET CARDIAC MYOSIN ; ATC (MAVACAMTEN) C01EB24 ; PDB 8QYR (BETA-CARDIAC MYOSIN MOTOR DOMAIN IN THE PRE-POWERSTROKE STATE COMPLEXED TO MAVACAMTEN) - ligand code XB2 ; Myosin-7 UNIPROT P12883 2043 ; VONOPRAZAN ; 881681-00-1 ; 2022 ; ; TARGET POTASSIUM-TRANSPORTING ATPASE ; ATC (VONOPRAZAN) A02BC08 A02BD17 A02BD14 A02BD15 ; PDB 5YLU (CRYSTAL STRUCTURE OF THE GASTRIC PROTON PUMP COMPLEXED WITH VONOPRAZAN) - ligand code HKT ; Potassium-transporting ATPase UNIPROT P20648 ATP4A 2044 ; ATOGEPANT ; 1374248-81-3 ; 2021 ; ; TARGET CALCITONIN GENE-RELATED PEPTIDE RECEPTOR ; ATC (ATOGEPANT) N02CD07 ; ; Calcitonin gene-related peptide type 1 receptor UNIPROT Q16602 2045 ; TAPINAROF ; 79338-84-4 ; 2022 ; ; TARGET ARYL HYDROCARBON RECEPTOR ; ATC (TAPINAROF) D05AX07 ; ; Aryl hydrocarbon receptor UNIPROT P35869 2046 ; MOBOCERTINIB ; 1847461-43-1 ; 2021 ; DISCONTINUED ; TARGET EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) (MUTATED) -- HER2 -- HER4 -- BLK ; ATC (MOBOCERTINIB) L01EB10 ; ; Epidermal growth factor receptor UNIPROT P00533 EGFR -- Receptor tyrosine-protein kinase erbB-2 UNIPROT P04626 ERBB2 2047 ; M MOBOCERTINIB ; 1847462-25-2 ; 0 ; ; TARGET EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) (MUTATED) ; ATC (MOBOCERTINIB) L01EB10 ; ; Epidermal growth factor receptor UNIPROT P00533 2048 ; M MOBOCERTINIB ; 1847461-70-4 ; 0 ; ; TARGET EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) (MUTATED) ; ATC (MOBOCERTINIB) L01EB10 ; ; Epidermal growth factor receptor UNIPROT P00533 2049 ; FINERENONE ; 1050477-31-0 ; 2021 ; ; TARGET MINERALOCORTICOID RECEPTOR ; ATC (FINERENONE) C03DA05 ; ; Mineralocorticoid receptor UNIPROT P08235 2050 ; ASCIMINIB ; 1492952-76-7 ; 2021 ; ; TARGET ABL1 KINASE ; ATC (ASCIMINIB) L01EA06 ; PDB 5MO4 (ABL1 KINASE (T334I_D382N) IN COMPLEX WITH ASCIMINIB AND NILOTINIB) - ligand code AY7 ; Tyrosine-protein kinase ABL1 UNIPROT P00519 2051 ; BELZUTIFAN ; 1672668-24-4 ; 2021 ; ; TARGET HYPOXIA-INDUCIBLE FACTOR-2 ALPHA ; ATC (BELZUTIFAN) L01XX74 ; PDB 5T0T (CRYSTAL STRUCTURE OF PT2399 BOUND TO HIF2A-B, ARNT-B COMPLEX) - ligand code 72Q ; Endothelial PAS domain-containing protein 1 UNIPROT Q99814 2052 ; ODEVIXIBAT ; 501692-44-0 ; 2021 ; ; TARGET ILEAL BILE ACID TRANSPORTER ; ATC (ODEVIXIBAT) A05AX05 ; ; Ileal sodium bile acid cotransporter UNIPROT Q12908 SLC10A2 2053 ; MARIBAVIR ; 176161-24-3 ; 2021 ; ; TARGET PUL97 KINASE ; ATC (MARIBAVIR) J05AX10 ; ; Serine threonine protein kinase UL97 UNIPROT P16788 UL97 2054 ; OTESECONAZOLE ; 1340593-59-0 ; 2022 ; ; TARGET STEROL 14-ALPHA DEMETHYLASE (CYP51) ; ATC (OTESECONAZOLE) J02AC06 ; PDB 5TZ1 (CRYSTAL STRUCTURE OF STEROL 14-ALPHA DEMETHYLASE (CYP51) FROM CANDIDA ALBICANS IN COMPLEX WITH THE TETRAZOLE-BASED ANTIFUNGAL DRUG CANDIDATE VT1161 (VT1)) - ligand code VT1 ; Lanosterol 14-alpha demethylase UNIPROT P10613 2055 ; GANAXOLONE ; 38398-32-2 ; 2022 ; ; TARGET GABA A ; ATC (GANAXOLONE) N03AX27 ; ; Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 2056 ; MITAPIVAT ; 1260075-17-9 ; 2022 ; ; TARGET PYRUVATE KINASE ; ATC (MITAPIVAT) B06AX04 ; PDB 8XFD (CRYSTAL STRUCTURE OF PYRUVATE KINASE TETRAMER IN COMPLEX WITH ALLOSTERIC ACTIVATOR, MITAPIVAT (MTPV, AG-348)) - ligand code WV2 ; Pyruvate kinase PKLR UNIPROT P30613 2057 ; TERLIPRESSIN ; 14636-12-5 ; 2022 ; ; TARGET VASOPRESSIN V1 RECEPTOR -- VASOPRESSIN V2 RECEPTOR ; ATC (TERLIPRESSIN) H01BA04 ; ; Vasopressin V1a receptor UNIPROT P37288 2058 ; BEXAGLIFLOZIN ; 1118567-05-7 ; 2023 ; ; TARGET SODIUM-GLUCOSE CO-TRANSPORTER 2 -- SGLT2 ; ATC (BEXAGLIFLOZIN) A10BK08 ; ; sodium-glucose co-transporter 2 UNIPROT P31639 2059 ; FUTIBATINIB ; 1448169-71-8 ; 2022 ; ; TARGET FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) -- FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FGFR1) -- FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) ; ATC (FUTIBATINIB) L01EN04 ; PDB 7D5O (C-SRC IN COMPLEX WITH TAS-120) - ligand code TZ0 ; Fibroblast growth factor receptor 1 UNIPROT P11362 FGFR1 2060 ; DEUCRAVACITINIB ; 1609392-27-9 ; 2022 ; ; TARGET TYROSINE KINASE 2 (TYK2) ; ATC (DEUCRAVACITINIB) L04AF07 ; PDB 6NZP (CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11) - ligand code LB7 ; tyrosine kinase 2 (TYK2) UNIPROT P29597 2061 ; M DEUCRAVACITINIB ; 1609393-48-7 ; 0 ; ; TARGET TYROSINE KINASE 2 (TYK2) ; ATC (DEUCRAVACITINIB) L04AF07 ; ; tyrosine kinase 2 (TYK2) UNIPROT P29597 2062 ; OMIDENEPAG ISOPROPYL ; 1187451-19-9 ; 2022 ; DISCONTINUED ; TARGET PROSTAGLANDIN E2 (EP2) RECEPTOR ; ATC (OMIDENEPAG ) S01EX06 ; ; Prostaglandin E2 receptor EP2 subtype UNIPROT P43116 PTGER2 2063 ; OMIDENEPAG ; 1187451-41-7 ; 0 ; ; TARGET PROSTAGLANDIN E2 (EP2) RECEPTOR ; ATC (OMIDENEPAG) S01EX06 ; ; Prostaglandin E2 receptor EP2 subtype UNIPROT P43116 2064 ; OLUTASIDENIB ; 1887014-12-1 ; 2022 ; ; TARGET ISOCITRATE DEHYDROGENASE-1 (IDH1) ; ; PDB 6U4J (CRYSTAL STRUCTURE OF IDH1 R132H MUTANT IN COMPLEX WITH FT-2102) - ligand code PWV ; Isocitrate dehydrogenase NADP cytoplasmic IDH1 UNIPROT O75874 IDH1 2065 ; RITLECITINIB ; 1792180-81-4 ; 2023 ; ; TARGET JANUS KINASE 3 (JAK3) ; ATC (RITLECITINIB) L04AF08 ; ; Tyrosine-protein kinase JAK3 UNIPROT P52333 2066 ; PHENOBARBITAL ; 50-06-6 ; 2022 ; ; TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA) ; ATC (PHENOBARBITAL) N03AA02 ; PDB 6X3W (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS PHENOBARBITAL) - ligand code UQA ; Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 GABRA1 2067 ; LENACAPAVIR ; 2189684-44-2 ; 2022 ; ; TARGET GAG POLYPROTEIN ; ATC (LENACAPAVIR) J05AX31 ; PDB 7RHN (CO-CRYSTAL STRUCTURE OF Q67H MUTANT OF DISULFIDE STABILIZED HIV-1 CA HEXAMER AND LENACAPAVIR) - ligand code QNG ; Gag polyprotein UNIPROT P12493 2068 ; PIRTOBRUTINIB ; 2101700-15-4 ; 2023 ; ; TARGET BTK KINASE ; ATC (PIRTOBRUTINIB) L01EL05 ; PDB 8FLL (CRYSTAL STRUCTURE OF BTK KINASE DOMAIN IN COMPLEX WITH PIRTOBRUTINIB) - ligand code Y7W ; Tyrosine-protein kinase BTK UNIPROT Q06187 2069 ; SOTAGLIFLOZIN ; 1018899-04-1 ; 2023 ; ; TARGET SODIUM-GLUCOSE COTRANSPORTER 2 (SGLT2) -- SODIUM-GLUCOSE COTRANSPORTER 1 (SGLT1) ; ATC (SOTAGLIFLOZIN) A10BK06 ; PDB 8HG7 (STRUCTURE OF HUMAN SGLT2-MAP17 COMPLEX WITH SOTAGLIFLOZIN) - ligand code LFL ; Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 -- Sodium,glucose cotransporter 1 UNIPROT P13866 SLC5A1 2070 ; ADAGRASIB ; 2326521-71-3 ; 2022 ; ; TARGET KRAS G12C ; ATC (ADAGRASIB) L01XX77 ; ; GTPase KRas UNIPROT P01116 2071 ; ZAVEGEPANT ; 1337918-83-8 ; 2023 ; ; TARGET CALCITONIN GENE-RELATED PEPTIDE (CGRP) RECEPTOR ; ; ; Calcitonin gene-related peptide type 1 receptor UNIPROT Q16602 CALCRL 2072 ; SPARSENTAN ; 254740-64-2 ; 2023 ; ; TARGET ANGIOTENSIN II TYPE 1 RECEPTOR (AT1R) -- ENDOTHELIN TYPE A RECEPTOR (ETAR) ; ; ; Type-1 angiotensin II receptor UNIPROT P30556 AGTR1 -- Endothelin-1 receptor UNIPROT P25101 EDNRA 2073 ; FEZOLINETANT ; 1629229-37-3 ; 2023 ; ; TARGET NEUROKININ 3 (NK3) RECEPTOR ; ATC (FEZOLINETANT) G02CX06 ; ; Neuromedin-K receptor UNIPROT P29371 2074 ; TAURURSODIOL ; 14605-22-2 ; 2022 ; ; ; ; PDB 5DLV (CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2) WITH TAUROURSODEOXYCHOLIC ACID (TUDCA)) - ligand code 5D5 ; UNKNOWN 2075 ; OMAVELOXOLONE ; 1474034-05-3 ; 2023 ; ; ; ; ; Nuclear factor erythroid 2-related factor 2 UNIPROT Q16236 2076 ; DAPRODUSTAT ; 960539-70-2 ; 2023 ; DISCONTINUED ; TARGET HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE HIF-PH1 -- HIF-PH2 -- HIF-PH3 ; ATC (DAPRODUSTAT) B03XA07 ; ; Egl nine homolog 1 UNIPROT Q9GZT9 EGLN1 -- Egl nine homolog 2 UNIPROT Q96KS0 EGLN2 2077 ; DURLOBACTAM ; 1467829-71-5 ; 2023 ; ; TARGET BETA LACTAMASE ; ; ; beta-lactamase UNIPROT S5MN77 2078 ; TROFINETIDE ; 853400-76-7 ; 2023 ; ; ; ; ; UNKNOWN 2079 ; NIRMATRELVIR ; 2628280-40-8 ; 2023 ; ; TARGET SARS-COV-2 MAIN PROTEASE MPRO ; ATC (NIRMATRELVIR) J05AE30 ; PDB 7SI9 (ROOM TEMPERATURE X-RAY STRUCTURE OF SARS-COV-2 MAIN PROTEASE (MPRO) IN COMPLEX WITH PF-07321332) - ligand code 4WI ; Replicase polyprotein 1ab rep UNIPROT P0DTD1 2080 ; REZAFUNGIN ; 1396640-59-7 ; 2023 ; ; TARGET 1,3-BETA-D-GLUCAN SYNTHASE ; ATC (REZAFUNGIN ACETATE) J02AX08 ; ; 1,3-beta-glucan synthase UNIPROT O13428 2081 ; ELACESTRANT ; 722533-56-4 ; 2023 ; ; TARGET ESTROGEN RECEPTOR ALPHA ; ATC (ELACESTRANT) L02BA04 ; PDB 7TE7 (ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH RAD1901) - ligand code I0V ; Estrogen Receptor Alpha ESR1 UNIPROT P03372 2082 ; LENIOLISIB ; 1354690-24-6 ; 2023 ; ; TARGET PHOSPHOINOSITIDE 3-KINASE DELTA (PI3K DELTA) ; ATC (LENIOLISIB) L03AX22 ; PDB 5O83 (DISCOVERY OF CDZ173 (LENIOLISIB), REPRESENTING A STRUCTURALLY NOVEL CLASS OF PI3K DELTA-SELECTIVE INHIBITORS) - ligand code 9NQ ; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform PK3CD UNIPROT O00329 2083 ; SORAVTANSINE ; 796073-69-3 ; 2022 ; ; TARGET TUBULIN ; ATC (MIRVETUXIMAB SORAVTANSINE) L01FX26 ; ; TUBULIN TBB1_HUMAN INHIBITOR UNIPROT P04350 2084 ; GEPIRONE ; 83928-76-1 ; 2023 ; DISCONTINUED ; TARGET 5HT1A RECEPTOR ; ATC (GEPIRONE) N06AX19 ; ; 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 2085 ; M GEPIRONE ; 477930-33-9 ; 0 ; DISCONTINUED ; TARGET 5HT1A RECEPTOR ; ATC (GEPIRONE) N06AX19 ; ; 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 2086 ; M GEPIRONE ; 20980-22-7 ; 0 ; DISCONTINUED ; TARGET ALPHA2 ADRENERGIC RECEPTOR ; ATC (GEPIRONE) N06AX19 ; ; 2087 ; CANTHARIDIN ; 56-25-7 ; 2023 ; ; ; ; ; UNKNOWN 2088 ; TAUROLIDINE ; 19388-87-5 ; 2023 ; ; ; ATC (TAUROLIDINE) B05CA05 ; ; UNKNOWN 2089 ; M GEPIRONE ; 477930-32-8 ; 0 ; DISCONTINUED ; TARGET 5HT1A RECEPTOR ; ATC (GEPIRONE) N06AX19 ; ; 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A 2090 ; VADADUSTAT ; 1000025-07-9 ; 2024 ; ; TARGET HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE (HIF PH) ; ATC (VADADUSTAT) B03XA08 ; PDB 5OPC (FACTOR INHIBITING HIF (FIH) IN COMPLEX WITH ZINC AND VADADUSTAT) - ligand code A1Z ; Egl nine homolog 1 UNIPROT Q9GZT9 EGLN1 -- Egl nine homolog 2 UNIPROT Q96KS0 EGLN2 2091 ; VAMOROLONE ; 13209-41-1 ; 2023 ; ; TARGET GLUCOCORTICOID RECEPTOR ; ATC (VAMOROLONE) H02AB18 ; PDB 6W9M (STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH VAMOROLONE AND SHP COREGULATOR FRAGMENT) - ligand code TUV ; 2092 ; PALOVAROTENE ; 410528-02-8 ; 2023 ; ; TARGET RETINOIC ACID RECEPTOR GAMMA (RAR GAMMA) ; ATC (M09AX11) PALOVAROTENE ; ; Retinoic acid receptor gamma UNIPROT P13631 2093 ; ENMETAZOBACTAM ; 1001404-83-6 ; 2024 ; DISCONTINUED ; TARGET BETA-LACTAMASE ; ; PDB 6T35 (CRYSTAL STRUCTURE OF AMPC FROM E.COLI WITH ENMETAZOBACTAM (AAI-101)) - ligand code M9W ; 2094 ; PIVMECILLINAM ; 32886-97-8 ; 2024 ; ; TARGET PENICILLIN-BINDING PROTEIN 2B ; ATC (J01CA08) PIVMECILLINAM ; ; Peptidoglycan D,D-transpeptidase MrdA UNIPROT P0AD65 2095 ; MOMELOTINIB ; 1056634-68-4 ; 2023 ; ; TARGET JANUS KINASE 1 AND 2 (JAK1/JAK2) ; ATC (L01EJ04) MOMELOTINIB ; PDB 8BXH (CRYSTAL STRUCTURE OF JAK2 JH1 IN COMPLEX WITH MOMELOTINIB) - ligand code C87 ; 2096 ; M MOMELOTINIB ; 1841094-23-2 ; 0 ; ; TARGET JANUS KINASE 1 AND 2 (JAK1/JAK2) ; ATC (L01EJ04) MOMELOTINIB ; ; 2097 ; ETRASIMOD ; 1206123-37-6 ; 2023 ; ; TARGET SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR ; ATC (ETRASIMOD) L04AE05 ; ; 2098 ; QUIZARTINIB ; 950769-58-1 ; 2023 ; ; TARGET TYROSINE KINASE FLT3 ; ATC (QUIZARTINIB) L01EX11 ; PDB 4XUF (CRYSTAL STRUCTURE OF THE FLT3 KINASE DOMAIN BOUND TO THE INHIBITOR QUIZARTINIB (AC220)) - ligand code P30 ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 2099 ; M QUIZARTINIB ; 1225542-12-0 ; 0 ; ; TARGET TYROSINE KINASE FLT3 ; ATC (QUIZARTINIB) L01EX11 ; ; Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 2100 ; SOFPIRONIUM ; 1628251-49-9 ; 2024 ; ; TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M3 ; ; ; Muscarinic acetylcholine receptor M3 UNIPROT P20309 2101 ; ZURANOLONE ; 1632051-40-1 ; 2023 ; ; TARGET GABA A RECEPTOR ; ; ; Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 2102 ; FRUQUINTINIB ; 1194506-26-7 ; 2023 ; ; TARGET VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS (VEGFR)-1, -2, AND -3 ; ATC (FRUQUINTINIB) L01EK04 ; ; 2103 ; LOTILANER ; 1369852-71-0 ; 2023 ; ; TARGET GAMMA-AMINOBUTYRIC ACID (GABA)-GATED CHLORIDE CHANNEL ; ; ; Gaba-gated chloride channel, putative UNIPROT E0V9W2 8233868 2104 ; NIROGACESTAT ; 1290543-63-3 ; 2023 ; ; TARGET GAMMA SECRETASE ; ; ; 2105 ; TOVORAFENIB ; 1096708-71-2 ; 2024 ; ; TARGET TYPE II RAF KINASE (MUTANT BRAF V600E, WILD-TYPE BRAF, AND WILD-TYPE CRAF) ; ; PDB 8F7O (BRAF KINASE IN COMPLEX WITH TAK580 (TOVORAFENIB)) - ligand code QOP ; 2106 ; RESMETIROM ; 920509-32-6 ; 2024 ; ; TARGET THYROID HORMONE RECEPTOR BETA ; ; ; 2107 ; GIVINOSTAT ; 497833-27-9 ; 2024 ; ; TARGET HISTONE DEACETYLASE ; ATC (GIVINOSTAT) M09AX14 ; PDB 6UOC (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 1 (CD1) K330L MUTANT COMPLEXED WITH GIVINOSTAT) - ligand code QCM ; 2108 ; DANICOPAN ; 1903768-17-1 ; 2024 ; ; TARGET COMPLEMENT FACTOR D ; ATC (DANICOPAN) L04AJ09 ; ; 2109 ; CAPIVASERTIB ; 1143532-39-1 ; 2023 ; ; TARGET SERINE THREONINE KINASE AKT1 AKT2 AND AKT3 ; ATC (CAPIVASERTIB) L01EX27 ; PDB 4GV1 (PKB ALPHA IN COMPLEX WITH AZD5363) - ligand code 0XZ ; 2110 ; REPOTRECTINIB ; 1802220-02-5 ; 2023 ; ; TARGET TYROSINE-PROTEIN KINASE ROS1 ; ; PDB 7VKN (CRYSTAL STRUCTURE OF TRKA (G595R) KINASE WITH REPOTRECTINIB) - ligand code 7GI ; 2111 ; CEFTOBIPROLE MEDOCARIL ; 376653-43-9 ; 2024 ; ; TARGET PENICILLIN-BINDING PROTEINS (PBPS) ; ATC (CEFTOBIPROLE MEDOCARIL) J01DI01 ; ; MecA UNIPROT Q7DHH4 mecA 2112 ; CEFTOBIPROLE ; 209467-52-7 ; 0 ; ; TARGET PENICILLIN-BINDING PROTEINS (PBPS) ; ATC (CEFTOBIPROLE MEDOCARIL) J01DI01 ; PDB 6VJE (CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA PENICILLIN-BINDING PROTEIN 3 (PBP3) COMPLEXED WITH CEFTOBIPROLE) - ligand code RB6 ; MecA UNIPROT Q7DHH4 2113 ; IPTACOPAN ; 1644670-37-0 ; 2023 ; ; TARGET COMPLEMENT FACTOR B ; ATC (IPTACOPAN) L04AJ08 ; PDB 6RAV (COMPLEMENT FACTOR B PROTEASE DOMAIN IN COMPLEX WITH THE REVERSIBLE INHIBITOR 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)PIPERIDIN-2-YL)BENZOIC ACID) - ligand code JGQ ; Complement factor B UNIPROT P00751 2114 ; MAVORIXAFOR ; 558447-26-0 ; 2024 ; ; TARGET CXC CHEMOKINE RECEPTOR 4 (CXCR4) ; ; ; 2115 ; ELAFIBRANOR ; 923978-27-2 ; 2024 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) ; ATC (ELAFIBRANOR) A05AX06 ; PDB 8HUQ (X-RAY STRUCTURE OF HUMAN PPAR ALPHA LIGAND BINDING DOMAIN-ELAFIBRANOR-SRC1 COACTIVATOR PEPTIDE CO-CRYSTALS OBTAINED BY SOAKING) - ligand code MUO ; 2116 ; BENZQUINAMIDE ; 63-12-7 ; 1974 ; DISCONTINUED ; TARGET P-GLYCOPROTEIN (PMID1362504) ; ; ; D(2) dopamine receptor UNIPROT P14416 DRD2 2117 ; ISOETHARINE ; 530-08-5 ; 1978 ; DISCONTINUED ; TARGET BETA-2 ADRENERGIC RECEPTOR ; ATC (ISOETARINE) R03AC07 R03CC06 ; ; Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 2118 ; M ELAFIBRANOR ; 1000334-85-9 ; 0 ; ; TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) ; ATC (ELAFIBRANOR) A05AX06 ; ;