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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TROGLITAZONE DISCONTINUED
| TROGLITAZONE | METABOLISM | ORAL | Cmax 6.39 MICROMOLAR (600 MILLIGRAM) VD 1202 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 29.7 LITER / HOUR HT 25 HOUR SOLUBILITY PRATICALLY INSOLUBLE IN WATER | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR) PDB 6DGO (CRYSTAL STRUCTURE OF HUMAN PPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH TROGLITAZONE) LIGAND CODE = GD4 (link to the list of PDB complexes) Download experimental 3D coordinates of GD4 with added hydrogens | Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG more at DrugCentral | EMA | |||
