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session 86295 - Total of 3 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
FOLIC ACID (is an active metabolite)	FOLIC ACID	ATC B03AD04 ATC B03AD01 ATC B03AD02 ATC B03AD05 ATC B03AD03 ATC B03BB01 ATC V04CX02 ATC B03BB51 ATC B03AE02 ATC B03AE01 BLOOD VITAMIN B9 DIETARY SUPPLEMENT	ORAL INJECTION INTRAVENOUS		PDB 4P3R (CRYOGENIC WT DHFR, TIME-AVERAGED ENSEMBLE) LIGAND CODE = FOL (link to the list of PDB complexes) Download experimental 3D coordinates of FOL with added hydrogens	Thymidylate synthase UNIPROT P04818 TYMS more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
LEUCOVORIN (has an active metabolite)	LEUCOVORIN	ATC B03AD04 ATC B03AD01 ATC B03AD02 ATC B03AD05 ATC B03AD03 ATC B03BB01 ATC V04CX02 ATC B03BB51 ATC B03AE02 ATC B03AE01 VARIOUS ANTIANEMIC ANTIDOTE TO FOLIC ACID ANTAGONISTS ANTINEOPLASTIC ADJUNCTS RESCUE AFTER HIGH-DOSE METHOTREXATE THERAPY IN OSTEOSARCOMA USE IN COMBINATION CHEMOTHERAPY WITH 5-FLUOROURACIL RAPIDLY ABSORBED AND ENTERS THE GENERAL BODY POOL OF REDUCED FOLATES CONVERTED TO 5-METHYLTETRAHYDROFOLIC ACID (5-METHYL-THF)	INJECTION ORAL	VD 16.2 LITER (65 KILOGRAM) PPB 91 PERCENT Cl 22.6 LITER / HOUR (65 KILOGRAM) HT 1.3 HOUR SOLUBILITY SOLUBLE IN WATER	PDB 4LXX (CRYSTAL STRUCTURE WLARD, A SUGAR 3N-FORMYL TRANSFERASE IN THE PRESENCE OF DTDP-FUC3NFO AND 5-N-FORMYL-THF) LIGAND CODE = FON (link to the list of PDB complexes) Download experimental 3D coordinates of FON with added hydrogens	Thymidylate synthase UNIPROT P04818 TYMS -- Dihydrofolate reductase UNIPROT P00374 DHFR more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
3	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
LEVOLEUCOVORIN (has an active metabolite)	LEVOLEUCOVORIN LEUCOVORIN	ATC B03AD04 ATC B03AD01 ATC B03AD02 ATC B03AD05 ATC B03AD03 ATC B03BB01 ATC V04CX02 ATC B03BB51 ATC B03AE02 ATC B03AE01 VARIOUS ANTIANEMIC ANTIDOTE TO FOLIC ACID ANTAGONISTS ANTINEOPLASTIC ADJUNCTS RESCUE AFTER HIGH-DOSE METHOTREXATE THERAPY IN OSTEOSARCOMA USE IN COMBINATION CHEMOTHERAPY WITH 5-FLUOROURACIL RAPIDLY ABSORBED AND ENTERS THE GENERAL BODY POOL OF REDUCED FOLATES CONVERTED TO 5-METHYLTETRAHYDROFOLIC ACID (5-METHYL-THF)	INJECTION ORAL INTRAVENOUS	VD 16.2 LITER (65 KILOGRAM) PPB 91 PERCENT Cl 22.6 LITER / HOUR (65 KILOGRAM) HT 1.3 HOUR SOLUBILITY SOLUBLE IN WATER	PDB 3UWL (CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE) LIGAND CODE = FOZ (link to the list of PDB complexes) Download experimental 3D coordinates of FOZ with added hydrogens	Unknown more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank