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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TECOVIRIMAT

TECOVIRIMAT


ATC J05AX24

ANTIINFECTIVES
ANTIVIRAL AGAINST VARIOLA
TREATMENT OF HUMAN SMALLPOX DISEASE
INHIBITOR OF THE ORTHOPOXVIRUS VP37 ENVELOPE
BLOCKS ITS INTERACTION WITH CELLULAR RAB9 GTPASE AND TIP47

ORAL INTRAVENOUS

Cmax 5.6 MICROMOLAR

Tmax 5 HOUR

VD 1030 LITER

PPB 79 PERCENT

Cl 31 LITER / HOUR

HT 20 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

VP37 PROTEIN

Envelope protein F13 UNIPROT P33815 C17L

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