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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M ROFLUMILAST (is an active metabolite)	ROFLUMILAST	ATC D05AX06 ATC R03DX07 RESPIRATORY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PHOSPHODIESTERASE PDE4 INHIBITORS ROFLUMILAST IS THREE TIMES MORE POTENT THAN ROFLUMILAST N-OXIDE AT INHIBITION OF THE PDE4 ENZYME IN VITRO THE PLASMA AUC OF ROFLUMILAST N-OXIDE ON AVERAGE IS ABOUT 10-FOLD GREATER THAN THE PLASMA AUC OF ROFLUMILAST	-	PPB 97 PERCENT HT 30 HOUR	PDE4 PHOSPHODIESTERASE 4	Phosphodiesterase 4 UNIPROT P27815 PDE4A more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
ROFLUMILAST (has an active metabolite)	ROFLUMILAST	ATC D05AX06 ATC R03DX07 RESPIRATORY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PHOSPHODIESTERASE PDE4 INHIBITORS ROFLUMILAST IS THREE TIMES MORE POTENT THAN ROFLUMILAST N-OXIDE AT INHIBITION OF THE PDE4 ENZYME IN VITRO THE PLASMA AUC OF ROFLUMILAST N-OXIDE ON AVERAGE IS ABOUT 10-FOLD GREATER THAN THE PLASMA AUC OF ROFLUMILAST	ORAL TOPICAL	F 80 PERCENT VD 188 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 9.6 LITER / HOUR HT 17 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER	PDE4 PHOSPHODIESTERASE 4 PDB 1XMU (CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH ROFLUMILAST) LIGAND CODE = ROF (link to the list of PDB complexes) Download experimental 3D coordinates of ROF with added hydrogens	Phosphodiesterase 4 UNIPROT P27815 PDE4A more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank