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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PHENYLBUTAZONE DISCONTINUED
| PHENYLBUTAZONE |
METABOLISM | ORAL | Cmax 138 MICROMOLAR Tmax 3 HOUR VD 10 LITER PPB 98.5 PERCENT Cl 1.36 LITER / HOUR (65 KILOGRAM) HT 79 HOUR (PMID23721873) | CARBONYL REDUCTASE PDB 2BXQ (HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE, PHENYLBUTAZONE AND INDOMETHACIN) LIGAND CODE = P1Z (link to the list of PDB complexes) Download experimental 3D coordinates of P1Z with added hydrogens | Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
