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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PHENYLBUTAZONE DISCONTINUED

PHENYLBUTAZONE


ATC M01AA01
ATC M02AA01
ATC M01BA01

METABOLISM
TREATMENT OF RHEUMATOID DISEASES
ANALGESIC

ORAL

Cmax 138 MICROMOLAR

Tmax 3 HOUR

VD 10 LITER

PPB 98.5 PERCENT

Cl 1.36 LITER / HOUR (65 KILOGRAM)

HT 79 HOUR (PMID23721873)

CARBONYL REDUCTASE

PDB 2BXQ (HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE, PHENYLBUTAZONE AND INDOMETHACIN)

LIGAND CODE = P1Z (link to the list of PDB complexes)

Download experimental 3D coordinates of P1Z with added hydrogens

CYCLOOXYGENASE INHIBITOR CHEMBL2094253 CYCLOOXYGENASE P23219 PROSTAGLANDIN G/H SYNTHASE 1 HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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