e-Drug3D

999

TROLEANDOMYCIN

DISCONTINUED

INN
TROLEANDOMYCIN

cas 2751-09-9

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
MACROLIDES
DERIVED ACETYLATED ESTER OF OLEANDOMYCIN, AN ANTIBIOTIC ELABORATED BY A SPECIES OF STREPTOMYCES ANTIBIOTICUS

ROUTE (list)

ORAL

ATC code

J01FA08

PK parameters

Solubility

INSOLUBLE IN WATER

Target

TARGET RIBOSOMAL SUBUNIT

PDB
3I56 (CO-CRYSTAL STRUCTURE OF TRIACETYLOLEANDOMCYIN BOUND TO THE LARGE RIBOSOMAL SUBUNIT)

Ligand code = TAO (link to the list of PDB complexes)

Download experimental 3D coordinates of TAO with added hydrogens

DrugCentral

Unknown

Download SDF file

[(3R,5S,6S,7R,8S,9R,12R,13S,14S,15R)-6-[(2S,3R,4S,6R)-3-acetyloxy-4-dimethylamino-6-methyloxan-2-yl]oxy-8-[(2R,4S,5S,6S)-5-acetyloxy-4-methoxy-6-methyloxan-2-yl]oxy-5,7,9,12,13,15-hexamethyl-10,16-dioxo-1,11-dioxaspiro[2.13]hexadecan-14-yl] acetate

Formula:
C41H67NO15

Calculated chemical properties:

MW 813.96
NB_atoms 57
XLogP 3.62
PSA 169.021
NB_HD 0
NB_HA 16
fsp3 0.88
Lipinski(0=no;1=yes) 0

FDA
NDA 050332 (pdf not found) INN (TROLEANDOMYCIN) TAO (PFIZER) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 050336 (pdf not found) INN (TROLEANDOMYCIN) TAO (PFIZER) APPROVAL= AP YEAR= 1969 DISCONTINUED