e-Drug3D

998

cas 154-21-2

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
PROTEIN SYNTHESIS INHIBITORS
A SUBSTANCE PRODUCED BY LINCOLNENSIS GROUP OF STREPTOMYCES LINCOLNENSIS

ROUTE (list)

ORAL INJECTION

PK parameters

VD 65 LITER (65 KILOGRAM)
Cl 8.2 LITER / HOUR (65 KILOGRAM)
PPB 57 PERCENT
t1/2 5.4 HOUR

TARGET 50S RIBOSOMAL PROTEIN

PDB
5HKV (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LINCOMYCIN)

Ligand code = 3QB (link to the list of PDB complexes)

Download experimental 3D coordinates of 3QB with added hydrogens

MW 406.54
NB_atoms 27
XLogP -0.86
PSA 104.062
NB_HD 5
NB_HA 8
fsp3 0.94
Lipinski(0=no;1=yes) 1

FDA
NDA 062784 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOMYCIN HCL (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 050316 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOCIN (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 050317 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOCIN (PFIZER) APPROVAL= AP YEAR= 1964
NDA 063180 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOMYCIN HYDROCHLORIDE (SLAYBACK) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 201746 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOMYCIN HYDROCHLORIDE (XGEN PHARMS) APPROVAL= AP YEAR= 2015
NDA 212770 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOMYCIN HYDROCHLORIDE (ARTHUR GRP) APPROVAL= AP YEAR= 2021
NDA 215082 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOMYCIN HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2021
NDA 215657 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOMYCIN HYDROCHLORIDE (GLAND) APPROVAL= AP YEAR= 2022
NDA 216662 (pdf not found) INN (LINCOMYCIN HYDROCHLORIDE) LINCOMYCIN HYDROCHLORIDE (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2022 DISCONTINUED