e-Drug3D

997

cas 10118-90-8

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
TETRACYCLINES

ROUTE (list)

ORAL INJECTION DENTAL TOPICAL

PK parameters

VD 104 LITER (65 KILOGRAM)
Cl 4.68 LITER / HOUR (65 KILOGRAM)
t1/2 19 HOUR

TARGET 30S RIBOSOMAL PROTEIN

PDB
4A99 (STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE)

Ligand code = MIY (link to the list of PDB complexes)

Download experimental 3D coordinates of MIY with added hydrogens

MW 457.48
NB_atoms 33
XLogP 0.19
PSA 156.1
NB_HD 6
NB_HA 10
fsp3 0.43
Lipinski(0=no;1=yes) 0

FDA
NDA 062139 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCIN (LEDERLE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 050315 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCIN (TRIAX PHARMS) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 050444 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCIN (REMPEX) APPROVAL= AP YEAR= 1972
NDA 050445 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCIN (BAUSCH) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 050451 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (TRIAX PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 050649 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCIN (BAUSCH) APPROVAL= AP YEAR= 1990
NDA 063066 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) DYNACIN (CNTY LINE PHARMS) APPROVAL= AP YEAR= 1990 DISCONTINUED OBSOLETE
NDA 063067 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) DYNACIN (ALVOGEN) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 063065 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1991
NDA 063181 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1991
NDA 063009 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (ZYDUS) APPROVAL= AP YEAR= 1992
NDA 063011 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (ZYDUS) APPROVAL= AP YEAR= 1992
NDA 065005 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (IMPAX LABS) APPROVAL= AP YEAR= 1999
NDA 065062 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2000
NDA 050781 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) ARESTIN (ORAPHARMA) APPROVAL= AP YEAR= 2001
NDA 065131 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2003
NDA 065156 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2004
NDA 050808 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) SOLODYN (BAUSCH) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065436 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2007
NDA 065470 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2008
NDA 065485 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (BARR LABS INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090024 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (IMPAX LABS INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090422 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 090911 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091424 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2011
NDA 201922 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) XIMINO (JOURNEY) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202261 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 090867 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2013
NDA 091118 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203443 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 204394 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 090217 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 204453 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2016
NDA 209269 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOLIRA (EPI HLTH) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 203553 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 201467 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212379 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) AMZEEQ (JOURNEY) APPROVAL= AP YEAR= 2019
NDA 213662 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2020
NDA 213690 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) ZILXI (JOURNEY) APPROVAL= AP YEAR= 2020
NDA 215466 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (BEXIMCO PHARMS USA) APPROVAL= AP YEAR= 2022
NDA 219015 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) EMROSI (JOURNEY) APPROVAL= AP YEAR= 2024
NDA 214934 (pdf not found) INN (MINOCYCLINE HYDROCHLORIDE) MINOCYCLINE HYDROCHLORIDE (NEXUS) APPROVAL= TA YEAR= 2025