e-Drug3D

996

cas 1397-89-3

CLASS

ANTIINFECTIVES
ANTIFUNGAL
AMEBICIDES
ANTI-BACTERIAL AGENTS
ANTIPROTOZOAL AGENTS
PRODUCED FROM A STRAIN OF STREPTOMYCES NODOSUS
HIGH AFFINITY FOR THE ERGOSTEROL COMPONENT OF THE FUNGAL CELL MEMBRANE

ROUTE (list)

TOPICAL ORAL INJECTION

PK parameters

VD 6.5 LITER (65 KILOGRAM)
Cl 0.715 LITER / HOUR (65 KILOGRAM)
PPB 90 PERCENT
t1/2 8.5 HOUR

TARGET MEMBRANE

PDB
7SHI (CRYSTAL STRUCTURE OF CYTOCHROME P450 AMPHL FROM STREPTOMYCES NODOSUS AND THE STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN MACROLIDE METABOLIZING P450S)

Ligand code = 4UH (link to the list of PDB complexes)

Download experimental 3D coordinates of 4UH with added hydrogens

MW 923.06
NB_atoms 65
XLogP -0.62
PSA 290.719
NB_HD 12
NB_HA 18
fsp3 0.66
Lipinski(0=no;1=yes) 0

FDA
NDA 060570 (pdf not found) INN (AMPHOTERICIN B) FUNGIZONE (APOTHECON) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 050313 (pdf not found) INN (AMPHOTERICIN B) FUNGIZONE (APOTHECON) APPROVAL= AP YEAR= 1965 DISCONTINUED
NDA 050314 (pdf not found) INN (AMPHOTERICIN B) FUNGIZONE (APOTHECON) APPROVAL= AP YEAR= 1966 DISCONTINUED
NDA 060517 (pdf not found) INN (AMPHOTERICIN B) FUNGIZONE (APOTHECON) APPROVAL= AP YEAR= 1966 DISCONTINUED
NDA 050341 (pdf not found) INN (AMPHOTERICIN B) FUNGIZONE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 062728 (pdf not found) INN (AMPHOTERICIN B) AMPHOTERICIN B (ABRAXIS PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 063206 (pdf not found) INN (AMPHOTERICIN B) AMPHOTERICIN B (XGEN PHARMS) APPROVAL= AP YEAR= 1992
NDA 050724 (pdf not found) INN (AMPHOTERICIN B) ABELCET (LEADIANT BIOSCI INC) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 064062 (pdf not found) INN (AMPHOTERICIN B) AMPHOTERICIN B (TEVA PARENTERAL) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 050729 (pdf not found) INN (AMPHOTERICIN B) AMPHOTEC (ALKOPHARMA USA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 064141 (pdf not found) INN (AMPHOTERICIN B) AMPHOTERICIN B (ABBOTT) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 050740 (pdf not found) INN (AMPHOTERICIN B) AMBISOME (ASTELLAS) APPROVAL= AP YEAR= 1997
NDA 212514 (pdf not found) INN (AMPHOTERICIN B) AMPHOTERICIN B (SPIL) APPROVAL= AP YEAR= 2021
NDA 214010 (pdf not found) INN (AMPHOTERICIN B) AMPHOTERICIN B (EUGIA PHARMA) APPROVAL= AP YEAR= 2022
NDA 212967 (pdf not found) INN (AMPHOTERICIN B) AMPHOTERICIN B (MYLAN LABS LTD) APPROVAL= AP YEAR= 2025
NDA 215354 (pdf not found) INN (AMPHOTERICIN B) AMPHOTERICIN B (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2025