e-Drug3D

987

cas 60-54-8

CLASS

ANTIINFECTIVES
ANTI-BACTERIAL AGENTS
ANTIPROTOZOALS
PROTEIN SYNTHESIS INHIBITORS
TETRACYCLINES
ANTIRICKETTSIAL
ANTIBIOTIC
ANTIAMEBIC
ANTIMALARIALS

ROUTE (list)

ORAL OPHTHALMIC INJECTION TOPICAL PERIODONTAL

PK parameters

Tmax 3.3 HOUR
VD 78 LITER (65 KILOGRAM)
Cl 5.8 LITER / HOUR (65 KILOGRAM)
PPB 22 PERCENT
t1/2 9.4 HOUR

TARGET 30S RIBOSOMAL PROTEIN

PDB
2HDN (TRYPSIN-MODIFIED ELONGATION FACTOR TU IN COMPLEX WITH TETRACYCLINE AT 2.8 ANGSTROM RESOLUTION)

Ligand code = TAC (link to the list of PDB complexes)

Download experimental 3D coordinates of TAC with added hydrogens

MW 444.43
NB_atoms 32
XLogP -0.21
PSA 171.308
NB_HD 7
NB_HA 10
fsp3 0.41
Lipinski(0=no;1=yes) 0

FDA
NDA 060059 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (ELKINS SINN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060082 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYN (PFIPHARMECS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060096 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYN (PFIZER) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060290 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060291 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060343 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACHEL (ANGUS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060446 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (PROTER) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060471 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (VALEANT PHARM INTL) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060633 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (ALPHARMA US PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061148 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (HEATHER) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061443 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) RETET (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061468 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRAMED (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061685 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (WYETH AYERST) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061705 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) PANMYCIN (PHARMACIA AND UPJOHN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061734 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) ROBITET (WYETH AYERST) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061802 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (ABBOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062300 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062332 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) CYCLOPAR (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062686 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (PVT FORM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 050273 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) ACHROMYCIN (LEDERLE) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 050276 (pdf not found) INN (PROCAINE HYDROCHLORIDE ; TETRACYCLINE HYDROCHLORIDE) ACHROMYCIN (LEDERLE) APPROVAL= AP YEAR= 1954 DISCONTINUED
NDA 060285 (pdf not found) INN (PROCAINE HYDROCHLORIDE ; TETRACYCLINE HYDROCHLORIDE) TETRACYN (PFIZER) APPROVAL= AP YEAR= 1954 DISCONTINUED
NDA 060347 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) PANMYCIN (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1954 DISCONTINUED
NDA 060429 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) SUMYCIN (APOTHECON) APPROVAL= AP YEAR= 1954 DISCONTINUED
NDA 050263 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) ACHROMYCIN V (LEDERLE) APPROVAL= AP YEAR= 1955 DISCONTINUED
NDA 050268 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) ACHROMYCIN (STORZ) APPROVAL= AP YEAR= 1955 DISCONTINUED
NDA 060095 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYN (PFIPHARMECS) APPROVAL= AP YEAR= 1955 DISCONTINUED
NDA 050212 (pdf not found) INN (TETRACYCLINE PHOSPHATE COMPLEX) TETREX (BRISTOL) APPROVAL= AP YEAR= 1957 DISCONTINUED
NDA 050266 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) ACHROMYCIN (STORZ) APPROVAL= AP YEAR= 1957 DISCONTINUED
NDA 050278 (label) INN (TETRACYCLINE HYDROCHLORIDE) ACHROMYCIN V (AVET) APPROVAL= AP YEAR= 1957
NDA 060400 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) SUMYCIN (PH HEALTH) APPROVAL= AP YEAR= 1957 DISCONTINUED
NDA 060704 (label) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1963 DISCONTINUED
NDA 060173 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (FERRANTE) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 060174 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (FERRANTE) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 060783 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 060469 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (IMPAX LABS) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 061147 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) SUMYCIN (STRIDES PHARMA) APPROVAL= AP YEAR= 1971
NDA 061214 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (ROXANE) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 061653 (pdf not found) INN (TETRACYCLINE PHOSPHATE COMPLEX) TETREX (BRISTOL) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 061658 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) BRISTACYCLINE (BRISTOL) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 061725 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) CYCLOPAR (WARNER CHILCOTT) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 061837 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1974
NDA 061888 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) BRISTACYCLINE (BRISTOL) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 061889 (pdf not found) INN (TETRACYCLINE PHOSPHATE COMPLEX) TETREX (BRISTOL) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 050493 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TOPICYCLINE (SHIRE) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 060768 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 062085 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (MAST MM) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 062103 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 062175 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) CYCLOPAR (WARNER CHILCOTT) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 050272 (pdf not found) INN (HYDROCORTISONE ; TETRACYCLINE HYDROCHLORIDE) ACHROMYCIN (LEDERLE) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 060736 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 062343 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 062540 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (SUPERPHARM) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 061471 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 062752 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (CHARTWELL TETRA) APPROVAL= AP YEAR= 1988
NDA 050653 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) ACTISITE (SCHIFF AND CO) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 050719 (label) INN (BISMUTH SUBSALICYLATE ; METRONIDAZOLE ; TETRACYCLINE HYDROCHLORIDE) HELIDAC (CASPER PHARMA LLC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 050786 (label) INN (BISMUTH SUBCITRATE POTASSIUM ; METRONIDAZOLE ; TETRACYCLINE HYDROCHLORIDE) PYLERA (LABS JUVISE) APPROVAL= AP YEAR= 2006
NDA 202584 (pdf not found) INN (BISMUTH SUBSALICYLATE ; METRONIDAZOLE ; TETRACYCLINE HYDROCHLORIDE) BISMUTH SUBSALICYLATE, METRONIDAZOLE AND TETRACYCLINE HYDROCHLORIDE (AILEX PHARMS LLC) APPROVAL= AP YEAR= 2018
NDA 210662 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (BRECKENRIDGE) APPROVAL= AP YEAR= 2018
NDA 210674 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (AMNEAL PHARMS NY) APPROVAL= AP YEAR= 2018
NDA 212635 (pdf not found) INN (TETRACYCLINE HYDROCHLORIDE) TETRACYCLINE HYDROCHLORIDE (ESJAY PHARMA) APPROVAL= AP YEAR= 2020
NDA 205770 (pdf not found) INN (BISMUTH SUBCITRATE POTASSIUM ; METRONIDAZOLE ; TETRACYCLINE HYDROCHLORIDE) BISMUTH SUBCITRATE POTASSIUM, METRONIDAZOLE AND TETRACYCLINE HYDROCHLORIDE (PAR PHARM) APPROVAL= AP YEAR= 2023
NDA 217511 (pdf not found) INN (BISMUTH SUBCITRATE POTASSIUM ; METRONIDAZOLE ; TETRACYCLINE HYDROCHLORIDE) BISMUTH SUBCITRATE POTASSIUM, METRONIDAZOLE AND TETRACYCLINE HYDROCHLORIDE (RICONPHARMA LLC) APPROVAL= AP YEAR= 2023