e-Drug3D

986

CLOXACILLIN

DISCONTINUED

INN
CLOXACILLIN

cas 61-72-3

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
PENICILLIN

ROUTE (list)

ORAL

ATC code

J01CF02

PK parameters

Target

TARGET PENICILLIN-BINDING PROTEINS 1A/1B
BETA-LACTAMASE

PDB
9BIT (CRYO-EM STRUCTURE OF THE MAMMALIAN PEPTIDE TRANSPORTER PEPT2 BOUND TO CLOXACILLIN, POSE 1)

Ligand code = CXN (link to the list of PDB complexes)

Download experimental 3D coordinates of CXN with added hydrogens

DrugCentral

Penicillin-binding protein UNIPROT P72355 pbp4

Download SDF file

(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Formula:
C19H18ClN3O5S

Calculated chemical properties:

MW 434.88
NB_atoms 29
XLogP 1.21
PSA 107.456
NB_HD 1
NB_HA 8
fsp3 0.37
Lipinski(0=no;1=yes) 1

FDA
NDA 050192 (pdf not found) INN (CLOXACILLIN SODIUM) TEGOPEN (APOTHECON) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061453 (pdf not found) INN (CLOXACILLIN SODIUM) TEGOPEN (APOTHECON) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062233 (pdf not found) INN (CLOXACILLIN SODIUM) CLOXAPEN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062978 (pdf not found) INN (CLOXACILLIN SODIUM) CLOXACILLIN SODIUM (TEVA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 061452 (pdf not found) INN (CLOXACILLIN SODIUM) CLOXACILLIN SODIUM (APOTHECON) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 061806 (pdf not found) INN (CLOXACILLIN SODIUM) CLOXAPEN (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 062240 (pdf not found) INN (CLOXACILLIN SODIUM) CLOXACILLIN SODIUM (TEVA) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 062268 (pdf not found) INN (CLOXACILLIN SODIUM) CLOXACILLIN SODIUM (TEVA) APPROVAL= AP YEAR= 1980 DISCONTINUED