e-Drug3D

96

cas 57-66-9

CLASS

METABOLISM
URICOSURIC AGENT
RENAL TUBULAR BLOCKING AGENT

ROUTE (list)

ORAL

PK parameters

VD 8.4 LITER (65 KILOGRAM)
Cl 0.97 LITER / HOUR (65 KILOGRAM)
PPB 97 PERCENT
t1/2 5.9 HOUR

TARGET ORGANIC ANION TRANSPORTER

PDB
8BVT (CRYO-EM STRUCTURE OF RAT SLC22A6 BOUND TO PROBENECID)

Ligand code = RTO (link to the list of PDB complexes)

Download experimental 3D coordinates of RTO with added hydrogens

MW 284.35
NB_atoms 19
XLogP 0.86
PSA 69.715
NB_HD 0
NB_HA 5
fsp3 0.46
Lipinski(0=no;1=yes) 1

FDA
NDA 050457 (pdf not found) INN (AMPICILLIN/AMPICILLIN TRIHYDRATE ; PROBENECID) POLYCILLIN-PRB (BRISTOL) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 050488 (pdf not found) INN (AMPICILLIN/AMPICILLIN TRIHYDRATE ; PROBENECID) PRINCIPEN W/ PROBENECID (APOTHECON) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062150 (pdf not found) INN (AMPICILLIN/AMPICILLIN TRIHYDRATE ; PROBENECID) PRINCIPEN W/ PROBENECID (APOTHECON) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083720 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (IMPAX LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 007898 (pdf not found) INN (PROBENECID) BENEMID (MERCK) APPROVAL= AP YEAR= 1951 DISCONTINUED
NDA 012383 (pdf not found) INN (COLCHICINE ; PROBENECID) COLBENEMID (MERCK) APPROVAL= AP YEAR= 1961 DISCONTINUED
NDA 061741 (pdf not found) INN (AMPICILLIN/AMPICILLIN TRIHYDRATE ; PROBENECID) PROBAMPACIN (COSETTE) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 061898 (pdf not found) INN (AMPICILLIN/AMPICILLIN TRIHYDRATE ; PROBENECID) POLYCILLIN-PRB (APOTHECON) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 083221 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID W/ COLCHICINE (WATSON LABS) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 080966 (pdf not found) INN (PROBENECID) PROBALAN (LANNETT) APPROVAL= AP YEAR= 1976
NDA 084211 (pdf not found) INN (PROBENECID) PROBENECID (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084279 (pdf not found) INN (COLCHICINE ; PROBENECID) COL-PROBENECID (WATSON LABS) APPROVAL= AP YEAR= 1976
NDA 084321 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (BEECHAM) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084442 (pdf not found) INN (PROBENECID) PROBENECID (WATSON LABS TEVA) APPROVAL= AP YEAR= 1977
NDA 085552 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBEN-C (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 083734 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (ANI PHARMS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 086150 (pdf not found) INN (PROBENECID) PROBENECID (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 086954 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID W/ COLCHICINE (LEDERLE) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 086130 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (SANDOZ) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 086917 (pdf not found) INN (PROBENECID) PROBENECID (LEDERLE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 083740 (pdf not found) INN (PROBENECID) PROBENECID (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 040618 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (NOVAST LABS) APPROVAL= AP YEAR= 2008
NDA 217020 (pdf not found) INN (PROBENECID) PROBENECID (RISING) APPROVAL= AP YEAR= 2023
NDA 217030 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (RISING) APPROVAL= AP YEAR= 2023
NDA 213972 (pdf not found) INN (PROBENECID ; SULOPENEM ETZADROXIL) ORLYNVAH (ITERUM THERAP) APPROVAL= AP YEAR= 2024 DISCONTINUED