e-Drug3D

952

MENTHOL

INN
MENTHOL

cas 89-78-1

CLASS

MUSCULO-SKELETAL SYSTEM
ANTIPRURITIC

ROUTE (list)

TOPICAL

NATURAL MOLECULE (link)

ATC code

M02AX10

PK parameters

Target

TARGET TRANSIENT RECEPTOR POTENTIAL MELASTATIN (TRPM8) ION CHANNEL (PMID25680765)

PDB
8UXY (CONSENSUS OLFACTORY RECEPTOR CONSOR1 BOUND TO L-MENTHOL AND IN COMPLEX WITH MINI-GS TRIMERIC PROTEIN)

Download experimental 3D coordinates of XUQ with added hydrogens

Transient receptor potential cation channel subfamily M member 8 UNIPROT Q7Z2W7 TRPM8

Download SDF file

(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol

Formula:
C10H20O

Calculated chemical properties:

MW 156.26
NB_atoms 11
XLogP 2.44
PSA 20.199
NB_HD 1
NB_HA 1
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 022029 (label) INN (MENTHOL ; METHYL SALICYLATE) SALONPAS (HISAMITSU PHARM CO) APPROVAL= AP YEAR= 2008