e-Drug3D

947

DASATINIB

INN
DASATINIB

cas 302962-49-8

CLASS

ANTINEOPLASTIC
PROTEIN KINASE INHIBITORS
TREATMENT OF CHRONIC MYELOID LEUKEMIA (CML) IN CHRONIC PHASE

ROUTE (list)

ORAL

ATC code

L01EA02

PK parameters

VD 2505 LITER
Cl 433 LITER / HOUR (EQN)
PPB 96 PERCENT
t1/2 4 HOUR

Solubility

INSOLUBLE IN WATER

Target

TARGET BCR-ABL ABL1
SRC FAMILY (SRC, LCK, YES, FYN)
C-KIT
EPHA2
PDGFR BETA

PDB
2Y6O (CRYSTAL STRUCTURE OF EPHA4 KINASE DOMAIN IN COMPLEX WITH DASATINIB.)

Ligand code = 1N1 (link to the list of PDB complexes)

Download experimental 3D coordinates of 1N1 with added hydrogens

DrugCentral

Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB

Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1

Download SDF file

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

Formula:
C22H26ClN7O2S

Calculated chemical properties:

MW 488.02
NB_atoms 33
XLogP 3.31
PSA 93.802
NB_HD 3
NB_HA 9
fsp3 0.36
Lipinski(0=no;1=yes) 1

FDA
NDA 021986 (label) INN (DASATINIB) SPRYCEL (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2006
NDA 022072 (label) INN (DASATINIB) SPRYCEL (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2006 NEWAPPLICATION
NDA 202103 (pdf not found) INN (DASATINIB) DASATINIB (APOTEX) APPROVAL= AP YEAR= 2016
NDA 203180 (pdf not found) INN (DASATINIB) DASATINIB (APOTEX) APPROVAL= AP YEAR= 2021
NDA 216261 (pdf not found) INN (DASATINIB) DASATINIB (ALEMBIC PHARMS LTD) APPROVAL= TA YEAR= 2022
NDA 211094 (pdf not found) INN (DASATINIB) DASATINIB (TEVA PHARMS USA INC) APPROVAL= TA YEAR= 2023
NDA 216099 (label) INN (DASATINIB) PHYRAGO (HANDA THERAP) APPROVAL= AP YEAR= 2023
NDA 214350 (pdf not found) INN (DASATINIB) DASATINIB (LUPIN) APPROVAL= AP YEAR= 2025
NDA 213383 (pdf not found) INN (DASATINIB) DASATINIB (DR REDDYS) APPROVAL= AP YEAR= 2025
NDA 216547 (pdf not found) INN (DASATINIB) DASATINIB (EUGIA PHARMA) APPROVAL= AP YEAR= 2025
NDA 217217 (pdf not found) INN (DASATINIB) DASATINIB (BIOCON PHARMA) APPROVAL= AP YEAR= 2025
NDA 218719 (pdf not found) INN (DASATINIB) DASATINIB (ZYDUS PHARMS) APPROVAL= AP YEAR= 2025