e-Drug3D

933

cas 196597-26-9

CLASS

NERVOUS SYSTEM
HYPNOTICS
SEDATIVES
TREATMENT OF INSOMNIA
AGONIST

ROUTE (list)

ORAL

PK parameters

F 1.8 PERCENT
Tmax 0.75 HOUR
VD 73.6 LITER
Cl 28.3 LITER / HOUR (EQN)
PPB 82 PERCENT
t1/2 1.8 HOUR

TARGET MELATONIN RECEPTOR MT1
MELATONIN RECEPTOR MT2

PDB
6ME2 (XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT1 IN COMPLEX WITH RAMELTEON)

Ligand code = JEV (link to the list of PDB complexes)

Download experimental 3D coordinates of JEV with added hydrogens

MW 259.34
NB_atoms 19
XLogP 2.57
PSA 40.205
NB_HD 1
NB_HA 3
fsp3 0.56
Lipinski(0=no;1=yes) 1

FDA
NDA 021782 (pdf not found) INN (RAMELTEON) ROZEREM (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2005
NDA 091693 (pdf not found) INN (RAMELTEON) RAMELTEON (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2013
NDA 091610 (pdf not found) INN (RAMELTEON) RAMELTEON (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2015
NDA 211567 (pdf not found) INN (RAMELTEON) RAMELTEON (ZYDUS PHARMS) APPROVAL= AP YEAR= 2019
NDA 212650 (pdf not found) INN (RAMELTEON) RAMELTEON (I3 PHARMS) APPROVAL= AP YEAR= 2020
NDA 213186 (pdf not found) INN (RAMELTEON) RAMELTEON (GRANULES) APPROVAL= AP YEAR= 2020
NDA 213815 (pdf not found) INN (RAMELTEON) RAMELTEON (APPCO) APPROVAL= AP YEAR= 2020
NDA 215435 (pdf not found) INN (RAMELTEON) RAMELTEON (ANDAS 5 HOLDING) APPROVAL= AP YEAR= 2022
NDA 216209 (pdf not found) INN (RAMELTEON) RAMELTEON (XIROMED) APPROVAL= AP YEAR= 2022
NDA 215243 (pdf not found) INN (RAMELTEON) RAMELTEON (MICRO LABS) APPROVAL= AP YEAR= 2023
NDA 215972 (pdf not found) INN (RAMELTEON) RAMELTEON (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023