e-Drug3D

932

ILOPROST

INN
ILOPROST

cas 78919-13-8

CLASS

BLOOD
ANTIHYPERTENSIVE
ANALOG OF PROSTACYLIN INDICATED FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)

ROUTE (list)

INHALATION INTRAVENOUS

ATC code

B01AC11

PK parameters

VD 24 LITER (65 KILOGRAM)
Cl 62 LITER / HOUR (65 KILOGRAM)
PPB 60 PERCENT
t1/2 0.57 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN DISTILLED WATER BUFFER PH 5

Target

TARGET PROSTACYCLIN RECEPTOR PGI2

DrugCentral

Prostacyclin receptor UNIPROT P43119 PTGIR

Download SDF file

(2-oxo-2-phenylethyl) (5Z)-5-[5-hydroxy-4-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoate

Formula:
C22H32O4

Calculated chemical properties:

MW 359.47
NB_atoms 26
XLogP 2.21
PSA 75.499
NB_HD 2
NB_HA 4
fsp3 0.68
Lipinski(0=no;1=yes) 1

FDA
NDA 021779 (pdf not found) INN (ILOPROST) VENTAVIS (ACTELION) APPROVAL= AP YEAR= 2004 NEWMOLECULARENTITY DISCONTINUED
NDA 217933 (pdf not found) INN (ILOPROST) AURLUMYN (BTG INTL) APPROVAL= AP YEAR= 2024