e-Drug3D
93
DYPHYLLINE
DISCONTINUED
INN
DYPHYLLINE
cas 479-18-5
CLASS
RESPIRATORY
BRONCHODILATOR AGENTS
PHOSPHODIESTERASE INHIBITORS
SMOOTH MUSCLE RELAXANTS
VASODILATOR AGENTS
ROUTE (list)
ORAL INJECTION
PK parameters
VD 27.3 LITER (65 KILOGRAM)
Cl 18.7 LITER / HOUR (65 KILOGRAM)
t1/2 2 HOUR
Solubility
FREELY SOLUBLE IN WATER
TARGET PHOSPHODIESTERASE
PDB
2X0Y (SCREENING-BASED DISCOVERY OF DRUG-LIKE O-GLCNACASE INHIBITOR SCAFFOLDS)
Ligand code = X0T (link to the list of PDB complexes)
Download experimental 3D coordinates of X0T with added hydrogens
cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A
cAMP-specific 3,5-cyclic phosphodiesterase 4B UNIPROT Q07343 PDE4B
Formula:
C10H14N4O4
Calculated chemical properties:
MW 254.25
NB_atoms 18
XLogP -2.21
PSA 88.608
NB_HD 2
NB_HA 8
fsp3 0.50
Lipinski(0=no;1=yes) 1
NB_atoms 18
XLogP -2.21
PSA 88.608
NB_HD 2
NB_HA 8
fsp3 0.50
Lipinski(0=no;1=yes) 1
FDA
NDA 007794 (pdf not found) INN (DYPHYLLINE) NEOTHYLLINE (TEVA) APPROVAL= AP YEAR= 1951 NEWMOLECULARENTITY DISCONTINUED
NDA 009088 (pdf not found) INN (DYPHYLLINE) NEOTHYLLINE (TEVA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 084514 (pdf not found) INN (DYPHYLLINE) DILOR (SAVAGE LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084566 (pdf not found) INN (DYPHYLLINE) LUFYLLIN (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084751 (pdf not found) INN (DYPHYLLINE) DILOR-400 (SAVAGE LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 007794 (pdf not found) INN (DYPHYLLINE) NEOTHYLLINE (TEVA) APPROVAL= AP YEAR= 1951 NEWMOLECULARENTITY DISCONTINUED
NDA 009088 (pdf not found) INN (DYPHYLLINE) NEOTHYLLINE (TEVA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 084514 (pdf not found) INN (DYPHYLLINE) DILOR (SAVAGE LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084566 (pdf not found) INN (DYPHYLLINE) LUFYLLIN (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084751 (pdf not found) INN (DYPHYLLINE) DILOR-400 (SAVAGE LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED