e-Drug3D
929
NEBIVOLOL
INN
NEBIVOLOL
cas 118457-14-0
CLASS
CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC BETA-ANTAGONISTS
VASODILATOR AGENTS
BETA BLOCKING AGENTS
ROUTE (list)
ORAL
PK parameters
Tmax 2.75 HOUR
VD 715 LITER (65 KILOGRAM)
Cl 54.6 LITER / HOUR
PPB 98 PERCENT
t1/2 15.5 HOUR
TARGET BETA-1 ADRENERGIC RECEPTOR
Beta-1 adrenergic receptor UNIPROT P08588 ADRB1
Beta-2 adrenergic receptor UNIPROT P07550 ADRB2
Formula:
C22H25F2NO4
Calculated chemical properties:
MW 405.43
NB_atoms 29
XLogP 2.36
PSA 72.798
NB_HD 3
NB_HA 5
fsp3 0.45
Lipinski(0=no;1=yes) 1
NB_atoms 29
XLogP 2.36
PSA 72.798
NB_HD 3
NB_HA 5
fsp3 0.45
Lipinski(0=no;1=yes) 1
FDA
NDA 021742 (label) INN (NEBIVOLOL HYDROCHLORIDE) BYSTOLIC (ALLERGAN) APPROVAL= AP YEAR= 2007 NEWMOLECULARENTITY
NDA 203828 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (INDCHEMIE HEALTH) APPROVAL= AP YEAR= 2015
NDA 203659 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 2015
NDA 203741 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203683 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (WATSON LABS INC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206302 (label) INN (NEBIVOLOL HYDROCHLORIDE ; VALSARTAN) BYVALSON (ABBVIE) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203821 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 203966 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2018
NDA 206729 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (MICRO LABS LTD) APPROVAL= TA YEAR= 2020
NDA 203825 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2020
NDA 208717 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2021
NDA 211053 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2021
NDA 212917 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (REYOUNG) APPROVAL= AP YEAR= 2021
NDA 212682 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 213349 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 213830 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2022
NDA 210596 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE ; VALSARTAN) VYDUO (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 216172 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 216568 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (BEXIMCO PHARMS USA) APPROVAL= AP YEAR= 2023
NDA 209741 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217397 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2024
NDA 212661 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025
NDA 021742 (label) INN (NEBIVOLOL HYDROCHLORIDE) BYSTOLIC (ALLERGAN) APPROVAL= AP YEAR= 2007 NEWMOLECULARENTITY
NDA 203828 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (INDCHEMIE HEALTH) APPROVAL= AP YEAR= 2015
NDA 203659 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 2015
NDA 203741 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203683 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (WATSON LABS INC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206302 (label) INN (NEBIVOLOL HYDROCHLORIDE ; VALSARTAN) BYVALSON (ABBVIE) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203821 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 203966 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2018
NDA 206729 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (MICRO LABS LTD) APPROVAL= TA YEAR= 2020
NDA 203825 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2020
NDA 208717 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2021
NDA 211053 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2021
NDA 212917 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (REYOUNG) APPROVAL= AP YEAR= 2021
NDA 212682 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 213349 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 213830 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2022
NDA 210596 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE ; VALSARTAN) VYDUO (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 216172 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 216568 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (BEXIMCO PHARMS USA) APPROVAL= AP YEAR= 2023
NDA 209741 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217397 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2024
NDA 212661 (pdf not found) INN (NEBIVOLOL HYDROCHLORIDE) NEBIVOLOL HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025