e-Drug3D

926

cas 226256-56-0

CLASS

HORMONES
CALCIMIMETICS
TREATMENT OF PARATHYROID CARCINOMA OR PRIMARY HYPERPARATHYROIDISM
BIAISING ALLOSTERIC MODULATOR (PREFERENTIAL EFFECT ON MEMBRANE RUFFLING VERSUS CALCIUM OR MAPK)

ROUTE (list)

ORAL

PK parameters

Tmax 4 HOUR
VD 1000 LITER
Cl 19.8 LITER / HOUR (EQN)
PPB 95 PERCENT
t1/2 35 HOUR

TARGET EXTRACELLULAR CALCIUM-SENSING RECEPTOR

PDB
7M3F (ASYMMETRIC ACTIVATION OF THE CALCIUM SENSING RECEPTOR HOMODIMER)

Ligand code = YP4 (link to the list of PDB complexes)

Download experimental 3D coordinates of YP4 with added hydrogens

MW 357.41
NB_atoms 26
XLogP 6.14
PSA 12.473
NB_HD 1
NB_HA 1
fsp3 0.27
Lipinski(0=no;1=yes) 0

FDA
NDA 021688 (pdf not found) INN (CINACALCET HYDROCHLORIDE) SENSIPAR (AMGEN) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 090476 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (BARR) APPROVAL= TA YEAR= 2010
NDA 090539 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (TEVA PHARMS) APPROVAL= TA YEAR= 2017
NDA 203422 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 206125 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018
NDA 208915 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (CIPLA) APPROVAL= AP YEAR= 2018
NDA 208971 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2018
NDA 209226 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2018
NDA 204377 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 2018
NDA 207008 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2018
NDA 210207 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (PIRAMAL) APPROVAL= AP YEAR= 2018
NDA 210570 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2019
NDA 210548 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211892 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2020
NDA 213325 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2020
NDA 208368 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2020
NDA 209403 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2020
NDA 204364 (pdf not found) INN (CINACALCET HYDROCHLORIDE) CINACALCET HYDROCHLORIDE (STEVENS J) APPROVAL= AP YEAR= 2021 DISCONTINUED