e-Drug3D

925

cas 123318-82-1

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
PURINE ANALOGUES
INHIBITS DNA SYNTHESIS

ROUTE (list)

INTRAVENOUS INJECTION

PK parameters

VD 276 LITER
Cl 46 LITER / HOUR
PPB 47 PERCENT
t1/2 5.2 HOUR

TARGET DEOXYCYTIDINE KINASE

PDB
2A7Q (CRYSTAL STRUCTURE OF HUMAN DCK COMPLEXED WITH CLOFARABINE AND ADP)

Ligand code = CFB (link to the list of PDB complexes)

Download experimental 3D coordinates of CFB with added hydrogens

MW 303.69
NB_atoms 20
XLogP -0.35
PSA 112.435
NB_HD 4
NB_HA 8
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 021673 (label) INN (CLOFARABINE) CLOLAR (GENZYME) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 208167 (pdf not found) INN (CLOFARABINE) CLOFARABINE (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2016
NDA 204029 (label) INN (CLOFARABINE) CLOFARABINE (ABON PHARMS LLC) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 205375 (pdf not found) INN (CLOFARABINE) CLOFARABINE (DR REDDYS) APPROVAL= AP YEAR= 2017
NDA 208857 (pdf not found) INN (CLOFARABINE) CLOFARABINE (AMNEAL) APPROVAL= AP YEAR= 2017
NDA 208860 (pdf not found) INN (CLOFARABINE) CLOFARABINE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2017
NDA 209775 (pdf not found) INN (CLOFARABINE) CLOFARABINE (MSN) APPROVAL= AP YEAR= 2017
NDA 207831 (pdf not found) INN (CLOFARABINE) CLOFARABINE (GLAND) APPROVAL= AP YEAR= 2018
NDA 210270 (pdf not found) INN (CLOFARABINE) CLOFARABINE (NOVAST LABS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 210283 (pdf not found) INN (CLOFARABINE) CLOFARABINE (HOSPIRA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 212034 (pdf not found) INN (CLOFARABINE) CLOFARABINE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2019
NDA 213461 (pdf not found) INN (CLOFARABINE) CLOFARABINE (MEITHEAL) APPROVAL= AP YEAR= 2020
NDA 212457 (pdf not found) INN (CLOFARABINE) CLOFARABINE (EUGIA PHARMA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 216233 (pdf not found) INN (CLOFARABINE) CLOFARABINE (SCINOPHARM TAIWAN) APPROVAL= AP YEAR= 2025