e-Drug3D

924

cas 91714-94-2

CLASS

SENSORY
ANALGESIC
ANTI-INFLAMMATORY AGENTS NON-STEROIDAL

ROUTE (list)

OPHTHALMIC

PK parameters

VD 7.15 LITER (65 KILOGRAM)
Cl 5 LITER / HOUR (65 KILOGRAM)
PPB 99 PERCENT
t1/2 2.6 HOUR

TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB
4MJQ (E. COLI SLIDING CLAMP IN COMPLEX WITH BROMFENAC)

Ligand code = 27R (link to the list of PDB complexes)

Download experimental 3D coordinates of 27R with added hydrogens

MW 333.15
NB_atoms 20
XLogP 1.55
PSA 74.465
NB_HD 2
NB_HA 4
fsp3 0.07
Lipinski(0=no;1=yes) 1

FDA
NDA 021664 (label) INN (BROMFENAC SODIUM) XIBROM (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 201211 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (COASTAL PHARMS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 202030 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (AMRING PHARMS) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203168 (label) INN (BROMFENAC SODIUM) PROLENSA (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2013
NDA 202435 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (APOTEX) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202620 (label) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (APOTEX) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203395 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (SENTISS) APPROVAL= AP YEAR= 2014
NDA 201941 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (CHARTWELL RX) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206911 (label) INN (BROMFENAC SODIUM) BROMSITE (SUN PHARM) APPROVAL= AP YEAR= 2016
NDA 203368 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (RISING) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210560 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 211029 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (GLAND) APPROVAL= AP YEAR= 2020
NDA 204813 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (EUGIA PHARMA) APPROVAL= AP YEAR= 2022
NDA 202903 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (LUPIN LTD) APPROVAL= AP YEAR= 2023
NDA 206027 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (LUPIN LTD) APPROVAL= AP YEAR= 2023
NDA 211239 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (LUPIN LTD) APPROVAL= AP YEAR= 2024
NDA 207334 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (APOTEX) APPROVAL= AP YEAR= 2024
NDA 210962 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (AMNEAL) APPROVAL= AP YEAR= 2024
NDA 214340 (pdf not found) INN (BROMFENAC SODIUM) BROMFENAC SODIUM (ALEMBIC) APPROVAL= AP YEAR= 2024