e-Drug3D

920

cas 179324-69-7

CLASS

ANTINEOPLASTIC AGENTS
PROTEASE INHIBITORS COVALENT BUT REVERSIBLE INHIBITOR

ROUTE (list)

INTRAVENOUS SUBCUTANEOUS INJECTION

PK parameters

VD 1917 LITER
Cl 32 LITER / HOUR
PPB 83 PERCENT
t1/2 92 HOUR

TARGET 26S PROTEASOME

PDB
4QW1 (YCP BETA5-A50V MUTANT IN COMPLEX WITH BORTEZOMIB)

Ligand code = BO2 (link to the list of PDB complexes)

Download experimental 3D coordinates of BO2 with added hydrogens

MW 384.24
NB_atoms 28
XLogP 0.36
PSA 115.633
NB_HD 4
NB_HA 8
fsp3 0.37
Lipinski(0=no;1=yes) 1

FDA
NDA 021602 (pdf not found) INN (BORTEZOMIB) VELCADE (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2003
NDA 208645 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (ACTAVIS LLC) APPROVAL= TA YEAR= 2016
NDA 205004 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 206927 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (DR REDDYS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 204405 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 205533 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (APOTEX) APPROVAL= AP YEAR= 2022
NDA 208392 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (PHARMASCIENCE INC) APPROVAL= AP YEAR= 2022
NDA 209191 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (HOSPIRA) APPROVAL= AP YEAR= 2022
NDA 210824 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (QILU PHARM HAINAN) APPROVAL= AP YEAR= 2022
NDA 203654 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (SANDOZ) APPROVAL= AP YEAR= 2022
NDA 211898 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (RELIANCE LIFE SCI) APPROVAL= AP YEAR= 2022
NDA 215011 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (JIANGSU HANSOH PHARM) APPROVAL= AP YEAR= 2022
NDA 205857 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (TEVA PHARMS USA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 209659 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2022
NDA 210204 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022
NDA 212825 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (EUGIA PHARMA) APPROVAL= AP YEAR= 2022
NDA 213823 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 202963 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (DR REDDYS) APPROVAL= AP YEAR= 2022
NDA 205160 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (PHARMOBEDIENT) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 208460 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (HOSPIRA) APPROVAL= AP YEAR= 2022
NDA 209622 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (MSN) APPROVAL= AP YEAR= 2022
NDA 212958 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (MEITHEAL) APPROVAL= AP YEAR= 2022
NDA 215331 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (MAIA PHARMS INC) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215441 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 216912 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (SCINOPHARM TAIWAN) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 212204 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (HETERO LABS LTD VI) APPROVAL= AP YEAR= 2024
NDA 212782 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (SHILPA) APPROVAL= AP YEAR= 2024
NDA 218688 (pdf not found) INN (BORTEZOMIB) BORTEZOMIB (MEDICAMEN BIOTECH) APPROVAL= AP YEAR= 2025