e-Drug3D

910

cas 55981-09-4

CLASS

ANTIPARASITIC
ANTHELMINTIC
ANTIPROTOZOAL
INTERFERENCE WITH PYRUVATE:FERREDOXIN OXIDOREDUCTASE (PFOR) ENZYME DEPENDENT ELECTRON TRANSFER REACTION WHICH IS ESSENTIAL TO ANAEROBIC ENERGY METABOLISM
RAPIDLY HYDROLYSED IN TIZOXANIDE

ROUTE (list)

ORAL

PK parameters

F 70 PERCENT

TARGET PYRUVATE:FERREDOXIN OXIDOREDUCTASE

PDB
3V35 (ALDOSE REDUCTASE COMPLEXED WITH A NITRO COMPOUND)

Ligand code = NTI (link to the list of PDB complexes)

Download experimental 3D coordinates of NTI with added hydrogens

MW 307.29
NB_atoms 21
XLogP 0
PSA 99.575
NB_HD 1
NB_HA 7
fsp3 0.08
Lipinski(0=no;1=yes) 1

FDA
NDA 021498 (pdf not found) INN (NITAZOXANIDE) ALINIA (ROMARK) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021497 (pdf not found) INN (NITAZOXANIDE) ALINIA (ROMARK) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021818 (pdf not found) INN (NITAZOXANIDE) ALINIA (ROMARK) APPROVAL= AP YEAR= 2005 NEWAPPLICATION
NDA 213820 (pdf not found) INN (NITAZOXANIDE) NITAZOXANIDE (RISING) APPROVAL= AP YEAR= 2020
NDA 214844 (pdf not found) INN (NITAZOXANIDE) NITAZOXANIDE (ANI PHARMS) APPROVAL= AP YEAR= 2025
NDA 218701 (pdf not found) INN (NITAZOXANIDE) NITAZOXANIDE (ANNORA PHARMA) APPROVAL= AP YEAR= 2025