e-Drug3D

909

cas 112811-59-3

CLASS

ANTIINFECTIVES
DNA GYRASE INHIBITOR
ANTIBIOTIC
ANTIBACTERIAL

ROUTE (list)

OPHTHALMIC

PK parameters

F 96 PERCENT
Tmax 1.5 HOUR
VD 104 LITER (65 KILOGRAM)
Cl 11.9 LITER / HOUR
PPB 20 PERCENT
t1/2 7.1 HOUR

TARGET DNA GYRASE
TOPOISOMERASE 4

PDB
5BTF (CRYSTAL STRUCTURE OF A TOPOISOMERASE II COMPLEX)

Ligand code = GFN (link to the list of PDB complexes)

Download experimental 3D coordinates of GFN with added hydrogens

MW 374.39
NB_atoms 27
XLogP 0.65
PSA 79.625
NB_HD 1
NB_HA 7
fsp3 0.47
Lipinski(0=no;1=yes) 1

FDA
NDA 021061 (label) INN (GATIFLOXACIN) TEQUIN (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1999 NEWMOLECULARENTITY DISCONTINUED OBSOLETE
NDA 021062 (label) INN (GATIFLOXACIN) TEQUIN IN DEXTROSE 5% IN PLASTIC CONTAINER (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1999 DISCONTINUED OBSOLETE
NDA 021404 (pdf not found) INN (GATIFLOXACIN) TEQUIN (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2002 NEWAPPLICATION DISCONTINUED OBSOLETE
NDA 021405 (pdf not found) INN (GATIFLOXACIN) TEQUIN (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2002 NEWAPPLICATION DISCONTINUED OBSOLETE
NDA 021493 (label) INN (GATIFLOXACIN) ZYMAR (ALLERGAN) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021678 (label) INN (GATIFLOXACIN) TEQUIN (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2004 DISCONTINUED OBSOLETE
NDA 076948 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (ZYDUS PHARMS USA) APPROVAL= TA YEAR= 2005 OBSOLETE
NDA 076950 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (TEVA PHARMS) APPROVAL= TA YEAR= 2005 OBSOLETE
NDA 022548 (label) INN (GATIFLOXACIN) ZYMAXID (ABBVIE) APPROVAL= AP YEAR= 2010
NDA 079084 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (APOTEX INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 202653 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (LUPIN LTD) APPROVAL= AP YEAR= 2013
NDA 203189 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (HIKMA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203190 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (HI-TECH PHARMACAL) APPROVAL= TA YEAR= 2014
NDA 204227 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (SANDOZ) APPROVAL= AP YEAR= 2016
NDA 206446 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (RISING) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 213542 (pdf not found) INN (GATIFLOXACIN) GATIFLOXACIN (CAPLIN) APPROVAL= AP YEAR= 2021 DISCONTINUED