e-Drug3D

907

cas 19982-08-2

CLASS

NERVOUS SYSTEM
MUSCLE RELAXANT (SKELETAL)
NMDA RECEPTOR ANTAGONIST (OPEN CHANNEL)
ANTI-ALZHEIMER'S DISEASE

ROUTE (list)

ORAL

PK parameters

Tmax 5 HOUR
VD 650 LITER (65 KILOGRAM)
Cl 6.4 LITER / HOUR (EQN)
PPB 45 PERCENT
t1/2 70 HOUR

TARGET GLUTAMATE [NMDA] RECEPTOR SUBUNIT
5HT3 RECEPTOR
NICOTINIC ACETYLCHOLINE RECEPTOR

PDB
4TWD (X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH MEMANTINE)

Ligand code = 377 (link to the list of PDB complexes)

Download experimental 3D coordinates of 377 with added hydrogens

MW 179.30
NB_atoms 13
XLogP 2.69
PSA 24.411
NB_HD 2
NB_HA 1
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 021487 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) NAMENDA (ABBVIE) APPROVAL= AP YEAR= 2003 NEWMOLECULARENTITY
NDA 021627 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) NAMENDA (ALLERGAN) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 090048 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2010
NDA 090058 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2010
NDA 022525 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) NAMENDA XR (ABBVIE) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090052 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090044 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (ORBION PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 206439 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) NAMZARIC (ABBVIE) APPROVAL= AP YEAR= 2014
NDA 079225 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 090041 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2015
NDA 090043 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2015
NDA 090051 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2015
NDA 090073 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (POINTVIEW HLDINGS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 200155 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 200022 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2015
NDA 091585 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 200891 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2015
NDA 202840 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2015
NDA 203175 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2015
NDA 204033 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2015
NDA 202790 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2015
NDA 205446 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (APOZEAL PHARMS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206528 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2015
NDA 206855 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (PURACAP PHARM LLC) APPROVAL= AP YEAR= 2015
NDA 206032 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2016
NDA 205825 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 205905 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 206028 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2016
NDA 206135 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 206310 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= TA YEAR= 2016
NDA 207236 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 090961 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2017
NDA 202350 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2017
NDA 203293 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 205784 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208328 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208672 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE AND MEMANTINE HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= TA YEAR= 2017
NDA 090244 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (CHARTWELL) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209527 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (RENATA) APPROVAL= AP YEAR= 2018
NDA 209955 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2018
NDA 205365 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 208173 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212947 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (YILING) APPROVAL= AP YEAR= 2020
NDA 210319 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (SETON PHARMS) APPROVAL= AP YEAR= 2020
NDA 210587 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (POLYGEN PHARMS) APPROVAL= AP YEAR= 2020
NDA 211100 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (YICHANG HUMANWELL) APPROVAL= AP YEAR= 2021
NDA 214651 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2021
NDA 204389 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2022
NDA 213985 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (XIAMEN LP PHARM CO) APPROVAL= AP YEAR= 2022
NDA 214731 (pdf not found) INN (MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE (NOVAST LABS LTD) APPROVAL= TA YEAR= 2022
NDA 216901 (pdf not found) INN (MEMANTINE ; DONEPEZIL HYDROCHLORIDES) MEMANTINE;DONEPEZIL HYDROCHLORIDES (XIAMEN LP PHARM CO) APPROVAL= TA YEAR= 2023
NDA 208237 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 2023