e-Drug3D

905

cas 114084-78-5

CLASS

MUSCULO-SKELETAL SYSTEM
ANTIHYPOCALCEMIC AGENTS
ANTIRESORPTIVES
BISPHOSPHONATES
BONE DENSITY CONSERVATION AGENTS

ROUTE (list)

ORAL INTRAVENOUS INJECTION

PK parameters

F 0.6 PERCENT
Tmax 1 HOUR
VD 90 LITER
Cl 5 LITER / HOUR
PPB 86 PERCENT
t1/2 97 HOUR

TARGET FARNESYL PYROPHOSPHATE SYNTHASE

PDB
4UMJ (NATIVE STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHASE FROM PSEUDOMONAS AERUGINOSA PA01, WITH BOUND IBANDRONIC ACID MOLECULES.)

Ligand code = BFQ (link to the list of PDB complexes)

Download experimental 3D coordinates of BFQ with added hydrogens

MW 315.19
NB_atoms 19
XLogP -2.03
PSA 133.816
NB_HD 1
NB_HA 8
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 021455 (pdf not found) INN (IBANDRONATE SODIUM) BONIVA (HOFFMANN LA ROCHE) APPROVAL= AP YEAR= 2003 NEWMOLECULARENTITY DISCONTINUED
NDA 021858 (pdf not found) INN (IBANDRONATE SODIUM) BONIVA (ROCHE) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 079194 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (TEVA PARENTERAL) APPROVAL= TA YEAR= 2009
NDA 079002 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (COBALT LABS INC) APPROVAL= TA YEAR= 2011
NDA 078995 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078998 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (ORBION PHARMS) APPROVAL= AP YEAR= 2012
NDA 079003 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (WATSON LABS TEVA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078996 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078948 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (APOTEX INC) APPROVAL= AP YEAR= 2012
NDA 078997 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2012
NDA 090853 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202235 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (CHEMI SPA) APPROVAL= AP YEAR= 2014
NDA 202671 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2014
NDA 203987 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 204222 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (APOTEX) APPROVAL= AP YEAR= 2015
NDA 205332 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (EUGIA PHARMA) APPROVAL= AP YEAR= 2015
NDA 204502 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 206058 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2016
NDA 206887 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 204329 (pdf not found) INN (IBANDRONATE SODIUM) IBANDRONATE SODIUM (NANG KUANG PHARM CO) APPROVAL= AP YEAR= 2021 DISCONTINUED