e-Drug3D

904

ADEFOVIR DIPIVOXIL

INN
ADEFOVIR DIPIVOXIL

(has an active metabolite)

cas 142340-99-6

CLASS

ANTIINFECTIVES
ANTIVIRAL AGENTS
REVERSE TRANSCRIPTASE INHIBITORS
TREATMENT OF CHRONIC HEPATITIS B

ROUTE (list)

ORAL

ATC code

J05AF08

PK parameters

Solubility

0.4 MILLIGRAM / MILLILITER AT PH 7.2

Target

TARGET HBV REVERSE TRANSCRIPTASE

DrugCentral

Protein P UNIPROT Q9IF40 P

Download SDF file

[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate

Formula:
C20H32N5O8P

Calculated chemical properties:

MW 501.48
NB_atoms 34
XLogP 2.70
PSA 158.168
NB_HD 2
NB_HA 13
fsp3 0.65
Lipinski(0=no;1=yes) 0

FDA
NDA 021449 (label) INN (ADEFOVIR DIPIVOXIL) HEPSERA (GILEAD) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 202051 (label) INN (ADEFOVIR DIPIVOXIL) ADEFOVIR DIPIVOXIL (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2013
NDA 205459 (pdf not found) INN (ADEFOVIR DIPIVOXIL) ADEFOVIR DIPIVOXIL (APOTEX) APPROVAL= AP YEAR= 2018