e-Drug3D

903

cas 148553-50-8

CLASS

NERVOUS SYSTEM
ANALGESICS
ANTICONVULSANTS
NEUROPATHIC PAIN

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT
Tmax 1.5 HOUR
VD 32.5 LITER (65 KILOGRAM)
Cl 3.7 LITER / HOUR (EQN)
PPB 0 PERCENT
t1/2 6 HOUR

TARGET ALPHA2-DELTA SITE OF VOLTAGE-GATED CALCIUM CHANNEL

PDB
3JBR (CRYO-EM STRUCTURE OF THE RABBIT VOLTAGE-GATED CALCIUM CHANNEL CAV1.1 COMPLEX AT 4.2 ANGSTROM)

Ligand code = - (link to the list of PDB complexes)

Download experimental 3D coordinates of - with added hydrogens

MW 158.22
NB_atoms 11
XLogP -0.25
PSA 58.583
NB_HD 2
NB_HA 3
fsp3 0.88
Lipinski(0=no;1=yes) 1

FDA
NDA 021446 (pdf not found) INN (PREGABALIN) LYRICA (UPJOHN) APPROVAL= AP YEAR= 2004
NDA 021723 (pdf not found) INN (PREGABALIN) LYRICA (CP PHARMS) APPROVAL= AP YEAR= 2004 NEWAPPLICATION
NDA 021724 (pdf not found) INN (PREGABALIN) LYRICA (CP PHARMS) APPROVAL= AP YEAR= 2005 NEWAPPLICATION
NDA 022488 (pdf not found) INN (PREGABALIN) LYRICA (UPJOHN) APPROVAL= AP YEAR= 2010
NDA 091229 (pdf not found) INN (PREGABALIN) PREGABALIN (SANDOZ INC) APPROVAL= TA YEAR= 2012
NDA 201989 (pdf not found) INN (PREGABALIN) PREGABALIN (LUPIN LTD) APPROVAL= TA YEAR= 2013
NDA 202269 (pdf not found) INN (PREGABALIN) PREGABALIN (NOVEL LABS INC) APPROVAL= TA YEAR= 2014
NDA 202998 (pdf not found) INN (PREGABALIN) PREGABALIN (APOTEX INC) APPROVAL= TA YEAR= 2014
NDA 203022 (pdf not found) INN (PREGABALIN) PREGABALIN (APOTEX INC) APPROVAL= TA YEAR= 2014
NDA 091221 (pdf not found) INN (PREGABALIN) PREGABALIN (WATSON LABS INC) APPROVAL= TA YEAR= 2015
NDA 209501 (pdf not found) INN (PREGABALIN) LYRICA CR (UPJOHN) APPROVAL= AP YEAR= 2017
NDA 091219 (pdf not found) INN (PREGABALIN) PREGABALIN (TEVA PHARMS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 091224 (pdf not found) INN (PREGABALIN) PREGABALIN (TEVA PHARMS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 091228 (pdf not found) INN (PREGABALIN) PREGABALIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 203459 (pdf not found) INN (PREGABALIN) PREGABALIN (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 207799 (pdf not found) INN (PREGABALIN) PREGABALIN (ALKEM LABS LTD) APPROVAL= AP YEAR= 2019
NDA 208677 (pdf not found) INN (PREGABALIN) PREGABALIN (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2019
NDA 210432 (pdf not found) INN (PREGABALIN) PREGABALIN (RISING) APPROVAL= AP YEAR= 2019
NDA 211384 (pdf not found) INN (PREGABALIN) PREGABALIN (INVAGEN PHARMS) APPROVAL= AP YEAR= 2019
NDA 207623 (pdf not found) INN (PREGABALIN) PREGABALIN (ALKEM LABS LTD) APPROVAL= AP YEAR= 2019
NDA 209357 (pdf not found) INN (PREGABALIN) PREGABALIN (MSN) APPROVAL= AP YEAR= 2019
NDA 091157 (pdf not found) INN (PREGABALIN) PREGABALIN (SUN PHARM) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 206912 (pdf not found) INN (PREGABALIN) PREGABALIN (HETERO LABS LTD III) APPROVAL= AP YEAR= 2019
NDA 209664 (pdf not found) INN (PREGABALIN) PREGABALIN (DR REDDYS) APPROVAL= AP YEAR= 2019
NDA 209743 (pdf not found) INN (PREGABALIN) PREGABALIN (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2019
NDA 210585 (pdf not found) INN (PREGABALIN) PREGABALIN (RENATA) APPROVAL= AP YEAR= 2019
NDA 210891 (pdf not found) INN (PREGABALIN) PREGABALIN (YILING) APPROVAL= AP YEAR= 2019
NDA 211177 (pdf not found) INN (PREGABALIN) PREGABALIN (ALKEM LABS LTD) APPROVAL= AP YEAR= 2019 OBSOLETE
NDA 091025 (pdf not found) INN (PREGABALIN) PREGABALIN (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212280 (pdf not found) INN (PREGABALIN) PREGABALIN (CIPLA) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212865 (pdf not found) INN (PREGABALIN) PREGABALIN (CHARTWELL RX) APPROVAL= AP YEAR= 2020
NDA 213423 (pdf not found) INN (PREGABALIN) PREGABALIN (CREEKWOOD PHARMS) APPROVAL= AP YEAR= 2020
NDA 211593 (pdf not found) INN (PREGABALIN) PREGABALIN (ALVOGEN) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211889 (pdf not found) INN (PREGABALIN) PREGABALIN (SUN PHARM) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211948 (pdf not found) INN (PREGABALIN) PREGABALIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213226 (pdf not found) INN (PREGABALIN) PREGABALIN (MSN) APPROVAL= AP YEAR= 2021
NDA 213313 (pdf not found) INN (PREGABALIN) PREGABALIN (APOTEX) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211431 (pdf not found) INN (PREGABALIN) PREGABALIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211685 (pdf not found) INN (PREGABALIN) PREGABALIN (APOTEX) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211687 (pdf not found) INN (PREGABALIN) PREGABALIN (ALVOGEN) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211967 (pdf not found) INN (PREGABALIN) PREGABALIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 214322 (pdf not found) INN (PREGABALIN) PREGABALIN (CHANGZHOU PHARM) APPROVAL= AP YEAR= 2021
NDA 091040 (pdf not found) INN (PREGABALIN) PREGABALIN (LUPIN LTD) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 207883 (pdf not found) INN (PREGABALIN) PREGABALIN (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 212604 (pdf not found) INN (PREGABALIN) PREGABALIN (ANDA REPOSITORY) APPROVAL= AP YEAR= 2022
NDA 212988 (pdf not found) INN (PREGABALIN) PREGABALIN (WESTMINSTER PHARMS) APPROVAL= AP YEAR= 2022
NDA 215249 (pdf not found) INN (PREGABALIN) PREGABALIN (RUBICON RESEARCH) APPROVAL= AP YEAR= 2022
NDA 206752 (pdf not found) INN (PREGABALIN) PREGABALIN (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215577 (pdf not found) INN (PREGABALIN) PREGABALIN (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215675 (pdf not found) INN (PREGABALIN) PREGABALIN (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 216197 (pdf not found) INN (PREGABALIN) PREGABALIN (ADAPTIS) APPROVAL= AP YEAR= 2022
NDA 205321 (pdf not found) INN (PREGABALIN) PREGABALIN (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2023
NDA 206452 (pdf not found) INN (PREGABALIN) PREGABALIN (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 214496 (pdf not found) INN (PREGABALIN) PREGABALIN (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2023
NDA 215755 (pdf not found) INN (PREGABALIN) PREGABALIN (STRIDES PHARMA) APPROVAL= AP YEAR= 2023
NDA 205924 (pdf not found) INN (PREGABALIN) PREGABALIN (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 208113 (pdf not found) INN (PREGABALIN) PREGABALIN (ADAPTIS) APPROVAL= AP YEAR= 2024
NDA 209883 (pdf not found) INN (PREGABALIN) PREGABALIN (STRIDES PHARMA) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 091222 (pdf not found) INN (PREGABALIN) PREGABALIN (HLTHCARE) APPROVAL= AP YEAR= 2025
NDA 206942 (pdf not found) INN (PREGABALIN) PREGABALIN (TORRENT) APPROVAL= AP YEAR= 2025
NDA 209530 (pdf not found) INN (PREGABALIN) PREGABALIN (JUBILANT GENERICS) APPROVAL= AP YEAR= 2025
NDA 217857 (pdf not found) INN (PREGABALIN) PREGABALIN (HQ PHARMA) APPROVAL= AP YEAR= 2025