e-Drug3D

901

EPLERENONE

INN
EPLERENONE

cas 107724-20-9

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ALDOSTERONE ANTAGONIST

ROUTE (list)

ORAL

ATC code

C03DA04

PK parameters

F 69 PERCENT
Tmax 1.5 HOUR
VD 66.5 LITER
Cl 10 LITER / HOUR
PPB 50 PERCENT
t1/2 5 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET MINERALOCORTICOID RECEPTOR

PDB
5MWY (THE STRUCTURE OF MR IN COMPLEX WITH EPLERENONE.)

Ligand code = YNU (link to the list of PDB complexes)

Download experimental 3D coordinates of YNU with added hydrogens

DrugCentral

Mineralocorticoid receptor UNIPROT P08235 NR3C2

Download SDF file

Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, .gamma.-lactone, 7-methyl ester, (7.alpha.,11.alpha.,17.alpha.)-

Formula:
C24H30O6

Calculated chemical properties:

MW 414.48
NB_atoms 30
XLogP 3.12
PSA 78.278
NB_HD 0
NB_HA 6
fsp3 0.79
Lipinski(0=no;1=yes) 1

FDA
NDA 021437 (pdf not found) INN (EPLERENONE) INSPRA (UPJOHN) APPROVAL= AP YEAR= 2002
NDA 078482 (pdf not found) INN (EPLERENONE) EPLERENONE (CHARTWELL RX) APPROVAL= AP YEAR= 2008
NDA 078510 (pdf not found) INN (EPLERENONE) EPLERENONE (SANDOZ) APPROVAL= AP YEAR= 2008
NDA 203896 (pdf not found) INN (EPLERENONE) EPLERENONE (THINKRX) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 206922 (pdf not found) INN (EPLERENONE) EPLERENONE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017
NDA 208283 (pdf not found) INN (EPLERENONE) EPLERENONE (BRECKENRIDGE) APPROVAL= AP YEAR= 2018
NDA 212765 (pdf not found) INN (EPLERENONE) EPLERENONE (ADAPTIS) APPROVAL= AP YEAR= 2020
NDA 207842 (pdf not found) INN (EPLERENONE) EPLERENONE (WESTMINSTER PHARMS) APPROVAL= AP YEAR= 2021
NDA 214663 (pdf not found) INN (EPLERENONE) EPLERENONE (RISING) APPROVAL= AP YEAR= 2022
NDA 213812 (pdf not found) INN (EPLERENONE) EPLERENONE (ANNORA PHARMA) APPROVAL= AP YEAR= 2023