e-Drug3D

897

cas 83015-26-3

CLASS

NERVOUS SYSTEM
NOREPINEPHRINE REUPTAKE INHIBITOR
TREATMENT OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

ROUTE (list)

ORAL

PK parameters

F 63 PERCENT
Tmax 1.5 HOUR
VD 55 LITER (65 KILOGRAM)
Cl 22.7 LITER / HOUR
PPB 98 PERCENT
t1/2 5.2 HOUR

TARGET NORADRENALINE TRANSPORTER

PDB
8ZP2 (CRYO-EM STRUCTURE OF HUMAN NOREPINEPHRINE TRANSPORTER NET BOUND WITH ATOMOXETINE IN AN OUTWARD-OPEN STATE AT A RESOLUTION OF 2.4 ANGSTROM)

Ligand code = A1LX4 (link to the list of PDB complexes)

Download experimental 3D coordinates of A1LX4 with added hydrogens

MW 255.35
NB_atoms 19
XLogP 3.72
PSA 23.267
NB_HD 1
NB_HA 2
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 021411 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) STRATTERA (LILLY) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 079017 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2010
NDA 079018 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (SANDOZ INC) APPROVAL= TA YEAR= 2012 OBSOLETE
NDA 079020 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (SUN PHARMA GLOBAL) APPROVAL= TA YEAR= 2012
NDA 078940 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= TA YEAR= 2012
NDA 079016 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2017
NDA 079019 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 079022 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2017
NDA 078983 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2017
NDA 090609 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2018
NDA 079021 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2021
NDA 202682 (pdf not found) INN (ATOMOXETINE HYDROCHLORIDE) ATOMOXETINE HYDROCHLORIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2021