e-Drug3D

894

cas 135729-61-2

CLASS

METABOLISM
ANTIEMETIC
SEROTONIN 5-HT3 RECEPTOR ANTAGONIST
PREVENT NAUSEA AND VOMITING

ROUTE (list)

INTRAVENOUS ORAL INJECTION

PK parameters

F 97 PERCENT
Tmax 5.1 HOUR
VD 539.5 LITER (65 KILOGRAM)
Cl 10.4 LITER / HOUR (65 KILOGRAM)
PPB 62 PERCENT
t1/2 40 HOUR

TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR

PDB
6Y1Z (MOUSE SEROTONIN 5HT3 RECEPTOR IN COMPLEX WITH PALONOSETRON)

Ligand code = O7B (link to the list of PDB complexes)

Download experimental 3D coordinates of O7B with added hydrogens

MW 296.40
NB_atoms 22
XLogP 2.66
PSA 24.131
NB_HD 0
NB_HA 3
fsp3 0.63
Lipinski(0=no;1=yes) 1

FDA
NDA 021372 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) ALOXI (HELSINN HLTHCARE) APPROVAL= AP YEAR= 2003 NEWMOLECULARENTITY DISCONTINUED
NDA 022233 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) ALOXI (HELSINN HLTHCARE) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 205718 (pdf not found) INN (NETUPITANT ; PALONOSETRON HYDROCHLORIDE) AKYNZEO (HELSINN HLTHCARE) APPROVAL= AP YEAR= 2014
NDA 202521 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2015
NDA 204731 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (AKORN INC) APPROVAL= TA YEAR= 2015
NDA 201533 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2016
NDA 203050 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) POSFREA (AVYXA HOLDINGS) APPROVAL= AP YEAR= 2016
NDA 207963 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 208109 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 090713 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2018
NDA 204702 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2018
NDA 210493 (pdf not found) INN (FOSNETUPITANT CHLORIDE HYDROCHLORIDE ; PALONOSETRON HYDROCHLORIDE) AKYNZEO (HELSINN HLTHCARE) APPROVAL= AP YEAR= 2018
NDA 204289 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 205648 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (QILU PHARM HAINAN) APPROVAL= AP YEAR= 2018
NDA 205870 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 206396 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (CIPLA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 206416 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2018
NDA 206801 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018
NDA 206802 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018
NDA 207005 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2018
NDA 209287 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2018
NDA 208789 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (NOVAST LABS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 202951 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2021
NDA 204615 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 206916 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2021
NDA 215861 (pdf not found) INN (PALONOSETRON HYDROCHLORIDE) PALONOSETRON HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2023