e-Drug3D

888

FONDAPARINUX

INN
FONDAPARINUX

cas 104993-28-4

CLASS

BLOOD
ANTICOAGULANTS
ANTITHROMBOTICS
FACTOR XA INHIBITOR

ROUTE (list)

SUBCUTANEOUS

ATC code

B01AX05

PK parameters

F 100 PERCENT
Tmax 2 HOUR
VD 9 LITER
Cl 0.32 LITER / HOUR (EQN)
PPB 0 PERCENT
t1/2 19 HOUR

Target

TARGET ANTITHROMBIN-III

PDB
4X7R (CRYSTAL STRUCTURE OF S. AUREUS TARM G117R MUTANT IN COMPLEX WITH FONDAPARINUX, ALPHA-GLCNAC-GLYCEROL AND UDP)

Ligand code = NTO (link to the list of PDB complexes)

Download experimental 3D coordinates of NTO with added hydrogens

DrugCentral

Antithrombin-III UNIPROT P01008 SERPINC1

Download SDF file

decasodium (2R,3S,4S,5R,6R)-3-[(2R,3R,4R,5R,6R)-5-[(2R,3R,4R,5S,6S)-6-carboxylato-5-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-3-(sulfonatoamino)-6-(sulfonatooxymethyl)oxan-2-yl]oxy-3,4-dihydroxyoxan-2-yl]oxy-3-(sulfonatoamino)-4-sulfonatooxy-6-(sulfonatooxymethyl)oxan-2-yl]oxy-4-hydroxy-6-[(2R,3S,4R,5R,6S)-4-hydroxy-6-methoxy-5-(sulfonatoamino)-2-(sulfonatooxymethyl)oxan-3-yl]oxy-5-sulfonatooxyoxane-2-carboxylate

Formula:
C31H53N3O49S8

Calculated chemical properties:

MW 1506.31
NB_atoms 91
XLogP -16.42
PSA 789.04
NB_HD 17
NB_HA 52
fsp3 0.94
Lipinski(0=no;1=yes) 0

FDA
NDA 021345 (label) INN (FONDAPARINUX SODIUM) ARIXTRA (MYLAN IRELAND LTD) APPROVAL= AP YEAR= 2001
NDA 091316 (pdf not found) INN (FONDAPARINUX SODIUM) FONDAPARINUX SODIUM (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2011
NDA 206918 (pdf not found) INN (FONDAPARINUX SODIUM) FONDAPARINUX SODIUM (EUGIA PHARMA) APPROVAL= AP YEAR= 2017
NDA 206812 (pdf not found) INN (FONDAPARINUX SODIUM) FONDAPARINUX SODIUM (HENGRUI PHARMA) APPROVAL= AP YEAR= 2018
NDA 208615 (pdf not found) INN (FONDAPARINUX SODIUM) FONDAPARINUX SODIUM (SCINOPHARM TAIWAN) APPROVAL= AP YEAR= 2018
NDA 216493 (pdf not found) INN (FONDAPARINUX SODIUM) FONDAPARINUX SODIUM (HANGZHOU ZHONGMEI) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 218312 (pdf not found) INN (FONDAPARINUX SODIUM) FONDAPARINUX SODIUM (BRIGHTGENE) APPROVAL= AP YEAR= 2024