e-Drug3D

885

ERTAPENEM

INN
ERTAPENEM

cas 153832-46-3

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
INHIBITION OF CELL WALL SYNTHESIS

ROUTE (list)

INTRAMUSCULAR INTRAVENOUS

ATC code

J01DH03

PK parameters

F 90 PERCENT
Tmax 2.3 HOUR
VD 7.8 LITER (65 KILOGRAM)
Cl 1.8 LITER / HOUR
PPB 90 PERCENT
t1/2 4 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET PENICILLIN-BINDING PROTEIN (PBP)

DrugCentral

D-alanyl-D-alanine carboxypeptidase DacB UNIPROT P24228 dacB

Penicillin-binding protein 1A UNIPROT P02918 mrcA

Download SDF file

(4R,5S,6S)-3-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Formula:
C22H25N3O7S

Calculated chemical properties:

MW 473.50
NB_atoms 33
XLogP -1.73
PSA 155.845
NB_HD 3
NB_HA 10
fsp3 0.45
Lipinski(0=no;1=yes) 0

FDA
NDA 021337 (pdf not found) INN (ERTAPENEM SODIUM) INVANZ (MSD SUB MERCK) APPROVAL= AP YEAR= 2001
NDA 208790 (pdf not found) INN (ERTAPENEM SODIUM) ERTAPENEM SODIUM (ACS DOBFAR SPA) APPROVAL= AP YEAR= 2018
NDA 209133 (pdf not found) INN (ERTAPENEM SODIUM) ERTAPENEM SODIUM (EUGIA PHARMA) APPROVAL= AP YEAR= 2018
NDA 207647 (pdf not found) INN (ERTAPENEM SODIUM) ERTAPENEM SODIUM (SAVIOR LIFETEC CORP) APPROVAL= AP YEAR= 2019
NDA 212040 (pdf not found) INN (ERTAPENEM SODIUM) ERTAPENEM SODIUM (GLAND) APPROVAL= AP YEAR= 2021
NDA 209145 (pdf not found) INN (ERTAPENEM SODIUM) ERTAPENEM SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 218067 (pdf not found) INN (ERTAPENEM SODIUM) ERTAPENEM SODIUM (QILU ANTIBIOTICS) APPROVAL= AP YEAR= 2024