e-Drug3D

884

ABARELIX

DISCONTINUED

INN
ABARELIX

cas 183552-38-7

CLASS

ANTINEOPLASTIC
ANTI-TESTOSTERONE AGENTS
GONADOTROPIN-RELEASING HORMONE (GNRH) ANTAGONIST (KD = 0.1 NANOMOLAR)

ROUTE (list)

INTRAMUSCULAR

ATC code

L02BX01

PK parameters

Tmax 72 HOUR
VD 4040 LITER
Cl 8.6 LITER / HOUR
t1/2 316 HOUR

Target

TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR

DrugCentral

Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR

Download SDF file

(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]-methylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide

Formula:
C72H95ClN14O14

Calculated chemical properties:

MW 1416.07
NB_atoms 101
XLogP 1.17
PSA 386.098
NB_HD 15
NB_HA 28
fsp3 0.46
Lipinski(0=no;1=yes) 0

FDA
NDA 021320 (pdf not found) INN (ABARELIX) PLENAXIS (SPECIALITY EUROPEAN) APPROVAL= AP YEAR= 2003 NEWMOLECULARENTITY DISCONTINUED