e-Drug3D

875

cas 81846-19-7

CLASS

BLOOD
ANTIHYPERTENSIVE AGENTS
ANTITHROMBOTIC AGENTS
PROSTACYCLIN ANALOGS
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)
PROSTACYCLIN (IP) RECEPTOR AGONIST

ROUTE (list)

INTRAVENOUS SUBCUTANEOUS INHALATION ORAL

PK parameters

F 72 PERCENT
Tmax 0.12 HOUR
VD 13 LITER (65 KILOGRAM)
Cl 27.8 LITER / HOUR (65 KILOGRAM)
PPB 91 PERCENT
t1/2 4 HOUR

TARGET PROSTACYCLIN RECEPTOR

PDB
8X7A (TREPROSTINIL BOUND PROSTACYCLIN RECEPTOR G PROTEIN COMPLEX)

Ligand code = Y9J (link to the list of PDB complexes)

Download experimental 3D coordinates of Y9J with added hydrogens

MW 389.49
NB_atoms 28
XLogP 2.25
PSA 86.789
NB_HD 2
NB_HA 5
fsp3 0.70
Lipinski(0=no;1=yes) 1

FDA
NDA 021272 (pdf not found) INN (TREPROSTINIL) REMODULIN (UNITED THERAP) APPROVAL= AP YEAR= 2002
NDA 022387 (pdf not found) INN (TREPROSTINIL) TYVASO (UNITED THERAP) APPROVAL= AP YEAR= 2009
NDA 203496 (pdf not found) INN (TREPROSTINIL DIOLAMINE) ORENITRAM (UNITED THERAP) APPROVAL= AP YEAR= 2013
NDA 203649 (pdf not found) INN (TREPROSTINIL) TREPROSTINIL (SANDOZ) APPROVAL= AP YEAR= 2017
NDA 208276 (pdf not found) INN (TREPROSTINIL) REMODULIN (UNITED THERAP) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209382 (pdf not found) INN (TREPROSTINIL) TREPROSTINIL (PH HEALTH) APPROVAL= AP YEAR= 2019
NDA 206648 (pdf not found) INN (TREPROSTINIL) TREPROSTINIL (TEVA PHARMS USA) APPROVAL= AP YEAR= 2019
NDA 210214 (pdf not found) INN (TREPROSTINIL) TREPROSTINIL (DR REDDYS) APPROVAL= AP YEAR= 2020
NDA 211574 (pdf not found) INN (TREPROSTINIL) TREPROSTINIL (ALEMBIC GLOBAL) APPROVAL= AP YEAR= 2021
NDA 214324 (pdf not found) INN (TREPROSTINIL) TYVASO DPI (UNITED THERAP) APPROVAL= AP YEAR= 2022
NDA 208906 (pdf not found) INN (TREPROSTINIL) TREPROSTINIL (ACTAVIS LABS) APPROVAL= TA YEAR= 2023
NDA 213005 (pdf not found) INN (TREPROSTINIL SODIUM) YUTREPIA (LIQUIDIA TECH) APPROVAL= AP YEAR= 2025