e-Drug3D

874

cas 137234-62-9

CLASS

ANTIINFECTIVES
ANTIFUNGAL
INHIBITION OF FUNGAL CYTOCHROME P-450-MEDIATED 14 ALPHA-LANOSTEROL DEMETHYLATION (CYP51) AN ESSENTIAL STEP IN FUNGAL ERGOSTEROL BIOSYNTHESIS

ROUTE (list)

ORAL INTRAVENOUS INJECTION IV

PK parameters

F 96 PERCENT
Tmax 1.5 HOUR
VD 299 LITER (65 KILOGRAM)
Cl 32.3 LITER / HOUR (65 KILOGRAM)
PPB 58 PERCENT
t1/2 5.6 HOUR

TARGET CYTOCHROME P450 CYP51

PDB
5HS1 (SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) COMPLEXED WITH VORICONAZOLE)

Ligand code = VOR (link to the list of PDB complexes)

Download experimental 3D coordinates of VOR with added hydrogens

MW 349.32
NB_atoms 25
XLogP 2.18
PSA 60.294
NB_HD 1
NB_HA 6
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 021266 (pdf not found) INN (VORICONAZOLE) VFEND (PF PRISM CV) APPROVAL= AP YEAR= 2002
NDA 021267 (pdf not found) INN (VORICONAZOLE) VFEND (PF PRISM CV) APPROVAL= AP YEAR= 2002
NDA 021464 (pdf not found) INN (VORICONAZOLE) VFEND (PFIZER) APPROVAL= AP YEAR= 2003 NEWAPPLICATION
NDA 021466 (pdf not found) INN (VORICONAZOLE) VFEND (PFIZER) APPROVAL= AP YEAR= 2003 NEWAPPLICATION
NDA 021630 (pdf not found) INN (VORICONAZOLE) VFEND (PF PRISM CV) APPROVAL= AP YEAR= 2003
NDA 090547 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2010
NDA 200265 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (SANDOZ INC) APPROVAL= AP YEAR= 2011
NDA 090862 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (SANDOZ INC) APPROVAL= AP YEAR= 2012
NDA 091658 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (TEVA PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202361 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (RISING) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203503 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2015
NDA 205034 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 206181 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2016
NDA 206398 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (ALMAJECT) APPROVAL= AP YEAR= 2016
NDA 206747 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (CADILA) APPROVAL= AP YEAR= 2016
NDA 206762 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (RISING) APPROVAL= AP YEAR= 2016
NDA 206799 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (NOVEL LABS INC) APPROVAL= AP YEAR= 2016
NDA 206837 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2016
NDA 207371 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (CHARTWELL RX) APPROVAL= AP YEAR= 2016
NDA 206654 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (PRINSTON INC) APPROVAL= AP YEAR= 2016
NDA 207049 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2016
NDA 208562 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (HIKMA) APPROVAL= AP YEAR= 2017
NDA 208983 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 211661 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2018
NDA 211099 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (GLAND) APPROVAL= AP YEAR= 2020
NDA 214516 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (MEITHEAL) APPROVAL= AP YEAR= 2022
NDA 210849 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 211264 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (UBI) APPROVAL= AP YEAR= 2023
NDA 212162 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 216805 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (ZHEJIANG POLY PHARM) APPROVAL= AP YEAR= 2024
NDA 218533 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (ASPIRO) APPROVAL= AP YEAR= 2024
NDA 211598 (pdf not found) INN (VORICONAZOLE) VORICONAZOLE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2025