e-Drug3D

868

TEGASEROD

DISCONTINUED

INN
TEGASEROD

cas 145158-71-0

CLASS

METABOLISM
PERISTALTIC STIMULANT
IRRITABLE BOWEL SYNDROME (THERAPEUTIC)
SEROTONIN AGONISTS
5-HT4 RECEPTOR PARTIAL AGONIST

ROUTE (list)

ORAL

ATC code

A06AX06

PK parameters

F 10 PERCENT
Tmax 1 HOUR
VD 368 LITER
Cl 77 LITER / HOUR
PPB 98 PERCENT
t1/2 11 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET 5-HYDROXYTRYPTAMINE 4 RECEPTOR

5-hydroxytryptamine receptor 4 UNIPROT Q13639 HTR4

Download SDF file

1-[[(Z)-[5-(hydroxymethyl)indol-3-ylidene]methyl]amino]-2-pentylguanidine

Formula:
C16H23N5O

Calculated chemical properties:

MW 301.39
NB_atoms 22
XLogP 2.81
PSA 82.885
NB_HD 4
NB_HA 6
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 021200 (pdf not found) INN (TEGASEROD MALEATE) ZELNORM (ALFASIGMA) APPROVAL= AP YEAR= 2002 NEWMOLECULARENTITY DISCONTINUED