e-Drug3D

867

CETRORELIX

INN
CETRORELIX

cas 120287-85-6

CLASS

HORMONES
GONADOTROPIN-RELEASING HORMONE RECEPTOR (GNRH) ANTAGONIST
INFERTILITY AGENTS

ROUTE (list)

SUBCUTANEOUS

ATC code

H01CC02

PK parameters

F 85 PERCENT
Tmax 1.5 HOUR
VD 75.4 LITER (65 KILOGRAM)
Cl 5 LITER / HOUR (65 KILOGRAM)
PPB 86 PERCENT
t1/2 62.8 HOUR

Target

TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR

DrugCentral

Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR

Download SDF file

1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide

Formula:
C70H92ClN17O14

Calculated chemical properties:

MW 1432.06
NB_atoms 102
XLogP -2.33
PSA 454.684
NB_HD 21
NB_HA 30
fsp3 0.43
Lipinski(0=no;1=yes) 0

FDA
NDA 021197 (label) INN (CETRORELIX ACETATE) CETROTIDE (EMD SERONO INC) APPROVAL= AP YEAR= 2000
NDA 215737 (pdf not found) INN (CETRORELIX ACETATE) CETRORELIX ACETATE (TEVA PHARMS INC) APPROVAL= AP YEAR= 2022
NDA 214540 (pdf not found) INN (CETRORELIX ACETATE) CETRORELIX ACETATE (LIVZON GRP) APPROVAL= AP YEAR= 2024
NDA 217776 (pdf not found) INN (CETRORELIX ACETATE) CETRORELIX ACETATE (QILU) APPROVAL= AP YEAR= 2024
NDA 218150 (pdf not found) INN (CETRORELIX ACETATE) CETRORELIX ACETATE (GLAND) APPROVAL= AP YEAR= 2024
NDA 218061 (pdf not found) INN (CETRORELIX ACETATE) CETRORELIX ACETATE (XIROMED) APPROVAL= AP YEAR= 2025