e-Drug3D
865
cas 100643-71-8
CLASS
RESPIRATORY
HISTAMINE H1 RECEPTOR ANTAGONIST
ANTIHISTAMINE
CHOLINERGIC ANTAGONISTS
ROUTE (list)
ORAL
ATC code
R06AX27
PK parameters
Tmax 3 HOUR
PPB 84 PERCENT
t1/2 27 HOUR
Solubility
SLIGHTLY SOLUBLE IN WATER
TARGET HISTAMINE H1 RECEPTOR
PDB
8X64 (CRYOEM STRUCTURE OF THE HISTAMINE H1 RECEPTOR-BRIL, ANTI BRIL FAB COMPLEX WITH DESLORATADINE)
Ligand code = Y5R (link to the list of PDB complexes)
Download experimental 3D coordinates of Y5R with added hydrogens
Histamine H1 receptor UNIPROT P35367 HRH1
Formula:
C19H19ClN2
Calculated chemical properties:
MW 310.81
NB_atoms 22
XLogP 4.02
PSA 21.772
NB_HD 1
NB_HA 2
fsp3 0.32
Lipinski(0=no;1=yes) 1
NB_atoms 22
XLogP 4.02
PSA 21.772
NB_HD 1
NB_HA 2
fsp3 0.32
Lipinski(0=no;1=yes) 1
FDA
NDA 021165 (label) INN (DESLORATADINE) CLARINEX (ORGANON) APPROVAL= AP YEAR= 2001 NEWMOLECULARENTITY
NDA 021297 (label) INN (DESLORATADINE) CLARINEX (SCHERING) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 021312 (label) INN (DESLORATADINE) CLARINEX (ORGANON) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021363 (label) INN (DESLORATADINE) CLARINEX (SCHERING) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 021300 (label) INN (DESLORATADINE) CLARINEX (MERCK SHARP DOHME) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021563 (label) INN (DESLORATADINE) CLARINEX (SCHERING) APPROVAL= AP YEAR= 2004
NDA 021605 (label) INN (DESLORATADINE ; PSEUDOEPHEDRINE SULFATE) CLARINEX D 24 HOUR (ORGANON) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 021313 (label) INN (DESLORATADINE ; PSEUDOEPHEDRINE SULFATE) CLARINEX-D 12 HOUR (ORGANON LLC) APPROVAL= AP YEAR= 2006
NDA 078362 (pdf not found) INN (DESLORATADINE) DESLORATADINE (GLENMARK GENERICS) APPROVAL= TA YEAR= 2009
NDA 078357 (pdf not found) INN (DESLORATADINE) DESLORATADINE (ORBION PHARMS) APPROVAL= AP YEAR= 2010
NDA 078352 (pdf not found) INN (DESLORATADINE) DESLORATADINE (LUPIN PHARMS) APPROVAL= AP YEAR= 2010
NDA 078359 (pdf not found) INN (DESLORATADINE) DESLORATADINE (SUN PHARM INDS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078367 (pdf not found) INN (DESLORATADINE) DESLORATADINE (REDDYS) APPROVAL= AP YEAR= 2010
NDA 078364 (pdf not found) INN (DESLORATADINE) DESLORATADINE (CHARTWELL RX) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078353 (pdf not found) INN (DESLORATADINE) DESLORATADINE (ZYDUS PHARMS USA) APPROVAL= TA YEAR= 2011
NDA 078365 (pdf not found) INN (DESLORATADINE) DESLORATADINE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2011
NDA 078366 (pdf not found) INN (DESLORATADINE ; PSEUDOEPHEDRINE SULFATE) DESLORATADINE AND PSEUDOEPHEDRINE SULFATE 24 HOUR (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2011
NDA 078361 (pdf not found) INN (DESLORATADINE) DESLORATADINE (PERRIGO) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 078351 (pdf not found) INN (DESLORATADINE) DESLORATADINE (DASH PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078355 (pdf not found) INN (DESLORATADINE) DESLORATADINE (AJENAT PHARMS) APPROVAL= AP YEAR= 2012
NDA 202592 (pdf not found) INN (DESLORATADINE) DESLORATADINE (TARO) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 202936 (pdf not found) INN (DESLORATADINE) DESLORATADINE (TARO) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 021165 (label) INN (DESLORATADINE) CLARINEX (ORGANON) APPROVAL= AP YEAR= 2001 NEWMOLECULARENTITY
NDA 021297 (label) INN (DESLORATADINE) CLARINEX (SCHERING) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 021312 (label) INN (DESLORATADINE) CLARINEX (ORGANON) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021363 (label) INN (DESLORATADINE) CLARINEX (SCHERING) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 021300 (label) INN (DESLORATADINE) CLARINEX (MERCK SHARP DOHME) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021563 (label) INN (DESLORATADINE) CLARINEX (SCHERING) APPROVAL= AP YEAR= 2004
NDA 021605 (label) INN (DESLORATADINE ; PSEUDOEPHEDRINE SULFATE) CLARINEX D 24 HOUR (ORGANON) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 021313 (label) INN (DESLORATADINE ; PSEUDOEPHEDRINE SULFATE) CLARINEX-D 12 HOUR (ORGANON LLC) APPROVAL= AP YEAR= 2006
NDA 078362 (pdf not found) INN (DESLORATADINE) DESLORATADINE (GLENMARK GENERICS) APPROVAL= TA YEAR= 2009
NDA 078357 (pdf not found) INN (DESLORATADINE) DESLORATADINE (ORBION PHARMS) APPROVAL= AP YEAR= 2010
NDA 078352 (pdf not found) INN (DESLORATADINE) DESLORATADINE (LUPIN PHARMS) APPROVAL= AP YEAR= 2010
NDA 078359 (pdf not found) INN (DESLORATADINE) DESLORATADINE (SUN PHARM INDS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078367 (pdf not found) INN (DESLORATADINE) DESLORATADINE (REDDYS) APPROVAL= AP YEAR= 2010
NDA 078364 (pdf not found) INN (DESLORATADINE) DESLORATADINE (CHARTWELL RX) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078353 (pdf not found) INN (DESLORATADINE) DESLORATADINE (ZYDUS PHARMS USA) APPROVAL= TA YEAR= 2011
NDA 078365 (pdf not found) INN (DESLORATADINE) DESLORATADINE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2011
NDA 078366 (pdf not found) INN (DESLORATADINE ; PSEUDOEPHEDRINE SULFATE) DESLORATADINE AND PSEUDOEPHEDRINE SULFATE 24 HOUR (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2011
NDA 078361 (pdf not found) INN (DESLORATADINE) DESLORATADINE (PERRIGO) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 078351 (pdf not found) INN (DESLORATADINE) DESLORATADINE (DASH PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078355 (pdf not found) INN (DESLORATADINE) DESLORATADINE (AJENAT PHARMS) APPROVAL= AP YEAR= 2012
NDA 202592 (pdf not found) INN (DESLORATADINE) DESLORATADINE (TARO) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 202936 (pdf not found) INN (DESLORATADINE) DESLORATADINE (TARO) APPROVAL= AP YEAR= 2016 DISCONTINUED