e-Drug3D

862

TELITHROMYCIN

DISCONTINUED

INN
TELITHROMYCIN

cas 191114-48-4

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTI-BACTERIAL AGENTS
KETOLIDE CLASS
BINDING TO DOMAINS II AND V OF 23S RRNA OF THE 50S RIBOSOMAL SUBUNIT

ROUTE (list)

ORAL

ATC code

J01FA15

PK parameters

F 57 PERCENT
Tmax 1 HOUR
VD 188 LITER
Cl 54.6 LITER / HOUR (65 KILOGRAM)
PPB 65 PERCENT
t1/2 10 HOUR

Target

TARGET 50S RIBOSOMAL SUBUNIT

PDB
4V7Z (STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH TELITHROMYCIN.)

Ligand code = TEL (link to the list of PDB complexes)

Download experimental 3D coordinates of TEL with added hydrogens

DrugCentral

Unknown

Download SDF file

(1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone

Formula:
C43H65N5O10

Calculated chemical properties:

MW 812.00
NB_atoms 58
XLogP 4.93
PSA 151.98
NB_HD 1
NB_HA 15
fsp3 0.72
Lipinski(0=no;1=yes) 0

FDA
NDA 021144 (pdf not found) INN (TELITHROMYCIN) KETEK (SANOFI AVENTIS US) APPROVAL= AP YEAR= 2004 NEWMOLECULARENTITY DISCONTINUED