e-Drug3D

860

cas 165800-03-3

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
PROTEIN SYNTHESIS INHIBITORS
OXAZOLIDINONE CLASS
BINDS 23S RIBOSOMAL RNA OF THE 50S SUBUNIT

ROUTE (list)

ORAL INTRAVENOUS

PK parameters

F 100 PERCENT
Tmax 0.51 HOUR
VD 45 LITER
Cl 7.38 LITER / HOUR
PPB 31 PERCENT
t1/2 4.8 HOUR

TARGET 50S RIBOSOMAL SUBUNIT

PDB
4WFA (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LINEZOLID)

Ligand code = ZLD (link to the list of PDB complexes)

Download experimental 3D coordinates of ZLD with added hydrogens

MW 337.35
NB_atoms 24
XLogP 1.12
PSA 76.003
NB_HD 1
NB_HA 7
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 021130 (pdf not found) INN (LINEZOLID) ZYVOX (PFIZER) APPROVAL= AP YEAR= 2000
NDA 021131 (pdf not found) INN (LINEZOLID) ZYVOX (PFIZER) APPROVAL= AP YEAR= 2000
NDA 021132 (pdf not found) INN (LINEZOLID) ZYVOX (PFIZER) APPROVAL= AP YEAR= 2000
NDA 200222 (pdf not found) INN (LINEZOLID) LINEZOLID (TEVA PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078061 (pdf not found) INN (LINEZOLID) LINEZOLID (TEVA PHARMS USA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 078845 (pdf not found) INN (LINEZOLID) LINEZOLID (RISING) APPROVAL= AP YEAR= 2015
NDA 078987 (pdf not found) INN (LINEZOLID) LINEZOLID (GLENMARK SPECLT) APPROVAL= AP YEAR= 2015
NDA 200068 (pdf not found) INN (LINEZOLID) LINEZOLID (HIKMA) APPROVAL= AP YEAR= 2015
NDA 200904 (pdf not found) INN (LINEZOLID) LINEZOLID (SANDOZ) APPROVAL= AP YEAR= 2015
NDA 206473 (pdf not found) INN (LINEZOLID) LINEZOLID IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (HOSPIRA) APPROVAL= AP YEAR= 2015
NDA 204239 (pdf not found) INN (LINEZOLID) LINEZOLID (HETERO LABS LTD V) APPROVAL= AP YEAR= 2015
NDA 204536 (pdf not found) INN (LINEZOLID) LINEZOLID (AMNEAL PHARMS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 205442 (pdf not found) INN (LINEZOLID) LINEZOLID (HOSPIRA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 205233 (pdf not found) INN (LINEZOLID) LINEZOLID (ALEMBIC) APPROVAL= AP YEAR= 2015
NDA 205517 (pdf not found) INN (LINEZOLID) LINEZOLID (ALKEM LABS LTD) APPROVAL= AP YEAR= 2015
NDA 091210 (pdf not found) INN (LINEZOLID) LINEZOLID (GATE PHARMS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 204764 (pdf not found) INN (LINEZOLID) LINEZOLID (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2016
NDA 206917 (pdf not found) INN (LINEZOLID) LINEZOLID (EUGIA PHARMA) APPROVAL= AP YEAR= 2016
NDA 207354 (pdf not found) INN (LINEZOLID) LINEZOLID (NANG KUANG PHARM CO) APPROVAL= AP YEAR= 2016
NDA 207526 (pdf not found) INN (LINEZOLID) LINEZOLID (NOVEL LABS INC) APPROVAL= AP YEAR= 2016
NDA 204696 (pdf not found) INN (LINEZOLID) LINEZOLID (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2017
NDA 206097 (pdf not found) INN (LINEZOLID) LINEZOLID (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 207001 (pdf not found) INN (LINEZOLID) LINEZOLID (HQ SPCLT PHARMA) APPROVAL= AP YEAR= 2017
NDA 205154 (pdf not found) INN (LINEZOLID) LINEZOLID (PHARMOBEDIENT) APPROVAL= AP YEAR= 2017
NDA 210702 (pdf not found) INN (LINEZOLID) LINEZOLID (CHARTWELL RX) APPROVAL= AP YEAR= 2019
NDA 206454 (pdf not found) INN (LINEZOLID) LINEZOLID (HIKMA) APPROVAL= AP YEAR= 2022
NDA 211813 (pdf not found) INN (LINEZOLID) LINEZOLID (HETERO LABS) APPROVAL= AP YEAR= 2022
NDA 210378 (pdf not found) INN (LINEZOLID) LINEZOLID (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024 DISCONTINUED