e-Drug3D

858

cas 51-48-9

CLASS

HORMONES
THYROMIMETIC
ANTICOAGULANTS
SYNTHETIC L-THYROXINE T4
ANTITHYROID AGENTS
HYPOTHYROIDISM

ROUTE (list)

ORAL INTRAVENOUS

PK parameters

F 94 PERCENT
PPB 99 PERCENT
t1/2 156 HOUR

TARGET THYROID HORMONE RECEPTOR

PDB
4X30 (CRYSTAL STRUCTURE OF HUMAN THYROXINE-BINDING GLOBULIN COMPLEXED WITH THYROINE AT 1.55 ANGSTROM RESOLUTION)

Ligand code = T44_4X30 (link to the list of PDB complexes)

Download experimental 3D coordinates of T44_4X30 with added hydrogens

MW 775.84
NB_atoms 24
XLogP 3.22
PSA 89.349
NB_HD 3
NB_HA 5
fsp3 0.13
Lipinski(0=no;1=yes) 0

FDA
NDA 021210 (label) INN (LEVOTHYROXINE SODIUM) UNITHROID (STEVENS J) APPROVAL= AP YEAR= 2000
NDA 021301 (label) INN (LEVOTHYROXINE SODIUM) LEVOXYL (KING PHARMS) APPROVAL= AP YEAR= 2001
NDA 021116 (label) INN (LEVOTHYROXINE SODIUM) THYRO-TABS (ALVOGEN) APPROVAL= AP YEAR= 2002
NDA 021292 (label) INN (LEVOTHYROXINE SODIUM) EUTHYROX (EMD SERONO INC) APPROVAL= AP YEAR= 2002
NDA 021342 (label) INN (LEVOTHYROXINE SODIUM) LEVO-T (CEDIPROF INC) APPROVAL= AP YEAR= 2002
NDA 021402 (label) INN (LEVOTHYROXINE SODIUM) SYNTHROID (ABBVIE) APPROVAL= AP YEAR= 2002
NDA 076187 (label) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (MYLAN) APPROVAL= AP YEAR= 2002
NDA 021137 (label) INN (LEVOTHYROXINE SODIUM) LEVOLET (GENUS LIFESCIENCES) APPROVAL= AP YEAR= 2003
NDA 076764 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (MYLAN) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076752 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (MERCK KGAA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 021924 (label) INN (LEVOTHYROXINE SODIUM) TIROSINT (IBSA) APPROVAL= AP YEAR= 2006
NDA 022121 (label) INN (LEVOTHYROXINE SODIUM) TIROSINT (INSTITUT BIOCHIMIQUE) APPROVAL= AP YEAR= 2007 NEWAPPLICATION OBSOLETE
NDA 202231 (label) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2011
NDA 205366 (label) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (PH HEALTH) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206163 (label) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (PIRAMAL CRITICAL) APPROVAL= AP YEAR= 2016
NDA 206977 (label) INN (LEVOTHYROXINE SODIUM) TIROSINT-SOL (IBSA) APPROVAL= AP YEAR= 2016
NDA 208749 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (MAIA PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 209713 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (LUPIN) APPROVAL= AP YEAR= 2019
NDA 210632 (label) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2019
NDA 210831 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (AMNEAL) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 208837 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (DR REDDYS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 211369 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212399 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2020
NDA 214047 (label) INN (LEVOTHYROXINE SODIUM) THYQUIDITY (STEVENS J) APPROVAL= AP YEAR= 2020
NDA 213256 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (ANI PHARMS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 214253 (label) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (HIKMA) APPROVAL= AP YEAR= 2021
NDA 207588 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (WATSON LABS TEVA) APPROVAL= AP YEAR= 2022
NDA 215809 (label) INN (LEVOTHYROXINE SODIUM) ERMEZA (MYLAN) APPROVAL= AP YEAR= 2022
NDA 211417 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2022
NDA 215259 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 217066 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023
NDA 216414 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217495 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (XIROMED) APPROVAL= AP YEAR= 2024
NDA 216729 (pdf not found) INN (LEVOTHYROXINE SODIUM) LEVOTHYROXINE SODIUM (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2025