e-Drug3D

856

ALOSETRON

INN
ALOSETRON

cas 122852-42-0

CLASS

METABOLISM
IRRITABLE BOWEL SYNDROME (THERAPEUTIC)
ANTIEMETIC
5-HT3 RECEPTOR ANTAGONIST
GASTROINTESTINAL AGENTS
SEROTONIN ANTAGONISTS

ROUTE (list)

ORAL

ATC code

A03AE01

PK parameters

F 55 PERCENT
Tmax 1 HOUR
VD 80 LITER
Cl 36 LITER / HOUR
PPB 82 PERCENT
t1/2 1.5 HOUR

Solubility

OF 61 MILLIGRAM / MILLILITER IN WATER

Target

TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR

DrugCentral

5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A

Download SDF file

5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one

Formula:
C17H18N4O

Calculated chemical properties:

MW 294.35
NB_atoms 22
XLogP 2.41
PSA 48.252
NB_HD 1
NB_HA 5
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 021107 (pdf not found) INN (ALOSETRON HYDROCHLORIDE) LOTRONEX (LEGACY PHARMA) APPROVAL= AP YEAR= 2000
NDA 200652 (pdf not found) INN (ALOSETRON HYDROCHLORIDE) ALOSETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206647 (pdf not found) INN (ALOSETRON HYDROCHLORIDE) ALOSETRON HYDROCHLORIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 206113 (pdf not found) INN (ALOSETRON HYDROCHLORIDE) ALOSETRON HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209180 (pdf not found) INN (ALOSETRON HYDROCHLORIDE) ALOSETRON HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2019
NDA 211621 (pdf not found) INN (ALOSETRON HYDROCHLORIDE) ALOSETRON HYDROCHLORIDE (HIBROW HLTHCARE) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 213614 (pdf not found) INN (ALOSETRON HYDROCHLORIDE) ALOSETRON HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2020