e-Drug3D

854

cas 151096-09-2

CLASS

ANTIINFECTIVE
FLUOROQUINOLONE ANTIBACTERIAL
ANTIBIOTIC
QUINOLONES

ROUTE (list)

ORAL INTRAVENOUS OPHTHALMIC

PK parameters

F 90 PERCENT
Tmax 2 HOUR
VD 143 LITER (65 KILOGRAM)
Cl 12 LITER / HOUR
PPB 40 PERCENT
t1/2 12.7 HOUR

TARGET TOPOISOMERASE II (DNA GYRASE)
TOPOISOMERASE 4

PDB
5CDQ (2.95A STRUCTURE OF MOXIFLOXACIN WITH S.AUREUS DNA GYRASE AND DNA)

Ligand code = MFX (link to the list of PDB complexes)

Download experimental 3D coordinates of MFX with added hydrogens

MW 400.42
NB_atoms 29
XLogP 1.04
PSA 77.919
NB_HD 1
NB_HA 7
fsp3 0.52
Lipinski(0=no;1=yes) 1

FDA
NDA 021085 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) AVELOX (BAYER HLTHCARE) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021277 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) AVELOX IN SODIUM CHLORIDE 0.8% IN PLASTIC CONTAINER (BAYER HLTHCARE) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 021334 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) AVELOX (BAYER PHARMS) APPROVAL= AP YEAR= 2001 NEWAPPLICATION
NDA 021598 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) VIGAMOX (HARROW EYE) APPROVAL= AP YEAR= 2003
NDA 078073 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (TEVA PHARMS) APPROVAL= TA YEAR= 2009
NDA 022428 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXEZA (HARROW EYE) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 076938 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2014
NDA 077437 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014
NDA 200160 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202632 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2014
NDA 202867 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2014
NDA 202525 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (ADAPTIS) APPROVAL= AP YEAR= 2015
NDA 204079 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2015
NDA 205572 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2015
NDA 204635 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (NATCO) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 205348 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (CROSSMEDIKA SA) APPROVAL= AP YEAR= 2016
NDA 090080 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2017
NDA 202916 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 205833 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE IN SODIUM CHLORIDE 0.8% IN PLASTIC CONTAINER (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017
NDA 207285 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2017
NDA 206242 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2017
NDA 208682 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2017
NDA 206295 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (SUNSHINE) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209469 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 206447 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 208778 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (GLAND) APPROVAL= AP YEAR= 2020
NDA 212616 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2021
NDA 204836 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2023
NDA 209698 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 217988 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2025
NDA 219475 (pdf not found) INN (MOXIFLOXACIN HYDROCHLORIDE) MOXIFLOXACIN HYDROCHLORIDE (FDC LTD) APPROVAL= AP YEAR= 2025