e-Drug3D

851

PROGUANIL

INN
PROGUANIL

(has an active metabolite)

cas 500-92-5

CLASS

ANTIPARASITIC
ANTIMALARIAL
ANTIMETABOLITES
DIHYDROFOLATE REDUCTASE INHIBITOR

ROUTE (list)

ORAL

ATC code

P01BB52
P01BB01
P01BB51

PK parameters

Tmax 3.5 HOUR
VD 2059 LITER
Cl 67.9 LITER / HOUR
PPB 75 PERCENT
t1/2 16.5 HOUR

Solubility

SPARINGLY SOLUBLE IN WATER

Target

TARGET DIHYDROFOLATE REDUCTASE

DrugCentral

Bifunctional dihydrofolate reductase-thymidylate synthase UNIPROT P13922

Download SDF file

1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-ylguanidine

Formula:
C11H16ClN5

Calculated chemical properties:

MW 253.74
NB_atoms 17
XLogP 1.79
PSA 71.021
NB_HD 5
NB_HA 5
fsp3 0.27
Lipinski(0=no;1=yes) 1

FDA
NDA 021078 (label) INN (ATOVAQUONE ; PROGUANIL HYDROCHLORIDE) MALARONE (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2000
NDA 091211 (pdf not found) INN (ATOVAQUONE ; PROGUANIL HYDROCHLORIDE) ATOVAQUONE AND PROGUANIL HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2011
NDA 202362 (pdf not found) INN (ATOVAQUONE ; PROGUANIL HYDROCHLORIDE) ATOVAQUONE AND PROGUANIL HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2014