e-Drug3D

850

cas 111025-46-8

CLASS

METABOLISM
ANTIDIABETIC
HYPOGLYCEMIC AGENTS
THAZOLIDINEDIONES
PPAR GAMMA AGONIST

ROUTE (list)

ORAL

PK parameters

Tmax 2 HOUR
VD 41 LITER (65 KILOGRAM)
Cl 6 LITER / HOUR
PPB 99 PERCENT
t1/2 5 HOUR

TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA

PDB
4A79 (CRYSTAL STRUCTURE OF HUMAN MONOAMINE OXIDASE B (MAO B) IN COMPLEX WITH PIOGLITAZONE)

Ligand code = P1B (link to the list of PDB complexes)

Download experimental 3D coordinates of P1B with added hydrogens

MW 356.44
NB_atoms 25
XLogP 3.16
PSA 69.489
NB_HD 1
NB_HA 5
fsp3 0.32
Lipinski(0=no;1=yes) 1

FDA
NDA 021073 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) ACTOS (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 1999
NDA 021842 (pdf not found) INN (METFORMIN HYDROCHLORIDE ; PIOGLITAZONE HYDROCHLORIDE) ACTOPLUS MET (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2005
NDA 076799 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE (ALPHAPHARM) APPROVAL= TA YEAR= 2005
NDA 021925 (pdf not found) INN (GLIMEPIRIDE ; PIOGLITAZONE HYDROCHLORIDE) DUETACT (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2006
NDA 022024 (pdf not found) INN (METFORMIN HYDROCHLORIDE ; PIOGLITAZONE HYDROCHLORIDE) ACTOPLUS MET XR (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090406 (pdf not found) INN (METFORMIN HYDROCHLORIDE ; PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 076798 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2012
NDA 076801 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078472 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (AVIV PHARMA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 200823 (pdf not found) INN (METFORMIN HYDROCHLORIDE ; PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2013
NDA 202001 (pdf not found) INN (METFORMIN HYDROCHLORIDE ; PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE (TORRENT PHARMS LTD) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202467 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2013
NDA 022426 (pdf not found) INN (ALOGLIPTIN BENZOATE ; PIOGLITAZONE HYDROCHLORIDE) OSENI (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2013
NDA 078383 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 078670 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2013
NDA 091273 (pdf not found) INN (METFORMIN HYDROCHLORIDE ; PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 091298 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (TORRENT PHARMS LTD) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 200044 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013
NDA 200268 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2013
NDA 201049 (pdf not found) INN (GLIMEPIRIDE ; PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE AND GLIMEPIRIDE (SANDOZ) APPROVAL= AP YEAR= 2013
NDA 202456 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2013
NDA 077210 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014
NDA 091155 (pdf not found) INN (METFORMIN HYDROCHLORIDE ; PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014
NDA 204133 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (ANNORA PHARMA) APPROVAL= AP YEAR= 2014
NDA 204802 (pdf not found) INN (METFORMIN HYDROCHLORIDE ; PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2015
NDA 206738 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (PURACAP PHARM LLC) APPROVAL= AP YEAR= 2017
NDA 207806 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (PRINSTON INC) APPROVAL= AP YEAR= 2018
NDA 210165 (pdf not found) INN (PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE (COREPHARMA) APPROVAL= AP YEAR= 2021