e-Drug3D

847

cas 153559-49-0

CLASS

ANTILEOPLASTIC
RETINOID RECEPTOR RXRS AGONIST
ANTINEOPLASTIC
ANTICANCER
ANTICARCINOGENIC AGENTS

ROUTE (list)

ORAL TOPICAL

PK parameters

Tmax 2 HOUR
PPB 99 PERCENT
t1/2 7 HOUR

TARGET RETINOIC ACID RECEPTOR RXR ALPHA
RETINOIC ACID RECEPTOR RXR BETA
RETINOIC ACID RECEPTOR RXR GAMMA

PDB
4K6I (CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH TARGRETIN AND THE COACTIVATOR PEPTIDE GRIP-1)

Ligand code = 9RA (link to the list of PDB complexes)

Download experimental 3D coordinates of 9RA with added hydrogens

MW 347.46
NB_atoms 26
XLogP 4.77
PSA 35.048
NB_HD 0
NB_HA 2
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 021055 (pdf not found) INN (BEXAROTENE) TARGRETIN (VALEANT LUXEMBOURG) APPROVAL= AP YEAR= 1999 NEWMOLECULARENTITY
NDA 021056 (pdf not found) INN (BEXAROTENE) TARGRETIN (BAUSCH) APPROVAL= AP YEAR= 2000
NDA 203174 (pdf not found) INN (BEXAROTENE) BEXAROTENE (BIONPHARMA) APPROVAL= AP YEAR= 2014
NDA 209861 (pdf not found) INN (BEXAROTENE) BEXAROTENE (ANI PHARMS) APPROVAL= AP YEAR= 2018
NDA 209886 (pdf not found) INN (BEXAROTENE) BEXAROTENE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2018
NDA 210105 (pdf not found) INN (BEXAROTENE) BEXAROTENE (AMNEAL PHARMS NY) APPROVAL= AP YEAR= 2018
NDA 203663 (pdf not found) INN (BEXAROTENE) BEXAROTENE (HIKMA) APPROVAL= AP YEAR= 2020
NDA 209931 (pdf not found) INN (BEXAROTENE) BEXAROTENE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2021
NDA 215398 (pdf not found) INN (BEXAROTENE) BEXAROTENE (AMNEAL) APPROVAL= AP YEAR= 2022
NDA 208628 (pdf not found) INN (BEXAROTENE) BEXAROTENE (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2024
NDA 210352 (pdf not found) INN (BEXAROTENE) BEXAROTENE (CIPLA) APPROVAL= AP YEAR= 2024 DISCONTINUED