e-Drug3D

844

ZANAMIVIR

INN
ZANAMIVIR

cas 139110-80-8

CLASS

ANTIINFECTIVES
ANTIVIRAL
ANTIINFLUENZA
NEURAMINIDASE INHIBITOR

ROUTE (list)

INHALATION

ATC code

J05AH01

PK parameters

F 10.5 PERCENT
Tmax 1.5 HOUR
VD 14.9 LITER (65 KILOGRAM)
Cl 6.7 LITER / HOUR
PPB 10 PERCENT
t1/2 3.8 HOUR

Solubility

18 MILLIGRAM / MILLILITER IN WATER

Target

TARGET NEURAMINIDASE

PDB
3TIC (CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR)

Download experimental 3D coordinates of ZMR with added hydrogens

Neuraminidase UNIPROT P03468

Neuraminidase UNIPROT P03474

Download SDF file

(4S,5R,6R)-5-acetamido-4-(diaminomethylideneamino)-6-[(1R,2R)-1,2,3-trihydroxypropyl]-5,6-dihydro-4H-pyran-2-carboxylic acid

Formula:
C12H20N4O7

Calculated chemical properties:

MW 331.31
NB_atoms 23
XLogP -5.12
PSA 189.872
NB_HD 8
NB_HA 11
fsp3 0.58
Lipinski(0=no;1=yes) 0

FDA
NDA 021036 (label) INN (ZANAMIVIR) RELENZA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1999