e-Drug3D

840

cas 59865-13-3

CLASS

IMMUNOMODULATORY AGENT
PRODUCED AS A METABOLITE BY THE FUNGUS SPECIES BEAUVERIA NIVEA

ROUTE (list)

OPHTHALMIC INJECTION ORAL

PK parameters

F 30 PERCENT
Tmax 3.5 HOUR
VD 214 LITER
Cl 29.2 LITER / HOUR
PPB 90 PERCENT
t1/2 19 HOUR

TARGET PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (CYCLOPHILIN)

PDB
2WFJ (ATOMIC RESOLUTION CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF HUMAN CYCLOPHILIN G IN COMPLEX WITH CYCLOSPORIN A)

Ligand code = CYCLOSPORINEA (link to the list of PDB complexes)

Download experimental 3D coordinates of CYCLOSPORINEA with added hydrogens

MW 1202.62
NB_atoms 85
XLogP 3.27
PSA 235.82
NB_HD 5
NB_HA 23
fsp3 0.79
Lipinski(0=no;1=yes) 0

FDA
NDA 050573 (pdf not found) INN (CYCLOSPORINE) SANDIMMUNE (NOVARTIS) APPROVAL= AP YEAR= 1983 NEWMOLECULARENTITY
NDA 050574 (pdf not found) INN (CYCLOSPORINE) SANDIMMUNE (NOVARTIS) APPROVAL= AP YEAR= 1983
NDA 050625 (pdf not found) INN (CYCLOSPORINE) SANDIMMUNE (NOVARTIS) APPROVAL= AP YEAR= 1990
NDA 050715 (pdf not found) INN (CYCLOSPORINE) NEORAL (NOVARTIS) APPROVAL= AP YEAR= 1995
NDA 050716 (pdf not found) INN (CYCLOSPORINE) NEORAL (NOVARTIS) APPROVAL= AP YEAR= 1995
NDA 050735 (pdf not found) INN (CYCLOSPORINE) NEORAL (NOVARTIS) APPROVAL= AP YEAR= 1997 NEWAPPLICATION
NDA 050736 (pdf not found) INN (CYCLOSPORINE) NEORAL (NOVARTIS) APPROVAL= AP YEAR= 1997 NEWAPPLICATION
NDA 050737 (pdf not found) INN (CYCLOSPORINE) NEORAL (NOVARTIS) APPROVAL= AP YEAR= 1997 NEWAPPLICATION
NDA 050738 (pdf not found) INN (CYCLOSPORINE) NEORAL (NOVARTIS) APPROVAL= AP YEAR= 1997 NEWAPPLICATION
NDA 064195 (pdf not found) INN (CYCLOSPORINE) SANGCYA (SANGSTAT MEDCL) APPROVAL= AP YEAR= 1998 DISCONTINUED OBSOLETE
NDA 065004 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (HIKMA) APPROVAL= AP YEAR= 1999
NDA 065003 (pdf not found) INN (CYCLOSPORINE) GENGRAF (ABBVIE) APPROVAL= AP YEAR= 2000
NDA 065017 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (SANDOZ) APPROVAL= AP YEAR= 2000
NDA 065025 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (ABBVIE) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 065044 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2000
NDA 065054 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 050790 (pdf not found) INN (CYCLOSPORINE) RESTASIS (ABBVIE) APPROVAL= AP YEAR= 2002
NDA 065040 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (APOTEX) APPROVAL= AP YEAR= 2002
NDA 021023 (pdf not found) INN (CYCLOSPORINE) RESTASIS (ALLERGAN) APPROVAL= AP YEAR= 2003
NDA 065151 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (PADAGIS US) APPROVAL= AP YEAR= 2003
NDA 065133 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (PHARMOBEDIENT CNSLTG) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 065078 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2005
NDA 065110 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2005
NDA 065167 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (PHARM ASSOC) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 210913 (pdf not found) INN (CYCLOSPORINE) CEQUA (SUN PHARM) APPROVAL= AP YEAR= 2018
NDA 210721 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (APOTEX) APPROVAL= AP YEAR= 2019
NDA 214965 (pdf not found) INN (CYCLOSPORINE) VERKAZIA (HARROW EYE) APPROVAL= AP YEAR= 2021
NDA 205894 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (MYLAN) APPROVAL= AP YEAR= 2022
NDA 216046 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2022
NDA 207606 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (APOTEX) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 217469 (pdf not found) INN (CYCLOSPORINE) VEVYE (HARROW EYE) APPROVAL= AP YEAR= 2023
NDA 203880 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2023
NDA 209811 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (DEVA HOLDING AS) APPROVAL= AP YEAR= 2024
NDA 211943 (pdf not found) INN (CYCLOSPORINE) CYCLOSPORINE (SAPTALIS PHARMS) APPROVAL= AP YEAR= 2024